Best Grants for Nonprofit Healthcare Programs in Puerto Rico

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Hemophilia Health Equity Fund

Help with healthcare costs for hemophilia (health equity fund)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type III (MPS III) Fund

Help with healthcare costs for mucopolysaccharidosis type III

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses. 

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type VII (MPS VII) Fund

Help with healthcare costs for mucopolysaccharidosis type VII

This TotalAssist Health Equity Fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type VII (MPS VII) Health Equity Fund

Help with healthcare costs for mucopolysaccharidosis type VII (health equity)

This TotalAssist Health Equity Fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code.

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

The Leukemia & Lymphoma Society's Equity in Access Research Grants aim to enhance equitable access to care for blood cancer patients and survivors. This program funds research to identify effective interventions that increase participation in clinical trials among underrepresented groups. Projects can receive up to $500,000 annually for a maximum of five years, with a total budget cap of $2.5 million. The initiative seeks to address systemic barriers that hinder clinical trial enrollment and improve healthcare access.

The Carolyn L. Kuckein Student Research Fellowship, awarded by Alpha Omega Alpha Honor Medical Society, supports first and second-year medical students conducting research over 2 to 12 months. With a total funding of $7,000, students can receive reimbursement for travel expenses up to $1,000 for presenting their findings at national conferences. Eligibility requires enrollment in schools with active AΩA chapters, while those taking a year off for research or holding a PhD are ineligible.

The CareQuest Institute for Oral Health® is inviting proposals for school-based and school-linked initiatives aimed at improving oral health access for high-risk children. This grant opportunity seeks to address systemic barriers to oral health through innovative programs that engage schools and communities. Ideal projects may include workforce development, community engagement strategies, policy advocacy, and the use of technology. Proposals should focus on creating equitable oral health solutions that enhance both health and academic success for children and their families.

The AHRQ Health Services Research Demonstration and Dissemination Grants (R18) aim to support innovative health services research that addresses priorities in quality, safety, and effective healthcare delivery. These grants encourage collaboration among various stakeholders, including patients and policymakers, to enhance healthcare practices across diverse settings. Applications are due by 5:00 PM local time of the applicant organization. This initiative fosters improvements in healthcare outcomes and delivery systems.

The AHRQ Health Services Research Projects (R01) aims to fund innovative health services research that aligns with AHRQ's priorities, such as enhancing healthcare quality and safety. This initiative encourages applications from various healthcare settings including hospitals and home care, promoting collaboration among diverse stakeholders like patients and policymakers. By addressing key areas of healthcare delivery improvement, this funding opportunity seeks to foster advancements in patient care and overall health system performance.

The AHRQ Small Health Services Research Grant Program (R03) invites applications for health services research focused on enhancing healthcare quality and patient safety. This funding opportunity supports diverse research settings, including hospitals and home healthcare. Projects may involve collaboration with various stakeholders such as patients, clinicians, and policymakers. By addressing AHRQ research priorities, this initiative aims to improve healthcare delivery and practice while promoting effective partnerships across the healthcare spectrum.

The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.

The Systems-Based Approaches to Improve Patient Safety program aims to enhance patient safety by prioritizing healthcare worker safety and well-being. By focusing on systemic improvements, this initiative seeks to create a safer healthcare environment, recognizing that worker safety is integral to patient safety. The funding opportunity encourages innovative proposals that bring new insights from healthcare professionals, ultimately supporting AHRQ's mission to strengthen the patient safety movement.

The National Institutes of Health (NIH) is dedicated to advancing emergency care through the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN). This initiative seeks to establish clinical enrollment hubs that will enhance the network's ability to conduct trials aimed at improving outcomes for patients experiencing neurological and cardiovascular emergencies. Although applications are not currently being accepted, this notice encourages potential applicants to prepare collaborative and impactful proposals.

The Rural Health Network Development Planning Program aims to enhance rural health care by fostering integrated health care networks. It focuses on collaboration among entities to bolster local capacity and improve care coordination in underserved areas. By achieving efficiencies and expanding access to essential services, the program seeks to strengthen the overall rural health system while promoting the use of health information technology and exploring innovative care delivery models.

