Best Grants for Small Nonprofits in New York

Improving Metastatic Prostate Cancer (mPCa) Care Through Innovative Strategies

The National Comprehensive Cancer Network® and Pfizer Global Medical Grants (Pfizer) are collaborating to offer a new grant opportunity seeking proposals for investigator-initiated research to improve mPCa care. Pfizer (hereafter, “Grantor”) is providing $1 Million in funding to support quality improvement studies to advance health care quality, the delivery of quality care, and improve health care provider performance in mPCa care. The Grantor will serve as the funding organization. Grants are available to all investigators from institutions within the United States. 

Aim

To promote the advancement of scientific knowledge, health care provider performance, and/or health care quality improvement focused on improving mPCa care.

A total of $1 Million is available to fund all projects. The intent is to fund 2-5 studies. There is a funding cap of $250,000 per study. Exceptional studies with budgets above this amount will be considered based on scientific merit and must contain a robust justification. All budgets must include line-item information and robust justification.

The Ramiro Cortes Scholarship, established by the Community Foundation of North Central Washington, honors the legacy of composer Ramiro Cortés, who was a pioneering Mexican-American musician. This scholarship supports graduating seniors from Chelan or Douglas counties who are pursuing full-time music studies. Funded entirely by concert proceeds, it aims to foster new talent in classical music while commemorating Cortés’ significant contributions to the field.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

The American Heart Association is seeking proposals for the RFP: Strategically Focused Research Network (SFRN) focused on the earlier detection and progression delay of Valvular Heart Disease (VHD). With 2.5% of the US population affected, this initiative aims to enhance understanding and improve diagnosis and treatment strategies for VHD, particularly in underrecognized and advanced cases. The network will support research in both human studies and animal models to tackle this growing health concern.

The Terry Lee Kaylor Memorial Scholarship, offered by the Central Kansas Community Foundation, aims to assist graduating high school seniors pursuing higher education or vocational training. Preference is given to students from Douglass High School with a minimum GPA of 2.85 and a demonstrated financial need. The scholarship amount varies based on available funds, and recipients will be notified of their award status in May. This scholarship is not renewable and encourages all eligible students to apply.

The National Institute of Environmental Health Sciences (NIEHS) invites applications for the Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional). This program supports interdisciplinary research centers focused on biomedical and environmental science. Eligible institutions must be accredited higher education establishments. Applications are due by 5:00 PM local time, and successful submissions will undergo a rigorous peer-review process to ensure quality and relevance in addressing hazardous substance issues.

The Career Guidance for Trainees Grant, offered by the Burroughs Wellcome Fund, aims to enhance the career development of early career administrators focused on PhD scientists. This grant supports a workshop that equips participants with research evaluation skills to create impactful career-focused interventions. Participants will receive a $15,000 grant to implement their projects, develop networks, and share findings at national meetings, fostering a diverse scientific workforce essential for research innovation and public service.

The Niagara Area Foundation Grant, established in 2000, aims to bridge the philanthropic gap in Niagara County. It focuses on funding projects that enhance youth development and environmental education. In 2025, the Foundation will accept applications that positively impact the community, emphasizing youth enrichment and ecosystem health. This grant presents an opportunity for organizations to contribute to meaningful community development and foster a vibrant, equitable future for Niagara County residents.

The Bloomberg Green Docs Contest invites filmmakers to create impactful short documentaries addressing climate change. Competing for a grand prize of $25,000, participants are encouraged to showcase urgent narratives about our climate future. The films should be under 10 minutes, including credits, and highlight both restoration efforts and the challenges posed by climate extremes. Winners will be revealed at the Bloomberg Green Docs Film Festival, making this a pivotal opportunity for storytellers passionate about environmental issues.

The SHC Student Research Grant supports research utilizing herbarium resources across various taxa, including plants, fungi, lichens, and algae. Eligible projects may involve fieldwork, data collection, or meta-analysis of herbarium data, with an emphasis on enhancing herbarium collections. Three grants are awarded annually: two for $500 and one specifically for undergraduates for $250. Applicants must be student SHC members with projects likely to lead to publication.

The NIDCD Early Career Research (ECR) Award (R21) supports early-stage scientists in establishing independent research careers in areas such as hearing, balance, and language. This grant facilitates small, innovative research projects and aims to generate preliminary data for future R01 applications. It is not intended for thesis work and is designed to enhance research methodologies and technologies in biomedical and behavioral sciences. Applications are due by 5:00 PM local time of the applicant organization.

