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Best Grants for 501(c)(3) in South Carolina

Find the perfect Grants for 501(c)(3) in South Carolina on Instrumentl. 9,000+ Grants for 501(c)(3) in South Carolina in the United States.

9,000+

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$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,441 Results based on applied filters

Program and Small Capital Grants - Health Care

Yawkey Foundation
Private
Barnstable County, Massachusetts, Bristol County, Massachusetts +6 more
Up to US $100,000

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved. The Yawkey Foundation is committed to providing support for program and small capital needs connected to a nonprofit’s established mission and proven program/service delivery connected to the mission.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Health Care Support

Access to high quality health care, particularly for those disadvantaged members of the community, was an issue of great importance to Tom and Jean Yawkey. Tom Yawkey was instrumental in the founding of Georgetown Memorial Hospital, which brought much-needed health care to the rural area of Georgetown, South Carolina. In addition, the Yawkeys first lent their extraordinary support to Dr. Sidney Farber by initiating the Red Sox relationship with Dr. Farber, and laid the groundwork for establishment of The Jimmy Fund in 1953. That relationship lasted throughout both of their lifetimes and continues to this day.

The Yawkey Foundation continues to support medical institutions, including transformational construction and renovation projects to help leading medical institutions expand their footprints and ability to provide expert medical care. Understanding the real link between medical needs and behavioral health needs, particularly in children, the Foundation has also played a leading role in supporting organizations providing access to behavioral and mental health treatment programs. 

Health Care Access & Delivery Health Disparities & Social Determinants of Health Children’s Mental Health

NAFC Patient Care Fund

National Association of Free and Charitable Clinics Inc
Private
United States
US $20,000

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Patient Care Fund

The NAFC Patient Care Fund supports direct patient services that expand immediate access to care. This funding is designed to help NAFC members meet urgent patient needs by supporting clinical supplies, expanded services, contracted providers, transportation assistance, medication access, and other direct care resources.

Patient Care & Services Health Care Access & Delivery Health Facilities & Clinics +1 more

Learning Seed Foundation Scholarship

Community Foundation of South Puget Sound
Private
United States
US $3,000

About Scholarships

Through the incredible generosity of our donors, the Community Foundation of South Puget Sound manages 26 scholarship funds that offer a wide range of scholarship awards and encourage students of all backgrounds and educational interests to apply. We also want to extend a sincere thank you to our many scholarship donors, advisors, and scholarship committee members for their investment in our student's bright futures this year and for many years to come!

Learning Seed Foundation Scholarship

The Learning Seed Foundation Scholarship Fund was established by the Learning Seed Foundation to assist graduating high school seniors in Thurston and Pierce counties in obtaining a higher education. This scholarship is designed to benefit primarily students of color who have overcome significant obstacles and demonstrate a commitment to others. The scholarship has the potential to be renewed for up to an additional 3 years of undergraduate education. Reapplication each year is required.

Education - Higher Education Career / College Preparation Black American Services +1 more

AISES RISE Scholarship

American Indian Science and Engineering Society (AISES)
Association/Society
American Samoa, Canada +5 more
US $2,000
The AISES RISE Scholarship offers $2,000 annually to support Indigenous students pursuing careers in STEM, particularly in the casino gaming industry. This initiative, powered by Aristocrat Gaming, aims to empower Indigenous talent through exposure, resources, and programming. Eligible applicants must be full-time students and current AISES members, demonstrating a commitment to their education and community. The scholarship seeks to enhance diversity in STEM fields by providing critical financial support to deserving students.
STEM / STEAM Education Diversity, Equity & Inclusion Academic Scholarship Programs +2 more

Seymour Siegel Youth Achievement Award

Jewish Community Foundation
Private
United States
Unspecified amount
The Seymour Siegel Youth Achievement Award, offered by the Jewish Community Foundation, provides financial support for high school students pursuing post-secondary education or vocational training. Open to applicants of the Jewish faith, this award prioritizes those from single-parent households, orphans, or foster children. Interested candidates must submit a personal narrative detailing their qualifications. The foundation, established in 1979, is a leading community resource in South Jersey, managing over $35 million in assets.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use

US DOJ: Office of Juvenile Justice & Delinquency Prevention (OJJDP)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use program aims to provide high-quality mentoring services to youth affected by substance use. This funding opportunity supports various mentoring formats, including one-on-one, group, and peer mentoring, to assist those currently using substances or at risk due to familial influences. The initiative seeks to enhance the well-being of these youth through supportive relationships and guidance.
Addiction & Substance Use Disorders Youth Development & Leadership Youth Services +2 more

Gropper Clement Legacy Scholarship

South Dakota Community Foundation
Private
United States
Unspecified amount

Gropper Clement Legacy Scholarship

To provide financial support to graduates of Huron, James Valley Christian, Kadoka and Miller High Schools.

