Best Large Grants for Nonprofit Organizations in South Carolina

The ACFM General Support Program provides funding ranging from $2,000 to $20,000 for organizations committed to contemporary American concert music and jazz. It supports performing ensembles, presenters, and music service organizations that enhance public appreciation of these genres. Eligible applicants must have a minimum of two years of programming history and a professional operational level. Activities must occur within the specified support year of September 1, 2026, to August 31, 2027.

The Native Arts & Cultures Foundation's LIFT program offers critical support to early career Native artists through one-year grants of $10,000. This initiative aims to nurture emerging voices and foster community engagement while promoting environmental sustainability. Selected artists will benefit from professional development training and culturally appropriate evaluations to enhance their artistic practices. By providing vital resources, LIFT empowers artists to advance their careers and contribute meaningfully to their communities.

The Youth Initiative Grant, provided by the Weyerhaeuser Family Foundation, aims to support innovative programs that enhance resilience and psycho-social health for youth aged 14-21 affected by trauma from Adverse Childhood Experiences (ACEs). Grants are available for new programs or therapeutic components within their first year. The foundation prioritizes organizations that actively engage with beneficiaries and implement holistic approaches to service delivery, ensuring long-term sustainability and effective evaluation of program impacts.

The Residential Treatment for Pregnant and Postpartum Women program aims to deliver essential services to women facing substance use disorders. By offering comprehensive residential treatment options, the program supports both recovery and the well-being of mothers and their children. Funded by the Substance Abuse and Mental Health Services Administration, this initiative addresses the unique challenges of pregnant and postpartum women, ensuring they receive the care necessary for a successful recovery journey.

The Bernie Bahr Forestry and Natural Resources Scholarship, managed by the Community Foundation of the Ozarks, awards a $1,000 grant to undergraduate students pursuing a Bachelor’s degree in Forestry or related fields. Eligible applicants must have completed at least two years of college and maintain a minimum GPA of 2.5. Preference is given to graduates from specific high schools in Missouri. This scholarship aims to support students dedicated to environmental and natural resource management.

The Chatlos Foundation provides grants to nonprofit organizations in the U.S. and globally, focusing on Bible colleges, religious causes, liberal arts colleges, medical concerns, and social issues. Grants typically range from $2,000 to $20,000, depending on the category. The Foundation prioritizes program support and typically funds requests under $10,000. Eligible organizations must be U.S.-based, tax-exempt for at least two years, and aligned with the Foundation's mission, ensuring that funded projects achieve independence.

What is Emergency Assistance Fund

Emergency Financial Assistance is available to eligible performing arts and entertainment professionals:

• In times of unexpected critical need.
• To assist towards basic living expenses, such as health care, housing and utilities to prevent eviction or shut-offs.

Hunter Brown Emergency Assistance Fund

The Hunter Brown Emergency Assistance Fund offers emergency financial assistance to current or former employees of Oregon Shakespeare Festival.

The SMSNA Scholars in Sexuality Research Grants Program supports junior investigators in exploring human sexuality and sexual wellness. Funded by the Sexual Medicine Society of North America, this initiative provides $5,000 to undergraduate, medical, and graduate school students. Awards are disbursed in two payments, with specific reporting requirements. This program aims to enhance research in sexual medicine and foster diversity in the field, particularly focusing on historically underserved populations.

The SMSNA Scholars in Sexuality Research Grants Program supports junior investigators in the field of human sexuality and sexual wellness. With a funding of $7,500, the program aims to attract emerging researchers and clinicians to sexual medicine. Applications are accepted from graduate students, residents, and post-doctoral fellows, with an emphasis on diverse backgrounds. The program promotes ethical research practices and requires mid-term and final progress reports to ensure accountability.

The ELCA World Hunger Program offers Domestic Hunger Grants to support U.S. and Caribbean congregations in addressing food security and other local issues. With a maximum award of $10,000 per year for three years, these grants prioritize organizations with strong community ties and a commitment to diversity and inclusion. The program aims to break the cycle of poverty and hunger through collaborative efforts and advocacy for systemic change.

The .ORG Impact Awards, organized by the Public Interest Registry, honor individuals and organizations connected to .ORG domains for their impactful contributions in areas such as health, education, diversity, and environmental stewardship. Participants can receive up to $50,000 for their chosen non-profit and gain visibility through various promotional platforms. This initiative not only recognizes excellence but also fosters community support and encourages innovative solutions to pressing societal issues.

