Best Large Grants for Nonprofit Organizations in South Carolina

The Northern Lowcountry Grants: Blackbaud Fund offers annual grants up to $5,000 for nonprofit organizations in Berkeley, Charleston, and Dorchester counties. Focused on supporting special needs youth and education for underserved youth, this fund encourages nonprofits that are 501(c)(3) compliant and do not engage in political lobbying. Organizations must not have received more than $5,000 in the previous grant cycle to be eligible.

The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.

The Guy Bradley Award, established in 1988 by the National Fish and Wildlife Foundation (NFWF), honors individuals who have made significant contributions to wildlife law enforcement. Named after the first wildlife officer killed in the line of duty, this award recognizes the vital role of law enforcement agents in wildlife conservation. Eligible candidates include current and retired personnel from state and federal agencies who have demonstrated exemplary dedication to protecting wildlife and advancing enforcement goals.

American Psychiatric Association Foundation

There is no health without mental health. The APA Foundation is working in your community to provide the support and resources we all need to prioritize mental wellbeing where you live, learn, work, worship, and play.

Backed by the medical expertise of the APA and industry-leading strategic partners, we administer community-changing programs, public education campaigns, grants, and awards aimed at increasing mental health literacy, connecting individuals to needed care, and shifting attitudes toward mental health.

Our Mission is to promote the mental health and well-being of individuals and communities. Our Vision is a mentally healthy nation for all – where we live, learn, work, worship, and play.

Diversity Leadership Fellowship

The Diversity Leadership Fellowship identifies and motivates minority psychiatry residents or those interested in minority and vulnerable populations to become well equipped to teach, administer, and provide culturally competent, evidence based mental health and substance abuse services to diverse minority groups and at-risk populations. These populations include—but are not limited to—American Indians/Native Alaskans, Asian Americans/Native Hawaiians/Native Pacific Islanders, Blacks/African Americans, Hispanics/Latinos, LGBTQ, and religious minorities. Program Benefits:

• Sponsorship to attend a minimum of four APA meetings:
  • Two APA Annual Meetings
  • Two Fellowship Forums
• Develop leadership skills in the field of psychiatry and advance understanding of the life experiences of racial ethnic minority communities
• Gain an understanding of APA/APAF Governance through observation and service on an APA Council, Committee, or APAF initiative
• Have the opportunity to sit on the APAF Board of Directors as a non-voting member (one Diversity Leadership fellow allowed)
• Cultivate a professional network with psychiatrists interested in minority mental health and services through exclusive events and engagements with APA leaders. Establish relationships and peer-mentorship with a diverse group of resident fellows with similar career interests and goals

The Jonathan Larson Grants provide essential support to emerging musical theatre artists, helping composers, lyricists, and librettists further their creative endeavors. Established in memory of Jonathan Larson, creator of the iconic musical "Rent," these grants empower artists to create impactful work that resonates with contemporary culture. The program, sustained by the American Theatre Wing and the Larson Family, encourages professional growth and artistic exploration without the limitations of specific projects.

The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.

The Harry Shwachman Clinical Investigator Award, offered by the Cystic Fibrosis Foundation, supports clinically trained physicians transitioning to independent researchers in cystic fibrosis. It provides up to $133,000 per year for three years to facilitate research tailored to individual interests. The funding covers personnel costs and supplies, promoting a strong mentorship during this critical stage of their academic careers.

The Cystic Fibrosis Foundation offers a Travel Award Supplement aimed at supporting Ph.D. students, postdoctoral fellows, and junior faculty. This funding of up to $3,000 enables trainees to participate in off-site workshops or training programs to enhance their research skills. Eligible applicants must be active researchers in CF projects, with a minimum of one year of experience. The program excludes conference attendance and for-profit entities, ensuring focused support for advancing cystic fibrosis research.

The Fetal, Infant, and Child Death Review Program aims to enhance the effectiveness of fetal, infant, and child death review teams across state, local, and tribal levels. By providing essential leadership and technical assistance, the program ensures standardized practices for conducting quality fatality reviews and collecting vital data. These efforts will facilitate the dissemination of findings, ultimately informing prevention strategies and improving outcomes for vulnerable populations.

