Best Large Grants for Nonprofit Organizations in South Carolina

The NFL Foundation Grassroots Program, in partnership with the Local Initiatives Support Corporation (LISC), aims to enhance the quality, safety, and accessibility of community football fields. With grants up to $250,000, this initiative addresses the critical lack of safe recreation spaces in low-income neighborhoods, ensuring children and adults have access to well-maintained facilities for gathering and exercise, ultimately fostering community health and well-being.

The Baltimore Life Community Grants Program, established by the Baltimore Life Foundation, awards grants of up to $500 to nonprofit organizations in various states, including Maryland and Virginia. This initiative aims to enhance community quality of life through projects that focus on family safety and community enhancement. Eligible applicants must be IRS-certified 501(c)(3) organizations, with priority given to those with volunteer support. This program reflects Baltimore Life's commitment to corporate citizenship and community involvement.

The Nationwide Fishing Trap Removal, Assessment, and Prevention (TRAP) Program aims to eliminate derelict fishing traps nationwide. Focused on collaboration, it emphasizes standardized data collection, quantifying impacts, and comprehensive data sharing. With an annual budget of up to $1,475,000, the program supports 6 to 15 projects, providing grants ranging from $50,000 to $200,000 for 18-month initiatives. This effort significantly enhances marine resource conservation by reducing bycatch mortality and removing abandoned traps.

The Abney Foundation Grant supports innovative and creative projects that address community needs in South Carolina, particularly in health, education, social services, and cultural affairs. With a strong focus on higher education, the foundation allocates 75-80% of its funding for this purpose. Eligible applicants include 501(c)(3) organizations, while individual grants and operational expenses are typically not funded. A Letter of Intent is encouraged for potential applicants.

The SEARCH Grant provides essential support for very small, financially distressed rural communities by funding predevelopment feasibility studies and technical assistance for water and waste disposal projects. Eligible applicants include state and local governments, nonprofits, and federally recognized tribes. Funds can be used for feasibility studies, design analysis, and technical help in securing financial assistance, ensuring improvements in rural infrastructure and community health.

The USDA Rural Development program provides essential loans and grants to improve water and waste disposal services in low-income communities, specifically targeting Colonias recognized before 1989. This initiative aims to alleviate health risks associated with inadequate access to safe drinking water and waste management. Eligible applicants include federally-recognized tribes and local governments, with funds supporting the construction of vital infrastructure to ensure community health and sustainability.

The Water and Waste Facility Loans and Grants program aims to provide safe drinking water and waste disposal services to low-income communities on Tribal lands, addressing significant health risks. Eligible applicants include federally-recognized Tribes, state and local governments, and nonprofit organizations. Funding can be used for constructing essential water and waste systems, and while matching funds are typically required, a full grant is possible under certain conditions. Applications are accepted year-round.

This funding opportunity invites innovative pilot studies focused on biological, behavioral, and social mechanisms related to HIV pathogenesis, aligning with NIDDK's mission and NIH HIV/AIDS research priorities. Topics may include exploring pathophysiological mechanisms of HIV comorbidities and coinfections, understanding HIV reservoirs in relevant tissues, and examining social determinants affecting health outcomes. Applications are due by 5:00 PM local time of the applicant organization.

The NIDCD is offering funding to advance HIV/AIDS research, particularly focusing on areas related to communication disorders. This initiative supports low-risk clinical trials and encourages researchers to align their proposals with high priority topics identified by the NIH Office of AIDS Research. Applications must be submitted by the local deadline, with optional Letters of Intent due 30 days prior to the proposal deadline. This opportunity aims to enhance understanding and treatment in this crucial health area.

The Patterson Foundation offers Assistance Dog Program Grants to support organizations providing service animals to veterans and individuals with disabilities. Funding is available for projects that expand capacity, personnel costs related to puppy training, and program support aimed at improving client experiences. Eligible organizations must be 501(c)(3) non-profits and can request grants up to $35,000 for capital projects or $10,000 for program support. Applications are accepted through a two-step process.

The Honda USA Foundation's Mobility Pillar Award aims to empower individuals with disabilities by funding programs that enhance access and mobility. The foundation supports nonprofit organizations and schools that provide therapeutic, adaptive, and comprehensive care programs, as well as mobility modifications and assistive technology. Applications are accepted from U.S.-based organizations with 501(c)(3) status or fiscal sponsors, ensuring that the joy of mobility is accessible to all.

