Best Large Grants for Nonprofit Organizations in South Carolina

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

LSTA Grants for Public Libraries: LSTA Impact Grants

Impact Grants are funded with Library Services and Technology Act funds provided by the Institute of Museum and Library Services and administered by the South Carolina State Library. Public library systems may apply for funds from $5,000 up to $50,000 for a project that must incorporate specific outcomes for the target audience.

In this funding cycle, the State Library is especially interested in projects that:

• Develop the preservation and digitization capabilities of public libraries.
• Better serve patrons with difficulties using the library through the purchase of bookmobiles, outreach vehicles, and/or book lockers.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Truliant Foundation offers the Fred J. Sarda Scholarships, providing $1,500 each to qualified applicants. Established in 1996, this program has awarded over $265,000 to more than 250 high school seniors who are members of a North or South Carolina credit union. Eligible candidates must have a GPA of 3.0 or higher and be first-time college students enrolled full-time for the 2025-2026 academic year.

The Mutual Self-Help Housing Technical Assistance Grants in South Carolina provide essential funding for qualified organizations to assist very-low- and low-income families in constructing their own homes through self-help projects. The program emphasizes community involvement, where participants help each other build homes, receiving technical support from grant recipients. This initiative aims to empower families and strengthen rural communities, ensuring affordable housing solutions while fostering collaboration and skill development.

The Truliant Foundation Scholarships, established in 1996, have awarded over $265,000 to more than 250 high school seniors pursuing higher education. These scholarships, funded by the Carolinas Credit Union Foundation, are open to members of any credit union in North and South Carolina, supporting both academic and needs-based candidates, including first-time college students and high school seniors. Eligible applicants must maintain a GPA of 3.0 or higher and enroll as full-time students.

The Southern Equality Research Grant, offered by the Campaign for Southern Equality, aims to empower students and early career researchers to conduct crucial studies on LGBTQ+ issues in the South. With over a third of LGBTQ+ Americans residing in this region, there is a significant need for research to address legal protections and social inequities. This initiative seeks to elevate the voices and experiences of LGBTQ+ Southerners, fostering a deeper understanding of the policies affecting their lives.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

South Carolina Arts Commission

The mission of the South Carolina Arts Commission is to expand access to the arts and foster creativity for all South Carolinians.

For more than 50 years, the agency has worked to build a thriving arts environment that benefits all South Carolinians, regardless of their circumstances or where they live.

We help artists and arts providers offer unique arts experiences to residents and visitors. From free poetry readings and gallery crawls to sweetgrass basketry workshops and ticketed dance, music, or theatre performances, they create an environment that contributes to quality of life from three “corner” counties of Oconee, Horry, and Beaufort to the 43 arranged inside.

Since 1967, the SCAC has awarded more than $132 million in grants to artists, arts organizations, school districts, schools, and teachers!

Public Art Grants

Purpose

This grant provides support for art that is created intentionally for a space in the public realm, regardless of whether it is situated on public or private property. Projects can be located indoors or outdoors, but must be free and accessible to everyone. Public art projects are limited to murals, sculptures, light installations, and sound installations.

Funding type: Reimbursement.

Use of Funds

Eligible expenses include, but are not limited to:

• Maintenance, repair, and revitalization of existing public art pieces.
• Artist stipends and fees including design, project management, and travel.
• Art installation, fabrication, and associated costs (site preparation, artwork transportation, machinery and equipment rental).
• Consultant and contractor fees (consultants and contractors can include architects, conservators, preservationists, historians, engineers, electricians, lighting consultants, etc.).
• Documentation, marketing, and signage.
• Development of a public art tour.
• Public art focused workshops and programs.

If you are hiring artists or teaching artists

For all grant-funded activities (including group lectures, demonstrations, performances, residencies, and short-term arts teaching experiences), the use of S.C. Arts Directory members is required for school and school district grantees and encouraged for grantees that are organizations.

