Best Grants for Rare Diseases in Puerto Rico

Nonprofit 501(c)(3) organizations in Puerto Rico supporting children, education, or health and human services may be eligible for charitable contributions to strengthen their community programs. Costco Foundation supports evidence-based initiatives with measurable outcomes and broad financial backing; local groups addressing rare or chronic respiratory conditions within these priorities may benefit.

Nonprofit 501(c)(3) organizations with innovative approaches to human and social services, health, or related societal issues can seek funding to develop or expand new solutions, including work in Puerto Rico. Grants from Creag Foundation help smaller or evolving programs test new models that may benefit people affected by rare or under-addressed diseases.

Nonprofit 501(c)(3) organizations serving children and youth worldwide can seek funding for health, education, development, and welfare programs, including basic needs and environmental education. Grants from Dan Paul Foundation help Puerto Rico organizations working with vulnerable children, homeless or refugee youth, or early childhood development access up to US $15,000 per year.

Early-stage nonprofit and impact-first for-profit organizations addressing critical social or environmental problems in Puerto Rico and beyond can apply for grants from Draper Richards Kaplan Foundation, with awards up to US $300,000. Funding supports scalable, systems-focused solutions that directly benefit underserved communities and demonstrate measurable impact, including ventures working in health, poverty, education, and related fields.

Educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies can seek State Farm support for safety, education, and community development initiatives, including in Puerto Rico. State Farm Companies Foundation funds projects such as auto and home safety, disaster preparedness and recovery, affordable housing, job training, financial literacy, and K-16 academic and career success.

Nonprofit cultural institutions in the U.S. offering arts, science, or STEAM programs can seek more than US $100,000 for program, capital, or limited general support, including those serving Puerto Rico. With a mission to strengthen cultural access, Hearst Foundation provides support to museums, theaters, symphonies, arts schools, and similar organizations, including those reaching underserved populations that may be affected by rare diseases.

With a mission to support strong social service programs, nonprofits in Puerto Rico can seek major grants from the William Randolph Hearst Foundation for program, capital, or general support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million working on poverty, housing, food access, or related services may be eligible for awards over More than US $100,000.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Organizations working on education, children’s health, or family economic stability projects in Puerto Rico may be eligible if their work serves urban low-income children in the U.S. and meets size and focus criteria. Grants from Michael & Susan Dell Foundation support project implementation or scaling, with awards of more than US $50,000 for aligned initiatives.

Accredited charities running humanitarian, social development, science education, community, environmental, or arts programs can apply for Roche’s Corporate Donations and Philanthropy support, including organizations in Puerto Rico. Funding prioritizes innovative, sustainable projects that may benefit rare disease communities and can actively involve Roche expertise, logistics, and employees in cultural, educational, or social activities.

Nonprofits and humanitarian organizations working on health, education, or disaster relief can seek support for marginalized communities worldwide, including Puerto Rico. Grants from Semnani Family Foundation help programs addressing healthcare access, disease, child and women’s health, and humanitarian services, which may benefit initiatives serving people with rare or complex conditions.

U.S.-based 501(c)(3) charitable, scientific, medical, and educational organizations, including those serving Puerto Rico, can apply for the Sidney Stern Memorial Trust’s broad program support. Funding must be used within the U.S. and may benefit nonprofits addressing respiratory or other rare diseases through research, treatment, or related services.

Puerto Rico 501(c)(3) nonprofits working on community development, basic needs, workforce education, or cultural programming can seek sponsorship support to strengthen local communities. Focused on housing, jobs, hunger, arts, environment, and inclusion, Bank of America Charitable Foundation’s regional sponsorships may benefit organizations that also address rare disease impacts through related services or outreach.

Nonprofit 501(c)(3) organizations working on health, education, social justice, or arts initiatives in Puerto Rico can seek funding for programs or general operating support. With a mission to further Gardner Cowles Jr.’s philanthropic legacy, Cowles Charitable Trust provides up to US $10,000, occasionally supporting mission-aligned national and international efforts, including medical and climate research that may intersect with rare disease work.

