Best Large Grants for Nonprofit Organizations in Missouri

The Missouri Housing Trust Fund, established in 1994, aims to address the housing needs of very low-income families and individuals in Missouri. Managed by the Missouri Housing Development Commission, it allocates funds for homeless prevention, rental assistance, and home repairs. The fund prioritizes individuals earning at or below 25% of the area median income, ensuring that resources effectively target the most vulnerable populations. Grants are capped at $150,000 per type and $300,000 per application.

The NCR-SARE Farmer Rancher Grant Program provides critical funding for farmers and ranchers seeking sustainable agricultural solutions. Launched in 1992, this competitive program supports innovative on-farm research and education projects, allowing individuals to apply for grants up to $15,000 or collaborate for up to $30,000. By empowering farmers with resources, NCR-SARE encourages practices that enhance livelihoods while promoting environmental stewardship.

The U.S. Healthcare Donations program by Amgen aims to support not-for-profit organizations in the healthcare sector. As a leading biotechnology company, Amgen provides funding for initiatives that improve science, technology, education, and public awareness on medical conditions. Organizations eligible for funding must be tax-exempt entities, focusing on genuine philanthropic efforts that align with Amgen's mission to enhance health outcomes and reduce the burden of diseases.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

The THCF: Community Grants for Wildlife Conservation supports initiatives across Missouri, encouraging proposals that enhance regional wildlife efforts. Starting in 2024, organizations can apply for funding for up to three consecutive years, promoting sustainability and impactful conservation projects. Eligible applicants include nonprofits dedicated to improving wildlife habitats and conservation strategies. This program aims to foster collaboration and maximize funding impacts to benefit the local ecosystem and communities throughout the state.

The Ralph J. Torraco Food Bank/Shelter Fund Grant, offered by the UNICO Foundation Inc., aims to combat hunger and provide shelter for the homeless and indigent. Eligible applicants include registered non-profit food pantries, soup kitchens, and shelters in 13 U.S. states. The grant focuses on direct services, ensuring that all funds are used for food and shelter, not for operating expenses, thereby promoting effective community support for vulnerable populations.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

The Community Development Block Grant (CDBG) program provides federal funding to non-entitlement cities and counties to improve infrastructure, support community facilities, and strengthen local economies in ways that primarily help low-to-moderate income people while addressing local health and safety concerns. Project awards are available in several categories for a wide range of community development initiatives.

The Water/Wastewater category provides funding for communities to make improvements to drinking water and wastewater systems, in partnership with the Missouri Department of Natural Resources and the US Department of Agriculture, Rural Development. Proposals can be obtained from the main funding partner at the time a gap in financing is identified. The Missouri Water and Wastewater Review Committee will help determine financing structures available among the participating agencies. If a need for CDBG funding is identified, the community will be invited to make full application.

Grants may be used for construction that is related to water treatment and distribution, and sewer treatment and collection for publicly owned systems. Operation and maintenance activities and not eligible. 

The WNAN Natural History Research Grant supports research in biological natural history within western North America. Grants of up to $2,500 are available for five authors to assist with travel, supplies, and other research-related expenses. This initiative particularly encourages applicants from institutions where research is not the primary focus, aiming to foster diverse contributions to natural history.

The Emergency Solutions Grant (ESG) Program, offered by the Missouri Housing Development Commission, aims to provide essential housing assistance to homeless or nearly homeless individuals in Missouri. With an anticipated funding of up to $2,858,041, the program prioritizes activities like rapid re-housing, street outreach, and homelessness prevention. The competitive allocation process ensures funds are effectively used to support community initiatives that stabilize housing and prevent homelessness, aligning with HUD regulations.

Missouri Department of Natural Resources

Missouri’s air, land and water resources play an important role in our health and are essential to the environmental and economic vitality of our state. The department aspires to help Missouri citizens thrive by advancing environmental and economic sustainability. The department provides a range of services to help Missouri citizens, communities and businesses in these efforts. The department also provides opportunities to learn more about Missouri’s natural and cultural history at our state parks and historic sites.

Our Mission: We serve as stewards of our natural resources to benefit Missourians. The department's values and Strategic Initiative Plan guide the department as it moves. The department accomplishes its mission through its Division of Administrative Support, Division of Environmental Quality, Division of Energy, Missouri Geological Survey and Missouri State Parks.

CWSRF On-site Wastewater Treatment System Grant

The Missouri Department of Natural Resources' grant program for on-site wastewater systems provides pass-through grant funding to one or more qualified nonprofits to implement the program in select areas of the state. The On-site Wastewater Treatment System Grants will assist private (non-commercial) and single-family homeowners in select watersheds with identified water quality concerns related to nutrients. It is anticipated that the grants will be used to either:

• Repair or replace failing or poorly functioning onsite wastewater systems or
• Connect to a larger decentralized or centralized wastewater treatment system

The goals of this grant program are to improve and protect public health and water quality by focusing on watersheds with nutrient impairments and implement infrastructure improvements, regardless of home lot size, with effective designs and proper installation that follow local and state health statutes and rules. Maintenance is also key to ensure the newly installed systems continue to provide protections for their expected useful life.

