Best Private Grants for Nonprofits in South Carolina

South Carolina agricultural producers, forest landowners, Tribes, and water management entities seeking conservation improvements can access funding through USDA Natural Resources Conservation Service. EQIP provides technical and financial assistance for practices that improve water and air quality, soil health, wildlife habitat, and climate resilience on eligible working lands, which may benefit nonprofit-led agricultural or conservation initiatives.

Nonprofit 501(c)(3) and 509(a) organizations in the greater Chicago area can receive US $2,000 - US $10,000 from McGraw Foundation for education, human services, conservation, health, and cultural programs. South Carolina nonprofits may be eligible if they operate qualified projects through a Chicago-area presence or partnership.

USDA: Natural Resources Conservation Service of South Carolina provides South Carolina agricultural and forest producers with financial and technical assistance to enhance conservation on working lands. Eligible individuals, entities, joint operations, and Tribes can receive more than US $4,000 annually to maintain and expand practices that improve soil, water, wildlife habitat, and overall environmental stewardship across their entire operation.

Nonprofit 501(c)(3) organizations with programs directly impacting Charleston County, South Carolina can receive grants up to Up to US $50,000 for community-focused work. Grants from BECU Foundation help South Carolina nonprofits advance education, health, basic needs, economic opportunity, arts and culture, environmental stewardship, and community development through the People Helping People Awards, which require nomination by a BECU member.

Graduate students conducting research in drinking water quality, environmental science, or public health can receive $3,000 to advance projects with timely, actionable outcomes for the water industry. Focused on water-related research, the American Water Works Association opportunity may benefit South Carolina nonprofits partnering with or supporting eligible graduate researchers.

Nonprofit 501(c)(3) public charities working in education, healthcare, human services, or Jewish values in South Carolina and North Carolina can seek program support and growth funding. With a mission to build self-sufficiency and permanent change, Leon Levine Foundation provides established Carolinas nonprofits sustaining over $500,000 in contributed revenue with strategic, long-term investment opportunities.

With a mission to support environmental sustainability, American Honda Motor provides South Carolina nonprofits and schools with US $25,000 - US $100,000 for programs in decarbonization, clean energy, and efficient use of natural resources. Eligible 501(c)(3) organizations and school districts must run projects that primarily benefit communities near Honda operations.

South Carolina 501(c)(3) nonprofits, public institutions, and qualified municipalities serving a Weyerhaeuser community can seek funding for community programs. Weyerhaeuser Giving Fund supports initiatives in areas like affordable housing, education and youth development, environmental stewardship, human services, civic and cultural growth, workforce development, and diversity, equity and inclusion, with awards of more than US $1,000.

Nonprofit organizations working on humanitarian aid, child welfare, education, health care, or disaster relief in South Carolina can apply for funding to build self-sufficiency and resilience for women and children. The Father's Table Foundation supports projects like homelessness services, employment assistance, microfinance, food security, anti-trafficking, and related programs, with awards up to US $750,000.

Nonprofit 501(c)(3) organizations in South Carolina can seek program or project support for education, environment, culture and arts, civic development, and health and human services. With a mission to strengthen communities, Dominion Energy Charitable Foundation provides US $1,000 - US $15,000 grants through two annual online cycles for work in its South Carolina service areas.

Undergraduate-focused higher education institutions conducting biomedical research in areas like public health, neuroscience, genetics, nursing, or HIV/AIDS in South Carolina can apply for Academic Research Enhancement Awards, with projects up to Up to US $375,000. The National Institutes of Health supports small-scale research that engages undergraduates and strengthens campus research capacity at institutions with limited prior NIH funding.

Nonprofit organizations in South Carolina seeking philanthropic support for humanitarian, educational, environmental, or arts initiatives may be eligible for funding, managed through local Roche affiliates. La Roche supports sustainable, high-quality projects worldwide that are run by accredited charities and can engage Roche expertise, logistics, and employees in community-focused activities.

Early-career research scientists at low- or middle-income country academic or research institutions conducting clinical trials can apply for the Emerging Global Leader Award, which provides approximately US $140,000 for mentored career development. Grants from the National Institutes of Health help South Carolina-based partners collaborating with LMIC investigators advance global health research across cancer, cardiovascular, neurological, mental health, and related fields.

Early-career health researchers at academic or research institutions in eligible low- or middle-income countries can apply for the Emerging Global Leader Award to support mentored research and career development; awards approximately US $140,000. South Carolina nonprofits partnering with LMIC investigators on health-related projects may benefit through collaboration opportunities with the National Institutes of Health.

