Best Large Grants for Nonprofit Organizations in South Carolina

The S.C. Arts Commission's Folklife & Traditional Arts Project Grants support non-profit organizations and government units in preserving and promoting South Carolina's traditional arts. This program aims to keep living cultural traditions vibrant through various projects, including workshops, festivals, and documentation efforts. Eligible applicants must be non-profit organizations with a valid DUNS number or government units. The grant encourages community engagement and the celebration of cultural heritage across the state.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

The Delta Dental of Missouri Grant Program aims to improve oral health in Missouri by funding initiatives that reduce oral disease, enhance access to quality dental care, and raise awareness, particularly among underserved populations. Grants range from over $5,000 to $100,000 and are awarded for one year, focusing on projects that increase access to care and demonstrate matching funds from other sources.

LSTA Grants for Public Libraries: LSTA Impact Grants

Impact Grants are funded with Library Services and Technology Act funds provided by the Institute of Museum and Library Services and administered by the South Carolina State Library. Public library systems may apply for funds from $5,000 up to $50,000 for a project that must incorporate specific outcomes for the target audience.

In this funding cycle, the State Library is especially interested in projects that:

• Develop the preservation and digitization capabilities of public libraries.
• Better serve patrons with difficulties using the library through the purchase of bookmobiles, outreach vehicles, and/or book lockers.

Stabilization Grants are awarded for “bid-ready projects” for the stabilization and weatherization of historic buildings. Stabilization and weatherization, as a treatment, is the act or process of applying measures designed to reestablish the structural stability of an unsafe or deteriorated property and a weather resistant enclosure while maintaining the essential form as it exists at present. The stabilization and weatherization must meet the Secretary of the Interior’s Standards for Rehabilitation. 

SC Federal Historic Preservation Grants

Historic Preservation Grants are federal funds from the US Department of the Interior, National Park Service, and administered by the South Carolina Department of Archives and History, State Historic Preservation Office (SHPO). Funds for the grant program are derived from Outer Continental Shelf mineral receipts. Each year the NPS allocates funds to the SHPO to help cover the cost of its operations, salaries and grants. Ten percent of those grant funds awarded to the SHPO must be passed through to Certified Local Governments (CLGs) per federal regulations.

Amounts available

Grant awards usually range from $5,000 to $35,000. The maximum amount awarded is $40,000. The SHPO anticipates that approximately $200,000 will be available for all grants. 

SC Historic Preservation State Grant Fund 

The purpose of the State Grant Fund is to support historic preservation projects that benefit local communities and the public through the physical repair and rehabilitation of South Carolina’s historic buildings. 

Historic buildings, for the purposes of the grant, are buildings that are listed as a contributing resource in a National Register of Historic Places district, or listed individually in the National Register, or determined by the SHPO to be individually eligible for listing in the National Register. The historic building must be located in South Carolina.

Planning Grants

Planning Grants are awarded to assist applicants in the development of conditions assessments and/or “bid-ready” plans and specifications that meet the Secretary of the Interior's Standards for Rehabilitation. Reimbursable planning grants up to $50,000 will be awarded. No cash match is required. 

Awarded funds are provided only as a reimbursement. SCDAH contributes its share and repays the grant recipient for eligible expenses through a reimbursement process. Applicants must document that they have a minimum of 50% of the Total Project Costs on hand designated specifically for the project and should be prepared to make whatever financial arrangements are necessary to ensure that project work is not delayed during the reimbursement process, which may take six (6) weeks. No work completed prior to the execution of the grant funding agreement will be eligible for reimbursement.

The Southern Equality Research Grant, offered by the Campaign for Southern Equality, aims to empower students and early career researchers to conduct crucial studies on LGBTQ+ issues in the South. With over a third of LGBTQ+ Americans residing in this region, there is a significant need for research to address legal protections and social inequities. This initiative seeks to elevate the voices and experiences of LGBTQ+ Southerners, fostering a deeper understanding of the policies affecting their lives.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The Jasiri L.K. Whipper Scholarship Endowment, established by the Coastal Community Foundation of South Carolina in 2009, honors Jasiri Whipper by providing an annual scholarship for students attending historically black colleges or state-supported colleges in South Carolina. This renewable scholarship aims to empower students and address educational equity, reflecting the Foundation's commitment to community development and support for future leaders.

The Jack and Anne Glenn Foundation, established in 2004, aims to support disadvantaged youth and their families through program and project grants. With a grant range of $5,000 to $25,000, the foundation focuses on organizations that are 501(c)(3) exempt. The foundation prioritizes applicants providing guidance to those at risk of poor educational and social outcomes in communities including Metro Atlanta, GA, and Charleston, SC.

South Carolina Arts Commission

The mission of the South Carolina Arts Commission is to expand access to the arts and foster creativity for all South Carolinians.