The Asian Cultural Council's Graduate Fellowship provides financial support for travel and living expenses to graduate students from Asia studying in the U.S. It offers $15,000 for one academic year, potentially renewable for another year, covering essential costs while pursuing full-time coursework. This initiative fosters international cultural exchange and enhances academic training in the arts. Eligible applicants must be enrolled full-time in accredited graduate programs and commit to at least two consecutive semesters of study.

The Education and Economic Development Act (EEDA) Preparing College- and Career-Ready Graduates Competitive Grant aims to support South Carolina schools in implementing effective strategies for students facing academic challenges. Funded by the South Carolina Department of Education, this initiative focuses on ensuring that all students, especially those with deficiencies, graduate equipped with the skills and knowledge outlined in the Profile of the South Carolina Graduate, thus enhancing their readiness for college and careers.

The Arts Fund Grants provide vital support for emerging artists from Australia and the USA, facilitating their artistic development through grants of up to $5,000. This funding can be used for travel, living expenses, tuition, and other related costs. Eligible applicants must be citizens or permanent residents of either country and have a formal offer from an accredited institution. The program emphasizes merit-based opportunities across various artistic fields, fostering international collaboration and cultural exchange.

Delta Dental of Missouri's Community Donation Program aims to enhance community health through charitable contributions, focusing on organizations that serve Missouri and South Carolina. Preference is given to those with an oral health component. Eligible organizations must be 501(c)(3) registered, address the needs of at-risk populations, and be represented by an authorized member for support requests. This initiative underlines Delta Dental's commitment to community well-being and support.

The Standard's Corporate Giving Program emphasizes community support and employee engagement, reflecting its foundational mission to enhance financial well-being. Established in 1906, the program focuses on Healthy Communities, Disability and Empowerment, Cultural Development, and Education. With a funding range of $500 to $25,000, it aims to make a substantial impact in the lives of individuals and families facing challenges. The Standard Charitable Foundation, launched in 2006, further extends this commitment by supporting organizations that align with its philanthropic goals.

The Nita M. Lowey 21st Century Community Learning Centers Program Subgrant, administered by the South Carolina Department of Education, aims to enhance academic enrichment opportunities for students in low-performing schools. This initiative supports a range of activities, including tutoring, youth development, health education, and family engagement, fostering a holistic approach to education that complements the regular academic curriculum and prepares students for successful futures.

The Rural Business Development Grants in South Carolina aim to provide technical assistance and training for small rural businesses, defined as those with fewer than 50 workers and less than $1 million in revenue. While there is no maximum grant amount, smaller requests are prioritized. Grant funds can be used for various projects, including training, land acquisition, pollution control, and community development, benefiting rural areas and enhancing economic growth.

The SPC Cares Foundation

The SPC Cares Foundation was established in 2024 as a way for SPC Credit Union to strategically support four key development issues identified within our community: Hunger, Housing, Employment, & Education. The Foundation supports our local communities through monetary donations, in-kind donation drives, and volunteerism.

SPC Scholarship Fund

SPC Scholarships are available to improve the lives of Members who want to further their education. Scholarship opportunities are available for high school students entering college, adults returning to college, and children of SPC CU employees and board members.

Applications are considered on both academic and needs-based criteria.

These funds are provided by SPC Credit Union in partnership with the Carolinas Credit Union Foundation.

The SPC Cares Foundation

The SPC Cares Foundation was established in 2024 as a way for SPC Credit Union to strategically support four key development issues identified within our community: Hunger, Housing, Employment, & Education. The Foundation supports our local communities through monetary donations, in-kind donation drives, and volunteerism.

Member Hardship Fund

SPC Cares Foundation's Member Hardship Fund provides financial assistance up to $1,500 in the form of a grant to Members who are experiencing financial hardship due to events beyond their control, including disasters, extended illnesses or injuries, and other special situations. The Member Hardship Fund does not aid with non-emergency situations or financial difficulties due to poor financial management, judgement, or negligence. Assistance for emergencies and crisis situations are considered on a case-by-case basis, and requested funding is not guaranteed.

This fund is intended to provide relief to SPC Members who are currently experiencing financial hardship. In accordance with the IRS, financial hardship must be demonstrated to receive grant funding and is understood to mean negative household income, meaning there is not enough income or limited to no savings to meet your required financial obligations. 