U.S.-based 501(c)(3) nonprofits addressing children’s services, education, humanitarian aid, or related programs in Puerto Rico can apply for Hansen Family Foundation grants of US $1,000 - US $10,000. Organizations working on rare disease support within these areas may be eligible if they meet the foundation’s mission and budget and overhead limits.

The Kroger Foundation is dedicated to uplifting communities through significant charitable contributions, having donated over $1.9 billion in the past six years. Their focus on combating hunger through the Zero Hunger | Zero Waste initiative exemplifies their commitment to social impact. Annually, they provide over $300 million to nonprofit organizations aligned with their mission, promoting health, education, and disaster relief while fostering diversity and inclusion. This initiative reflects Kroger's belief that strong communities are a shared responsibility.

Puerto Rico nonprofits and aligned for-profit organizations working in preservation, education, or wellness can access funding through Jesse W Couch Charitable Foundation to tell powerful stories about their impact. This national Storytelling Grant supports 501(c)(3)s and similar groups, which may include organizations addressing rare or respiratory diseases within the foundation’s program areas.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

Nonprofit 501(c)(3) organizations working on community services, environmental conservation, or peacebuilding in Puerto Rico may be eligible for flexible project or program support. Focused on broad social and environmental impact, the Dudley T Dougherty Foundation invites applicants whose work could intersect with health or rare disease challenges in their communities.

Nonprofit 501(c)(3) organizations, public schools, and libraries in Puerto Rico working on environmental or human services programs can apply for the Lawrence Foundation’s unrestricted grants, typically US $5,000 - US $10,000. Funding can support general operating or project costs, which may help organizations serving people affected by rare or chronic diseases.

Nonprofit 501(c)(3) organizations in Puerto Rico working on basic needs, community vitality, or volunteer-driven programs may be eligible for Ameriprise Financial Community Grants. Grants from Ameriprise Financial help U.S. nonprofits address hunger, shelter, housing stability, financial literacy, workforce readiness, and culturally enriching community development that could benefit people with rare diseases.

Puerto Rico 501(c)(3) nonprofits providing basic needs or economic mobility opportunities for youth and families can access funding through Nordstrom, with awards ranging from US $5,000 - US $20,000. Organizations serving communities near Nordstrom store locations may be eligible, and unrestricted grants can support local programs addressing food, shelter, clothing, or workforce development.

Health and social service nonprofits in Puerto Rico can seek project-based funding for education, health care, social services, civic and cultural, or environmental initiatives. Dr Scholl Foundation supports 501(c)(3) organizations, primarily in the U.S., with grants ranging from US $5,000 - US $25,000 for one year of funding.

Nonprofit 501(c)(3) organizations improving health, economic stability, or basic needs can seek project, operating, or capital support that benefits local communities where O’Reilly Auto Parts operates, including Puerto Rico. With a mission to strengthen underserved individuals and families, O'Reilly Automotive Foundation provides funding for health and social services, workforce development, poverty relief, and disaster response initiatives.

Nonprofit 501(c)(3) organizations with programs for youth and families, food insecurity, housing, or environmental stewardship in Puerto Rico can apply for US $30,000 - US $350,000 grants. Chick Fil A Foundation’s True Inspiration Awards fund initiatives like academic enrichment, youth leadership, family services, food access, and community or environmental projects that may benefit those affected by rare diseases.

Nonprofit organizations with strong community partnership programs in Puerto Rico and across the U.S. can apply for Mutual of America Foundation’s Community Partnership Award to recognize exemplary collaborative leadership. This national competition honors partnerships that measurably improve communities, can be replicated elsewhere, and introduce innovative approaches to significant social issues, which may include rare or respiratory diseases.

Non-sectarian nonprofits addressing poverty, disability, social disadvantage, or disaster relief can apply for Gupta Family Foundation grants of US $5,000 - US $250,000. The foundation supports smaller, founder-led organizations worldwide, primarily 501(c)(3)s or qualifying foreign entities, whose programs help disadvantaged people become self-reliant and may include work related to rare or chronic conditions.