Best Large Grants for Nonprofit Organizations in South Carolina

The Emergent Fund Grant, established in 2016, supports BIPOC-led social justice movements through rapid response funding. It addresses urgent community needs by providing low-barrier grants to organizations facing crises such as family separation and systemic oppression. The fund prioritizes initiatives that foster Black liberation, multiracial solidarity, and empower communities to build transformative power. By investing in innovative strategies, the Emergent Fund aims to challenge oppressive structures and advance social justice, ensuring that impacted communities are at the forefront of their own advocacy.

The Sandusky-Firelands Alzheimer’s Scholarship provides financial support to residents of Erie County, Ohio, pursuing degrees in the Medical and Health Care fields, particularly those interested in working with geriatric patients. Established in 1995 by a dedicated non-profit organization, this scholarship aims to enhance community well-being and quality of life. Renewals for up to three additional years are possible, depending on financial need and the discretion of the Scholarship Advisory Committee.

About Us

The Food Allergy Fund is the leading nonprofit dedicated to funding food allergy research. FAF's grants support the creation of new treatments that will address the root causes of food allergies. Through our ground-breaking research and unique thought leadership summits, we accelerate innovation to find solutions.

Food Allergy Fund Drug Repurposing Program

Grants will be awarded to research teams that propose innovative approaches to repurposing therapeutics for the prevention or treatment of food allergy. We would welcome proposals identifying either an existing FDA-approved drug or drug in development with human safety data that has a rationale for the prevention of food allergies, prevention or treatment of food induced anaphylaxis, or an improved method for maintaining food allergic tolerance in previously allergic patients.

We are particularly interested in either small molecule drugs or biologicals that have well defined mechanisms of action that provide a scientific rationale for use in food allergies. Examples could involve drugs such as enzyme inhibitors or immunomodulators with specific activities that lend themselves to alter intestinal, mucosal or immune function.

The Kors, Lois E., Educational Scholarship, established by the Beatrice Educational Foundation, aims to support Beatrice High School graduates in pursuing higher education. With a strong commitment to academic achievement and civic involvement, the Foundation awards over $55,000 annually in scholarships. Applicants must demonstrate financial need, citizenship, and academic merit. This scholarship encourages students to enter the teaching profession, providing essential funds to help them achieve their educational goals.

Scholarship Overview

Since 1980, the Northern New York Community Foundation has awarded more than $28 million in scholarships to students from Jefferson, Lewis, and St. Lawrence counties.

Evergreen STEM Scholarship

The Evergreen STEM Scholarship is a $3,000 award for the first year of undergraduate study. Scholarship award decisions will be made in the summer 2026. Scholarship award checks are not presented until summer 2027 as students head to college.

The Roger Arliner Young (RAY) Fellowship Program, managed by the Environmental Leadership Program, aims to foster conservation and clean energy careers for emerging leaders of color. This two-year paid fellowship provides recent graduates with professional development, mentorship, and networking opportunities. Ideal candidates are those with a passion for social and environmental justice, who identify as part of historically marginalized groups, and are committed to community engagement. The program emphasizes diversity, equity, and inclusion in the environmental sector.

The Dan D. Nale Engineering Scholarship, established by the Community Foundation of the Lowcountry in 2019, supports academic excellence among dependents of Gulfstream Aerospace employees. Eligible students must pursue a Bachelor of Science in Engineering with a GPA of 2.5 or higher, focusing on Civil, Mechanical, Electrical, or Aerospace disciplines. Preference is given to applicants attending the Citadel or those who have participated in Gulfstream co-op or internship programs.

The Native Entities Grant Program, initiated by NTIA under the Digital Equity Act of 2021, aims to support Indian Tribes, Alaska Native entities, and Native Hawaiian organizations. This program streamlines funding through a unified application for two significant initiatives: the State Digital Equity Capacity Grant and the Digital Equity Competitive Grant. By focusing on reducing administrative burdens, it enhances access to digital resources and equity in underserved communities.

