Best Large Grants for Nonprofit Organizations in South Carolina

The DOJ's FY 2026 BIDEN Program aims to address immigration-related challenges by providing funding to eligible state and local governments. This initiative focuses on enhancing law enforcement's capacity to apprehend criminal aliens, investigate gang activities, and manage court operations related to crimes committed by aliens. By supporting these critical efforts, the program aims to improve public safety and uphold the rule of law in communities across the nation.

The Health Promotion and Disease Prevention Research Centers are offering supplemental funding for Special Interest Projects (SIPs) aimed at enhancing public health practices. These projects will focus on innovative health promotion and disease prevention strategies to mitigate leading health risks in the U.S. The initiative supports ten specific SIPs, including studies on cancer care, alcohol use reduction, and emergency preparedness, thereby fostering research that translates into real-world health improvements.

The US Flu Vaccine Effectiveness (VE) Network aims to enhance the effectiveness of vaccines against influenza and other respiratory pathogens, which are significant contributors to morbidity and mortality. This funding opportunity invites proposals for surveillance studies, including annual VE assessments, acute respiratory illness tracking, household transmission research, and immunogenicity studies. Applicants can apply for either Component A or B, with the option to include additional components based on their primary selection.

The James McKeen Cattell Sabbatical Grant, provided by the James McKeen Cattell Fund, offers supplementary financial support for psychologists' sabbaticals. This grant is designed for faculty members at U.S. and Canadian institutions who meet specific eligibility criteria, including tenure status and recent leave history. The maximum award is capped at $40,000 or half the recipient's salary, ensuring that recipients can extend their research time effectively.

The FY26 Spinal Cord Injury Research Program Clinical Trial Award supports innovative clinical trials aimed at significantly improving spinal cord injury treatment. This funding opportunity encourages collaboration by allowing two Principal Investigators, including an early-career investigator, to drive the research forward. Applicants must partner with at least two SCI community members, ensuring that the project is informed by lived experiences and community needs throughout its development and implementation.

The NIOSH Centers of Excellence for Total Worker Health® (U19) aims to enhance worker well-being by funding research and translation activities that address harmful exposures and improve working conditions. Priority areas include high-risk occupations, young workers, and chronic diseases. The initiative emphasizes strong project coordination, scientific rigor, and economic evaluations. Projects must utilize the NIOSH Worker Well-Being Questionnaire and share findings with the HERO Clearinghouse, fostering innovative solutions for employers and workers.

The Breed Promotion Grant Program, offered by the American Morgan Horse Association (AMHA), supports AMHA clubs and Morgan-related organizations in promoting the Morgan horse breed. Eligible entities can request funding for various promotional activities. In 2021, AMHA awarded nine grants across the U.S. and Australia, demonstrating their commitment to breed promotion. This grant aims to enhance the visibility and appreciation of Morgans within the equestrian community.

The FY26 Spinal Cord Injury Research Program (SCIRP) Investigator-Initiated Research Award (IIRA) supports innovative research aimed at enhancing patient care and quality of life for individuals with spinal cord injuries. This award encourages collaboration, allowing an Early-Career Partnership Option for two Principal Investigators, where one must be an early-career investigator. Focused on impactful research from basic to translational science, this opportunity is crucial for advancing SCI knowledge and interventions.

The Research Scholar Grants (RSG) by the American Cancer Society support independent researchers engaged in cancer-related studies. Eligible applicants must be affiliated with US academic institutions and have been appointed as independent faculty for less than ten years. Grants provide funding up to $215,000 annually for direct costs and allow for 10% indirect costs, with project durations of up to four years, fostering innovative cancer research across various priority areas.

Stark Community Foundation

Since 1963, Stark Community Foundation has been helping individuals, families, businesses and nonprofits like you support the causes you care about.

In addition to personalized donor services, we manage a competitive grantmaking program and award grants to address local needs. Today, the Foundation stewards over 1,000 charitable funds totaling $485 million in assets and has granted more than $300 million to nonprofits in our community and beyond.

Scholarships

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties.

The Louise Nader Khourey Memorial Scholarship Fund

The Louise Nader Khourey Memorial Scholarship Fund assists graduating high school seniors planning careers in foreign language education OR senior-level undergraduate or graduate foreign language students who have met the criteria for student teaching in a licensure program. 

This scholarship is renewable.

The Coors Light Líderes Grant Program honors exceptional Latino leaders across the U.S. and Puerto Rico, awarding five individuals with a $10,000 grant each for their nonprofit organizations. This initiative, active for 17 years, aims to empower emerging leaders who demonstrate significant community impact through innovative programs. Eligible nominees must be between 21-39 years old, associated with a 501(c)(3) nonprofit, and committed to fostering positive change in their communities.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

The Tim Moffatt Career Advancement Award

This scholarship will be awarded to deserving students who are graduating from a WCPS high school, or are a non-traditional learner with equivalent education, who have been accepted into a trade school/program/apprenticeship, or who have enlisted in the military. 

