Best Capacity Building Grants for Nonprofits in South Carolina

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Clancy & Theys 1949 Fund, managed by the Triangle Community Foundation, supports nonprofits in Central Florida, North Carolina, Upstate South Carolina, and Virginia. This donor-advised fund prioritizes initiatives in education, workforce development, youth programming, and community well-being, focusing on measurable impacts. The Foundation seeks to strengthen community ties and enhance quality of life by connecting donors with local organizations that address pressing needs. Both established partners and new applicants are encouraged to apply.

The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Jolley Foundation Grant offers up to $100,000 to charitable organizations that are 501(c)(3) exempt and based in South Carolina. This grant aims to address poverty and discrimination through systemic solutions, capacity-building for nonprofits, and collaborative efforts. Priority is given to projects in arts, education, health, and human services, particularly those benefiting residents of Greenville County. Applicants must demonstrate financial sustainability for their programs.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The Spartanburg County Foundation offers Nonprofit Effectiveness Grants of up to $10,000 to enhance the internal capacity of community-based organizations in Spartanburg County. These grants aim to strengthen governance, financial management, and overall organizational effectiveness. Eligible organizations must be recognized 501(c)(3) nonprofits serving Spartanburg residents, demonstrating alignment with the Foundation's mission and measurable impact. The Foundation seeks to promote philanthropy and community engagement, ensuring that funds are utilized to benefit local residents directly.

The CFG Capacity Building Grants support established 501(c)(3) organizations in Greenville County, SC, aiming to enhance their operational capabilities and governance. Funding opportunities include projects for client engagement, management innovation, collaborative ventures, technology improvements, and revenue diversification. Examples of capacity building encompass financial planning, organizational assessments, strategic planning, and leadership development. Grants are awarded competitively, allowing one application per agency per year, excluding individuals and certain ineligible expenses.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

The Dr. Scholl Foundation offers grants annually to IRS 501(c)(3) organizations, primarily focusing on U.S. applicants. The foundation supports projects in education, social services, healthcare, civic and cultural initiatives, and environmental efforts. While the grant cycle runs from October 1 to March 1, it encourages innovative solutions to global challenges. Only one application per organization is accepted each year, and funding is limited to one year. Unqualified organizations, including political entities, are ineligible.

The Resilient and Connected Appalachians Grant Program, offered by The Nature Conservancy, provides up to $100,000 for projects that acquire land and easements throughout the Appalachian region. This program emphasizes equitable conservation, aiming to support historically marginalized communities and enhance access to nature while addressing climate change impacts. Projects must demonstrate community engagement and align with the program's goals to protect vital habitats and foster resilience in the face of environmental challenges.

The Arts Project Support Grants by the South Carolina Arts Commission aim to fund quality arts projects and programs for artists and organizations. Eligible applicants include artists, nonprofit organizations, and government units, with funds supporting project costs such as technical capacity building and professional development. Priority is given to projects in specific counties within South Carolina. Applications should be submitted at least five weeks prior to project commencement, with all activities funded to occur between August 11, 2025, and May 31, 2026.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The Battlefield Preservation Fund Grant aims to support initiatives that preserve battlefields and related historic sites. This funding encourages planning and educational efforts, particularly those that engage new audiences in preservation activities. Eligible applicants include public agencies and nonprofits in specified states. Grants can be used for staff support, consultant fees, and educational materials. Applicants must provide a one-to-one match for funding, ensuring strong community involvement in preservation efforts.