Best Large Grants for Nonprofit Organizations in Missouri

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA State Fund Grant Program - Missouri

The Friends of NRA State Fund Grant Program provides supplies, equipment, and financial support to a variety of qualified groups and programs at the local level; geared towards youth, women, law enforcement, veterans, the disabled, and the general public, including:

• General shooting programs
• Competitive shooting
• Education, training and safety
• Hunting and conservation
• Community outreach
• Historical education

Grant funding must be used to further a charitable purpose as defined by the Internal Revenue Code under section 501(c)(3) and accompanying rules, regulations, and other IRS law and materials.

SITKA Ecosystem Grants support projects that enhance ecosystems and promote conservation efforts. These grants encourage both grassroots initiatives and larger organizational projects, aiming to improve habitat restoration, biodiversity, and the hunting experience. With funding ranging from $3,000 to $20,000, applicants must be 18 years or older and have relevant experience. The review process is ongoing, and projects should emphasize collaboration and measurable impacts on environmental goals, benefiting both society and ecosystems.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The Norfolk Southern In-Kind Donation Grant supports organizations seeking physical donations of materials that align with their focus areas, including safety, sustainability, workforce development, and thriving communities. This grant is available year-round, with no application deadline. Recipients must be located within Norfolk Southern territory and are encouraged to apply for resources that will enhance their community projects and initiatives, fostering growth and resilience.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Community Development Block Grant (CDBG) program provides federal funding to non-entitlement cities and counties to improve infrastructure, support community facilities, and strengthen local economies in ways that primarily help low-to-moderate income people while addressing local health and safety concerns. Project awards are available in several categories for a wide range of community development initiatives.

Emergency funding is available for projects that address a serious and immediate threat to the health and welfare of the community. The condition must be of recent origins (within 18 months of the event that caused the emergency), and the applicant must demonstrate that other financial resources are not available to address the need. All proposed activities must meet applicable CDBG eligibility requirements and a national objective. Emergency projects are typically evaluated under the Urgent Need national objective. Proposals are accepted at any time, but must be submitted within the required 18-month period. CDBG staff will review the proposal for eligibility and then invite the community to apply if conditions are met. 

To apply for an emergency project, please first reach out to the CDBG Project Development team for consult on the project. This will help ensure eligibility. Once the approval has been given for submitting an application, one of the team members will provide an application. It is encouraged to also reach out to the environmental review team to better understand what is needed and what can be waived for the emergency project.

The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Missouri Building Entrepreneurial Capacity: Operations Support Grant, provided by the Missouri Technology Corporation, aims to enhance the growth of high-tech companies in Missouri. This grant supports the operational needs of organizations fostering entrepreneurship and innovation. With funding amounts ranging from $150,000 for one year to $500,000 for three years, it facilitates day-to-day operations and strategic projects, excluding those already receiving MOBEC Project Support funding.

The Missouri Building Entrepreneurial Capacity (MOBEC) program, led by the Missouri Technology Corporation, aims to foster innovation and entrepreneurship. By providing targeted project support grants, MOBEC facilitates the growth of high-tech companies in Missouri. This initiative strengthens the state's innovation economy and supports entrepreneurs in commercializing new technologies. The funding is strictly allocated to specific projects, ensuring that resources are used effectively to enhance the entrepreneurial ecosystem and promote sustainable economic development.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

About

Being deeply connected to the community means more than providing access to excellent healthcare. It means understanding, and investing in, the health needs of our community.

Through our Community Investment Fund (CIF), Endeavor Health has awarded more than $38.5 million to 59 local partnerships dedicated to enhancing community health and wellbeing, advancing health equity and supporting local economic growth. Together, we’re committed to helping everyone in our communities be their best.

Award categories

Through the CIF, we will make meaningful and intentional investments through impact awards and capacity builder awards. These awards are intended to meaningfully advance the health of our community over time towards three bold aspirations through investments in five areas of focus.

We aspire to a future where:

• A person’s zip code does not determine how long they will live
• Hunger and homelessness in our communities are history
• The healthcare workforce is thriving and representative of the communities we serve

To help advance these aspirations, the CIF will invest in the following areas:

• Access to healthcare
• Behavioral health
• Food insecurity
• Housing insecurity
• Workforce development for careers in healthcare

Impact awards

• Designed for 5-year initiatives where organizations come together to drive measurable impact and longer-term change in the communities we serve by improving existing systems and innovation
• Emphasize strategic cross-sector and/or intra-sector partnerships between community-based organizations
• Uplift community members of greatest need
• Directly align with CIF areas of focus and meaningfully contribute to CIF goals
• Award amount: $1 million per year, up to 5 years

The CIF Capacity Builder Awards by Endeavor Health focus on enhancing community health through strategic investments. With over $38.5 million allocated to local partnerships, these awards aim to address critical areas like healthcare access, food insecurity, and workforce development. Designed for nonprofit organizations, the awards range from $100,000 to $500,000 annually for 1-2 years, fostering long-term community impact and advancing health equity in the service areas.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

• Creating Safe Communities
  • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
  • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

• Creating Strong Communities
  • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
  • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
  • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
• Additional Community Commitments
  • United Way: Employee donation matching in all markets.
  • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
  • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

Carney’s Kids Foundation is dedicated to improving the lives of children and young adults through financial support and positive publicity for non-profit organizations. By hosting community events and fundraising activities, the foundation partners with over 50 charities to enhance children's physical, emotional, and mental well-being. Their mission includes providing educational assistance and supporting families in need, ensuring disadvantaged children have pathways to realize their potential. This commitment reflects a holistic approach to child welfare in the community.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Kerr Foundation Inc. offers grants to 501(c)3 organizations, focusing on education, arts, health, and human services. Priority is given to Oklahoma entities, but applications from neighboring states and Washington D.C. are also accepted. The foundation supports various project types, including capital, program, and operating expenses. Note that back-to-back grants are not allowed, enforcing a three-year gap for reapplication after funding. This ensures a broad and impactful reach for community development.

The Patterson Family Foundation is inviting innovative proposals to enhance community engagement in rural areas. With a focus on projects that foster long-term involvement from all generations, the Foundation aims to support initiatives that contribute to the mission of thriving rural communities. To apply, organizations must be located within the Foundation's Kansas and western Missouri catchment and possess nonprofit status. Early submission of the Letter of Intent is highly recommended for timely review.

Mid-America Arts Alliance

Mid-America Arts Alliance (M-AAA) believes art can be a catalyst for expression, connection, collaboration, and community. This philosophy is reflected in our mission and values.

M-AAA is a nonprofit, regional arts organization representing Arkansas, Kansas, Missouri, Nebraska, Oklahoma, Texas, and beyond. We focus on strengthening communities and improving lives by supporting artists, elevating arts organizations, and connecting people to extraordinary cultural experiences.

Artistic Innovations Grants for Individual Artists

Program Objectives

The Artistic Innovations program supports the development of new or original works of art across all disciplines, created exclusively by in-region individual artists and art-based organizations in M-AAA’s six-state region (Arkansas, Kansas, Missouri, Nebraska, Oklahoma, Texas, and the Native Nations in this geography). Eligible applicants include individual artists and nonprofit 501(c)(3) arts organizations in the region.

Individual Artist Grant Considerations

The Artistic Innovations grant program supports direct project expenses incurred in the art-making process and production of public-facing engagements to individuals through private funds. These grants are funded through private support and, unlike Artistic Innovations grants to organizations, are not supported by the National Endowment for the Arts.