Best Large Grants for Nonprofit Organizations in South Carolina

South Carolina agricultural producers, non-industrial private forest landowners, Tribes, and water management entities can receive technical and financial assistance to implement conservation practices on working lands. Through the Environmental Quality Incentives Program, USDA Natural Resources Conservation Service of South Carolina supports projects improving water, air, and soil quality, conserving water, enhancing wildlife habitat, and building climate resilience.

Nonprofit 501(c)(3) and 509(a) organizations working in education, human services, conservation, health, or cultural programs can access funding through McGraw Foundation; awards US $2,000 - US $10,000 for general operating support, projects, or occasional capital needs. Grants are generally limited to organizations in the greater Chicago area, which may include South Carolina partners only if they meet this geographic focus.

South Carolina agricultural and forest producers seeking support to enhance conservation on working lands can receive more than US $4,000 to maintain and expand stewardship practices. USDA Natural Resources Conservation Service of South Carolina provides five-year CSP contracts with annual payments for activities like improving soil health, water quality, wildlife habitat, and climate resilience across entire operations.

Nonprofit organizations with 501(c)(3) status working in Charleston County, South Carolina can be nominated for funding that supports education, health, basic needs, environment, arts, economic opportunity, or community-strengthening programs. Grants from BECU Foundation help South Carolina nonprofits access up to US $50,000 through its People Helping People Awards when nominated by a BECU member.

Graduate students conducting research in drinking water quality, environmental science, or public health can receive US $3,000 to advance actionable solutions for current water industry challenges. Focused on water-related research, American Water Works Association invites students whose work may benefit communities and nonprofit partners in South Carolina and beyond to apply.

Nonprofit 501(c)(3) public charities in South Carolina and North Carolina can seek funding for education, healthcare, human services, and Jewish values programs that serve Carolinians. With a mission to foster self-sufficiency and lasting change, Leon Levine Foundation provides support to organizations with strong leadership, proven results, and at least $500,000 in contributed revenue.

Nonprofit 501(c)(3) organizations and schools with environmental programs in South Carolina can seek US $25,000 - US $100,000 for decarbonization, clean energy, and efficient resource use projects. With a mission to support sustainability, American Honda Motor provides programmatic funding for initiatives like energy upgrades, solar or wind installations, recycling, composting, and other green infrastructure benefiting Honda communities.

Nonprofit 501(c)(3) organizations, public institutions, and qualified municipalities serving Weyerhaeuser communities in South Carolina can seek funding for community programs. Weyerhaeuser Giving Fund supports initiatives in affordable housing, education and youth development, environmental stewardship, human services, civic and cultural growth, workforce development, and diversity, equity and inclusion, with awards of more than US $1,000.

Nonprofit organizations in South Carolina addressing humanitarian aid, child welfare, education, or health care can apply for funding up to US $750,000 to expand or create programs that build self-sufficiency for women and children. The Father's Table Foundation seeks partners with a proven record of service and capacity to scale sustainable, community-strengthening projects.

Nonprofit 501(c)(3) organizations in South Carolina seeking support for programs in education, environment, culture and arts, civic development, or health and human services can apply for grants ranging from US $1,000 - US $15,000. With a mission to strengthen communities, Dominion Energy Charitable Foundation offers two online grant cycles each year focused on specific programs and projects.

Undergraduate-focused higher education institutions conducting biomedical research and located in South Carolina can apply for NIH Academic Research Enhancement Awards to support small-scale research projects and student research experiences. US Dept. of Health & Human Services: National Institutes of Health provides up to US $375,000 to institutions with limited prior NIH funding to strengthen their research environment.

Nonprofit organizations in South Carolina seeking support for humanitarian, educational, environmental, or arts and culture projects may be eligible for this corporate donations program. La Roche prioritizes accredited charities leading innovative, sustainable initiatives that can engage its expertise, logistics, and employees, with local affiliate offices funding organizations operating within the same country.

Early-career clinical and health researchers at low- or middle-income country institutions conducting disease-focused studies can apply for the Emerging Global Leader Award, which offers approximately US $140,000 for mentored career development. Grants from the National Institutes of Health help South Carolina-based nonprofits partnering with LMIC investigators or hosting collaborations support this multi-year research and training program.

Early-career health researchers in eligible low- and middle-income countries can apply for the Emerging Global Leader Award, which provides approximately US $140,000 for mentored research and career development. Funded by the National Institutes of Health, this award may benefit South Carolina-based nonprofits partnering with LMIC institutions or mentoring LMIC investigators.