Artists identified as Verified Teaching Artists on the S.C. Arts Directory have been additionally vetted by SCAC through the submission of sample lesson plans, recorded teaching samples, and letters of recommendation. For any grantee whose grant-funded activities are for K-12 student services, SCAC encourages the use of Verified Teaching Artists. Many school districts require the use of SCAC Verified Teaching Artists for classroom residencies. If working in a school environment, always check with both the individual school and the school district about policies related to hiring artists, arts organizations, and teaching artists.

Indirect Cost Limitation

No more than 10% of the total grant funds may be used for indirect costs (general overhead expenses not directly tied to the project). The remaining 90% must go toward direct costs, which are necessary to carry out the funded project.

• Examples of direct costs: Artist fees, program supplies, travel for project activities, and venue rental.
• Examples of indirect costs: Administrative salaries not directly working on the project, office rent, utilities, and general office supplies.

This ensures that most of the funding directly benefits the project while allowing some flexibility for necessary overhead costs.

Matching Requirements

1:1 (grantee:SCAC)

• Up to 50% of the grantee’s match may be through an in-kind donation of materials and/or contracted services.
• An example of “in-kind” is a contracted fee that is waived or discounted as a donation to your project.
• Another SCAC grant and/or federal funds may not be used to match your award.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

The NCAA Division II Degree Completion Award provides financial assistance to student-athletes who have exhausted their athletics eligibility, enabling them to complete their first undergraduate degree. Since its inception in 2001, nearly $9 million has supported approximately 1,875 athletes, with a remarkable 90 percent graduation rate among recipients. The award covers tuition costs up to $15,000 for remaining credits and may be used in the summer term or short terms surrounding the final undergraduate year.

The Dominion Energy Educational Equity Scholarship Program aims to support students from specific states pursuing higher education. With awards of $5,000 for 2-year programs and $10,000 for 4-year degrees, this program emphasizes both need and merit in its selection process. Administered by Scholarship America®, it is open to high school seniors and undergraduates maintaining a GPA of 3.0. Awards may be renewed for up to three years or until a bachelor's degree is obtained.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

Dabo's All in Team Foundation Grant Program aims to support local South Carolina organizations in need of financial assistance for projects that align with its mission to address critical education and health issues. By providing funding opportunities, the program seeks to empower organizations with innovative solutions that can positively impact their communities. This initiative fosters collaboration among groups dedicated to improving lives across the state, ensuring that valuable ideas receive the support they deserve.

The Ashland County Wildlife Conservation League David McClure Memorial Scholarship supports graduating seniors from Ashland County high schools and alternative education programs pursuing a degree in wildlife-related fields. Applicants must maintain a GPA of 3.0 or higher and be accepted into accredited colleges or vocational programs. This scholarship fosters educational growth while promoting conservation efforts, reflecting the commitment of the Ashland County Community Foundation to enhance community development and support future leaders in wildlife conservation.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5424 - Adaptive Control Frameworks to Unlock Full-Scale BNR Potential

Grant Information

• Identify and categorize the dominant failure modes of current aeration and process control implementations under real-world operating conditions.
• Develop guidance on data and instrumentation requirements for utilities to support adaptive control, including the characterization of existing sensor infrastructure and the use of soft sensors where hard sensors are limited.
• Develop practical adaptive control frameworks and implementation guidance that utilities can deploy without dependence on proprietary black-box tools or specialized data science expertise, including hybrid approaches that augment conventional controls with data-driven models (e.g., artificial intelligence (AI)/machine learning (ML), digital twins) for variable flow and concentration conditions.
• Benchmark control performance against biological capacity indicators across multiple full-scale facilities to quantify the gap between achievable and realized biological nutrient removal (BNR) performance.