The Oak Advisors Scholarship of Excellence, offered by the Community Foundation of the Lowcountry, supports southern Beaufort County high school seniors pursuing a major in business, economics, or finance. Established by philanthropic leaders, the scholarship recognizes students for their academic achievements, talents, and community involvement. With a minimum GPA of 3.2 required, this scholarship aims to empower students to make a positive impact in their communities.

The Rachael and Ben Vaughan Foundation offers grants ranging from $2,000 to $20,000 for projects focused on animal rights, education, environmental preservation, poverty reduction, and religious initiatives. The foundation prioritizes local Texas projects but accepts applications from outside the state. Grants are awarded only to tax-exempt organizations, and projects should be completed within twelve months. The foundation aims to support initiatives that benefit local communities without duplicating existing efforts.

The Norman Foundation Grants aim to empower communities in the U.S. to enhance their economic, environmental, and social well-being. By supporting projects that promote economic justice, prevent toxic waste disposal, and link grassroots efforts to broader reform, the foundation seeks to foster systemic change. It prioritizes organizations with annual budgets under $1 million, ensuring funds are directed to initiatives that resonate with the aspirations of those most affected by social issues.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

JustJane Art Scholarship Fund for Women

Truly unique humans like Jane Marie Ewing do not populate the universe very often, and the JustJane Art Scholarship for Women was created to honor her remarkable spirit.

Jane was an artist at heart, finding joy in countless creative pursuits – whether baking delectable treats, capturing life’s beauty through photography, or expressing her imagination in fashion and digital illustration. Her zest for life was infectious, often bringing laughter through her playful “Jane Pranks”, which will forever live in the hearts of family and friends. Jane shared an inseparable bond with Kyle, each the center of the other’s universe. Tragically, Jane was taken from this world unexpectedly in 2025.

Her vibrant artistic soul touched every aspect of her life – from painting and interior design to crafting costumes for parties and pranks. Though her passion for art wasn’t fully nurtured early on, once she embraced it later in life, creativity flowed freely, illuminating the lives of everyone around her. Jane saw beauty everywhere, and her art became a reflection of that vision.

This scholarship carries forward Jane’s legacy, helping future generations cultivate their own artistic passions. It is a reminder to future generations that art has the power to transform lives.

Cumberland Community Foundation ("CCF") manages more than 60 scholarship endowment funds created by local individuals, families, civic organizations, and corporations who want to provide a path to higher education for future generations. 

Each year, Cumberland Community Foundation announces more than $1,000,000 in college scholarships to students from southeastern North Carolina.

Beth Bryan Creative Arts Fund Scholarship

Graduating senior from any high school in Cumberland County.

Timothy B. Snyder Memorial Scholarship Fund

Fund provides financial scholarships to deserving young men and women from high schools in the counties of Botetourt, Halifax and Shenandoah.

Amount

• $1,000+

The National Cancer Institute (NCI) plans to issue a Notice of Funding Opportunity (NOFO) for the Paul Calabresi Career Development Award in Clinical Oncology (K12). This program aims to enhance training for clinician-scientists in cancer research, fostering their career development and collaboration with basic research scientists. It mandates diverse oncology specialties in faculty, individualized career development plans, and mentorship, supporting Scholars for up to three years to promote their research initiatives in clinical trials.

The Jerome H. & Dr. Elizabeth Emling Post Graduate Fund, established by the Erie Community Foundation, supports Erie County residents pursuing doctorate degrees or advancing master's degrees in Social Service or Education. In 2023, over $800,000 was awarded to more than 500 students for post-secondary education. Priority is given to doctoral candidates already enrolled in relevant fields, ensuring support for those committed to making a difference in their communities.

The Transformative Organizing Grants, funded by the Arch Community Fund, aim to bolster grassroots movements advocating for systemic change. These grants, ranging from $15,000 to $25,000, prioritize organizations with 501(c)(3) status and an annual budget under $1 million. The focus is on empowering community leadership through anti-capitalist solutions, promoting intersectionality, and addressing immediate needs while fostering long-term structural change. Eligible groups are encouraged to apply for support in their transformative organizing efforts.

