Best Large Grants for Nonprofit Organizations in South Carolina

The Collins Medical Trust Grant, established in 1956, supports health-related research and professional education for tax-exempt organizations. Eligible applicants include institutions with approved tax status and a commitment to equal opportunity. Early career investigators are encouraged to apply, but funds cannot be used for individual benefits or political activities. The Trust prioritizes projects in Oregon and does not support product development for industry. Applications are accepted thrice yearly, with specific deadlines for timely consideration.

The Radiation Exposure Screening and Education Program aims to support organizations in their efforts to screen and educate individuals who have been exposed to radiation from uranium mining and U.S. nuclear weapons testing. This initiative emphasizes the importance of awareness and education in mitigating health risks associated with radiation exposure, ensuring affected communities receive the necessary resources and support for health management.

The Stanley B. Farbstein Grant Program, established by Mr. Farbstein’s estate in 2014, is an invitation-only initiative focused on preserving Jewish life and education in South Carolina's Beaufort, Berkeley, Charleston, and Dorchester counties. Each year, selected organizations can request funding up to $20,000. Since its inception, the program has allocated over $500,000, demonstrating a strong commitment to enhancing Jewish culture and supporting STEM education for youth.

The Donors Choose Teacher Mini Grants program offers financial support for innovative classroom projects initiated by teachers in selected South Carolina counties. These grants aim to encourage creative educational approaches and enhance learning experiences. Applications are processed through Donors Choose, a platform that facilitates community support for classrooms in need. This initiative not only addresses immediate educational requirements but also fosters long-term community engagement and empowerment.

The Jim and Shirley Cook Scholarship offers a $750 award for graduating high school seniors pursuing higher education at accredited institutions. Applicants must demonstrate financial need through FAFSA-SAI and provide evidence of community service and extracurricular involvement. Preference will be given to candidates with leadership experience in FFA or the GO CAPS program, specifically those studying Mechanical Engineering, CNC programming, Welding, or Machine Tool Technology. This scholarship aims to support students who embody commitment and community engagement.

The Maximizing Investigators' Research Award (MIRA) program, established by NIGMS, aims to enhance research funding efficiency by providing stable financial support to investigators. This allows for greater scientific flexibility and encourages innovative studies. MIRA is pivotal for distributing funding among promising researchers, fostering groundbreaking research. The program invites applications from eligible NIGMS-funded and NIH-defined New Investigators, as well as current MIRA grantees seeking renewal, ensuring a broad and inclusive approach to advancing science.

The AOAP Swim Lesson Grant aims to enhance drowning prevention by providing financial support to aquatic facilities for swim lessons and life jackets. With a minimum allocation of $10,000 annually, the program seeks to offer at least 100 free lessons to low-income participants and distribute 500 life jackets each year. It encourages non-profit organizations to apply, ensuring a focus on education and safety in aquatic environments. This grant represents a significant step towards making swimming accessible and safe for all.

The BJS FY 2026 National Incident-Based Reporting System Estimation Program aims to enhance statistical protocols for crime and arrest data collection in the U.S. This funding opportunity supports the ongoing development of the NIBRS Estimation System, focusing on improving data quality, timeliness, and estimation methodologies. By refining these processes, the program seeks to address public safety challenges and provide reliable national estimates, thereby ensuring effective law enforcement and crime prevention efforts.

The Wolcott Family Foundation focuses on funding grassroots organizations that drive social change and environmental stewardship. They prioritize support for projects that empower communities, strengthen civil liberties, and address ecological challenges. Eligible applicants are nonprofit organizations in Colorado classified under section 501(c)(3), with grants awarded for one year. The foundation values projects emphasizing environmental preservation and community involvement aimed at tackling societal issues.

The Camille Dreyfus Teacher-Scholar Awards Program supports talented early career faculty in the chemical sciences by providing an unrestricted research grant of $100,000. Nominees must demonstrate outstanding research achievements and a commitment to education. Each institution can submit one nomination annually. The program emphasizes innovation and leadership in research while considering factors such as awards, publication success, and contributions to education, particularly at the undergraduate level.

The Robert P. Wadell Transportation Engineering Scholarship, established in 2022 by Robert P. Wadell, P.E., MSCE, F.ASCE, supports undergraduate students in civil engineering with a focus on transportation. Funded through the ASCE Foundation, the scholarship aims to aid up to two deserving students annually with tuition and fees. Eligible applicants must be U.S. citizens enrolled in an ABET-accredited program and members of the ASCE. Preference is given to those in their final two years of study.

The Robert B. B. and Josephine N. Moorman Scholarship, established in 2008 by the American Society of Civil Engineers (ASCE), provides financial support for undergraduate students pursuing degrees in civil engineering or related fields. This scholarship honors Robert B.B. Moorman, a dedicated civil engineering professor. Eligible applicants must be enrolled in an ABET-accredited program and maintain good standing with ASCE. This award aims to alleviate tuition costs for deserving students committed to the civil engineering profession.

The Lawrence W. & Francis W. Cox Scholarship, established by Mrs. Wahneta T. Hinrichs in 2008, honors the legacy of her husband and father-in-law. This scholarship is awarded annually to one undergraduate civil engineering student enrolled in an ABET-accredited program. It aims to support students with tuition expenses, furthering their education in civil engineering disciplines, thus contributing to the profession's growth and sustainability.