The Rural Health Network Development Program aims to enhance health care access in rural areas by supporting integrated health care networks. It offers two funding tracts: the Network Advancement Tract for established networks to overcome operational barriers and the Network Development Tract for early-stage networks to plan and expand services. Both tracts focus on improving care coordination, health outcomes, and operational efficiency, thereby strengthening the rural health care system.

The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.

The AHRQ Improving Diagnostic Safety in Ambulatory Care (R18) program invites proposals aimed at enhancing diagnostic safety in ambulatory settings. This initiative supports the development, testing, and evaluation of strategies and interventions that address diagnostic challenges in healthcare. The goal is to improve patient safety and quality of care through innovative solutions tailored to the diverse needs of ambulatory care environments.

The HEAL Initiative aims to address the significant overlap between chronic pain (CP) and opioid use disorder (OUD), with 40-75% of individuals affected by both. The IMPOWR project focuses on testing innovative interventions and implementation strategies to integrate care for CP and OUD across various health systems. The BEACON Center will enhance network coordination, build capacity, and develop resources to address barriers in service delivery, ultimately improving sustainability and scalability of evidence-based practices.

The Centers of Excellence in Healthcare Quality and Safety program aims to establish a collaborative network of healthcare systems and public health partners to enhance patient and healthcare worker safety. This initiative focuses on improving the quality and resilience of U.S. healthcare delivery across various settings, including hospitals and outpatient facilities. By fostering partnerships, the program seeks to effectively detect, respond to, and prevent safety threats, ensuring a higher standard of care and safety for all.

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

The NIH is set to release a funding opportunity for pragmatic and implementation trials aimed at evaluating the effectiveness of interventions in real-world healthcare settings. This initiative encourages collaborations across various health systems to assess the effectiveness and feasibility of interventions. By focusing on commonly encountered conditions in everyday clinical care, the trials aim to provide actionable insights for patients, clinicians, and policymakers. Interested investigators are encouraged to start developing their project proposals.

The CDC's NCIPC is seeking research proposals to tackle implementation challenges in providing linkage to care services for individuals with opioid use disorder (OUD). This initiative encourages partnerships with public health entities and local healthcare champions to create actionable, evidence-based strategies. The goal is to enhance care access and ensure comprehensive overdose prevention services are available in real-world healthcare settings, thereby improving outcomes for those at risk of opioid overdose.

The Telehealth Nutrition Services Network Grant Program, funded by the Health Resources and Services Administration, aims to enhance access to quality health care through innovative telehealth nutrition services. This program focuses on preventing and managing chronic diseases by leveraging telehealth technology, ensuring that individuals receive essential nutrition guidance remotely. With a commitment to improving health outcomes, this initiative will significantly benefit communities seeking better access to healthcare resources.

The FY 2027 Service Area Competition (SAC) funding aims to enhance healthcare access in underserved communities across the U.S. by providing grants for comprehensive primary and preventive health services. This initiative addresses essential health needs through competitive funding opportunities, ensuring that health centers can effectively serve their designated areas. Additional service areas may be announced as needed if current centers are unable to continue their operations, thus maintaining service continuity.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. and its territories. This funding opportunity supports comprehensive preventive and primary health care delivery. Each SAC announcement details service areas available for competition, with potential additional areas announced throughout the year. This initiative is crucial for ensuring continuous access to quality health care for vulnerable populations.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive primary and preventive care. This initiative will support health centers in delivering high-quality services, addressing the needs of populations that face barriers to care. Each funding opportunity will specify service areas available for competition, ensuring effective resource allocation to improve community health outcomes.

The FY 2027 Service Area Competition (SAC) funding aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive preventive and primary health care. The initiative supports health centers in delivering essential services, ensuring that vulnerable populations receive the care they need. Service areas for competition are announced periodically, and additional areas may be added if existing centers are unable to continue their services.