Best Grants for 501(c)(3) in South Carolina

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Healthcare Services Expansion Fund

The NAFC Healthcare Services Expansion Fund supports the launch or expansion of clinical programs and new service areas that increase access to care for underserved patients. This funding is designed to help NAFC members introduce new services or grow existing programs that address unmet community health needs and improve access to comprehensive, patient-centered care.

The OECD Conference Sponsorship aims to enhance scientific knowledge and provide essential information to influence policy decisions on sustainable resource use in food, agriculture, forestry, and fisheries. It supports international events that showcase innovative research and developments, inviting applications from scientists in these fields. The event sponsorship encourages collaboration among policymakers, industry, and academia, ensuring that research insights are effectively communicated and utilized in decision-making processes.

The RNRF Planning and Small Grants program provides funding up to $50,000 to support projects that enhance collaboration among community partners in addressing critical environmental issues. Eligible applicants must be 501c3 organizations in the U.S. and demonstrate multidisciplinary cooperation. Projects should align with RNRF's mission and focus areas, including air quality, biodiversity, and renewable energy. The initiative aims to create sustainable and impactful outcomes by bridging research and practical implementation.

The RNRF Implementation/Collaboration Grants support innovative projects that enhance collaboration among stakeholders to address critical challenges in environmental, social, and economic systems. Offering up to $200,000 for initiatives lasting 12 months or more, these grants aim to implement evidence-based practices and facilitate multidisciplinary teamwork. Eligible applicants must be from 501c3 organizations in the U.S., ensuring alignment with RNRF's mission and focus areas, fostering sustainable and impactful outcomes.

The Siletz Tribal Charitable Contribution Fund, established by the Confederated Tribes of Siletz Indians, has distributed over $16.3 million in grants since 1999. It supports charitable organizations and local governments in eleven Oregon counties, as well as Native American initiatives across the U.S. The fund prioritizes education, health, public safety, addiction prevention, housing, arts, and environmental preservation, ensuring the Tribe's commitment to community support and cultural heritage.

RBC Foundation – USA aims to enhance community quality of life by supporting non-profit organizations that promote diversity and positive change. In 2023, it awarded over $2.8 million in grants, prioritizing youth programs for ages 15-29, arts access for diverse populations, and mental well-being initiatives. The foundation encourages sustainable projects that foster economic independence, providing critical support for education, mental health, and cultural enrichment, thereby making a significant impact across various communities.

The Stantec Community Engagement Grant is dedicated to enhancing the quality of life in communities where Stantec operates. Focused on arts, education, environment, and health and wellness, the grant supports initiatives that foster sustainable development and responsible practices. Organizations seeking funding must align with Stantec's values, emphasizing ethical practices and community impact. Preference is given to projects located near Stantec offices, ensuring a more significant local impact through their contributions.

South Arts Inc

Headquartered in Atlanta, Georgia, South Arts is a nonprofit regional arts organization empowering artists, organizations, and communities, and increasing access to arts and culture.

In partnership with the National Endowment for the Arts and the State Arts Agencies of Alabama, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee — with additional funding from other public and private donors such as the Doris Duke Foundation, the Ford Foundation, and Mellon Foundation — South Arts supports artists and organizations through a rich and responsive portfolio of grants, fellowships, and programs. Why? Because South Arts believes that the arts elevate the region, increasing connectedness and inspiring meaningful change in the process.

Our mission: Advancing Southern vitality through the arts.

Arts in Community Grants

Program Description

Arts in Community Grants are designed to support deeper engagements between Southern communities and artists. Through these grants supported by the National Endowment for the Arts, we aim to increase access to the arts, expand audiences for artists, and broaden our reach. Eligible projects require a Southern artist/company visiting another Southern state for public activities, offering access to arts programming by professional artists. Funding supports Southern film directors, traditional artists, visual artists, performing artists, or writers:

• film (documentary, fiction, experimental, and animation),
• traditional arts (music, dance, storytelling, and visual arts/crafts),
• visual arts (crafts, drawing, experimental, painting, photography, sculpture, and mixed media),
• performing arts (theater, music, opera, musical theater, and dance), and
• literary arts (fiction, creative nonfiction, and poetry).

Projects require an artist or artist ensemble and a host or partner organization. Project must include at least two in-person or live, virtual public activities – both a public presentation (a film screening, performance, reading, or exhibition) and an educational/community engagement activity (a workshop, demonstration, lecture, facilitated discussion, or master class). The grant requires a dollar-for-dollar cash match.

The Philip L. Van Every Foundation provides grants to 501(c)(3) organizations in North and South Carolina, focusing on education, healthcare, human services, and the arts. With a commitment to strengthen communities and support fiscal responsibility, the foundation aims to enhance lives through meaningful projects. Organizations must demonstrate a track record of success to be eligible for funding, which is generally awarded for special projects and capital needs.

The FY26 Defense Established Program to Stimulate Competitive Research (DEPSCoR) aims to enhance research capabilities in eligible states by increasing the number of university researchers and institutions conducting relevant science and engineering research. Sponsored by the Department of Defense, this program will fund multiyear awards to promote research aligned with national security needs. Applications require a multi-stage submission process, emphasizing early registration and timely proposal submissions.

Sanofi Philanthropic Donations support non-profit organizations aligned with Health Equity, STEM Education Equity, and Local Communities. Applications are accepted year-round, with a review process of 8 to 16 weeks. The initiative focuses on improving healthcare access, fostering innovation, and addressing social determinants of health. Sanofi emphasizes collaboration and sustainable solutions, advocating for equal opportunities in health and education, and nurturing future talent to tackle medical challenges.