Nonprofit 501(c)(3) organizations seeking funding for education-focused programs, youth initiatives, arts and culture, or community services in South Carolina may be eligible for US $5,000 - US $20,000 grants. Focused on education, John Ben Snow Memorial Trust invites U.S. nonprofits to propose new or enhanced programs or short-term support to sustain critical services.

Nonprofit organizations and institutions hosting medical or scientific congresses, events, or initiatives in South Carolina can receive sponsorship funding in exchange for tangible benefits like exhibit space or marketing visibility. Biogen Foundation considers a wide range of disease areas, and South Carolina nonprofits planning large events may be eligible if standard sponsorship opportunities are available to multiple sponsors.

Nonprofit 501(c) or 170(c) organizations in South Carolina working on economic and community development, education and workforce readiness, financial wellness, arts and culture, veterans, or disability services can benefit from Regions Bank’s employee Matching Gifts Program. Eligible organizations within the Regions footprint receive matched donations when full-time associates or recent retirees give tax-deductible contributions.

South Carolina nonprofits, government agencies, and tax-exempt educational or research institutions can seek funding for programs improving health outcomes and access to care, especially for economically vulnerable residents. South Carolina health organizations can access funding through Blue Cross and Blue Shield of South Carolina Foundation for initiatives in oral health, mental health, primary care, prevention, and community health education.

Nonprofit 501(c) and 170(c) organizations in South Carolina working in economic and community development, education and workforce readiness, financial wellness, arts and culture, veterans, or disability services can benefit from this matching-gift program. Regions Bank provides South Carolina nonprofits with up to US $1,000 per recent retiree in matched donations when a qualifying retiree gives $25 or more.

Nonprofit 501(c)(3) organizations, including those in South Carolina, can seek general operating support for grassroots work in regenerative agriculture, climate justice, healthy food access, and environmental health. Focused on community-centered solutions, Clif Family Foundation offers US $5,000 - US $50,000 one-year grants, with priority for U.S.-based groups with strong local ties and budgets under $8MM.

The Data Center Community Grants Program (US-CBF) supports nonprofit organizations that enhance their local communities surrounding Google data centers. Funding is available for projects focused on education, economic opportunity, bridging the digital divide, sustainability, health, and arts. Grants typically range from $5,000 to $50,000, prioritizing measurable community benefits and innovative approaches. Eligible projects must demonstrate long-term impact, while operational expenses are generally ineligible. This initiative aims to empower underserved groups and foster collaboration within local ecosystems.

The William and Helen Thomas Charitable Trust provides funding to nonprofit organizations focused on education, environmental protection, medical research, and support for the underprivileged. This trust, based in Florida, primarily serves communities in Palm Beach, Martin, and St. Lucie Counties, along with select areas in Appalachia. It seeks to assist public charities classified under Section 501(c)(3) of the Internal Revenue Code, ensuring support for impactful charitable initiatives.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Frances P. Bunnelle Foundation offers the Grants for the Common Good in Fall to support organizations in Georgetown County, SC. Grants of up to $15,000 can fund general operations or special projects addressing poverty, basic human needs, economic vitality, and environmental preservation. Eligible entities include IRS-certified 501(c)(3) charities and government bodies, with a limit of one grant per year. Applications must demonstrate impactful use of funds within a nine-month term.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Healthcare Services Expansion Fund

The NAFC Healthcare Services Expansion Fund supports the launch or expansion of clinical programs and new service areas that increase access to care for underserved patients. This funding is designed to help NAFC members introduce new services or grow existing programs that address unmet community health needs and improve access to comprehensive, patient-centered care.

The Spartanburg County Foundation's Continuous Improvement Grant aims to enhance the lives of Spartanburg County residents by funding nonprofit organizations that focus on quality of life, educational achievement, and economic mobility. Grants of up to $35,000 are available to eligible 501(c)(3) organizations. The foundation prioritizes projects that demonstrate alignment with its mission, utilize data-driven strategies, and foster community engagement, ensuring diverse populations receive necessary support and resources.

The Spartanburg County Foundation offers Nonprofit Effectiveness Grants of up to $10,000 to enhance the internal capacity of community-based organizations in Spartanburg County. These grants aim to strengthen governance, financial management, and overall organizational effectiveness. Eligible organizations must be recognized 501(c)(3) nonprofits serving Spartanburg residents, demonstrating alignment with the Foundation's mission and measurable impact. The Foundation seeks to promote philanthropy and community engagement, ensuring that funds are utilized to benefit local residents directly.