Best Large Grants for Nonprofit Organizations in Missouri

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

The Looking Out Foundation Grant supports social justice and humanitarian initiatives, having donated nearly $6 million to various causes globally. With an average donation of $25 per campaign, it aids organizations focused on disaster relief, racial justice, and support for marginalized communities. Eligible applicants must be tax-exempt public charities under Section 501(c)(3). The foundation prioritizes diverse funding sources and encourages organizations to adapt to changing needs, with grant allocations ranging from $5,000 to $25,000.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

Ecolab Foundation

Ecolab Foundation is a philanthropic arm of Ecolab dedicated to advancing community well-being through programs that promote education, environmental stewardship, and public health. Its mission is to create positive social impact by supporting initiatives that strengthen communities and foster sustainable development.

The foundation’s primary areas of engagement include educational programs that enhance learning and workforce readiness, environmental projects that encourage conservation and sustainability, and health-related initiatives that improve hygiene and safety. It focuses on partnerships that deliver measurable benefits and long-term impact.

Ecolab Foundation operates primarily within the United States while also supporting global initiatives aligned with its corporate responsibility goals. Its geographic scope reflects a commitment to addressing local community needs and contributing to broader sustainability efforts.

The foundation collaborates with nonprofit organizations, educational institutions, and community-based groups. It prioritizes partnerships that demonstrate strong governance, clear objectives, and alignment with its mission of education, health, and environmental responsibility.

Ecolab Match Program

Ecolab established the Volunteer and Community Relations programs to encourage and reward Ecolab employee and alumni involvement in the communities where people live and work. There are three programs including the Board Leadership Volunteer Grant.

Board Leadership Volunteer Grant

Ecolab will donate up to $500 USD annually to a qualifying 501(c)3 organization (some restrictions apply) for which an eligible person serves on the Board of Directors. 

Focus Areas of Giving

• Youth and Education: programs that promote youth development, particularly for programs that ensure all students are successful
• Civic & Community Development: affordable housing, work readiness, crisis assistance and hunger relief
• Environment & Conservation: hands-on environmental learning programs, environment and conservation organizations
• Arts & Culture: arts education for children and youth as well as support for museums and the performing arts

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. 

Connors, Helen L Memorial Scholarship

This fund was established in memory of Jim and Helen Connors by their family to provide academic scholarships to graduating seniors attending public and private schools in St Joseph, MO or Mid-Buchanan High School, majoring in nursing, music, law enforcement or theatre. Jim had many occupations throughout his life including actor, weatherman for KQ2, wresting announcer, but most notably retiring from the St Joseph Police Department as Commander after 33 years. Helen was a CRNA for 40 years and a lifelong musician. She specialized in piano and voice but also played the trombone.

Scholarships will be awarded on an annual basis and disbursed in August.

The IWF General Operating Grant, offered by the Incarnate Word Foundation Missouri, supports organizations committed to community empowerment through equity and compassion. Grants typically range from $3,000 to $10,000 and can be utilized for general operating support rather than specific projects. Eligible applicants should demonstrate a strong mission commitment, maintain community partnerships, and possess valid 501(c)(3) status, among other criteria. This grant seeks to foster innovative solutions for systemic social issues.

The Doree Taylor Charitable Foundation supports charitable organizations focused on basic provisions for underserved populations, humane care of animals, health care services, public media, and environmental initiatives. The foundation prioritizes organizations in Boothbay Harbor, Southport, and Brunswick, and encourages requests for general operating support, program support, and capital projects, while maintaining a focus on the impact of their services.

The Japan – U.S. Global Partnership Grant Program aims to foster collaborative projects addressing global issues through partnerships between Japanese and American organizations. It focuses on policy-oriented research and dialogue among diverse professionals, including academia and grassroots practitioners. Key thematic areas include resilience, inclusivity, and advancements in science and technology. Projects outside these themes may also be eligible if aligned with grant goals, covering topics like climate change, public health, and digital transformation.

