Best Large Grants for Nonprofit Organizations in South Carolina

The Corning Nonprofit Grants program supports community-based initiatives in education, human services, and culture. Eligible nonprofits that align with our criteria may apply for funding on a rolling basis. The application window for invited organizations runs from February 10 to September 15. We emphasize local impact within a 20-mile radius of Corning, NY, ensuring that our contributions foster collective growth and engagement in the community.

The South Arts State Fellowship offers a $5,000 grant to artists reflecting the rich visual arts culture of the Southern U.S. It aims to support individual artists or collaborative teams creating original works. Each state will select one awardee based on artistic excellence. Applicants must be legal U.S. residents and provide proof of residency. The application deadline is December 10, 2025, and awardees must attend an awards ceremony in summer 2026.

The South Arts Southern Prize provides a unique opportunity for individual artists in the Southern region of the U.S. to showcase their scriptwriting talents. With a total of $35,000 in grants available, including a $25,000 Southern Prize and a $10,000 runner-up prize, this program supports artistic excellence and offers a two-week residency at The Hambidge Center. Eligible applicants must be legal residents of the Southern states and adhere to specific requirements. The program celebrates the rich cultural diversity of the American South.

Mission

The Foundation was established in December 2013 by Kathryn B. McQuade, after retiring from 33 years of working in the business community. I was blessed to have been born into a loving middle class family. My father worked very hard to insure that all of his children were given an opportunity for a good education and my mother, “a stay at home Mom’ was always there for us. My world was safe and comfortable. My life is in stark contrast to how much of the rest of the world lives. I continue to read of the terrible injustices waged against women and children globally and hope that this foundation can provide them the opportunity and resources to succeed. We will support organizations that help us achieve our goal of Striving to make sustainable improvements in women and children’s rights education and welfare.

Kathryn McQuade Foundation Grant

The Foundation will make timely decisions on your grant request and provide clear communications on our expectations of reporting progress.

Women

The Foundation’s goal is to provide women assistance and provide them an opportunity to succeed. Assistance can take many forms, however our goal is to help them become self sufficient and enable them to lift themselves out of poverty and provide for their children. Access to education, job training and professional skills, even access to capital in order to build a business are possible ways we will consider helping women to succeed. Grant requests should focus on enabling the women to sustain financial independence.

We look forward to hearing of the many creative ways organizations are working on helping women succeed through out the world. To help women is to help their children and the communities they live in.

Children

Too many children in the US and across the world live in poverty and lack the access to education. Education and/or appropriate skills training are necessary to break the cycle of poverty and crime. While the assistance to women may take many forms, the foundation’s focus for children will target education and/ or skills training. The Foundation is open to many ideas on how to accomplish this goal and look forward to receiving proposals to help all children achieve their potential.

The Arts Curricular Innovation Grants -- Arts Teacher Institutes program aims to enhance the professional development of South Carolina arts teachers by offering tuition-free graduate courses and quality arts education programs. Through collaboration with accredited colleges, participants can earn graduate credits or educator certificate renewal credits. The program emphasizes standards-based arts curricula and assessment, ensuring a significant impact on student achievement in the arts.

The SCAC Term Arts Education Project Grants support quality arts education for preschool and K-12 students during the 2025-2026 academic year. The grants aim to enhance access to arts education, integrate arts with school curricula, and address South Carolina’s educational standards. Eligible applicants include colleges, local governments, and nonprofit organizations. Priority is given to projects serving underserved communities and addressing learning loss caused by COVID-19, ensuring a broad impact on students' educational development.

Bristol Myers Squibb Foundation Inc supports independent medical education to enhance healthcare professional competence and improve patient health outcomes. Their mission is to be a global leader in innovative medical education, focusing on evidence-based activities that address critical gaps in knowledge. By fostering excellence in healthcare, they aim to ensure measurable improvements in performance and patient outcomes across various disease areas.

The Toy Foundation Program offers a unique opportunity for nonprofit organizations to apply for toy donations to support children in need. The application period runs from January to June, with approved applicants receiving toys by the end of the year. This initiative, part of the Toy Chest program, has positively impacted over 35 million children since 2003, promoting play as essential for emotional and educational development.

The Jasiri L.K. Whipper Scholarship Endowment, established by the Coastal Community Foundation of South Carolina in 2009, honors Jasiri Whipper by providing an annual scholarship for students attending historically black colleges or state-supported colleges in South Carolina. This renewable scholarship aims to empower students and address educational equity, reflecting the Foundation's commitment to community development and support for future leaders.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The Artist Creative Practice Grant by South Arts supports individual artists in various disciplines by funding professional development opportunities. This grant ensures that artists can access vital experiences that enhance their careers, covering up to 2/3 of the total costs with awards ranging from $500 to $3,000. By promoting artistic growth, South Arts aims to elevate the cultural landscape of the Southern United States and foster meaningful connections within communities.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The IDeA Networks of Biomedical Research Excellence (INBRE) program aims to enhance biomedical research capacity in underfunded states by fostering collaborations among research institutions. By supporting faculty research, mentoring, and student involvement, INBREs create pathways for undergraduate students to enter biomedical careers. This initiative not only promotes institutional partnerships but also strengthens research infrastructure, ultimately contributing to a more robust scientific community in IDeA states.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5416 - Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations

Grant Information

• Identify and evaluate innovative design, construction, and management approaches that extend the functional lifetime of nature-based installations and reduce ongoing operations and maintenance (O&M) requirements.
• Develop practical guidance on key factors affecting nature-based solution (NbS) longevity, including hydraulic optimization, engineered media selection and replacement, plant selection, sediment management, and construction-phase best practices.
• Survey utilities and other NbS owners to document current maintenance practices, costs, and hours, and establish benchmarks to inform targets for improvement.