Education - Higher Education Diabetes Physical Disabilities

Herbek Humanitarian Award

College Of American Pathologists Foundation
Private
United States
Up to US $1,500
The Herbek Humanitarian Award honors a CAP member pathologist for significant contributions to the See, Test & Treat® program, which offers free cancer screenings to underserved women. Established in 2011, it commemorates Gene N. Herbek, MD, FCAP, who pioneered this initiative for Native Americans. Nominees must have led or significantly contributed to the program, with submissions due by May 3, 2024. Self-nominations or incomplete entries will not be accepted, ensuring high standards in recognition.
Reproductive Health Breast Cancer Women's Health

Harry Sudakoff Foundation Grant

Harry Sudakoff Foundation
Private
United States
US $5,000 - US $40,000
The Harry Sudakoff Foundation Grant supports qualified charities in Sarasota, Florida, focusing on arts, community, education for youth, environment, human services, and science. Established by builder Harry Sudakoff, the foundation prioritizes organizations with a history of support. Grants are restricted to 501(c)(3) entities, excluding individuals and certain funding types like endowments and operating expenses. A commitment to impactful contributions is central to the foundation's mission.
Art & Culture Community Services Senior Services +6 more

Native Voices Rising Grants

Common Counsel Foundation
Private
United States
Unspecified amount
Native Voices Rising (NVR) offers grants to empower Native-led grassroots organizations in the U.S. With over $16 million awarded since inception, NVR focuses on enhancing lives through collective action and advocacy. Eligible organizations must be Native-led and engage community members in policy improvement efforts. NVR supports initiatives addressing environmental justice, health, and youth involvement, with a commitment to fostering leadership and social change within Native communities.
Indigenous Sovereignty & Rights Native American Culture & Heritage Native American Services +1 more

Imogene Coca Compassion in Care Scholarship

Delaware Community Foundation
Private
United States
US $2,000
The Imogene Coca Compassion in Care Scholarship, offered by the Delaware Community Foundation, aims to support Delaware residents pursuing degrees in nursing or medical fields. Applicants must demonstrate financial need and either have been employed for at least five years or hold an Associate's degree from a community college. This one-time award of $2,000 is part of DCF's broader commitment to enhancing educational opportunities and equity in Delaware.
Education - Higher Education Nursing Medical Education & Professional Training +2 more

Heiser Fund for Leprosy Research Grant

The New York Community Trust
Private
United States
US $87,500 - US $250,000
The Heiser Program for Research in Leprosy, established by Dr. Victor G. Heiser, focuses on innovative biomedical research to combat leprosy. Since 1975, it has funded over 200 grants totaling more than $20 million, supporting early-career researchers and significant projects. The program aims to enhance diagnostic tools, improve treatments, and implement effective surveillance strategies. With a dedicated Scientific Advisory Committee, it ensures rigorous proposal reviews and fosters collaboration among grantees, ultimately advancing leprosy elimination efforts.
Pharmacology Eye Diseases & Disorders Respiratory Diseases & Systems +1 more

Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative

Appalachian Regional Commission
State/Local Government
Adair County, Kentucky, Adams County, Ohio +428 more
Up to US $2,500,000
The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.
Economic Services & Development Workforce Preparation & Job Readiness Job Creation +1 more

Steven Berkeley Marine Conservation Fellowship

American Fisheries Society
Association/Society
North America
US $15,000
The Steven Berkeley Marine Conservation Fellowship, established by the American Fisheries Society in 2007, honors a dedicated fisheries scientist. This $15,000 award supports graduate students engaged in thesis research on marine conservation topics. Applicants must be enrolled in a North American university's M.S. or Ph.D. program and be AFS members in good standing. The fellowship encourages innovative research addressing various conservation issues, not limited to fisheries.
Marine Biology Fisheries Marine / Ocean Conservation

Multiple Sclerosis Scholarship

Battle Creek Community Foundation
Private
United States
Unspecified amount

Every Battle Creek area resident shall have the resources to access post-secondary education and training.