For more than 50 years, the agency has worked to build a thriving arts environment that benefits all South Carolinians, regardless of their circumstances or where they live.

We help artists and arts providers offer unique arts experiences to residents and visitors. From free poetry readings and gallery crawls to sweetgrass basketry workshops and ticketed dance, music, or theatre performances, they create an environment that contributes to quality of life from three “corner” counties of Oconee, Horry, and Beaufort to the 43 arranged inside.

Since 1967, the SCAC has awarded more than $132 million in grants to artists, arts organizations, school districts, schools, and teachers!

Public Art Grants

Purpose

This grant provides support for art that is created intentionally for a space in the public realm, regardless of whether it is situated on public or private property. Projects can be located indoors or outdoors, but must be free and accessible to everyone. Public art projects are limited to murals, sculptures, light installations, and sound installations.

Funding type: Reimbursement.

Use of Funds

Eligible expenses include, but are not limited to:

• Maintenance, repair, and revitalization of existing public art pieces.
• Artist stipends and fees including design, project management, and travel.
• Art installation, fabrication, and associated costs (site preparation, artwork transportation, machinery and equipment rental).
• Consultant and contractor fees (consultants and contractors can include architects, conservators, preservationists, historians, engineers, electricians, lighting consultants, etc.).
• Documentation, marketing, and signage.
• Development of a public art tour.
• Public art focused workshops and programs.

If you are hiring artists or teaching artists

For all grant-funded activities (including group lectures, demonstrations, performances, residencies, and short-term arts teaching experiences), the use of S.C. Arts Directory members is required for school and school district grantees and encouraged for grantees that are organizations.

Artists identified as Verified Teaching Artists on the S.C. Arts Directory have been additionally vetted by SCAC through the submission of sample lesson plans, recorded teaching samples, and letters of recommendation. For any grantee whose grant-funded activities are for K-12 student services, SCAC encourages the use of Verified Teaching Artists. Many school districts require the use of SCAC Verified Teaching Artists for classroom residencies. If working in a school environment, always check with both the individual school and the school district about policies related to hiring artists, arts organizations, and teaching artists.

Indirect Cost Limitation

No more than 10% of the total grant funds may be used for indirect costs (general overhead expenses not directly tied to the project). The remaining 90% must go toward direct costs, which are necessary to carry out the funded project.

• Examples of direct costs: Artist fees, program supplies, travel for project activities, and venue rental.
• Examples of indirect costs: Administrative salaries not directly working on the project, office rent, utilities, and general office supplies.

This ensures that most of the funding directly benefits the project while allowing some flexibility for necessary overhead costs.

Matching Requirements

1:1 (grantee:SCAC)

• Up to 50% of the grantee’s match may be through an in-kind donation of materials and/or contracted services.
• An example of “in-kind” is a contracted fee that is waived or discounted as a donation to your project.
• Another SCAC grant and/or federal funds may not be used to match your award.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The National Institute on Drug Abuse is funding pilot and feasibility studies aimed at preparing for substance use and HIV prevention research trials. The program encourages innovative interventions for substance use disorders and HIV eradication, focusing on stakeholder collaboration and practical application. Projects may include assessment of service models, intervention development, and community engagement. This initiative is designed to fill critical research gaps and enhance partnerships, although applications are not currently being accepted.

The Mutual Self-Help Housing Technical Assistance Grants in South Carolina provide essential funding for qualified organizations to assist very-low- and low-income families in constructing their own homes through self-help projects. The program emphasizes community involvement, where participants help each other build homes, receiving technical support from grant recipients. This initiative aims to empower families and strengthen rural communities, ensuring affordable housing solutions while fostering collaboration and skill development.

The Growing Justice Fund provides grants ranging from $25,000 to $250,000 to support community-led initiatives that enhance equitable food procurement. This initiative aims to empower Tribal, Indigenous, Black, Latinx, Asian, and immigrant communities by facilitating access to institutional contracts and promoting local economic viability. With a focus on health, environmental justice, and collective action, these grants are designed to foster sustainable food systems and build wealth in historically marginalized communities.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Artist Creative Practice Grant by South Arts supports individual artists in various disciplines by funding professional development opportunities. This grant ensures that artists can access vital experiences that enhance their careers, covering up to 2/3 of the total costs with awards ranging from $500 to $3,000. By promoting artistic growth, South Arts aims to elevate the cultural landscape of the Southern United States and foster meaningful connections within communities.

The Truliant Foundation offers the Fred J. Sarda Scholarships, providing $1,500 each to qualified applicants. Established in 1996, this program has awarded over $265,000 to more than 250 high school seniors who are members of a North or South Carolina credit union. Eligible candidates must have a GPA of 3.0 or higher and be first-time college students enrolled full-time for the 2025-2026 academic year.