Nonprofit 501(c)(3) organizations seeking funding for education-focused programs, youth initiatives, arts and culture, or community services can apply for grants of US $5,000 - US $20,000, including in South Carolina. Focused on education, John Ben Snow Memorial Trust invites U.S. nonprofits to propose new or enhanced programs or short-term support to sustain existing efforts.

Organizations hosting health-related congresses, events, or initiatives in South Carolina can seek corporate sponsorship funding to support their activities in areas like neurology, dementia, multiple sclerosis, Parkinson’s disease, and related fields. Biogen Foundation provides sponsorships in exchange for tangible benefits such as exhibit space, recognition, or marketing opportunities, with requests reviewed on a rolling basis.

Nonprofit 501(c) or 170(c) organizations in South Carolina can benefit from Regions Bank’s employee Matching Gifts Program, which doubles eligible associates’ tax-deductible donations. Funding supports work in economic and community development, education and workforce readiness, financial wellness, arts and culture, veterans, and disability services within the Regions service footprint.

South Carolina nonprofits, government agencies, and tax-exempt educational or research institutions can seek funding to improve health outcomes and expand access to care, especially for economically vulnerable residents. South Carolina health organizations can access funding through Blue Cross and Blue Shield of South Carolina Foundation for oral health, mental health, community health education, primary care, and related public health initiatives.

Nonprofit 501(c) or 170(c) organizations in South Carolina working in economic and community development, education and workforce readiness, financial wellness, arts and culture, veterans, or disability services can receive matching donations through this program. Regions Bank provides up to US $1,000 per recent retiree annually for eligible monetary gifts within its footprint.

Nonprofit 501(c)(3) organizations, or those with a fiscal sponsor, working on regenerative agriculture, climate justice, healthy food access, or related environmental initiatives can seek general operating support in South Carolina and nationwide. Focused on grassroots, community-based efforts, Clif Family Foundation offers US $5,000 - US $50,000 one-year grants reviewed twice annually.

The Data Center Community Grants Program (US-CBF) supports nonprofit organizations that enhance their local communities surrounding Google data centers. Funding is available for projects focused on education, economic opportunity, bridging the digital divide, sustainability, health, and arts. Grants typically range from $5,000 to $50,000, prioritizing measurable community benefits and innovative approaches. Eligible projects must demonstrate long-term impact, while operational expenses are generally ineligible. This initiative aims to empower underserved groups and foster collaboration within local ecosystems.

The William and Helen Thomas Charitable Trust provides funding to nonprofit organizations focused on education, environmental protection, medical research, and support for the underprivileged. This trust, based in Florida, primarily serves communities in Palm Beach, Martin, and St. Lucie Counties, along with select areas in Appalachia. It seeks to assist public charities classified under Section 501(c)(3) of the Internal Revenue Code, ensuring support for impactful charitable initiatives.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Frances P. Bunnelle Foundation offers the Grants for the Common Good in Fall to support organizations in Georgetown County, SC. Grants of up to $15,000 can fund general operations or special projects addressing poverty, basic human needs, economic vitality, and environmental preservation. Eligible entities include IRS-certified 501(c)(3) charities and government bodies, with a limit of one grant per year. Applications must demonstrate impactful use of funds within a nine-month term.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Healthcare Services Expansion Fund

The NAFC Healthcare Services Expansion Fund supports the launch or expansion of clinical programs and new service areas that increase access to care for underserved patients. This funding is designed to help NAFC members introduce new services or grow existing programs that address unmet community health needs and improve access to comprehensive, patient-centered care.

The Spartanburg County Foundation's Continuous Improvement Grant aims to enhance the lives of Spartanburg County residents by funding nonprofit organizations that focus on quality of life, educational achievement, and economic mobility. Grants of up to $35,000 are available to eligible 501(c)(3) organizations. The foundation prioritizes projects that demonstrate alignment with its mission, utilize data-driven strategies, and foster community engagement, ensuring diverse populations receive necessary support and resources.

The Spartanburg County Foundation offers Nonprofit Effectiveness Grants of up to $10,000 to enhance the internal capacity of community-based organizations in Spartanburg County. These grants aim to strengthen governance, financial management, and overall organizational effectiveness. Eligible organizations must be recognized 501(c)(3) nonprofits serving Spartanburg residents, demonstrating alignment with the Foundation's mission and measurable impact. The Foundation seeks to promote philanthropy and community engagement, ensuring that funds are utilized to benefit local residents directly.