The Cystic Fibrosis Foundation's Student Traineeship Award supports students in engaging with cystic fibrosis research through hands-on projects. With a maximum funding of $4,000 for one year, the program aims to inspire students to pursue careers in CF research or care. Eligible applicants must be enrolled in a degree program and collaborate with a faculty mentor on a relevant project. This initiative also emphasizes the importance of maintaining interest in CF-related research among new generations.

The Maternal and Child Health Encounters Networks (MCHEK) program, funded by the US HHS: Health Resources & Services Administration, aims to enhance maternal and infant health by preventing exposure to harmful substances throughout pregnancy. Through a national expert call center, it provides evidence-based guidance on medications, nutrition, and environmental factors. By translating complex scientific data into accessible information, MCHEK empowers families and healthcare providers to make informed choices that improve health outcomes.

This funding opportunity invites applications for R01 grants focused on molecular imaging methods to explore cancer inflammation in vivo. It aims to enhance understanding of dynamic interactions between inflammation and cancer through innovative imaging techniques. The initiative encourages collaborations between cancer researchers and imaging scientists to leverage molecular imaging for identifying cellular physiology changes in response to treatment. Deadline dates for applications range from February 2025 to October 2027, emphasizing timely submission for prospective researchers.

The Marcy Shulman Memorial Organization Grant Program, established by the Colburn-Keenan Foundation, supports organizations improving the lives of individuals with chronic illnesses, particularly within the bleeding disorders community. Proposals should enhance health and quality of life, with examples including educational programs and facility upgrades. Only 501(c)3 organizations are eligible, and they may receive one grant per cycle. Applications must be submitted at least two months prior to the project start date.

The Family Fun & Connections Event Grant Program, initiated by the Colburn-Keenan Foundation, aims to support community engagement through events for families affected by bleeding disorders. This program, established after a successful 10th Anniversary Celebration, offers $1,000 grants for various fun activities such as dance parties, BBQs, and outdoor adventures. It emphasizes the foundation's commitment to enhancing the lives of those with chronic illnesses and promoting community strength and advocacy.

Better Food Policy Fund 

Since its inception, the Better Food Policy Fund has set its strategic direction in a participatory fashion. We are intentionally building capacity for engagement to ensure the Fund aligns with the needs of food policy council stakeholders.   

Thus far, the Fund has engaged 300+ food policy council stakeholders to help co-develop the Fund. We are immensely grateful for the individuals who helped shape the initial direction of this fund. We view this growing stakeholder audience as the people to whom the Fund’s governing body, the Independent Advisory Committee, is ultimately accountable.

Grantmaking

The Better Food Policy Fund invests in US-based food policy councils, empowering community and government collaboration for progressive food policy. We utilize participatory processes to enhance equity and redistribute power in the funding landscape. We seek to celebrate and uplift the work of food policy councils, and believe every food policy council is worthy of financial support.

We define “food policy councils” as councils, networks, coalitions, or other groups working across boundaries at the tribal, municipal, county, state, or regional level.  

We support actions aimed at ensuring an enabling environment for policy change, such as: 

• increasing levels of inclusive and equitable stakeholder engagement in public processes
• engaging systems thinking when tackling complex food system challenges
• facilitating collaboration with and across local government agencies and departments 
• developing or revising local policies and plans  

We define “better food policy” as practices, procedures, ordinances, laws, etc. of governing institutions which strengthen community-based food systems.

We define “civic collaboration” as people joining together at the intersection of community and government to address public issues.

The NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32) supports rigorous biomedical research training and dissertation research for doctoral candidates in clinical, behavioral, or biomedical sciences. Funded by the NIH, this fellowship aims to enhance research capabilities and knowledge in the field of audiology. Key deadlines for applications include April 8, August 8, and December 8 for the years 2025 to 2027, ensuring timely opportunities for aspiring researchers.

The Home Builders' Association of the GT Area Scholarship, offered by the Grand Traverse Regional Community Foundation, supports residents from Antrim, Benzie, Grand Traverse, Kalkaska, or Leelanau Counties. This scholarship targets individuals pursuing education in the home building industry. Applicants must provide a letter of reference from a member of the Home Builders Association, maintain a minimum GPA of 2.5, and demonstrate community involvement or leadership.

The ChemClub Student Scholarship, offered by the American Chemical Society and the American Association of Chemistry Teachers, supports high school seniors who are active members of a Chartered ChemClub. Eligible students must demonstrate academic excellence and express their commitment to STEM fields. This scholarship provides financial assistance directly to the recipient's chosen college, fostering future leaders in chemistry and related disciplines.

