Best Large Grants for Nonprofit Organizations in South Carolina

Invest in Others

The Invest in Others 501(c)(3) Charitable Foundation amplifies, celebrates, and inspires the charitable work of the financial services community.

We provide a platform for financial professionals to make an impact on the causes they care about, channeling the philanthropy and volunteerism of the finance industry to make a difference where it’s needed most. We provide critical grant funding for nonprofits nationwide, helping fill gaps left by shrinking budgets and growing need.

Invest in Others Awards

About the Awards

The Invest in Others Awards recognize the charitable work of financial advisors and honors recipients at an annual awards gala in Boston.

Nominations are evaluated based on an advisor’s leadership, dedication, contribution, inspiration and impact on a nonprofit and the community it serves. Three finalists will be selected in each of the five categories with one recipient being chosen for each award.

Award finalists and recipients will receive grants from Invest in Others for their designated charities:

• Honorable mentions will receive $2,000
• Finalists in all five categories will receive $25,000
• Recipients in the Catalyst, Community Service, Emerging Impact, and Volunteer of the Year categories will receive $60,000
• The Lifetime Achievement Award recipient will receive $100,000

Community Service Award

Presented to an advisor who has made an outstanding impact on a community through leadership contributions to a nonprofit organization for at least 3 years. He or she has not only contributed to the long-term sustainability of the nonprofit, but also has an established record of motivating and inspiring others. This includes serving with distinction as a fundraiser, board member, or other executive position.

Invest in Others

The Invest in Others 501(c)(3) Charitable Foundation amplifies, celebrates, and inspires the charitable work of the financial services community.

We provide a platform for financial professionals to make an impact on the causes they care about, channeling the philanthropy and volunteerism of the finance industry to make a difference where it’s needed most. We provide critical grant funding for nonprofits nationwide, helping fill gaps left by shrinking budgets and growing need.

Invest in Others Awards

About the Awards

The Invest in Others Awards recognize the charitable work of financial advisors and honors recipients at an annual awards gala in Boston.

Nominations are evaluated based on an advisor’s leadership, dedication, contribution, inspiration and impact on a nonprofit and the community it serves. Three finalists will be selected in each of the five categories with one recipient being chosen for each award.

Award finalists and recipients will receive grants from Invest in Others for their designated charities:

• Honorable mentions will receive $2,000
• Finalists in all five categories will receive $25,000
• Recipients in the Catalyst, Community Service, Emerging Impact, and Volunteer of the Year categories will receive $60,000
• The Lifetime Achievement Award recipient will receive $100,000

Emerging Impact Award

Presented to an advisor 45 years of age or younger who is making a mark in their community through their outstanding commitment of time, talent, and resources to a nonprofit over a period of at least 3 years, demonstrating exceptional promise in what they have already contributed and paving the way for the future.

The Inja & Kwang Choi, MD Family Scholarship, awarded by the Erie Community Foundation, supports deserving seniors from local high schools who aspire to pursue careers in medicine or engineering. With over $800,000 in scholarships distributed in 2023, this initiative helps students with a GPA of 3.0 or higher achieve their educational goals, fostering the next generation of professionals in critical fields.

John J. Murphy Family Scholarship

Named in honor of John J. "Jack" Murphy, Olean native and former CEO and Chairman of Dresser Industries, this scholarship was established initially through a grant from the Communities Foundation of Texas and is continued with donations from generous donors. Selection criteria includes scholastic achievement, school and community participation, demonstrated leadership potential and financial need.

Invest in Others

The Invest in Others 501(c)(3) Charitable Foundation amplifies, celebrates, and inspires the charitable work of the financial services community.

We provide a platform for financial professionals to make an impact on the causes they care about, channeling the philanthropy and volunteerism of the finance industry to make a difference where it’s needed most. We provide critical grant funding for nonprofits nationwide, helping fill gaps left by shrinking budgets and growing need.

Invest in Others Awards

About the Awards

The Invest in Others Awards recognize the charitable work of financial advisors and honors recipients at an annual awards gala in Boston.

Nominations are evaluated based on an advisor’s leadership, dedication, contribution, inspiration and impact on a nonprofit and the community it serves. Three finalists will be selected in each of the five categories with one recipient being chosen for each award.