Speedway Children's Charities (SCC) is a 501(c)(3) organization dedicated to supporting children in need across the nation. With over $61 million granted since 1982, SCC is refocusing its efforts to address the urgent challenges of homelessness and human trafficking in the Charlotte area. This shift aims to prioritize funding for organizations that assist orphaned and foster children, ensuring that critical needs such as food, shelter, and education are met for vulnerable populations.

The Robert F. Schumann Foundation Grant supports organizations dedicated to environmental sustainability, education, and the arts. Founded by Robert F. Schumann, an environmentalist, the foundation aims to enhance the quality of life for both humans and animals. It prioritizes projects that would not have been pursued without its assistance, particularly in ornithology and open space habitats. Organizations must be 501(c)(3) exempt to apply, ensuring a focus on impactful community initiatives.

The Josh Dubin Fellowship, launched in January 2022 by the Shawn Carter Foundation, is a seven-week paid program designed for five exceptional students interested in the legal field. This immersive experience includes mentorship from legal professionals, direct involvement in case analysis, and off-site visits to courtrooms. Fellows not only gain invaluable insights into legal practices but also receive additional scholarship support for their educational pursuits, empowering them to overcome socio-economic barriers and achieve their dreams.

Takeda's Corporate Giving program focuses on enhancing community well-being in the U.S. by supporting initiatives in two key areas: Food is Health and Building STEM Foundations. Through employee engagement and partnerships, Takeda aims to provide access to nutritious food and foster STEM education, addressing social disparities and empowering future innovators. This commitment reflects Takeda's mission of better health and a brighter future for all.

The Hanger Foundation's Empowerment Grants aim to positively impact individuals with physical challenges by supporting 501(c)(3) organizations in the U.S. The foundation focuses on rehabilitation services, athletic programs, and social activities that empower those with limb loss or differences. Grants are available for one year and prioritize projects that engage communities and enhance the quality of life for those in need. Organizations are encouraged to apply for funding that directly supports these goals.

Arnold Ventures is dedicated to enhancing lives in America through evidence-based policies that address social injustices. Their Evidence and Evaluation team seeks to discover and evaluate solutions for pressing social issues by funding rigorous causal research. This initiative focuses on studies that employ quasi-experimental methods to assess the impact of programs and policies in key areas like education and public finance, ultimately guiding effective resource allocation and policy reform.

The Mathers Charitable Foundation Grant focuses on advancing basic scientific research with the potential to transform human health. It supports institutions and investigators in fields such as immunology, cancer biology, and neuroscience while prioritizing impactful, foundational discoveries. The foundation empowers researchers to drive innovative solutions and foster meaningful contributions to science and society. Eligibility includes U.S.-based institutions and principal investigators with equipped labs, while ineligible entities include overseas institutions and private foundations.

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

The Tribal Colleges Research Grants Program (TCRGP) aims to enhance research capacity at Tribal colleges, focusing on agriculture, natural resources, and human sciences. By fostering leadership skills and knowledge, the program prepares students for competitive careers in agriculture and related fields. Projects involving innovative agricultural technologies, such as AI and data science, are encouraged. TCRGP also emphasizes training opportunities for undergraduate students to equip them for success in a digital society and explore pathways in AI for food and agricultural sciences.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

Women's Wildlife Management Conservation Scholarship

The Women’s Wildlife Conservation Scholarship, established by the NRA Women’s Policies Committee, is a renewable one-year $5,000 scholarship available to full-time college sophomores, juniors, or seniors. Thank you for your interest in the field of wildlife management, forestry, parks, or fish and wildlife conservation.

Scholarship Value

$2,500 per semester for up to two semesters. Recipients must maintain qualifications listed above to receive second installment.

The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity (R21 Clinical Trial Optional) aims to fund projects that explore policies related to tobacco, alcohol, and cannabis in the U.S. The focus is on understanding how these policies affect usage and exposure among disadvantaged populations. Engaging community organizations is essential for promoting equity in cancer prevention. This initiative is crucial for advancing health equity and reducing disparities in substance use.

The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity grant aims to support research on policies affecting tobacco, alcohol, and cannabis use in the U.S. This initiative focuses on how these policies impact populations facing health disparities. Key components include engaging community organizations to advance equity in cancer prevention. Important deadlines for applications range from February 2025 to October 2027, providing opportunities for both standard and renewal submissions.

The Small Grants for New Investigators program aims to enhance participation in health-related research by supporting new investigators from diverse backgrounds. This initiative encourages projects in the scientific areas of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Eligible applicants may receive funding for small research projects, promoting research independence and innovation while addressing the underrepresentation in biomedical research.