The FY26 Reconstructive Transplant Research Program (RTRP) Investigator-Initiated Research Award supports innovative studies aimed at enhancing reconstructive transplant research and patient care. It emphasizes projects with military relevance, focusing on all research phases from basic to clinical. Essential components include rigorous study design, preliminary data, and the potential for significant short- and long-term impacts on patients and the reconstructive transplant field.

The Alzheimer’s Association Research Fellowship for All (AARFA) Program aims to support early career researchers dedicated to advancing the understanding and treatment of Alzheimer’s and other dementias. By providing funding to postdoctoral researchers under established mentorship, the program fosters the development of independent scientists. It encourages applications from individuals in underrepresented groups, recognizing the value of diverse perspectives in scientific inquiry and clinical practice, ultimately contributing to the fight against dementia.

The Alzheimer’s Association Clinician Scientist Fellowship for All (AACSFA) aims to support the training of clinician scientists in Alzheimer’s and other dementias. This program encourages applications from individuals in underrepresented groups, emphasizing the value of diverse representation in clinical and scientific fields. The fellowship is designed for professionals with patient contact or diagnostic roles, fostering advancements in dementia research and care.

About PLTW GatewayPLTW Gateway (6-8) opens paths that create meaningful futures. It connects students to careers in areas they can, and can't, imagine.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunitiesEnhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• The purpose of this grant is to assist the grantee's implementation of the PLTW Gateway program.
• Grantee must offer at least one PLTW Gateway unit in the 2027-2028 academic year.
• Grantee may implement any PLTW Gateway unit of their choosing.

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

About PLTW EngineeringPLTW Engineering students adopt a problem-solving mindset, are engaged in compelling, real-world challenges that help them become better collaborators and thinkers, and are prepared with skills to step into any career path they take.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunitiesEnhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Engineering program.
  • Example expansion activities include but are not limited to adding an additional PLTW Engineering course not previously offered,
  • and/or adding additional class periods of an existing PLTW Engineering courses previously offered,
  • and/or training additional teachers in PLTW Engineering courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

Grand Traverse Regional Community Foundation

The Grand Traverse Regional Community Foundation began in 1992 when a group of community champions came together around a vision to give back to our region then, now, and forever.

This vision lives on within our organization today as we support the people and places of Antrim, Benzie, Grand Traverse, Kalkaska, and Leelanau Counties and the Grand Traverse Band of Ottawa & Chippewa Indians.

Together with our partners, we spark positive change for a variety of local causes, including youth, arts and culture, education, environment, and health and human services, across our region.

Traverse City Area Public Schools (TCAPS) Scholarships

The Community Foundation is home to a variety of scholarships designated to benefit a graduating senior from Traverse City Area Public Schools (TCAPS). 

The Les and Anne Biederman Foundation, Inc. Scholarship Fund (Central, West)

In keeping with the visions and determinations that were held by the late Les Biederman, this scholarship is available to students who endeavor to pursue careers in nursing or business.

One scholarship awarded annually at each Central and West for a student pursuing a career in business and one scholarship awarded annually at each Central and West for a student pursuing a career in nursing.

The Ittleson Foundation Environmental Program Grants support innovative projects that enhance environmental activism through education and grassroots efforts. In 2025, grants will focus on initiatives that strengthen environmental movements and engage new constituencies, particularly in environmental equity. The Foundation has provided resources since 1932 to improve public policy and community welfare, alternating its grantmaking focus annually between mental health and environmental initiatives.

This grant aims to enhance cooperation and regulatory standards among animal food safety programs by funding national feed associations. It promotes inter-agency collaboration, strengthens state regulatory frameworks, and supports the Animal Feed Regulatory Program Standards (AFRPS). By leveraging resources and aligning with federal and state initiatives, the program seeks to improve animal food safety and ensure comprehensive surveillance and protection.

The Parkinson Association of the Rockies Eric Wright Memorial Fund honors Eric Wright's legacy by providing scholarships to high school seniors and college students affected by Parkinson Disease. Recipients, eligible for up to $20,000 over four years, are selected based on merit and financial need. This fund aims to inspire the next generation while supporting students who have experienced loss or hardship due to this condition, promoting education and resilience within the community.