TC Energy’s Build Strong program supports vital organizations in communities near its operations. By providing grants, scholarships, and in-kind support, the program aims to enhance safety, education, environmental protection, and community well-being. Eligible applicants include non-profits and community groups addressing local needs. Ineligible activities include operational expenses and for-profit endeavors. The program prioritizes projects demonstrating measurable community impact, fostering a collaborative relationship between TC Energy and local stakeholders.

Missouri Department of Natural Resources

Missouri’s air, land and water resources play an important role in our health and are essential to the environmental and economic vitality of our state. The department aspires to help Missouri citizens thrive by advancing environmental and economic sustainability. The department provides a range of services to help Missouri citizens, communities and businesses in these efforts. The department also provides opportunities to learn more about Missouri’s natural and cultural history at our state parks and historic sites.

Our Mission: We serve as stewards of our natural resources to benefit Missourians. The department's values and Strategic Initiative Plan guide the department as it moves. The department accomplishes its mission through its Division of Administrative Support, Division of Environmental Quality, Division of Energy, Missouri Geological Survey and Missouri State Parks.

CWSRF Integrated Management Plan Grant

Under the Clean Water State Revolving Fund (CWSRF) program, the department provides Integrated Management Plan Grants to small and medium communities for developing integrated management plans. These plans identify and prioritize existing and future investments for municipal wastewater and stormwater management, and may include drinking water management, in a manner that is affordable to ratepayers.

Funding is provided by the CWSRF fund, capitalization grant additional subsidization allocation. Funding is offered through a competitive, annual funding cycle. 

The Herbert A. and Adrian W. Woods Foundation, founded in 1999, supports charitable organizations primarily in the greater St. Louis area. Funding interests focus on aiding abused children, the poor, the Episcopal Church and its affiliates, arts and culture, animal welfare, and victims of illness. The foundation accepts special project requests, capital campaigns, matching grants, and general operation funding, while multi-year grants and endowment funding are excluded.

The Ron Goellner Conservation Fund Award, administered by the Cryptobranchid Interest Group, offers grants up to $2,000 for projects focused on the conservation of giant salamanders. This initiative supports innovative research, field conservation, and educational initiatives that aim to protect these species and their habitats. Open to all applicants, the fund prioritizes projects that demonstrate broad conservation impact and partnerships. Applications are automatically considered for two separate grants of up to $1,000 each.

Missouri Department of Conservation (MDC)

Our work began in 1937, when citizen-led efforts created the Department of Conservation to restore, conserve and regulate Missouri's over-stressed fisheries, forests and wildlife populations. During our first 40 years, hunting, fishing, and trapping permits provided most of our funding, but in 1976 an expanded program, the "Design for Conservation," was passed to set aside one-eighth of one percent sales tax directly to the agency. That consistent funding, plus a strong, non-political structure and very supportive public helped make Missouri a national leader in conservation. Today we continue our legacy of protecting our state's wild resources and helping Missourians connect with their natural heritage. Our goal is to sustain diverse, healthy plant and animal communities — well into the future.

We protect and manage the fish, forest, and wildlife of the state. We facilitate and provide opportunity for all citizens to use, enjoy, and learn about these resources.

Community Forestry Cost Share Program

Community Forestry Cost-Share is designed to assist Missouri communities with improving their community forest. This cost-share program encourages communities to have a sustainable, balanced, and comprehensive community forestry program based on a current tree inventory and managed with the guidance of a community forestry professional. Lastly, Community Forestry Cost-Share is designed to promote community forest benefits through the proper management and care of trees.

Cost-share opportunities are available beginning in July. Due to limited funding, applications are funded on a first-come, first-served basis. For more information about the cost-share opportunities, please contact your regional office. 

Missouri Department of Natural Resources

Missouri’s air, land and water resources play an important role in our health and are essential to the environmental and economic vitality of our state. The department aspires to help Missouri citizens thrive by advancing environmental and economic sustainability. The department provides a range of services to help Missouri citizens, communities and businesses in these efforts. The department also provides opportunities to learn more about Missouri’s natural and cultural history at our state parks and historic sites.

Our Mission: We serve as stewards of our natural resources to benefit Missourians.

Water Safety and Security Act Project Grant

The Missouri Water Safety and Security Act, found in Missouri Revised Statutes section 640.144, RSMo, requires certain community public water systems to develop valve and fire hydrant inspection programs. The Act also requires systems to develop an accurate map identifying shut-off valve and hydrant locations using a geographic information system (GIS) or an alternative physical mapping system and create a hydrant inspection program.