The Community Facilities Grant Program in South Carolina offers funding for essential community facilities in rural areas, promoting development and enhancing quality of life. Eligible areas include communities with populations of up to 20,000 residents. The program supports various projects, from healthcare facilities to public safety services, with grant assistance varying based on median household income. This program aims to empower local governments and nonprofits to address community needs and improve infrastructure.

The Clarence H. and Anna Elizabeth Lutz Foundation Grant aims to support a variety of community needs, including health, education, and religious projects. Established in 1995, the foundation encourages innovative proposals that enhance community welfare, with a preference for projects in Chester, York, and Lancaster counties. Organizations with IRS 501(c)(3) status are eligible to apply, limited to one application per year, while individuals and for-profit entities are ineligible.

Southern SARE offers Graduate Student Grants to support Master’s and PhD students engaged in sustainable agriculture research. This initiative encourages impactful research across various topics, including production, marketing, and social sciences. By providing funding opportunities, Southern SARE aims to foster the next generation of researchers committed to advancing sustainable agricultural practices throughout the Southern region.

The Edward Byrne Memorial Justice Assistance Grant (JAG) Program is the leading source of federal criminal justice funding to states and units of local government. The South Carolina Department of Public Safety’s Office of Highway Safety and Justice Programs (OHSJP) has been designated as the State Administrative Agency (SAA) of the JAG Program for the state of South Carolina. The purpose of the JAG Program is to support state agencies and units of local government in carrying out specific programs, which offer a high probability of improving the criminal justice system. JAG funds may be used to provide additional personnel, equipment, supplies, contractual support, training, technical assistance, and information systems for criminal justice purposes. Nine authorized federal program areas define the nature and scope of eligible programs and projects. The program areas are as follows:

• Law enforcement programs
• Prosecution and court programs
• Prevention and education programs
• Corrections and community corrections programs
• Drug treatment and enforcement programs
• Planning, evaluation, and technology improvement programs
• Crime victim and witness initiatives (other than compensation) programs
• Mental health programs and related law enforcement and corrections programs, including behavioral programs and crisis intervention teams
• Implementation of state crisis intervention court proceedings and related programs or initiatives (i.e. mental health courts, drug courts, veteran’s courts, etc.) 

The Atlantic Flyway Shorebird Initiative Grant supports crucial conservation efforts for shorebirds during their migration along the Atlantic Flyway. This initiative addresses threats such as human disturbance, habitat loss, and hunting in critical areas from the U.S. Atlantic coast to the Caribbean and South America. By promoting coordinated research and management, the initiative aims to ensure the survival of species like the American oystercatcher and red knot, fostering healthy migratory pathways.

South Carolina State Firefighters’ Association

The South Carolina State Firefighters’ Association was founded in 1905 by a group of determined fire service leaders committed to strengthening the fire service through education, training, benefit provision, and legislative representation. Today, our mission stands: to serve the membership as the leader in fire service advocacy, benefits, education, and safety, while acting as the steward of the Firemen’s Insurance and Inspection Fund.

To fulfill this mission, the Association is supported by a family of programs and organizations that extend our reach and impact. These include the South Carolina Firefighters Foundation, the South Carolina Burned Children’s Fund (operating under the Foundation), the South Carolina Firefighters Insurance Services, and the South Carolina Firefighters Assistance Team.

Chief Louis Behrens Scholarship

Co-founder of the South Carolina State Firefighters’ Association, Chief Louis Behrens was fire chief in the City of Charleston for 25 years and was a faithful member of his department for a total of 58 years. Chief Behrens was the creative visionary and served as the Association’s first and longest serving President. Chief Behrens worked to promote and led the South Carolina Firefighters’ Association for 27 years and was instrumental in the passing of the Fireman’s Fund Bill, known today as the One Percent Fund.

The Foundation has established an annual scholarship to honor the dedication and love that Chief Louis Behrens gave to the citizens of the state of South Carolina and South Carolina’s fire service.

Applicants must complete the application, offer a letter of support from the applicant’s Fire Chief, and provide a general reference letter of support from a person of the applicant’s choosing. 

The Undiscovered SC Grant Program aims to enhance South Carolina's tourism by supporting counties and municipalities in developing public attractions. With a focus on projects that showcase the state's unique cultural and recreational experiences, the program seeks to stimulate local economies through increased visitor spending. Eligible applicants must demonstrate financial stability and a clear project plan to ensure effective use of funds within the specified grant period, ultimately fostering tourism growth in underrepresented areas.