Best Large Grants for Nonprofit Organizations in South Carolina

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

Jean M. Brown Nursing Scholarship Fund 

Jean M. Brown graduated from the St. Francis School of Nursing in 1938. She went on to become Caterpillar’s first Industrial Nurse, a role she deeply valued. Inspired by her career, she wanted to help others pursue nursing as well.

Through her will, Ms. Brown established an endowed scholarship to support nursing students with financial need, with preference given to those pursuing a career in Occupational Nursing. The scholarship fund was created following her passing in October 2000.

The Home Depot Foundation's Veteran Housing Grants Program aims to enhance the lives of U.S. veterans by funding the construction or rehabilitation of supportive housing. Grants, ranging from $100,000 to $500,000, are awarded to 501(c)(3) nonprofit organizations with experience in veteran housing. Since 2011, the Foundation has committed over $550 million to veteran causes and seeks to invest an additional $750 million by 2030, focusing on projects in major cities across the U.S.

Jean Griswold Foundation 

The Jean Griswold Foundation (JGF) is a non-profit organization dedicated to supporting Caregivers through educational opportunities and scholarships. 

Mission

The mission of the Jean Griswold Foundation is to support Caregivers by providing educational scholarships* to enable them to further their training, enhance their careers, and better assist the clients they serve.

By offering educational scholarships, our Foundation will not only make a positive impact on the Caregivers themselves, but also the clients they assist and the home healthcare agencies where they are employed, as well as help advance the overarching home-care industry.

The Jean Griswold Foundation is proud to continue the service created by Dr. Jean Griswold, through spearheading this strategic journey of growth and professional development.

Scholarships

The Jean Griswold Foundation Scholarship Program awards scholarships to deserving Caregivers who wish to further their education in a care-related field. Applicants do not have to be associated with Griswold in any way, and the funds will be paid directly to the institution where the caregiver will be receiving education.  

Summer Scholarship Program

The Jean Griswold Foundation has awarded over $150,000 in scholarships to exceptional Caregivers nationwide since 2022. 

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Amyloidosis

Help with healthcare costs for amyloidosis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Amyloidosis is characterized by a build-up in amyloid protein in specific organs or throughout the body. It is a rare disease that affects multiple systems. Subtypes include hereditary amyloidosis, light chain amyloidosis (AL amyloidosis), and amyloid A (AA) amyloidosis (secondary amyloidosis).

The James Hantak Scholarship, established by The Columbus Foundation, supports graduating seniors from Columbus City Schools, Upper Arlington High School, or volunteers and athletes from Lancaster Special Olympics with special needs. The scholarship offers $5,000 annually for educational pursuits, with an additional $10,000 scholarship awarded based on financial need. Preference is given to athletes and volunteers from Special Olympics. This initiative aims to enhance opportunities for students in central Ohio, promoting inclusivity and community engagement.

The Indian Land Tenure Foundation's Legal Reform Grant Program aims to empower American Indian nations by addressing systemic barriers to land ownership and control. This initiative promotes collaboration on projects like estate planning, land policy reform, and engaging government leaders in discussions about tribal sovereignty. By focusing on legal reforms, the program seeks to rectify longstanding inequities and enhance the ability of tribes to manage their land effectively.

The Rotary Club of Hagerstown Sunrise Foundation Scholarship Fund provides financial assistance to graduating high school students and non-traditional learners pursuing a degree or certificate in various fields. This initiative, supported by the Community Foundation of Washington County, aims to honor local contributions and foster educational opportunities. Applicants must demonstrate commitment to community service and leadership. Scholarships open annually in January and close on April 1st, benefiting the community for generations.

The Arthur L. and Elaine V. Johnson Foundation Grants, established in 1990, aim to support organizations that assist individuals with physical disabilities through guide dogs and other assistance animals. The foundation also prioritizes wildlife conservation efforts, particularly for endangered species and their habitats. Grants are awarded to charitable organizations under specific IRS classifications, focusing on long-term impactful projects. Applications for ongoing operational funding are discouraged, and priority is given to conservation activities that are science-based.