Award finalists and recipients will receive grants from Invest in Others for their designated charities:

• Honorable mentions will receive $2,000
• Finalists in all five categories will receive $25,000
• Recipients in the Catalyst, Community Service, Emerging Impact, and Volunteer of the Year categories will receive $60,000
• The Lifetime Achievement Award recipient will receive $100,000

Volunteer of the Year Award

Presented to an advisor who has made a significant impact on a nonprofit as a volunteer of at least 3 years by working hands-on and giving of their time, talent, and energy to make a lasting impact on the organization, those it serves, and the community at large.

Invest in Others

The Invest in Others 501(c)(3) Charitable Foundation amplifies, celebrates, and inspires the charitable work of the financial services community.

We provide a platform for financial professionals to make an impact on the causes they care about, channeling the philanthropy and volunteerism of the finance industry to make a difference where it’s needed most. We provide critical grant funding for nonprofits nationwide, helping fill gaps left by shrinking budgets and growing need.

Invest in Others Awards

About the Awards

The Invest in Others Awards recognize the charitable work of financial advisors and honors recipients at an annual awards gala in Boston.

Nominations are evaluated based on an advisor’s leadership, dedication, contribution, inspiration and impact on a nonprofit and the community it serves. Three finalists will be selected in each of the five categories with one recipient being chosen for each award.

Award finalists and recipients will receive grants from Invest in Others for their designated charities:

• Honorable mentions will receive $2,000
• Finalists in all five categories will receive $25,000
• Recipients in the Catalyst, Community Service, Emerging Impact, and Volunteer of the Year categories will receive $60,000
• The Lifetime Achievement Award recipient will receive $100,000

Lifetime Achievement Award

Presented to an advisor who has made a profound contribution to a non-profit organization through an established history of distinguished service, where he or she exhibited leadership, provided inspiration, and gained recognition and respect from peers and the community over a period of at least 20 years, helping the organization evolve and creating a lasting impact on the future of the organization.

What We Do

At the North Carolina Community Foundation, we bring together generous people and connect them to causes and organizations they care about.

Our mission is to inspire North Carolinians to make lasting and meaningful contributions to their communities.

Our Philanthropic Network

We believe in the power of permanent philanthropy to strengthen our communities and people. By stewarding and growing donors’ gifts, our philanthropic network makes a powerful impact through robust grants and scholarships programs.

Humphrey-Ragsdale Scholarship Fund

Criteria

Residents of Craven County or graduates of a Craven County high school who are pursuing higher education at a two-year or four-year college or university, community or technical college, apprenticeship program, or pursuing graduate school or other professional degree such as dental, medical, law or seminary. Preference for those with a connection to First Baptist Church of New Bern, including but not limited to a church member, family of a church member, employee or former employee, family of employee or former employee, or youth group member.

The Tennant Foundation offers equipment donations to eligible 501(c)(3) nonprofit organizations in the U.S. that promote a cleaner, safer, and healthier world. Donations focus on organizations that are charitable, educational, scientific, or literary. However, certain groups such as political or religious organizations, social clubs, and private foundations are ineligible. The foundation also considers the impact of donations on its partners and distributors before making decisions.

About Us

We are one of more than 750 similar tax-exempt public charities throughout the United States that work to make their community a better place to live. We are a local organization staffed by residents of the community and led by a board of trustees who have an in-depth knowledge of the issues that shape our County.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

About Our Scholarships

Our scholarships exist thanks to local families, friends, and organizations who have partnered with the Community Foundation to memorialize or honor someone, celebrate their alma mater, or promote a chosen career field. The creation of a scholarship fund can affect the donor as much as the recipient. 

The Community Foundation of Washington County, MD offers more than 100 scholarships for graduating high school students and non-traditional students in continuing education. 

The Thomas J. Bowers Aviation Scholarship Fund

A scholarship fund created in honor of Thomas J. Bowers to provide scholarships to deserving Washington County students who are active members of the Civil Air Patrol and express a desire to pursue a degree in an aviation-related field.

The Resilient Student Scholarship, established in 2023 by AIAA and Club for the Future, aims to support high school seniors pursuing STEM degrees at U.S. institutions. This $10,000 scholarship is designed for students facing unique challenges, including disabilities or socioeconomic hardships. Recipients will receive mentorship from AIAA professionals to guide them toward successful careers in aerospace, fostering a new generation of innovators in the field.

Waneta Drake Miller Edmison Memorial Scholarship

Awarded to graduating seniors of accredited high schools in the Sioux Falls area. Plans to attend an accredited college, university, community college or technical school.

Multiple scholarships are awarded.