Your dreams matter — and we want to help you achieve them. Whether you’re a graduating high school senior, an adult returning to school, or a graduate student pursuing advanced education, we’re here to support you by opening doors to opportunity.

Beyond tuition, many funds support total cost of attendance — books, fees, equipment, and in some cases childcare or transportation.

Checks are made payable to the educational institution indicated on the follow-up and mailed directly to the educational institution. Checks are typically mailed in early August.

Multiple Sclerosis Scholarship

Dr. Rose Marie Lovio designed this scholarship with her favorite quote in mind: "Life is 10% what happens to us and 90% how we react to it". This scholarship is designed for a student who has been directly diagnosed with the disease or who has a close family member who lives with multiple sclerosis. This chronic illness offers a multitude of challenges and this scholarship seeks a recipient who exudes positivity despite those challenges.

Education - Higher Education Multiple Sclerosis Chronic Illnesses

Ben & Rose Schwabenbauer Educational Scholarship

Cattaraugus Region Community Foundation
Private
United States
Unspecified amount

Ben & Rose Schwabenbauer Educational Scholarship

Established by Ben and Rose Schwabenbauer, former long-time teachers in the Olean City School District, this fund awards scholarships for graduating seniors from Olean High School, Otto-Eldred High School, Portville Central School or Bradford Area High School who will be attending a 4-year college with a preference for students majoring in education, particularly elementary education; criminal justice or a law enforcement-related field; or healthcare-related fields of study. 

Education - Higher Education Crime & Justice Police & Law Enforcement +2 more

Elisa B. Hughey Scholarship for the Arts

Cattaraugus Region Community Foundation
Private
United States
US $500 - US $1,000

Elisa B. Hughey Scholarship for the Arts

Scholarships will be awarded annually from this fund for college-bound students from any Cattaraugus County High School committed to advancing their skills in any aspect of the arts. Preference will be for graduating seniors of Ellicottville, Cattaraugus-Little Valley, West Valley, Salamanca or Franklinville/Ten-Broeck Academy high schools. First preference will be for students pursuing the fine arts, with second preference for students pursuing performing arts fields. This award is not limited to students majoring in art.

Education - Higher Education Performing Arts Fine Art +2 more

Epilepsy Scholarship

Community Foundation of Central Illinois
Private
United States
US $700

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

Epilepsy Scholarship Fund

The Epilepsy Scholarship Fund was established in memory of David S. Izard, who lived in Canton, Illinois, and was active in football, track, and basketball. He graduated from Western Illinois University and worked as an Assistant Manager at Wal-Mart in Georgia. Diagnosed with epilepsy at age 3½, David lived a full and active life. He passed away on December 5, 1992, just fifteen days before his 27th birthday. Additional contributions have also been made in memory of other individuals. 

The fund provides scholarships to students pursuing an education at a junior college or four-year college or university.

Education - Higher Education Epilepsy Educational Access & Equity

Jeannett Slesnick Community Spirit Scholarship

Coral Gables Community Foundation
Private
Alachua County, Florida, Charlottesville City, Virginia +3 more
US $500 - US $2,500
The Jeannett Slesnick Community Spirit Scholarship offers up to four years of college tuition assistance for graduating seniors from Coral Gables High School, Miami Senior High School, or ISPA. Applicants should demonstrate an interest in communications, journalism, leadership, or historic preservation, and must maintain a 3.0 GPA. Established in 2022 by Jeannett and Don Slesnick, this scholarship honors Jeannett's commitment to community service and education, supporting local high school graduates in their academic pursuits.
Civic Engagement & Education Academic Scholarship Programs College Success / Persistence +2 more

BIE Professional Examination Funding

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The BIE Professional Examination Funding, provided by Native Forward Scholars Fund in partnership with BIE, offers financial assistance to support Native students in taking professional examinations, including Bar Examination funding. This award covers registration fees, preparatory course costs, and other exam-related expenses. Applicants must have graduated within one year and can only receive assistance for one exam. This initiative aims to empower Native scholars and enhance their professional visibility and opportunities.
Education - Higher Education Academic Success & Enrichment Native American Services +2 more

Native Forward Community Impact Research Funding

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Native Forward Community Impact Research Funding supports doctoral candidates conducting research that addresses issues affecting Indian Country. This initiative provides essential financial assistance for data collection, analysis, and research travel, ensuring that Native perspectives are included in academic discourse. By fostering the next generation of Native leaders, this funding aims to empower scholars and enhance community impact through education and advocacy, ultimately preserving and enriching Native cultures.
Education - Higher Education Academic Success & Enrichment Native American Services +2 more