New York State Office of Mental Health

The New York State Office of Mental Health (OMH) oversees a large multi-faceted mental health system serving nearly 800,000 individuals each year. This includes operating 23 psychiatric centers and overseeing the Nathan S. Kline Institute and New York Psychiatric Institute. OMH regulates and certifies more than 6,500 programs operated by local governments and nonprofit agencies.

Mission

Our mission is to promote the mental health of all New Yorkers, with a particular focus on providing hope and recovery for adults with serious mental illness and children with serious emotional disturbances.

Housing First Scattered Site Supportive Housing for Homeless Adults Western New York and Long Island Region

The Office of Mental health is announcing funds to develop 45 units of Housing First Supportive Housing for homeless individuals in the following counties:

• 20 units in Steuben and Chemung counties
• 25 units in Nassau and Suffolk counties

Notification of intent to apply should be made to the Local Governmental Unit (county director of community services) for each county to be served under the program application, as defined in Section 41 of the New York State Mental Hygiene Law. Proof of this notification is required to be uploaded in SFS and should not be sent directly to the procurement unit.

Target Population

Individuals eligible for this program will be homeless and be enrolled in a Safe Options Support (SOS) team, Intensive and Sustained Engagement Team (INSET), or Assertive Community Treatment (ACT) Team. SPOA/SPA referrals are not a requirement of this RFP.

Please note that within this target population group, individuals with an Assisted Outpatient Treatment (AOT) order must receive priority access. 

The CFECFL Community Grant Program offers competitive grants to nonprofit organizations serving Chemung and Southeastern Steuben counties. Grants support diverse areas including the arts, education, environment, and human services. Eligible organizations must be locally based, IRS 501(c)(3) classified, and demonstrate successful prior grant completion. The program focuses on direct service, capital projects, and organizational development, providing unrestricted funding to enhance nonprofit missions and community impact.

The Lois Lenski Covey Foundation offers the Bookmobile Grant to promote literacy among underserved children. Grants range from $500 to $3,000 specifically for purchasing books for youth from preschool to grade 8. Eligible organizations include 501(c)(3) nonprofits and public libraries that operate lending bookmobiles. The Foundation aims to ensure access to quality literature, fostering a love of reading in disadvantaged communities while addressing their limited book budgets.

The Manning Family Foundation offers Health and Life Sciences Research Grants to support innovative research aimed at finding effective treatments and cures for diseases like diabetes and macular degeneration. Since 2003, they have funded 501(c)(3) nonprofits that contribute to these fields, emphasizing entrepreneurialism and impactful research. Applications are accepted on a rolling basis, with awards given three times a year, fostering advancements in health and community well-being.

The Everett & Roy Hill Music Scholarship, managed by the Community Foundation of North Central Washington, supports graduating seniors from Chelan, Douglas, or Okanogan counties who are pursuing further education in music. This scholarship emphasizes the importance of musical education, reflecting the philanthropic spirit of Everett Hill, who aimed to enrich his community. Eligible candidates must demonstrate financial need and maintain a minimum GPA of 2.5 to continue receiving support for up to two years.

The Quailwood Fund, established by Jonathan Schor, aims to enhance community life in Red Rock, NY, through grants for public services, conservation, and educational scholarships. The fund supports nonprofit organizations and public entities serving Red Rock residents, with awards typically ranging from $500 to $10,000, and up to $20,000 for significant projects. A 1:1 matching requirement applies, ensuring community investment in grant-funded initiatives.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Senior Master Sergeant Texie C. Taylor, USAF Memorial Scholarship

Applicant must be a junior or senior undergraduate or graduate student majoring in physics, chemistry, biology, medicine, nursing (RN), engineering (aerospace, civil, chemical, electrical, mechanical) or mathematics with a minimum 3.0 GPA. This is a one-year scholarship reserved for Cherokee Nation citizens residing within the Cherokee Nation jurisdictional area.

The Carnahan-Jackson Foundation Grant supports 501(c)(3) and religious organizations in Chautauqua County, focusing on educational initiatives such as scholarships and libraries, as well as addressing basic human needs. The foundation operates exclusively for charitable, educational, and scientific purposes. Interested applicants must request grant guidelines and submit a written paper application to be considered for funding.

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

The Stout Foundation Grant supports organizations aligned with the values of its founder, Mr. Stout. Grants are awarded exclusively to entities with 501(c)(3) tax-exempt status and focus on charitable, educational, and scientific purposes. Preference is given to organizations with low overhead costs and those located in areas frequented by Foundation members. The Foundation aims to promote effective use of funds while remaining flexible in its grant-making approach.