The NIH Blueprint for Neuroscience Research Network aims to enhance foundational research on human consciousness, addressing critical biomedical issues such as coma and dementia. By fostering a collaborative framework among 14 NIH institutes, the initiative seeks to improve diagnosis and treatment of neurological disorders through interdisciplinary approaches. Key objectives include detecting consciousness in minimally responsive patients, enhancing understanding of sleep disorders, and exploring new methodologies. This effort will ultimately strengthen U.S. leadership in neuroscience and improve patient outcomes.

Mary Jo DeVleeschower Scholarship

Mary Jo DeVleeschower was a native of South Bend, Indiana, born January 14th, 1941. She graduated in 1968 from Andrew Jackson High School in South Bend, and graduated from Ball State University in Muncie, Indiana in 1972 with a degree in “special education.” Mary Jo taught at the Alexander Graham Bell School beginning in 1972 working with students who were hearing impaired. She attended the University of Southern California (John Tracy Clinic) and received her Master’s degree in 1978 from Xavier University in Cincinnati, Ohio. As a teacher at the Alexander Graham Bell School, Mary Jo worked through a grant with Gallaudet University in Washington D.C. for the Wole Language Program for the hearing impaired, publishing a related article in a national magazine. Mary Jo DeVleeschower loved the children with whom she worked, and poured her whole heart into her work. She had a special relationship with her students, demonstrated on the day of her memorial when some shared a tribute to her in American Sign Language. She further demonstrated her love and support for her students through the creation of the scholarship through her will.

Award Amount:

• Minimum $500

The Stop & Shop School Food Pantry Program addresses childhood food insecurity by partnering with schools to establish or support food pantries. More than 9 million children in the U.S. face hunger, and this initiative ensures students from pre-K through college have access to meals, so they can focus on their education rather than their hunger. Currently, new applications are not accepted from schools in Boston or NYC boroughs due to capacity issues.

The BJA FY 2026 Harold Rogers Prescription Drug Monitoring Program aims to enhance the capabilities of agencies in collecting and analyzing prescription data for controlled substances. By establishing a centralized database, this initiative will aid in the prevention of drug diversion and abuse, particularly of opioids. The program emphasizes the integration of data with health information exchanges and electronic health records, fostering local decision-making while addressing the needs of tribal and rural areas to combat substance abuse effectively.

The Quinn Alec Hoover Legacy Scouting America Scholarship Fund supports graduating seniors from Scouting America in the Mason Dixon District, encompassing Washington County, MD, and parts of Pennsylvania. Established by the Community Foundation of Washington County, this scholarship honors the legacy of Quinn Alec Hoover, aiming to recognize and assist students who embody the values of scouting. Applications open annually in January, closing by April 1st, promoting community engagement and educational advancement.

The NIH grant focuses on elucidating the role of transporters in key perinatal barriers such as the placenta and blood-brain barrier. By establishing a multi-barrier transport network, the initiative aims to enhance understanding of maternal and infant health regarding nutrient and medication transport. This research will create essential resources and standards, fostering future studies on perinatal exposure and intervention strategies. Ultimately, it aims to advance knowledge in pediatric pharmacology and neurodevelopment.

The BJA FY 2026 Investigating and Prosecuting Sexual Assaults in Confinement Facilities Program aims to enhance state, local, and tribal capacities to investigate and prosecute sexual assault incidents within confinement facilities. This funding opportunity is designed for law enforcement and prosecutorial agencies to effectively address and reduce sexual assault occurrences while improving prosecution success rates. Applications are due by September 30, 2026, at 8:59 PM ET.

The Fishel Scholarship Fund, managed by The Columbus Foundation, offers financial assistance to children of active Teammates pursuing higher education. This initiative aims to alleviate college-related expenses, thus supporting families and encouraging academic achievement. As one of the largest community foundations, The Columbus Foundation is dedicated to enriching the quality of life in the Columbus, Ohio region through impactful philanthropic efforts.