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

The Allen P. and Josephine B. Green Foundation Grant aims to enhance the quality of life in Missouri by supporting 501(c)(3) non-profit organizations. With a focus on human services, education, and community health, the foundation provides grants ranging from $1,000 to $50,000 annually. The application process is competitive, with deadlines twice a year, ensuring substantial support for impactful community projects. Interested organizations can find more details and apply through the foundation's website.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

The External Collaborative Research (ECR) program by Boehringer Ingelheim invites academic and community scientists to propose collaborative studies aimed at protocol development and result publication. This program offers potential drug and financial support, excluding direct salary for the Principal Investigator. Budgets must represent fair market value and will be negotiated further. Research interests span therapeutic areas including Cardio-Renal-Metabolic, Mental Health, Dermatology, and Oncology, encouraging innovative solutions to unmet medical needs.

SITKA Ecosystem Grants support projects that enhance ecosystems and promote conservation efforts. These grants encourage both grassroots initiatives and larger organizational projects, aiming to improve habitat restoration, biodiversity, and the hunting experience. With funding ranging from $3,000 to $20,000, applicants must be 18 years or older and have relevant experience. The review process is ongoing, and projects should emphasize collaboration and measurable impacts on environmental goals, benefiting both society and ecosystems.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research. 

Distinguished Contribution Award

The purpose of the Distinguished Contribution Award is to recognize the scientific contribution of a member who has conducted or promoted research, which has enhanced the science and practice of nursing in the MNRS region.

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research. 

Harriet H. Werley New Investigator Award

The purpose of the Harriet H. Werley New Investigator Award is to recognize the scientific contribution of a new investigator who has conducted nursing research that has the potential to enhance the science and practice of nursing.

The Postdoctoral Grant Program at the University of Wisconsin School of Medicine and Public Health aims to support the growth and professional development of postdoctoral trainees, fellows, and associates. With funding up to $20,000 for one year, recipients can engage in independent research projects, attend workshops, or cover open-access publication fees. This initiative enhances research capacity and promotes health equity in Wisconsin, addressing critical health challenges while fostering career advancement in the medical field.

The NRCS' Feral Swine Eradication and Control Pilot Program for FY 2026 aims to combat the environmental and agricultural threats posed by invasive feral swine. With over $3.4 billion in annual damage attributed to these species, the program seeks to mitigate their impact on ecosystems and human health. Funded by the USDA, this initiative targets states with high feral swine populations, emphasizing collaborative efforts with State Technical Committees to implement effective control measures.

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research.

MNRS Distinguished Service Award

The Distinguished Service Award recognizes an MNRS member who has demonstrated sustained influential leadership and service to the organization, such as chairing committees, organizing annual conference activities, or serving on the Board of Directors. 

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research.

MNRS Lifetime Achievement Award

The Lifetime Achievement Award recognizes an MNRS member who has significantly advanced the profession of nursing either through an extensive program of research or creation of environments where research can flourish, and whose sustained leadership and distinguished career yielded outstanding and noteworthy accomplishments. 

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

Midwest Nursing Research Society (MNRS)

The MNRS originally began to provide a place for nurses to collaborate, and collaborate they did! Over time, the founding members began to realize the benefits of having an organization dedicated specifically to nursing research. With some careful attention and a lot of hard work, we have grown into the organization it is today. We're a society where scientists, innovators, and drivers of clinical practice across the career trajectory, come together to share ideas and grow our field through innovative research.

The mission of the MNRS is to generate knowledge, translate evidence into practice, and enhance careers through collaborative engagement, implementation, and dissemination among diverse scholars. Our Vision to be the premier society that advances science, fosters leadership, and drives dissemination to improve health equity for all people.

It is an honor to recognize the important contributions of our nursing colleagues. MNRS accepts nominations for our five very prestigious awards to selected members of the Society who have made significant and notable contributions to the field of nursing through research.

The Excellence in Diversity, Equity, & Inclusion Award

The purpose of the Excellence in Diversity, Equity, and Inclusion Award is to recognize the contribution of a member who has demonstrated outstanding commitment and made significant contributions to advance equitable health outcomes and reduce health disparities through research, which has enhanced the science and practice of nursing in the MNRS region.  

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

The Norfolk Southern In-Kind Donation Grant supports organizations seeking physical donations of materials that align with their focus areas, including safety, sustainability, workforce development, and thriving communities. This grant is available year-round, with no application deadline. Recipients must be located within Norfolk Southern territory and are encouraged to apply for resources that will enhance their community projects and initiatives, fostering growth and resilience.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.