The Frances P. Bunnelle Foundation offers Mini Grants to support special projects that enhance the quality of life in Georgetown County, SC. With funding up to $5,000, these grants aim to address poverty, promote economic vitality, and encourage youth development. Eligible applicants include IRS-certified 501(c)(3) public charities, government entities, and houses of worship. This initiative is focused on providing quick support for impactful community projects.

The Frances P. Bunnelle Foundation offers the Youth Board Grants to enhance Georgetown County's quality of life. With a focus on addressing poverty, meeting basic needs, and promoting economic vitality, grants up to $2,500 support special projects. Eligible entities include IRS-certified charities and government entities. Funds must be spent within six months, with a final report due seven months after funding. This initiative encourages positive youth development and aims for impactful community engagement.

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The Nord Family Foundation Grant Program focuses on supporting a variety of initiatives in the areas of arts and culture, civic affairs, education, and health and social services. The foundation prioritizes projects that engage youth, strengthen communities, and address basic human needs, particularly in Lorain County, Ohio. Grants are awarded to nonprofit organizations and selected public sector activities that can demonstrate a significant impact and engagement with disadvantaged populations.

The L.B. Research and Education Foundation Grant Program supports U.S.-based nonprofits focusing on innovative education and health solutions for underserved populations. Eligible organizations can apply by submitting a 400-word concept paper, and selected applicants may receive funding ranging from $10,000 to $75,000. The Foundation prioritizes projects that foster critical thinking and creativity, address health disparities, and encourage collaboration. There are no application deadlines, promoting year-round engagement.

The SC Agricultural Conservation Easement Program (ACEP) supports landowners in protecting agricultural viability and conservation values by limiting non-agricultural land uses. It features two main components: Agricultural Land Easements (ALE) that safeguard croplands and grasslands, and Wetland Reserve Easements (WRE) for restoring degraded wetlands. Additionally, the program includes the Wetland Reserve Enhancement Partnership (WREP) to enhance wetland protection efforts, ensuring sustainable agricultural practices and improved wildlife habitats.

The Impact100 Global Veterans Awards empower women to make a significant difference by awarding grants up to $100,000 to nonprofits that serve veterans. Focus areas include art and culture, education, health and wellness, environment, and family initiatives, promoting the well-being and support of veterans across the United States. Eligible organizations must meet specific criteria, including tax-exempt status, and are encouraged to submit proposals that utilize funds effectively within two years.

Power:Ed offers grants ranging from $25,000 to $100,000 for initiatives benefiting South Carolina residents and students. The program focuses on supporting low-income, underserved, and first-generation students, improving access to college, and creating pathways to quality workforce opportunities. Applications are accepted year-round with quarterly reviews following set deadlines. Eligible organizations must be dedicated to enhancing education and career readiness for South Carolina's residents, while ineligible projects include Pre-K programs and routine operating expenses.

The AWG Geoscience Idea Scholarship supports women from under-served communities to pursue careers in Earth Sciences, a field known for its lack of diversity. It offers $2,500 to three upper-division and $500 to one lower-division undergraduate student, along with a one-year AWG membership. Recipients can also be matched with mentors, enhancing their educational journey and career prospects in geoscience disciplines. This initiative aims to promote inclusion and diversity in the geoscience workforce.

The TD Charitable Foundation has been dedicated to improving community quality of life since 2002, contributing over $254 million to non-profit organizations. They fund initiatives aligned with their corporate citizenship goals, focusing on Better Health, Connected Communities, Financial Security, and Vibrant Planet. Special consideration is given to programs that support inclusivity for diverse and historically underserved communities. Their commitment to enhancing lives through targeted grants reflects their core values and social responsibility.

Cell Signaling Technology’s Environmental Grants support initiatives aimed at ecosystem protection, wildlife research, and environmental education. Priority is given to action-oriented projects with at least 70% of funding allocated to those directly impacting the environment. Applications are accepted annually until May 1st, with a focus on organizations in Massachusetts, particularly the North Shore of Boston. Non-profit status is required, and discriminatory projects will not be funded.

The South Carolina Biennial Sea Grant Program, managed by the S.C. Sea Grant Consortium, aims to enhance coastal conservation and sustainable development through research. With approximately $500,000 available annually for one- to two-year projects, grants typically range from $30,000 to $80,000. The program encourages collaboration among faculty from member institutions and supports initiatives that improve the social and economic well-being of coastal residents while conserving marine resources.

The Anonymous Was A Woman Environmental Art Grants offer up to $20,000 for environmental art projects led by women-identifying artists in the U.S. and territories. Focused on themes like regeneration and eco-social engagement, the grants encourage projects that address ecological issues through ethical engagement. For the 2025 cycle, over $520,000 will be distributed, doubling previous funding. Eligible applicants must be 18+, lead artists, and not enrolled in degree programs during the grant term.

The Biophilia Foundation Grants support biodiversity conservation on private lands, focusing on systemic change through community engagement. The foundation encourages organizations to submit letters of inquiry detailing their mission, tax status, funding requests, and intended outcomes. They prioritize private land conservation, ecosystem restoration, and innovative policy initiatives, especially in the arid Southwest and Chesapeake Bay regions. Grants typically range from $5,000 to $25,000, with larger amounts available for established partnerships.

The Fund for Southern Communities Grant supports grassroots social change organizations in North Carolina, South Carolina, and Georgia. Established in 1981, this foundation offers grants and technical assistance to groups fighting discrimination, promoting worker rights, and advocating for environmental protection. Eligible organizations must be registered non-profits with 501(c)(3) tax status. The Fund prioritizes groups with budgets of $150,000 or less focused on long-term social change.