The Kevin Ernst Memorial Scholarship, established in 1995, honors a compassionate young man who aspired to teach mathematics. Offered by the Grand Haven Area Community Foundation, this competitive scholarship supports students residing in the Tri-Cities studying mathematics or accounting, with a priority on financial need. Applicants are required to submit academic transcripts and additional documents as needed. This fund reflects the legacy of Kevin Ernst, encouraging future educators to pursue their dreams.

The Alliance Global Partners Scholarship, established in August 2022 by the Community Foundation of the Lowcountry, offers post-secondary financial aid to graduating students from southern Beaufort County high schools. This scholarship aims to support those pursuing business education at accredited institutions. With a commitment to enhancing educational opportunities, this initiative reflects the foundation's mission to empower local communities and ensure that students can thrive in their academic and professional pursuits.

Transportation Assistance Grant

The Transportation Assistance Grant program was established to help members of the MS community remain as independent as possible, and ensure all people with MS have the transportation necessary to get the best medical care.

The program provides funding for reasonable paratransit fees. In partnership with Lyft and Uber, the program can also provide funding for transportation to and from appointments for MS care, limited to neurologist visits and infusion centers, at no cost to the person with MS.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The KUH P30 Resource Core Center funding opportunity invites applications for centers aimed at enhancing research in Kidney, Urology, and Hematology diseases. These centers will provide essential resources, including data and tools, to the research community, fostering collaboration through a national network with the Center Coordinating Hub. This initiative by the National Institutes of Health aims to drive innovative research and shared expertise for improved health outcomes.

Camillo Family Scholarship 

Benefiting dependents of Camillo Properties, Camcorp Entities, or LCI Services employees.

The Camillo Family Scholarship was created to provide dependents of employees of Camillo Companies (Camillo Holdings, LCI Services, Legend Homes, Millmark Capital, and SimplyHome) with scholarships to further their education.

This is a renewable scholarship, meaning recipients can renew the award and claim up to 4 years of funding if they meet the GPA and enrollment requirements and complete the renewal application for each academic year they plan to be enrolled.

Multiple scholarships awarded for the 2026-27 academic year. Award amount varies by college/degree type:

• 4-Year College/University - The scholarship is comprised of up to four annual awards of $5,000, for a total award of up to $20,000. The four annual awards may be received over a period of up to five years.
• 2-Year College/Trade School - The scholarship award is comprised of up to two annual awards of $2,500, for a total award of up to $5,000. The two annual awards may be received over a period of up to three years.

What can the scholarship be used for?

The scholarship will be mailed directly to the student's college to be used towards tuition, required academic fees, and/or book expenses. 

Scholarship funding cannot be distributed directly to the student. 

Arnold Ventures

Arnold Ventures (AV) is a philanthropy dedicated to improving the lives of Americans through evidence-based policy solutions that maximize opportunity and minimize injustice. We focus on improving systems where outcomes are falling short, incentives are misaligned, and the time is right for change. To advance this mission, we invest in rigorous research to strengthen the evidence base on what works to improve outcomes for individuals, families, and communities, and to inform policy and practice at scale.

AV’s Higher Education team seeks to fund rigorous, causal research on programs, policies, and practices that improve student outcomes and deliver stronger returns on investment for students and taxpayers. Our work focuses on strengthening the evidence base on effective student success models and aligning policy and funding incentives to support their adoption and scale.

Causal Research to Improve Outcomes for Part-Time Students

Purpose of the RFP

This RFP seeks to fund rigorous causal research that builds the evidence base on effective programs and policies for part-time students and identifies scalable, cost-effective approaches to improve completion and labor market outcomes. Findings should generate actionable insights to inform institutional practice, system-level decision making, and state policy, with the goal of improving outcomes and maximizing return on investment for students and taxpayers.

Population of Interest

Because enrollment intensity is fluid, proposals do not need to limit eligibility to students who are enrolled part-time at baseline. Instead, studies should focus on interventions that primarily serve or are expected to meaningfully impact students who are more likely to enroll part-time, including:

• Adult learners (age 25+)
• Student parents and caregivers
• Working adults

Interventions may serve mixed-enrollment populations, so long as the proposed study is clearly designed to improve outcomes for these populations.

Pfizer’s Core Values of Social Responsibility and Philanthropy

About

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. It was Charles Pfizer’s vision at the beginning and it holds true today.

