Best Large Grants for Nonprofit Organizations in South Carolina

Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Eula M. Rhoads ScholarshipThe Eula M. Rhoads Scholarship Fund makes awards to Marion area high school seniors in the top 25 percent of their graduating class and graduates who maintain a college GPA of 3.0 or better. Special consideration is given to those pursuing a degree in pharmacy or veterinary medicine at an Ohio college.

Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Eugene & Cecilia Reszczynski ScholarshipThe Reszczynski Scholarship, created in 2002, is one of the oldest at Marion Community Foundation. It makes awards each year to students who score in the top 50th percentile of the ACT or SAT and have attended a high school in Marion County for two or more years. This scholarship honors the late Eugene and Cecilia Reszczynski and their passion for helping others. 

The Cushing Scholarship was created in 2014. According to Marsha, “We are not as interested in a student’s financial status as we are on how they look at life.”

Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Rocco Nicolosi Memorial ScholarshipIndividuals selected for the Nicolosi Scholarship must have attended a high school located in Marion County throughout his or her entire high school experience and have ranked in the upper 25th percentile of his or her high school senior class.To preserve Rocco’s memory and discourage future tragedies, applicants must write an essay on the topic of “Why Young People in Marion Need to be Drug, Alcohol, and Substance Free.”

Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Quintin & Alice Linn ScholarshipThe Linn Fund is a scholarship, created in 2022, to support Marion County students pursing degrees and careers in economics, finance, mathematics, and statistics.

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds. The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Canton Professional Educators' Scholarships FundThe Canton Professional Educators’ Scholarships Fund was established to assist high school graduates enrolled in an academic plan (college/university, 2-year vocational, technical or advanced study). Applicants must be the natural or adopted child of a CPEA member, must have achieved a cumulative high school GPA of 3.0 or above, and college students must be “a student in good standing.”Renewable scholarship: No

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Canton Advertising Federation Endowment for Creative Enrichment FundThe Canton Advertising Federation Endowment for Creative Enrichment Fund assists graduating high school seniors or current college students majoring in advertising, graphic design, communication or related fields. Applicants must reside in Stark County.Renewable Scholarship: Yes

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.Adrienne O’Neill Scholarship FundThe Adrienne O’Neill Scholarship Fund was established to assist students who are the first generation in their family to attend college. Applicant must have a cumulative GPA of 2.5, demonstrate financial need and intend to utilize this scholarship as the “last dollars” after all aid/scholarships have been awarded.Renewable Scholarship: Yes

This funding opportunity aims to establish a U.S. network for active surveillance of pediatric acute respiratory illnesses and gastroenteritis. The initiative will focus on respiratory and enteric viruses, assessing the effectiveness of prevention products such as vaccines. Recipients will follow CDC protocols to enroll patients and confirm viral infections, ultimately reducing hospitalizations and enhancing public health strategies for children's healthcare.

The National Cancer Institute (NCI) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing informatics technologies for cancer research. This initiative will support the development of tools that enhance data acquisition, management, and analysis throughout the cancer continuum. By focusing on technologies with proven impact, the NOFO seeks to optimize and sustain resources critical for cancer biology, diagnosis, treatment, and epidemiology.

The Rural Health Network Development Program aims to enhance health care access in rural areas by supporting integrated health care networks. It offers two funding tracts: the Network Advancement Tract for established networks to overcome operational barriers and the Network Development Tract for early-stage networks to plan and expand services. Both tracts focus on improving care coordination, health outcomes, and operational efficiency, thereby strengthening the rural health care system.

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Wayne D. Ackerman Scholarship FundThe Wayne D. Ackerman Scholarship Fund assists seniors from Stark County high schools who will graduate in May/June. Applicants must be accepted as full-time students at a four-year college or university, have a GPA of at least 3.0, and have demonstrated outstanding involvement in academics and extracurriculars.Renewable Scholarship: No

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Thelma N. Cotey ScholarshipApplicants must be planning to pursue further education in the areas of medicine, business, or forestry. 

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.

ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Simonen ScholarshipThe Paul & Alice Simonen Scholarship is offered to any Alger County resident planning to pursue post-secondary education at a college, university, vocational, or technical institute.

Preference will be given to an individual with future potential as evidenced by an exceptional record of achievement in school, community, and/or employment. Examples of achievement may include, but are not limited to, areas such as academics, fine arts, athletics, technology, volunteerism, service clubs, work/military experience.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.

ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Native American Education AwardGiven to a Native American graduate, applicants must have participated in Native Cultural/Academic activities, projects, or programs while attending MHS, be a participant in community service activities, and must have a minimum 2.0 overall GPA.

The Rural Health Network Development Planning Program aims to enhance rural health care by fostering integrated health care networks. It focuses on collaboration among entities to bolster local capacity and improve care coordination in underserved areas. By achieving efficiencies and expanding access to essential services, the program seeks to strengthen the overall rural health system while promoting the use of health information technology and exploring innovative care delivery models.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Michael G. Lindquist, PhD ScholarshipA scholarship will be given to a graduate of any Alger County high school planning to pursue a degree in engineering, chemistry, math, or physics. Academic excellence coupled with financial need are prime considerations.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.

ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community. Lloyd C. Artibee ScholarshipApplicants must be planning to attend a university, college, technical, or vocational institution, and have been involved in community and/or school activities. 

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships. ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Frank & Mary Hausler Scholarship FundApplicants must be planning to pursue educational advancement in medicine, law, dentistry, engineering or the priesthood.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Eric & Danielle Beverly Scholarship FundThe Eric and Danielle Beverly Scholarship Fund was established in 2006 to recognize outstanding student-athletes graduating from Munising High School and extended in 2018 to recognize outstanding student-athletes graduating from other Alger County high schools. The annual program awards two (2) one-time grants each academic year. The recipients must be student-athletes who have demonstrated leadership and academic excellence during their high school career. Preference is given to students who plan to pursue a baccalaureate degree in a medical-related field. Awards will be sent to the applicant’s selected college/university on their behalf. Applications are available in the spring of each year.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Barbara Golenda Forsberg ScholarshipA scholarship will be given to a graduate of Munising, Superior Central, or Burt Township Schools pursuing a higher degree in arts, education, or music. Applicants must have a minimum of a 3.0 GPA, demonstrate financial need, good attendance, and a history of community involvement. Students must submit a completed Forsberg Scholarship application and as essay of 300-500 words that includes insights about why they chose their field of study.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Barbara J. “BJ” Wells Scholarship

The Barbara J. “BJ” Wells Scholarship benefits graduating Napa County high school seniors and community college transfer students who will find the cost of higher education a financial hardship and who grew up in a household where English was not their first language spoken. Recipients must be planning to pursue a bachelor’s degree, either by enrolling directly at a four-year college/university or by beginning their studies at a community college before transferring. Recipients of the scholarship will receive funding for up to four years while working to complete their bachelor’s degree.

The Mentored Research Scientist Career Development Award (KR1) offers crucial support for researchers aiming for independence. Funded by the US Dept. of Health & Human Services through the NIH, this award allows candidates to engage in intensive research training under a mentor's guidance for up to five years. It is designed for those with research doctoral degrees, facilitating their transition into independent research roles and enhancing their contributions to the scientific community.