Section 1452(g) and (k) of the federal Safe Drinking Water Act authorizes the Missouri Department of Natural Resources to distribute part of the Drinking Water State Revolving Fund (DWSRF) to public water systems to improve system capacity, promote asset management and maintain compliance with federal and state drinking water laws. Through this grant program, the department provides financial assistance to eligible community public water systems to develop accurate maps that satisfy the requirements of the Missouri Water Safety and Security Act.

Eligible Projects and Costs

Eligible projects are limited to contractual agreements to develop valve and hydrant inspection programs and accurate valve and hydrant maps that include all shut-off valve and hydrant locations throughout the applying water system’s distribution system and to satisfy the requirements of Section 640.144, RSMo.

A finalized valve and hydrant inspection program plan and/ or a map accurately depicting the locations of all system shut-off valves and hydrants must be provided to the department for a project to be considered complete. Reimbursement for pre-approved project-related costs is only issued following completion of awarded projects and submission of a finalized map to the department.

Award Amounts and Match

Funding is awarded on a first-come, first-served basis after the priority application period. Matching funds are not required, but may contribute to project selection and ranking according to the priority point criteria described in section 4 of the grant application form.

The Patterson Family Foundation offers funding for advanced and specialized course access, aiming to enhance educational opportunities for rural students in Kansas and western Missouri. Organizations can apply after registering through the Grants Portal. The foundation focuses on collaborative initiatives that ensure thriving rural communities by providing essential resources like dual-credit and STEM courses. Eligible applicants include 501(c)(3) organizations, school districts, or government entities, while projects outside the foundation's catchment area are ineligible.

The Patterson Family Foundation supports healthcare workforce development in rural communities across Kansas and western Missouri. The foundation encourages programs that enhance education, licensure, and retention of healthcare professionals. Organizations must register for grant consideration, and eligibility includes being a 501(c)(3) nonprofit or government entity. The foundation's mission focuses on strategic initiatives to ensure rural communities thrive, emphasizing collaboration and investment in essential services.

The CDBG: Water/Wastewater Grant provides essential funding for communities to enhance their drinking water and wastewater systems. This grant, in collaboration with the Missouri Department of Natural Resources and USDA-Rural Development, invites applications year-round following a preliminary proposal review. The maximum funding available is $750,000, or $5,000 per household, targeting construction projects related to public water treatment and sewer systems, while excluding maintenance activities.

Investing in Our Communities

Regions Bank and Regions Foundation are committed to helping individuals, families, and businesses achieve financial success.

We work alongside nonprofit organizations, local businesses, government and service agencies to address social and economic issues, assist in building inclusive economic prosperity and help more members of our communities benefit from the rewards of a growing economy.

We make strategic and disciplined community investments in programs that seek to achieve three target outcomes:

Economic and Community Development

• Affordable housing
• Job creation
• Small business development
• Homebuyer education and retention
• Neighborhood revitalization and stabilization

Education and Workforce Readiness

• Student competency and skill building
• College and career readiness
• Educational access and success
• Credential building and employment
• Educator training and resources

Financial Wellness

• Financial education to youth, adults, and vulnerable populations
• Financial planning tools and resources, including Regions Next Step®
• Integrated asset-building

The Professional Development Award aims to enhance the capabilities of individuals affiliated with Region 3 Network Member institutions. This funding supports attendance at seminars and workshops focused on data science and health information access, promoting improved health literacy and equity. The NNLM encourages projects that empower underrepresented communities and healthcare professionals. Applications are open until funds are exhausted or April 1, 2024, with a singular award per annual performance cycle.

The Trio Foundation of St. Louis Grant aims to enhance community well-being and promote equity through its new funding framework. Established over two decades ago, the foundation focuses on empowering marginalized groups, particularly those facing discrimination based on race, gender, and socioeconomic status. The grant supports initiatives in women's economic empowerment, arts accessibility, and environmental justice, fostering authentic relationships with community partners to create lasting impact in the St. Louis region.

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The Virtual Professional Development Award aims to enhance professional knowledge and experience for individuals in Region 3 Network Member institutions. By funding attendance at seminars and conferences related to data science and health information access, this award supports the goals of the Network of the National Library of Medicine (NNLM). It seeks to improve health information access for healthcare providers and consumers, particularly among underrepresented populations, fostering health equity and literacy.

The NACD Technical Assistance Grants program, in partnership with NRCS, has been enhancing conservation district support since 2018. By funding staff hires, it aims to improve service for agricultural producers and address conservation workload challenges. The initiative focuses on outreach, education, and civic engagement to empower local communities, promote sustainability, and support historically underserved producers in implementing conservation practices, thereby fostering both individual and community resilience.