Youth and Child Welfare Grants from DanPaul Foundation
501(c)(3) nonprofits supporting youth health, education, development, or welfare in South Carolina can apply for DanPaul Foundation grants, with awards up to US $15,000. Grassroots organizations serving children through advocacy, homelessness services, poverty relief, early childhood development, or refugee enrichment may be especially competitive, alongside related environmental and clean water education programs for young people.
The Dan Paul Foundation
Draper Richards Kaplan Foundation Grants for Scalability
Early-stage nonprofit and impact-first, mission-driven for-profit organizations tackling major social or environmental challenges can use this funding to scale innovative solutions in South Carolina and beyond. Grants from Draper Richards Kaplan Foundation help grassroots and other organizations with up to US $300,000 in flexible support, plus intensive capacity-building and community connections for ventures serving underserved populations.
Draper Richards Kaplan Foundation
Tech-Enabled Social Impact Funding from Cisco
Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment in South Carolina and worldwide can apply for Global Impact Cash Grants, with awards up to US $100,000. Cisco Systems Foundation prioritizes innovative, early-stage solutions serving mostly economically underserved communities, including grassroots initiatives that build skills, jobs, and climate resilience.
Cisco Systems Foundation
South Carolina Community Health Funding via Labcorp
South Carolina grassroots 501(c)(3) and equivalent charitable organizations can seek funding for health, education, or community initiatives that expand equitable care and learning opportunities. Labcorp Charitable Foundation provides support for projects such as food pantries, healthcare for underserved populations, STEM programming, and healthy lifestyle initiatives, with eligibility open to U.S.-based organizations.
Labcorp Charitable Foundation
Michael & Susan Dell Foundation Youth Grants
Organizations serving children and youth in education, health, or family economic stability can apply for Michael & Susan Dell Foundation grants of more than US $50,000 to support projects or scaling efforts. South Carolina grassroots groups that qualify as eligible entities and work with urban low-income communities may be competitive.
Michael & Susan Dell Foundation
Community Development Grants for Nonprofits from PNC Foundation
Nonprofit 501(c)(3) organizations working on early childhood education or community and economic development can apply for funding from PNC Foundation in South Carolina communities where PNC has a significant presence. Grants may support early learning programs, affordable housing, small business support, job training, arts and culture, and revitalization efforts serving low- and moderate-income residents.
PNC Foundation
Community Development Funding for Charities from Roche
Focused on community, education, environment, and culture, this program invites accredited charities in South Carolina to propose innovative projects in areas like humanitarian aid, youth services, STEM education, health, and the arts. Eligible grassroots organizations apply through local Roche affiliate offices when their work is based and delivered in the same country as the affiliate.
La Roche, Inc.
Health and Human Services Funding from Semnani Family Foundation
Nonprofits providing health, education, or humanitarian services can seek support for programs serving marginalized communities in South Carolina and worldwide. Semnani Family Foundation provides global grassroots and community organizations with funding for healthcare access, disaster relief, child and women’s services, literacy, and other human and social services initiatives focused on vulnerable populations.
Semnani Family Foundation
Sidney Stern Memorial Trust Grants for South Carolina Nonprofits
With a mission to support charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides South Carolina grassroots 501(c)(3) organizations with funding for programs that advance general welfare. Eligible nonprofits must be tax-exempt and use awarded funds within the U.S., making this a potential fit for locally focused initiatives.
Sidney Stern Memorial Trust
Grassroots Justice Funding from Southern Partners Fund
Grassroots, rural community groups in South Carolina working on social, economic, or environmental justice can access funding through Southern Partners Fund for organizing, capacity building, and travel assistance. Eligible groups use grassroots organizing strategies and are self-governed by the rural communities they serve, with priorities including education reform, immigration rights, and voter engagement, up to US $3,500.
Southern Partners Fund
Bank of America Support for Community Programs
Grassroots and other 501(c)(3) nonprofits in South Carolina can seek sponsorship support for community-focused programs, events, and initiatives. Bank of America supports efforts preserving neighborhoods, expanding workforce education, addressing hunger and emergency shelter, advancing arts and culture, protecting the environment, and promoting diversity and inclusion through its regional U.S. sponsorship program.
Bank Of America Charitable Foundation Inc
South Carolina Human Services Funding via Gupta Family Foundation
Applications due Jul 31, 2026
Grassroots and smaller human and social services nonprofits in South Carolina and other eligible countries can seek grants to help disadvantaged people become self-reliant. With a mission to support those facing poverty, disability, social alienation, or disasters, Gupta Family Foundation provides US $5,000 - US $250,000 to primarily 501(c)(3) organizations meeting its criteria.
Gupta Family Foundation
South Carolina Systems Change Funding via Sisters of Charity Foundation
Letter of inquiry due Aug 4, 2026
Grassroots and other nonprofit organizations in South Carolina working on systems change for economic mobility or housing security can apply for Sisters of Charity Foundation’s Systems Change Grants, with awards of US $15,000 - US $20,000. Funding can support general operations, specific programs, and capacity-building for work impacting any of the state’s 46 counties.
Sisters of Charity Foundation of South Carolina
South Carolina Community Funding via Sisters of Charity Foundation
Applications due Oct 5, 2026
Grassroots organizations in South Carolina planning outreach, events, trainings, workshops, celebrations, or similar one-time activities for communities experiencing poverty can receive up to US $1,500. Sisters of Charity Foundation of South Carolina supports efforts tied to economic mobility, housing security, or health care, with preference for community-led projects and persistent poverty counties.
