Best Large Grants for Nonprofit Organizations in New York

The Will Rogers Motion Picture Pioneers Assistance Fund offers crucial financial support and counseling for individuals in the theatrical exhibition and distribution sectors facing health-related challenges. This fund assists with medical expenses, housing emergencies, and essential services like vocational rehabilitation and equipment aid. Eligible applicants must have a minimum of three years in exhibition or five years in distribution. The fund aims to provide a safety net for those impacted by illness, injury, or significant life changes.

The Brockport Arts Fund, supported by the Rochester Area Community Foundation, aims to enhance the cultural landscape of Brockport in 2025. This initiative focuses on funding performing arts events and public art installations that benefit both residents and visitors, promoting community engagement and artistic expression. By aligning with the Foundation's mission of supporting equity and vibrant neighborhoods, the fund seeks to create a lasting impact through accessible and inclusive arts programming.

The A.I.R. Fellowship Program, established in 1993, empowers emerging women and non-binary artists in New York City by providing them with their first solo exhibition, mentorship, and professional development opportunities. Each year, six artists benefit from a 12-month fellowship that includes workshops, curatorial support, and a stipend of $3,000, fostering an inclusive community that encourages creative exploration and dialogue among diverse artists.

The SUNY Open Educational Resources (OER) Impact Grants aim to enhance accessibility and affordability in education by promoting the use of OER across the State University of New York system. These grants support initiatives that reduce textbook costs and foster innovative teaching methods using openly licensed materials. By facilitating the adoption of OER, SUNY is committed to improving academic success and ensuring equitable access to high-quality educational resources for all students.

New York State Homes and Community Renewal

HCR develops, preserves and protects affordable housing and invests in economically vibrant communities. We work with many private, public and nonprofit partners to create safe, healthy and affordable housing opportunities for all New Yorkers.

HCR is charged with carrying out Governor Hochul’s new $25 billion, five-year, comprehensive housing plan to increase housing supply by creating or preserving 100,000 affordable homes across New York including 10,000 with support services for vulnerable populations, plus the electrification of an additional 50,000 homes.

Community Development Block Grant

The NYS Community Development Block Grant or CDBG Program is a unique source of federal funding for Cities, Town, Villages, and Counties to assist low- and moderate-income communities, households, and people.

CDBG funding assistance can include everything from drinking water and sanitary sewer projects to grants for home repair, senior and community center improvements to grants to small business for start-up and expansion.

The NYS CDBG program provides financial assistance to eligible cities, towns, and villages with populations under 50,000 and counties with an area population under 200,000, in order to develop viable communities by providing decent, affordable housing, and suitable living environments, as well as expanding economic opportunities, principally for persons of low and moderate income. 

Expert technical assistance is always available to help your community apply for and administer CDBG funds, and to help direct assistance to where it is needed most.

Eligible Activities

CDBG funding may be used for eligible activities as outlined below. This is not intended to be an exhaustive list of eligible activities and applicants are encouraged to develop projects in response to local need that may not fit neatly in any one category. In these cases, applicants are encouraged to contact OCR for additional guidance prior to applying.

Funding is available for the following activities: 1) Public Facility; 2) Community Planning; 3) Economic Development - Stand-Alone Business Assistance; 4) Economic Development - Microenterprise Assistance; and 5) Imminent Threat.

Community Planning

CDBG Community Planning grants enable communities to conduct assessments and develop clearly articulated strategies for addressing local community development issues. The study, analysis and planning of any community planning activity should identify eligible projects for subsequent CBDG funding. There are two categories of planning grants:

• Community Needs Assessments
• Project Readiness Plans

The Pipeline Grants Competition by the Russell Sage Foundation aims to bolster early-career scholars and enhance diversity in the social sciences. It supports innovative research focusing on economic mobility and systemic inequalities in the U.S. Eligible applicants can receive up to $35,000 individually or $50,000 in teams. The foundation emphasizes methodological diversity and interdisciplinary collaboration, encouraging novel data usage. Projects should align with RSF's mission to improve social conditions, prioritizing underrepresented scholars from under-resourced institutions.

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

About the New York State Education Department

The New York State Education Department is part of the University of the State of New York (USNY), one of the most complete, interconnected systems of educational services in the United States.

Our mission is to raise the knowledge, skill, and opportunity of all the people in New York. Our vision is to provide leadership for a system that yields the best educated people in the world.

Conservation/Preservation Discretionary Grants

Purpose of Grant

To encourage the proper care and accessibility of research materials in the State, to promote the use and development of guidelines and standards for conservation/preservation work, and to support the growth of local and cooperative preservation programs. To provide modest financial support for projects that contribute to the preservation of significant research materials in libraries, archives, historical societies, and other agencies within the State of New York, whether by improving collection storage environments, reformatting or treating collections or other preservation activities described in these guidelines.

Description of Program

The New York State Discretionary Grant Program for the Conservation and Preservation of Library Research Materials was authorized under Education Law, Section 273.6(c) in 1984, expanded in 1986 and revised in Part O, Chapter 57, of the Laws of 2005. Its purpose is to encourage the proper care and accessibility of research materials in the State, to promote the use and development of guidelines and standards for conservation/preservation work, and to support the growth of local and cooperative preservation programs.