The Patient-Centered Outcomes Research Institute (PCORI) intends to release an Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund implementation projects that promote the uptake of peer-reviewed findings from specific PCORI-funded patient-centered comparative clinical effectiveness research (CER) in the context of the body of related evidence. This PFA is an open competition opportunity for principal investigators to propose implementation projects that move evidence toward practical use in improving health care and health outcomes. Applicants may propose projects with budgets up to $1.8 million in total direct costs.

PCORI seeks to fund implementation projects that incorporate active, multicomponent strategies that will lead to uptake and integration of evidence generated by PCORI-funded research in practice settings. Implementation should target specific end users with a clear interest in — and ability to benefit from — the evidence. Proposed implementation projects will adapt findings as needed to facilitate uptake in the proposed settings and accomplish scale-up to reach larger numbers and/or scale-out to reach broader populations and settings. Applicants must demonstrate commitment and buy-in — including from leadership as well as frontline staff critical to the success of the project — from proposed implementation sites across multiple health systems, such that they provide a supportive context and infrastructure for undertaking the proposed project. In addition, projects should involve regional and national stakeholder organizations positioned to extend uptake in broader venues.  

Applications must be guided by an established conceptual model or framework and, where possible, by evidence regarding effective strategies for implementing evidence-based practices and interventions. Additionally, applications must include a rigorous evaluation plan that documents the successful execution of the implementation approach and the impact of the project on health care and health outcomes as feasible and appropriate within the project scope.

Joyful Heart Foundation

Since 2004, Joyful Heart has been a leading national organization with a mission to transform society’s response to sexual assault, domestic violence and child abuse by building a world that prioritizes survivors’ healing.

Our Areas of Focus

We continue to carry out our mission through programming centered on survivors’ needs. We strive to fill gaps where those needs aren’t being met, without duplicating existing programs. In order to build a more compassionate, more informed culture rooted in the possibility and promise of healing, we focus on three key areas: Awareness and Community Building, Policy and Advocacy and Healing Programs.

• Healing Programs and Resources: Creating and fostering a culture of healing and nurturing for survivors and the professionals who support them.
• Policy and Advocacy: Advocating for policies and practices that forge a path to safety, justice and hope for survivors.

• Awareness and Community Building: Creating spaces and conversations that channel a drive for change into action and transformation.

Heal the Healers Grant 

Helping alleviate the effects of secondary trauma for the long-term wellbeing of professionals who support survivors

Building for a System of Care and Compassion

Heal the Healers Grantmaking Program provides critical support for professionals who help survivors heal and seek justice. People working on the frontlines of survivor-centered services are subject to the often overlooked effects of secondary trauma that can emerge as a result of continuous exposure to people who have recently experienced abuse and violence.

The Heal the Healers Grant Fund and Grantee Learning Cohorts provide resources to mitigate the effects of secondary trauma among the practitioners responsible for the earliest stages of survivors’ paths to justice and healing. Creating a safer, more compassionate world for the people who do this work helps lay a foundation for lasting change and a world where every survivor’s healing is prioritized.

The Heal the Healers Fund provides micro-grants of up to $5,000 to nonprofit, Tribal, or governmental organizations supporting survivors for training, small capital projects, or organizational activities.

Areas of Support

The Joyful Heart Foundation has established the following guidelines for its Heal the Healers Fund grants to support those working directly with survivors in the following areas.

• Training and/or program development on self-care practices such as training in trauma-informed yoga, breathwork, somatic therapy, etc.
• Small capital items and equipment that specifically allow staff and volunteers to address their self care needs such as daylight lamps for staff or new furniture for a break room.
• Staff activities to build and support connections between colleagues such as, trust building experiences, monthly pizza nights, or bagel Fridays.
• Or any combination of the above. 

In addition to the financial support, grantees will also be invited to join a peer learning community cohort that includes:

• Opportunities to amplify their fellowship/cohort experiences to inspire others in the field
• Virtual peer-to-peer networking opportunities
• Virtual training/presentations by leading healers, therapists and other professionals with expertise in cutting edge vicarious trauma, empowerment, leadership and therapeutic modalities

The Crawford Taylor Foundation focuses on enhancing programs that create lasting legacies in St. Louis. With priorities in community development, women's health, animal welfare, and environmental preservation, the foundation seeks to support 501(c)(3) organizations that meet specific eligibility criteria. They avoid funding multi-year grants or for-profit initiatives, emphasizing support for local causes and relief efforts deemed important by the Taylor family.