Sisters of Charity Foundation of South Carolina
Social Change Grants for Grassroots Nonprofits from Fund for Southern Communities
Applications due Oct 15, 2026
Grassroots 501(c)(3) nonprofits and fiscally sponsored groups working on progressive social change can apply for US $1,000 - US $5,000 to support organizing and advocacy efforts in South Carolina. Grants from Fund for Southern Communities help small-budget organizations address discrimination, workers’ rights, environmental justice, peace, and community-based arts and media.
Fund for Southern Communities
South Carolina Community Services Funding via Robinson Foundation
Applications due Oct 15, 2026
South Carolina grassroots 501(c)(3) organizations serving communities in the Southern region can access funding for programs such as poverty relief, education, children and families, health, disaster relief, veterans, and faith-based services. The Robinson Foundation supports single-year, program-focused projects from fiscally responsible nonprofits that have operated for more than three years and can demonstrate tangible, meaningful impact.
Robinson Foundation
Insperity Community Services Grants in South Carolina
Applications due Oct 16, 2026
South Carolina 501(c)(3) nonprofits seeking support for community services, programs, or fundraising events can apply for grants or event sponsorships that aid important service and financial goals. With a mission to help communities where employees live and work, Insperity provides eligible charities with philanthropic grants and event sponsorships once per year.
Insperity
Dudley T Dougherty Foundation Support for Grassroots
Applications due Oct 31, 2026
Grassroots and other 501(c)(3) nonprofit organizations in South Carolina can seek funding for community services, environmental conservation, and peacebuilding projects. Focused on broad social and environmental impact, the Dudley T Dougherty Foundation invites eligible charities to propose initiatives that respect people, life, and the environment and contribute to meaningful change.
Dudley T Dougherty Foundation Inc
South Carolina Community Programs Funding via Georgia-Pacific Foundation
Applications due Oct 31, 2026
Grassroots 501(c)(3) nonprofits, public schools, and local government entities in South Carolina within 30 miles of a Georgia-Pacific manufacturing community can apply for Georgia-Pacific Foundation’s grants to support education, entrepreneurship, community enrichment, and environmental initiatives. Eligible organizations serving GP communities may benefit from this corporate community investment program.
Georgia-Pacific Foundation
Youth and Basic Needs Grants from TJX Foundation
Letter of inquiry due Oct 31, 2026
Grassroots 501(c)(3) nonprofits supporting basic needs, at-risk youth enrichment, workforce readiness, or domestic violence safety in South Carolina can seek funding to expand community programs. The Tjx Foundation invites eligible organizations located within 15 miles of a TJX store, distribution center, or office and aligned with its mission to submit a letter of inquiry.
The Tjx Foundation Inc
Max and Victoria Dreyfus Grants for South Carolina Community Programs
Applications due Nov 11, 2026
IRS-qualified nonprofit organizations in South Carolina seeking US $1,000 - US $20,000 for community-based programs, education, arts, health facilities, or environmental activities can apply to the Max and Victoria Dreyfus Foundation. This national funder provides support where modest grants can significantly strengthen grassroots and local initiatives across the U.S.
Max and Victoria Dreyfus Foundation
Ameriprise Financial Support for Community Vitality
Applications due Jan 15, 2027
Focused on community development and basic needs, Ameriprise Financial invites U.S. 501(c)(3) nonprofits to apply for grants supporting hunger relief, shelter, adult self-sufficiency, and community vitality initiatives. South Carolina grassroots organizations that meet these focus areas and demonstrate Ameriprise volunteer engagement and strong outcomes may be competitive.
Ameriprise Financial
Jewish Life and STEM Grants from Coastal Community Foundation
Applications due Jan 15, 2027
Grassroots and other organizations in South Carolina preserving Jewish identity and culture or providing STEM education for children and young adults can apply for Coastal Community Foundation’s Stanley B. Farbstein Endowment, with awards of approximately US $7,500. Invitation-only applicants in Beaufort, Berkeley, Charleston, and Dorchester counties may benefit from this funding.
Coastal Community Foundation of South Carolina
Dr Scholl Foundation Grants for South Carolina Programs
Letter of inquiry due Jan 31, 2027
Grassroots 501(c)(3) organizations in South Carolina seeking project funding for education, social services, health care, civic and cultural, or environmental work can apply for grants of US $5,000 - US $25,000. Grants from Dr Scholl Foundation help U.S. nonprofits with one year of support through an annual October–March application cycle.
Dr Scholl Foundation
Chick Fil A Foundation Grants for South Carolina Youth and Families
Applications due May 1, 2027
South Carolina grassroots nonprofits supporting youth, families, education, housing, food security, or environmental stewardship can access funding through Chick Fil A Foundation’s True Inspiration Awards. U.S. 501(c)(3) organizations may receive US $30,000 - US $350,000 for programs such as leadership development, academic support, hunger relief, housing services, community gardens, or environmental projects benefiting young people and their families.
Chick Fil A Foundation Inc
Southern Partners Fund Support for Grassroots Justice
Applications due May 6, 2027
Rural, grassroots 501(c)(3) organizations focused on social, economic, or environmental justice in South Carolina and other Southeastern states can seek general or project support through the Hubert E. Sapp Regular Grant Cycle. Southern Partners Fund prioritizes community-led groups using grassroots organizing strategies to build leadership, strengthen rural communities, and advance equitable policy change.
Southern Partners Fund