L’Oréal Paris Celebrates 20 Years of Women of Worth

For 20 years, L’Oréal Paris has honored women who uplift their communities through service. These non-profit leaders, our Women of Worth, each receive $25,000 to support their causes, mentorship from the L’Oréal Paris network and a national platform to share their stories.

This funding opportunity supports research aimed at improving health among Native American populations by developing, adapting, and testing interventions. It addresses significant health disparities and seeks culturally informed solutions. The initiative encourages research that informs intervention strategies tailored to community needs, focusing on sustainability and scalability. The program is vital for enhancing health equity and resilience in Native American communities, ultimately aiming to reduce morbidity and mortality through effective health interventions.

The Elsie Beavers Carver and E. Lois Carver Educational Fund Grant supports K-12 educational programs in Horry and Georgetown Counties. It aims to enhance children's learning experiences in core subjects such as language arts, math, and the arts. Eligible applicants must be 501(c)(3) nonprofit organizations. The fund provides resources for equipment, supplies, and special projects, ensuring that no qualified individual is excluded from participation based on various factors.

Donald and Mary Frink Scholarship

The scholarship provides support for students who are hearing impaired.

Award Amount:

• Minimum $1,000

The Logan Nainoa Fujimoto Memorial Scholarship, established in 2005, supports students pursuing Automotive Technology at the Universal Technical Institute or community colleges in Hawaii. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and be residents of Hawaii. Preference is given to past recipients and those attending the Universal Technical Institute. This scholarship honors the legacy of Logan Nainoa Fujimoto, encouraging academic and vocational excellence in the automotive field.

This funding opportunity announcement aims to enhance health interventions for Native American populations. It supports research to develop, adapt, and test culturally informed health promotion and disease prevention strategies. The initiative addresses significant health disparities faced by these communities, emphasizing sustainable and adaptable solutions. Researchers are encouraged to build on community strengths and resilience, focusing on effective dissemination and integration of interventions. The program welcomes applications targeting diverse Native American groups, including Alaska Natives and Native Hawaiians.

The Kiwanis Club of Columbus offers the Service Leadership Scholarship to graduating seniors of Columbus City Schools. This scholarship aims to recognize students with a minimum 3.0 GPA who have demonstrated a commitment to community service. The club, part of Kiwanis International, fosters leadership and service through various local initiatives. By supporting these students, the Kiwanis Club contributes to their educational pursuits and encourages ongoing community engagement, making a lasting impact on both the individuals and the community.

The Mary Eleanor Morris Scholarship, established by the estate of Mary Eleanor Leonard Morris, supports educational opportunities for graduating seniors from Logan County, Ohio. This scholarship reflects Morris's enduring commitment to community service, benefiting students from various local high schools. Eligible candidates must not hold significant national scholarships and must plan to attend an accredited educational institution in the U.S. This initiative aims to empower local youth and foster their educational aspirations.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Cushing’s disease or syndrome

Help with healthcare costs for Cushing's disease or syndrome

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Cushing’s Disease or Syndrome, also known as Cushing’s Syndrome, hypercortisolism and hyperadrenalism, is a condition where the pituitary gland releases high levels of the hormone cortisol. It is a rare disease that affects the endocrine system.

The Samuel Hunter Agricultural Education Scholarship, offered by the Community Foundation of Washington County, MD, aims to support students graduating from WCPS high schools, especially those from Smithsburg High School. This scholarship is designed for students pursuing post-secondary education in agricultural fields, with a preference for FFA/4-H participants. With its commitment to enhancing local education, this scholarship not only honors community contributions but also promotes vital career paths in agriculture.

The Artist’s Palette Scholarship Fund, managed by the Community Foundation of Washington County, MD, supports students pursuing careers in cosmetology, aesthetics, barbering, nail technology, and massage therapy. This fund is designed to assist deserving individuals from Maryland, West Virginia, and Pennsylvania in achieving their educational goals. Scholarships are made possible by local families and organizations dedicated to enhancing community welfare and honoring significant contributions to the community. Applications open annually from January to April.