August Corso Scholarship Fund

Scholarships shall be awarded to residents of Erie County, Ohio pursuing a post-secondary education. Preference shall be given to students pursuing a degree in Horticulture, Environmental Science or Agricultural Business. Financial need is a consideration for the scholarship award.

Scholarships are available for students planning to attend an accredited nonprofit college or university, or planning to receive licensure, accreditation, or a certificate from a nonprofit vocational or apprenticeship program in the United States.

The scholarship may be renewed for a second, third, and fourth year.

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Kichler, Tony and Gertrude Scholarship Fund

For high school seniors or college students who reside in Green or Noble TOWNSHIPS (not county) in Noble County who are pursuing a college education in music, medicine or religion. One-time payment of $3,500. May reapply.

The NEA Foundation's Student Success Grants support educators in creating innovative learning experiences that foster critical thinking, problem-solving, and cultural understanding among students. This initiative encourages project-based and personalized learning, enabling students to engage with real-world challenges. Applicants must be members of the National Education Association and can use grant funds for educational materials and experiences. The focus is on enhancing academic skills, communication, and collaboration, ultimately promoting joy in learning.

The U.S. Department of Energy (DOE) is launching the PROSPECT Program to enhance education in critical technologies, targeting an investment of up to $100 million. This initiative aims to develop a skilled workforce across the critical minerals and materials sector, supporting the entire value chain from resource extraction to recycling. By fostering collaboration among academia, industry, and national laboratories, the program seeks to strengthen U.S. economic competitiveness and energy security.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Easterby Family Scholarship ($7,000)

This renewable scholarship is for students from Laurens County, South Carolina who are pursuing graduate or post-graduate education in the fields of theology or medicine. 

The Tuttleman Foundation, established in Philadelphia in 2003, provides grants ranging from $1,000 to $250,000 to 501c3 organizations. Guided by the legacy of Stanley and Edna Tuttleman, the foundation focuses on areas such as education, community building, health care, arts and museums, basic human services, and spirituality. Their engaged philanthropy aims to support enduring benefits for the communities they serve, reflecting the founders' commitment to impactful giving.

The Fred C. Gloeckner Foundation Research Fund Grant, established in 2024, supports innovative floriculture research and education. This partnership between the Gloeckner Foundation and AFE aims to enhance advancements in floriculture through substantial funding. Grants are available for university and college projects, emphasizing significant research importance and public accessibility. Projects can include funding for research assistants and must be accompanied by detailed outlines. Indirect costs and salaries are not covered.

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

HOLA at Microsoft Scholarship

This scholarship supports high school seniors who self-identify as Hispanic/Latino decent and is a U.S. citizen, permanent legal resident or be an individual granted deferred action status under the Deferred Action for Childhood Arrivals Program. Eligible applicants must plan to study Engineering, Computer Science, Computer Information Systems, Business Administration, Finance or Marketing at an accredited two- or four-year college, university, or vocational school. This scholarship is a $5,000 award with up to five (5) scholarships granted.

Feld Entertainment's Charitable Contributions aim to support children in need through various initiatives. Their donations have significantly impacted organizations like St. Jude Children's Research Hospital and the Make-A-Wish Foundation. They offer cash and in-kind contributions to help underserved communities, providing tickets to nonprofit youth organizations and funding educational programs in the performing arts. Employees are encouraged to engage in local charity events, reinforcing the company's commitment to making a difference in the communities they serve.

The Impact Aid Discretionary Construction Grant Program (84.041C) offers $19M in funding to Local Educational Agencies (LEAs) to address urgent school facility needs. This initiative supports repairs, renovations, or replacements required to maintain safe educational environments. Grants cover projects that improve accessibility in compliance with the Americans with Disabilities Act (ADA) and ensure that facilities meet health standards. The program aims to enhance learning conditions by responding effectively to emergency situations.