Native Forward CPA Examination Funding

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Native Forward CPA Examination Funding provides crucial financial assistance to American Indians and Alaska Natives for covering the costs associated with the CPA examination. This initiative empowers students and professionals to pursue CPA licensure by assisting with application, registration, and exam fees. Eligible applicants can receive support for one section of the exam at a time, ensuring access to essential resources for advancing their careers and contributing positively to their communities.
Education - Higher Education Academic Success & Enrichment Native American Services +2 more

Native Forward Direct Scholarship

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Native Forward Direct Scholarship supports American Indian and Alaska Native students by providing mid-year funding opportunities to alleviate educational costs. With over 50 years of experience, Native Forward has empowered more than 22,000 students from diverse backgrounds. This scholarship recognizes the limited access these students face in higher education and aims to enhance their academic journeys while fostering community engagement and mentorship through a strong alumni network.
Education - Higher Education Academic Success & Enrichment Native American Services +2 more

David Bruce Belcher Fund Scholarship

Benton Community Foundation
Private
United States
Unspecified amount

About

Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

David Bruce Belcher Fund

About the fund

The David Bruce Belcher Scholarship Fund was established for the training of professionals in nursing, special education, and therapy (physical, speech and occupational) as a legacy of David Bruce Belcher and the caregivers who comforted him. This fund reflects David’s rare spirit and bright love in its support of those who seek to advance their nurturing skills in nursing, therapy, and special education.

Education - Higher Education Nursing Physical Therapy +2 more

Stanford Childern's Health Center for IBD and Celiac Disease - Intramural Seed Grants Research Program

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Children's Health Center for IBD and Celiac Disease offers Intramural Seed Grants to promote innovative research in pediatric diseases. This program supports high-risk, high-reward projects, encouraging multi-PI collaborations across disciplines. Awards of up to $100,000 per year for two years are available, aimed at generating preliminary data for future funding applications. Eligible applicants include Stanford faculty holding specific university positions. Proposals should focus on advancing understanding of pediatric IBD and celiac disease through various research approaches.
Digestive System Health & Diseases Maternal And Perinatal Health Children’s Health & Pediatrics

Stanford Medicine Children’s Health Center for IBD and Celiac Disease Postdoctoral and Early Career Support Award

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Medicine Children’s Health Center for IBD and Celiac Disease offers funding for postdoctoral fellows and instructors to conduct innovative research focused on pediatric IBD and celiac disease. This initiative aims to nurture future researchers and prepare them for independent funding opportunities. Eligible research includes basic, clinical, epidemiological, and health policy studies related to maternal and child health. Funding supports substantial salary and benefits, ensuring commitment to impactful research in this critical area.
Digestive System Health & Diseases Children’s Health & Pediatrics Maternal And Perinatal Health

Leonard Litz Foundation-TransPLUS Resource Grants

Leonard Litz Foundation
Private
United States
Unspecified amount
The Leonard Litz LGBTQ+ Foundation, via its TransPLUS Resource Center, supports transgender, gender-nonconforming, non-binary, and intersex individuals. By providing grants and resources, the Foundation aims to address urgent needs in healthcare, housing, and legal services while fostering community connections. They build peer-support networks, publish updates, and support initiatives to empower TGNCNBI individuals and their allies, ensuring that marginalized voices are heard and uplifted.
Sexuality & LGBTQIA+ Rights LGBTQIA+ Services Intersex & Transgender Rights

Grants for 501(c)(3) in South Carolina Highlights

Looking for grants for 501(c)(3) in South Carolina?


Read more about each grant below or start your 14-day free trial to see all grants for 501(c)(3) in South Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grants for 501(c)(3) in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Grants for 501(c)(3) in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Grants for 501(c)(3) in South Carolina over $25K in average grant size

40 Grants for 501(c)(3) in South Carolina over $50K in average grant size

32 Grants for 501(c)(3) in South Carolina supporting general operating expenses

100+ Grants for 501(c)(3) in South Carolina supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

1,000+ Grants on Instrumentl focused on Health Care Access & Delivery

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for grants for 501(c)(3) in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
25.2%
Q3
24.8%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Grants for 501(c)(3) in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$535,356 $535.4 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Grants for 501(c)(3) in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Grants for 501(c)(3) in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Grants for 501(c)(3) in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081