The Howard D. Colman Scholarship supports high school seniors from Boone and Winnebago Counties pursuing degrees in engineering or technology fields. Established in memory of entrepreneur Howard D. Colman, the scholarship offers $2,500 in the first year, with potential renewal up to $10,000 for three additional years, contingent on meeting criteria. Recipients gain hands-on experience through internships with local firms, fostering connections to the Rockford area.

Foundation of the Federal Bar Association

The Foundation of the Federal Bar Association provides the best way for practitioners to give back to the Federal legal community. Chartered by Congress in 1954, the Foundation serves people in communities across the United States through its generous grants, scholarships, and programming.

Our Mission: The Foundation’s mission is to:

• Promote and support legal research and education;
• Advance the science of jurisprudence;
• Facilitate the administration of justice;
• Foster improvements in the practice of Federal law

Foundation Grants

Foundation grants support community service projects and civics programs which comply with the Foundation’s mission to promote and support legal research and education; advance the science of jurisprudence; facilitate the administration of justice; and foster improvements in the practice of Federal law.

Civics Education Grant

The Civics Grant Program is designed to support projects and initiatives that promote a wider public understanding of democratic principles, the judicial system and the rule of law. Through targeted funding, the program empowers FBA chapters, sections, divisions, national standing committees (FBA entity), and other organizations to develop and support projects in their communities that foster public understanding of the rights and responsibilities of American citizenship, particularly among younger Americans.

Applicants may only receive one (1) Foundation grant per year.

The Inspire Grants for Small Museums (2027) initiative, funded by the Institute of Museum and Library Services, aims to empower small museums across various disciplines. This program focuses on project-based funding to enhance public service through educational programs, exhibits, and community partnerships. By supporting small, often underfunded institutions, Inspire seeks to strengthen their capacity to engage communities and improve collections management, fostering experiential learning and discovery.

Howard Hughes Medical Institute

More than 70 years ago, the Howard Hughes Medical Institute (HHMI) was founded with a mission to advance basic biomedical research and science education. Today, we invest in exceptional scientists at all career stages, catalyzing breakthroughs, new technologies, and the next generation of transformative clinical therapies. Our pathbreaking science takes place at more than 60 host institutions across the US, and at our Janelia Research Campus.

Cech Fellows Program

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders. 

The Summer Undergraduate Research Program (the Cech Fellows Program) gives undergraduate students in the life sciences the opportunity to conduct hands-on research alongside leading scientists at HHMI laboratories across the US, from universities and research institutions to HHMI’s research campus outside of Washington, DC. Students are matched with HHMI scientists conducting fundamental research that advances our understanding of biology and health.

This immersive program gives students the chance to contribute to real scientific discovery, gain professional mentorship, and explore potential careers in biological and biomedical research.

Gain Hands-On Experience in Research & Lab Work

Through the summer, students will:

• Work full time conducting research and contributing to ongoing projects in an HHMI laboratory
• Learn and practice new techniques and approaches in disciplines such as cell biology, genetics, neuroscience, and more
• Work closely with and be mentored by exceptional scientists, from lab heads to PhD students
• Build critical thinking and communication skills necessary for future research careers

What the Program Offers

Beyond meaningful lab work, the program provides:

• A stipend to support summer travel, housing, and living expenses 
• An opportunity for participants to present their research and connect with a national cohort of peers at an end-of-summer research symposium at HHMl’s research campus outside of Washington, DC 
• An engaging virtual seminar series with HHMI scientists as well as professional development sessions focused on relevant skills building

The Community Foundations of the Hudson Valley offers Community Grants to provide unrestricted General Operating Support (GOS) for nonprofits in Dutchess, Putnam, and Ulster Counties. These grants, capped at $5,000, focus on supporting organizations that serve historically marginalized communities. Funding can be used for administrative costs, capacity building, and essential program maintenance, addressing needs in areas such as human services, arts, education, health, and civic affairs, promoting community well-being.

The Eppley Foundation for Research, established in 1947, supports advanced scientific research in chemistry, physics, and biology. It prioritizes innovative studies, particularly in medical investigations and climate change. The foundation does not fund social sciences or projects with ample existing financial support. Applicants must hold a PhD or MD and be associated with a nonprofit in the US. The foundation aims to foster groundbreaking research that is unlikely to be replicated elsewhere.