Improving Health Outcomes in Patients with ATTR-CM Through the Development of a Shared Decision-Making Tool (Decision Aid)

Overview

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a progressive, lifethreatening condition associated with significant morbidity, mortality, and burden on patients, caregivers, and healthcare systems. The multisystemic disease course is often characterized by diagnostic delays, complex treatment pathways, and evolving therapeutic options, which can create uncertainty and decisional conflict for patients and clinicians alike. Shared decision-making (SDM) has emerged as a critical component of patientcentered care1, particularly in complex and preference-sensitive conditions such as ATTR-CM. Well-designed decision aids can support meaningful dialogue between patients and healthcare professionals by improving understanding of disease trajectory, treatment options, risks and benefits, and alignment of care with individual patient values and goals.

The Pfizer Clostridioides difficile Research Collaboration aims to engage innovative researchers to explore the burden of C. difficile infections. Selected investigators will collaborate with Pfizer's medical team to design a research project and publication. The initiative covers multiple countries, including France and the US, acknowledging the significant health risks posed by C. difficile. Projects can request funding up to $500,000 USD, with a maximum duration of 12 months, emphasizing the urgent need for further studies in this area.

The Ryder Sroufe Memorial Scholarship, established by the Community Foundation of Whitley County in 2025, honors the legacy of Ryder Carl Sroufe. This scholarship supports young individuals who embody enthusiasm, humility, and compassion, reflecting Ryder's spirit of kindness and service. It aims to empower the next generation of leaders and helpers, ensuring that Ryder's values of hard work and community commitment continue to thrive. Eligible students are recognized for their efforts to strengthen their communities.

The Emily Trussell Stupak Scholarship Fund, established by the Maine Community Foundation, supports graduating seniors from high schools in Penobscot, Piscataquis, and Hancock Counties. It aims to assist those pursuing higher education at accredited colleges or universities, particularly those who have shown dedication and talent in their chosen athletic pursuits. This fund exemplifies the Foundation's commitment to fostering educational opportunities and community support, making a positive impact on students' futures.

AD Osherman Scholarship

Benefiting first-generation students in Texas.

Funding

Four (4) scholarships awarded out:

• $3,500 for students pursuing a 4-year degree
• $2,500 for students pursuing a 2-year degree

One-time award. Previous recipients may reapply as long as all eligibility requirements are met.

About

Community Foundation of Greenville bridges philanthropy and purpose in Greenville County, helping people make their charitable giving simpler and more powerful for 70 years. We strategically match diverse needs and opportunities in Greenville County with philanthropic resources.

Vision:

Community Foundation of Greenville will be the leading catalyst for developing assets and unlocking potential to meet the needs of an inclusive and equitable community.

Mission:

Community Foundation of Greenville improves the lives of Greenville County residents through strategic philanthropy, community investment, and collaborative leadership.

Obermier Scholarship Fund in Memory of John N. Obermier, Edith M. Obermier and Mary Belle Obermier

Purpose

Mary Belle Obermier established this scholarship with a gift from her estate in 2012. Her intent was to help academically deserving students who need financial assistance to be able to attend college and to give preference to qualified students who are committed to a career in the United States Navy. The preference for naval students is in recognition of the US Navy careers of her deceased husband, John, and his deceased first wife, Edith, who were both veterans of World War II.

Criteria:

• Applicants must demonstrate financial need (economically disadvantaged).
• Applicants must have a current academic GPA of 3.0 or higher.
• Applicants must be enrolled/accepted to an institution of higher learning prior to applying.
• Applicants must submit one letter of recommendation from a teacher, employer, or clergy.

Preference in the selection process will be given in the following order to qualified students who are:

students who are committed to a career in the United States Navy

residents of Greer, SC

residents of South Carolina and

residents of all other states

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Dobe E. and Jacqueline C. Ulmer Scholarship

Purpose of Scholarship

For a graduating senior who is hard-working, focused, thoughtful, caring, selfless, and dedicated to continuous learning.

Number and Size of Awards

One award of $1,000; paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters. A second award of $500 may also be given.

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

Ethan J. Hazelwood Heart of Gold Memorial Scholarship

The Ethan J. Hazelwood Heart of Gold Memorial Scholarship was established in 2025 by family and friends of Ethan as a lasting tribute to his life and giving spirit.

Those who knew Ethan remember him as a kind, creative, and giving person. He was always helping others and once gave the boots on his feet to a fellow student who had none.

Open to individuals in Whitley and Noble County, the scholarship is for high school seniors as well as non-traditional students, who wish to pursue additional education in the field of agriculture or diesel mechanics.