The South Carolina Department of Education (SCDE) will award Gifted and Talented (GT) Graduate Course Program grants to institutions of higher education (IHEs) that offer tuition-free graduate courses for teachers who are pursuing either endorsement or certification in GT education. These courses will be designed for the following topics:

• Nature and Needs of Gifted and Talented Students
• Introduction to Curriculum and Instruction for Gifted and Talented Students
• Advanced Curriculum for Gifted and Talented Students
• Student Identification, Current Trends, and Issues in Gifted and Talented Education
• Social and Emotional Needs of Gifted Learners
• Special Topic Seminars in Gifted and Talented Education; and
• Other topics applicable to gifted education.

The Delta Dental of Missouri Grant Program aims to improve oral health in Missouri by funding initiatives that reduce oral disease, enhance access to quality dental care, and raise awareness, particularly among underserved populations. Grants range from over $5,000 to $100,000 and are awarded for one year, focusing on projects that increase access to care and demonstrate matching funds from other sources.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The Day-End Dough-Nation® Program by Panera Bread exemplifies community generosity through the donation of unsold bakery products to local charities. This impactful initiative supports various organizations that distribute food to those in need, including shelters, health centers, and youth programs. By partnering with thousands of non-profits nationwide, Panera Bread not only reduces food waste but also plays a crucial role in addressing hunger and promoting equality within communities.

The SCAC Emerging Artist Grants aim to support emerging artists in South Carolina through funding of up to $1,800, along with mentorship and professional development. This initiative is designed for artists active for one to five years across various disciplines, including visual arts, music, and theatre. Priority is given to projects in designated Opportunity Initiative Counties, ensuring a focus on local artistic growth and sustainability.

The Dollar General Literacy Foundation offers the DGLF Summer Reading Grants, which support the development and expansion of summer reading programs aimed at Pre-K to 12th grade students, particularly new and below-grade-level readers, including those with learning disabilities. Eligible organizations, such as nonprofits, schools, and libraries within 15 miles of a Dollar General store, can apply for grants up to $3,000 to foster literacy and education initiatives.

The SPC Cares Foundation

The SPC Cares Foundation was established in 2024 as a way for SPC Credit Union to strategically support four key development issues identified within our community: Hunger, Housing, Employment, & Education. The Foundation supports our local communities through monetary donations, in-kind donation drives, and volunteerism.

General Fund Scholarships

These funds are provided by the Carolinas Credit Union Foundation. Scholarships are available to Members of any credit union in North and South Carolina. Both academic and need-based scholarships for all levels of higher education are awarded, including technical and community college scholarships.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

The Dunkin' Joyful Spaces Grant supports children's hospitals and community health centers in creating joyful environments for pediatric patients. Launched in 2022, this initiative helps fund play areas, healing gardens, and other kid-friendly spaces, enhancing the hospital experience. Grants typically range from $25,000 to $65,000 annually, with a maximum of $150,000 over three years. This opportunity encourages creativity in designing spaces that provide comfort and joy to children and their families during hospital stays.

Who We Are

For nearly 30 years, the Carolinas Credit Union Foundation has served as a partner in philanthropy to credit unions, with a mission to empower and inspire credit unions in the Carolinas through collaborative opportunities to enrich our communities. The results of our work are visible across North and South Carolina, proving that by leveraging our cooperative spirit, we can change our communities.

Hero Awards

Each year, the Foundation honors people and organizations who have made or continue to make a transformational impact on the credit union movement. Hero Award winners are honored at the Foundation’s Awards Gala each year.  

Nominations for the following awards categories are accepted: The Lifetime Achievement Award, The Individual Achievement Award, The Partner in Philanthropy Award and The Advancing Equity Award.

The Advancing Equity Award

Honors an individual, credit union, business partner, or community non-profit for their commitment to the credit union industry’s 8th Cooperative Principle of DEI. This award recognizes the proactive efforts of people or organizations who cultivate belonging for all through fair and equitable policies, products, programs, and initiatives that enhance the well-being of employees, members, and/or surrounding communities. This award seeks to encourage those who, through committing time and resources to promote diversity, equity, and inclusion, live out the cooperative principle to engage everyone in governance, management and representation.