The Eugene C. Figg, Jr. Civil Engineering Scholarship, established by Figg Engineering Group in 2002, honors the legacy of Gene Figg, who was renowned for his artistic bridge designs. This scholarship aims to support undergraduate civil engineering students with a passion for bridge design and construction, facilitating their education in an ABET-accredited program. Eligible candidates must be U.S. citizens and Student Members of the American Society of Civil Engineers in good standing.

The B. Charles Tiney Memorial ASCE Student Chapter Scholarship, established in 1980 by Mrs. Hazel M. Tiney, provides financial support to deserving undergraduate civil engineering students. This scholarship aims to assist with tuition expenses for those enrolled in ABET-accredited programs. Recipients are chosen based on their commitment to the civil engineering field and must be members in good standing of the American Society of Civil Engineers and their respective student chapters.

The Survivor Fellowship Program for Students, initiated by Everytown for Gun Safety in 2015, empowers individuals directly affected by gun violence. This year-long volunteer advocacy training helps survivors share their narratives, fostering awareness and mobilizing communities to combat gun violence. Participants must be at least 18 years old and enrolled in an educational institution, with a personal connection to gun violence, ensuring diverse experiences are represented in this impactful initiative.

The Northern Lowcountry Grants - Cooper River Bridge Run Grants Fund, established in 2006 by the Coastal Community Foundation, aims to enhance community health through physical activity. This fund specifically supports 501(c)(3) organizations serving Berkeley, Charleston, and Dorchester counties, promoting exercise initiatives that benefit local residents. Applications are accepted from organizations committed to fostering wellness and active lifestyles within the Tricounty area.

The Tommy Wilson Memorial Grant, established by Dr. George T. Wilson and his wife Irene, honors their son Tommy, who had cerebral palsy. This grant supports recreational programs for individuals with disabilities and aims to positively impact their lives. Applicants must be nonprofit organizations with a successful history of programming for individuals with disabilities. The grant prioritizes programs serving economically disadvantaged individuals and may only fund applicants once every five years.

The AWG Mid-Career Excellence Award honors outstanding mid-career women scientists contributing significantly to geosciences. It recognizes achievements across academia, industry, and government, with nominees evaluated on their scientific impact and community service. This prestigious award encourages nominations from the AWG membership and the broader geoscience community, fostering recognition of women's vital contributions in the field. With a commitment to diversity, the award aims to inspire future generations of women in geoscience careers.

The Institute of Education Sciences (IES) offers research training programs aimed at advancing education research through two key initiatives: the Early Career Development and Mentoring Program and the Methods Training Program. These programs support emerging researchers in developing their skills and enhancing their research capabilities to address vital education issues. The funding is designed for early career investigators and current education researchers, fostering rigorous and relevant research that informs education policy and practice.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The CHEERS Open Period 2 initiative invites white papers from researchers in various technical fields, focusing on projects that align with the objectives of the Continuing Enabling, Enhancing, Restoring, and Sustaining (CHEERS) MAA. This funding opportunity, backed by the US DOD's Air Force Materiel Command, is aimed at advancing national defense capabilities through innovative research and development in areas such as ordnance, telecommunications, and medical supplies.

The Congressional Science Fellowship Program offers a unique opportunity for Ph.D. holders to work at the intersection of science and government in Washington D.C. This prestigious fellowship, sponsored by ASA, CSSA, and SSSA, allows participants to apply their expertise as special assistants to Congress members. The fellowship begins in September 2025 and concludes in August 2026, providing an annual stipend and relocation expenses. Ideal for early to mid-career scientists, it encourages the use of scientific knowledge in public policy.

The Orphan Kitten Club’s Mightycat Grant Program offers financial assistance to individuals and organizations dedicated to saving neonatal kittens. Funding supports essential needs such as medical care, supplies, and innovative programs aimed at improving survival rates. Eligible applicants include 501(c)(3) organizations and independent rescuers with a proven track record in kitten care. The program's mission is to enhance rescue efforts and provide vulnerable kittens the opportunity to thrive and find loving homes.

The Louisville Institute offers the Grant for Researchers to support academic research in North American Christianity and related fields. Grants of up to $55,000 are available for sabbatical leaves, research projects, and necessary resources. This flexible program combines previous grants to meet contemporary academic needs. Applicants can apply individually or as teams of up to three, provided they are based in the U.S. or Canada. Projects bridging scholarship and church life are of particular interest.

This grant aims to enhance safety and health in U.S. mining operations through research in automation, robotics, and intelligent systems. It addresses critical issues like emergency communication and self-escape reliability while supporting the development of field-ready solutions. By leveraging advanced technologies, the initiative seeks to improve miner safety and health, reduce hazardous exposures, and foster community engagement. Applicants must be U.S. academic institutions with accredited mining programs, linking project goals to documented health burdens.

The I9 Sports Association provides scholarship grants to support youth sports participation for children under 18 in the U.S. Grants of up to $150 help offset registration fees for various recreational activities. With a focus on inclusivity and access, the association aims to foster athletic development and participation among young athletes. Applications are accepted year-round, with grants awarded in February, May, August, and November, ensuring ongoing support for youth sports engagement.