The Discretionary Grant Program provides modest financial support for projects that contribute to the preservation of significant research materials in libraries, archives, historical societies and other agencies within the State of New York, whether by improving collection storage environments, reformatting or treating collections or other preservation activities described in these guidelines.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The Chautauqua Region Community Foundation offers CRCF General Grants aimed at enhancing community welfare through flexible funding for emerging needs and one-time costs. Eligible applicants include 501(c)(3) organizations serving Southern Chautauqua County, with a focus on mission alignment and broad impact. This bi-monthly grant process facilitates support for program enhancements, capital improvements, and technology upgrades, ensuring that community needs are met effectively.

The David M. Dolan Scholarship, offered by the International Association for Great Lakes Research, supports master's and Ph.D. students engaged in applied environmental statistics and modeling related to the Great Lakes. The scholarship provides a $3,000 award, complimentary conference registration, and IAGLR membership. Recipients must present their research at the annual IAGLR conference. Eligibility is limited to those whose research aligns with Dr. Dolan's work, and previous awardees are not eligible.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The Veterans Assistance & Service Dog Funding Program, established by the Cornelia T. Bailey Foundation, aims to support 501(c)(3) nonprofit organizations serving veterans. This initiative enhances services like healthcare, housing, and employment support, while also facilitating the provision of service dogs for veterans facing disabilities. Applications for 2025 are closed, but interested organizations can check back in January 2026. Grants will empower nonprofits to better assist veterans in their transition to civilian life.

The AMA Foundation's Physicians of Tomorrow Scholarship provides $10,000 in tuition assistance to medical students nearing their final year. With a strong commitment to supporting diverse medical students, the Foundation has awarded over $61 million in scholarships since 1950. Eligible applicants must attend a medical school in New York and demonstrate involvement in organized medicine. This scholarship focuses on promoting equity in healthcare by assisting those underrepresented in the medical field.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

The Dollar General Literacy Foundation offers the DGLF Summer Reading Grants, which support the development and expansion of summer reading programs aimed at Pre-K to 12th grade students, particularly new and below-grade-level readers, including those with learning disabilities. Eligible organizations, such as nonprofits, schools, and libraries within 15 miles of a Dollar General store, can apply for grants up to $3,000 to foster literacy and education initiatives.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The Book Seminar Legacy Fund Annual Grant, established by the Community Foundation of New Jersey, honors the legacy of Professor Samuel Freedman by providing three annual grants starting in 2026. These grants support various stages of book projects, including proposals, initial research, and manuscript writing. Eligible applicants include former students and auditors from the Book Seminar class, which ran from 1991 to 2025. This initiative fosters literary creativity and supports authors in their publishing journeys.

The Great Lakes Protection Fund Grant aims to support projects that deliver significant ecological improvements to the Great Lakes region. The Fund seeks transformative initiatives that involve collaboration among diverse stakeholders and rely on scientific rigor. Eligible applicants include non-profits, universities, and businesses, and the projects must demonstrate a positive environmental impact on the Great Lakes ecosystem. Importantly, the Fund does not support advocacy or compliance-related activities.

The New York State Department of Agriculture and Markets is offering funding through the Companion Animal Capital Projects Fund to eligible not-for-profit shelters and humane societies. This grant supports capital projects that enhance the health and care of sheltered dogs and cats, such as construction, renovation, or expansion of facilities. Organizations can apply for funding for specific components of larger projects, ensuring better containment and welfare of animals.

The Northeast SARE: Farmer Grant Program supports innovative sustainable agriculture projects by providing funding to farmers. Grants ranging from $5,000 to $30,000 enable farmers to conduct research, implement new ideas, and address issues affecting long-term sustainability. This program encourages proposals that explore diverse topics such as crop production, livestock raising, urban agriculture, and climate-smart practices. Successful projects promise significant benefits to farming communities while fostering collaboration and education within the agricultural sector.

The Historic Preservation Grant Program, part of the Environmental Protection Fund, supports projects enhancing parks and historic sites in New York. This matching grant program aims to acquire, develop, and improve properties listed on state or national registers, ensuring long-term public benefits through preservation covenants and conservation easements. Applicants, including municipalities and nonprofits, are evaluated on criteria such as project significance, public awareness, and the ability to complete the project effectively, fostering stewardship of historic resources.

The National Institute on Drug Abuse is funding pilot and feasibility studies aimed at preparing for substance use and HIV prevention research trials. The program encourages innovative interventions for substance use disorders and HIV eradication, focusing on stakeholder collaboration and practical application. Projects may include assessment of service models, intervention development, and community engagement. This initiative is designed to fill critical research gaps and enhance partnerships, although applications are not currently being accepted.

The NCAA Division II Degree Completion Award provides financial assistance to student-athletes who have exhausted their athletics eligibility, enabling them to complete their first undergraduate degree. Since its inception in 2001, nearly $9 million has supported approximately 1,875 athletes, with a remarkable 90 percent graduation rate among recipients. The award covers tuition costs up to $15,000 for remaining credits and may be used in the summer term or short terms surrounding the final undergraduate year.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.