The Emerging Traditional Artists Program (ETAP), presented by South Arts Inc., supports early-career traditional artists from Appalachian Regional Commission-designated counties. With a $5,000 award, artists can access training, networking, and mentorship opportunities to enhance their skills and community impact. This initiative aims to preserve traditional arts and culture while fostering a new generation of artists dedicated to their craft and cultural heritage.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

The Litter Enforcement Grant, funded by PalmettoPride, has been pivotal in South Carolina for 20 years, providing up to $5,000 for equipment and resources to support litter control efforts. This competitive grant encourages law enforcement and code enforcement agencies to actively engage in litter prevention initiatives, bolstered by community support. Priority is given to groups without recent funding and those collaborating with volunteer organizations focused on litter reduction and beautification.

The Carolina Foundation for Jewish Seniors (CFJS) enhances the lives of Jewish seniors in the Carolinas by funding organizations that provide essential services and programs. In 2022, it supported 50 initiatives across 19 nonprofits, addressing health, wellness, and community engagement. CFJS prioritizes collaboration, measurable outcomes, and innovative solutions to combat social isolation among Jewish seniors, making it a unique and dedicated resource for improving their quality of life.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

Benefitting people in the places making the AI future possible

The Future is for Everyone Fund

Meta is investing directly in education, community enhancement, workforce development and sustainability projects in locations where we have a data center in the United States.

The AI future we are building is for everyone. That starts with making sure everyone in the places that are home to a Meta data center feel the benefits in their communities. We want students to have bright futures, small businesses to flourish and communities to be prosperous.

Our commitment to the communities we call home.

The Future is for Everyone Fund supports investments and programs that address local community priorities in the United States, where we have a Meta data center:

We invest in the people and shared spaces that help a community thrive. That includes the parks, trails, and gathering places where neighbors come together, the technology and access that keep them connected, and first responders - like police officers, firefighters, and paramedics — who keep our communities safe.

We support the people and organizations that power local economies - helping workers gain the skills, certifications, and hands-on experience the modern economy rewards, and backing initiatives that create jobs and give a community its character.

We fund the programs, spaces, and tools that help learners of every age discover what they're capable of - from early literacy and the arts to hands-on science, technology, and problem-solving - and we equip the educators who make it happen with the resources to bring their most ambitious lessons to life.

We invest in the long-term health of the land, water, and wildlife that make our communities home - supporting things like habitat restoration and resource conservation that connects people to the natural world.

What is the Future is for Everyone Fund?

The Future is for Everyone Fund is Meta’s $1 billion commitment to invest directly in the U.S. communities that are home to a Meta data center. The Fund supports local schools, nonprofits, and community organizations and is organized into four focus areas that reflect local priorities: Community Enhancement, Economic Vitality, Education, and Sustainability. It builds on the over $70 million in grant funding we’ve provided to our data center communities since 2011.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

The General Operating Support (GOS) Grants offer three years of unrestricted funding to arts organizations in South Carolina. These grants aim to strengthen organizations that provide ongoing arts experiences and services. Eligible applicants include various arts organizations focused on producing, presenting, or education. Funding is contingent upon factors like panel review and the size of the applicant's budget, with awards varying annually based on available funds.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

The SC Arts Commission offers Accessibility Grants to assist organizations in making arts programs and facilities accessible to individuals with disabilities. Funded projects may include adaptations such as Braille materials, sign language interpretation, and facility modifications. Eligible applicants include government units and charitable organizations registered in South Carolina. The program emphasizes cash matching and limits awards to one per fiscal year, prioritizing projects in designated Opportunity Initiative Counties.

The SESAPS Francis Slack Award, established by the Southeastern Section of the American Physical Society, honors individuals who have selflessly contributed to advancing physics in the Southeast. It recognizes efforts in enhancing research facilities, strengthening academic departments, and fostering regional physics organizations. Nominations remain active for three years, with a focus on encouraging women and minority candidates. This prestigious award commemorates the legacy of Francis G. Slack, a pivotal figure in the development of the Southeastern Section.

The Dale Jr. Foundation, founded by NASCAR driver Dale Earnhardt Jr., has raised over $8 million since 2007 to support various charities focusing on youth and underprivileged communities. The foundation emphasizes empowerment, education, wellness, hunger relief, and hope, aiming to provide resources that enhance confidence and opportunities for children facing hardships. Through fundraising efforts and partnerships with organizations like Make-A-Wish, the foundation strives to positively impact lives and foster a sense of normalcy among children in need.