Who We Are

For nearly 30 years, the Carolinas Credit Union Foundation has served as a partner in philanthropy to credit unions, with a mission to empower and inspire credit unions in the Carolinas through collaborative opportunities to enrich our communities. The results of our work are visible across North and South Carolina, proving that by leveraging our cooperative spirit, we can change our communities.

Hero Awards

Each year, the Foundation honors people and organizations who have made or continue to make a transformational impact on the credit union movement. Hero Award winners are honored at the Foundation’s Awards Gala each year.  

Nominations for the following awards categories are accepted: The Lifetime Achievement Award, The Individual Achievement Award, The Partner in Philanthropy Award and The Advancing Equity Award.

The Advancing Equity Award

Honors an individual, credit union, business partner, or community non-profit for their commitment to the credit union industry’s 8th Cooperative Principle of DEI. This award recognizes the proactive efforts of people or organizations who cultivate belonging for all through fair and equitable policies, products, programs, and initiatives that enhance the well-being of employees, members, and/or surrounding communities. This award seeks to encourage those who, through committing time and resources to promote diversity, equity, and inclusion, live out the cooperative principle to engage everyone in governance, management and representation.

The NCAA Division II Degree Completion Award provides financial assistance to student-athletes who have exhausted their athletics eligibility, enabling them to complete their first undergraduate degree. Since its inception in 2001, nearly $9 million has supported approximately 1,875 athletes, with a remarkable 90 percent graduation rate among recipients. The award covers tuition costs up to $15,000 for remaining credits and may be used in the summer term or short terms surrounding the final undergraduate year.

Barry and Elaine Nocks Scholarship

Barry and Elaine Nocks established this scholarship fund to provide educational scholarships to first generation college students who reside in Greenville County, SC.

Amount

• Award amount and number of awards are determined annually based on the Community Foundation of Greenville’s Spending Policy for Endowment Funds.
• Scholarship funds are paid to an approved educational institution in the name of the student.
• Scholarship funds are awarded for one academic year and are not subject to automatic renewal.
• Prior recipients may apply for subsequent awards not to exceed four academic years.

Mission

The Foundation was established in December 2013 by Kathryn B. McQuade, after retiring from 33 years of working in the business community. I was blessed to have been born into a loving middle class family. My father worked very hard to insure that all of his children were given an opportunity for a good education and my mother, “a stay at home Mom’ was always there for us. My world was safe and comfortable. My life is in stark contrast to how much of the rest of the world lives. I continue to read of the terrible injustices waged against women and children globally and hope that this foundation can provide them the opportunity and resources to succeed. We will support organizations that help us achieve our goal of Striving to make sustainable improvements in women and children’s rights education and welfare.

Kathryn McQuade Foundation Grant

The Foundation will make timely decisions on your grant request and provide clear communications on our expectations of reporting progress.

Women

The Foundation’s goal is to provide women assistance and provide them an opportunity to succeed. Assistance can take many forms, however our goal is to help them become self sufficient and enable them to lift themselves out of poverty and provide for their children. Access to education, job training and professional skills, even access to capital in order to build a business are possible ways we will consider helping women to succeed. Grant requests should focus on enabling the women to sustain financial independence.

We look forward to hearing of the many creative ways organizations are working on helping women succeed through out the world. To help women is to help their children and the communities they live in.

Children

Too many children in the US and across the world live in poverty and lack the access to education. Education and/or appropriate skills training are necessary to break the cycle of poverty and crime. While the assistance to women may take many forms, the foundation’s focus for children will target education and/ or skills training. The Foundation is open to many ideas on how to accomplish this goal and look forward to receiving proposals to help all children achieve their potential.

The Truliant Foundation Scholarships, established in 1996, have awarded over $265,000 to more than 250 high school seniors pursuing higher education. The Clyde Padgett Scholarship specifically offers $2,500 to eligible applicants who are members of a North or South Carolina credit union, maintain a GPA of 3.0 or higher, and enroll as full-time students in the 2025-2026 academic year. This initiative supports first-time college students, including dependents of Truliant employees.

The Southern SARE: On-Farm Research Grant supports agricultural professionals in collaborating with farmers to conduct innovative on-farm research projects focused on sustainable agriculture. This initiative emphasizes building strong relationships between researchers and farmers while addressing agricultural production challenges. By fostering new practices in production and marketing, it aims to enhance sustainability in the agricultural sector, thereby benefiting local communities and the environment.

The Emerging Traditional Artists Program (ETAP), presented by South Arts Inc., supports early-career traditional artists from Appalachian Regional Commission-designated counties. With a $5,000 award, artists can access training, networking, and mentorship opportunities to enhance their skills and community impact. This initiative aims to preserve traditional arts and culture while fostering a new generation of artists dedicated to their craft and cultural heritage.