The Northern California DX Foundation Grant supports amateur radio projects that promote education and international goodwill. It provides financial assistance for well-designed DXpeditions to rare locations, especially those generating global interest. Grants are typically awarded to expeditions that align with the foundation's mission, ensuring participants have a financial stake in their initiatives. The foundation emphasizes thorough review of operator qualifications, equipment appropriateness, and operational plans before granting support.

Extreme Terrain’s Clean Trail Initiative Program aims to enhance trail integrity by supporting groups in the U.S. with grants for projects like trail clean-up, restoration, and expansion. Eligible applicants include Wrangler and 4x4 clubs, environmental organizations, and those managing public or private trails. The initiative emphasizes responsible off-roading while encouraging volunteers to engage in improving our natural landscapes. This program fosters community involvement and promotes sustainable practices in outdoor activities.

The James & Ursula Williams Teacher Grants Program : Field Trip Grants

As a born native of Vallejo, James was generationally admired for his enduring work ethic and was lovingly embraced for his dedication and support to family, friends, and community. Ursula’s self-motivation, persistence, and quest for excellence brought her professional recognition. As a community activist, she shared her leadership organizational skills as a member of community and political organizations who made positive contributions to the community.

In life, they created and took advantage of all opportunities presented to them. Both recognized the important role that education made in creating healthy, happy, and productive lives for themselves, their children, and their grandchildren. The Williams Family hopes to continue their legacy through The James & Ursula Williams Family Fund.

Field Trip Grants:

Grants of up to $1,000 are available to fund 1-day excursions; field trips should have an academic component that supplements your classroom curriculum. Funds can cover the cost of transportation, and admission fees. Examples: Vallejo Flood and Water District, the Exploratorium, etc. The purpose of this program is to bring learning outside of the classroom and provide hands-on experiences to students.

The Nicholas R. Rizzi Foundation Grant aims to assist individuals in financial need who seek to further their education through accredited programs. Established in 2005 to honor Nicholas R. Rizzi, the foundation has awarded over $38,000 in scholarships and grants. Each year, eligible applicants can receive up to $1,000 for tuition and related expenses based on financial need, academic performance, and recommendations. The foundation prioritizes direct payments to educational institutions.

Deputy Patrick Mayfield Scholarship

This scholarship is awarded to a North Georgia First Responder, their child or spouse who are pursuing their post-secondary education. For this scholarship, a first responder is defined as Police (including local and state), Fire, EMS workers, and Communications officers. In 2026, one scholarship award of $500 will be offered.

Vitamin Angels offers grants to US-based organizations dedicated to improving nutrition for pregnant women, infants, and young children. By providing prenatal multivitamins and technical support, the initiative aims to reach underserved communities facing nutritional barriers. Eligible organizations must serve at least 500 children or 100 pregnant women annually and distribute the vitamins without financial support from Vitamin Angels. This collaborative effort enhances health outcomes for vulnerable populations across the nation.

The American Speech Language Hearing Foundation offers Clinical Research Grants aimed at fostering independent research studies that enhance treatment efficacy for communication disorders. These grants support early-career investigators and experienced researchers embarking on new projects. Proposals must demonstrate potential for significant impact, and funding of up to $75,000 over two years is available. This initiative seeks innovative solutions to improve the lives of individuals with communication challenges.

Spencer Educational Foundation Inc

The Spencer Educational Foundation was founded by the Rims Atlanta Chapter in 1979. To this day, Spencer remains the premier organization funding the education of tomorrow's risk management and insurance leaders.

The Spencer Educational Foundation: awards merit-based scholarships and grants to university students pursuing careers in risk management, insurance, and/or actuarial science; provides grants that create experiential learning opportunities both on and off campus; funds the development of risk management and insurance curricula in colleges and universities; supports Risk Managers by creating internship opportunities within the risk management function of their companies; and operates across the United States and Canada. 

Spencer Educational Foundation: Internship Grants

Through our Internship Grant Program, Spencer aims to support tomorrow’s Risk Management and Insurance leaders through experiential learning opportunities. 

Spencer provides internship grants of up to $7,500 to Risk Managers to hire interns in the risk management function of their organizations. Employers apply for grants from Spencer, and students then apply directly with the companies for internship opportunities.

Since 1999, Spencer has awarded $3.5 million to create over 650 risk management internships. Through the internship program, students learn about the field in a real-world business setting where they can quickly apply what they know, respond to new experiences, and begin to develop contacts in the industry. 

The ARS Resident Research Grant aims to foster innovative research in rhinology, supporting residents engaged in basic, translational, or clinical projects. Applicants must collaborate with a preceptor and obtain departmental approval. Eligible residents in U.S. or Canadian programs can apply, ensuring that their projects align with the standards of the American Rhinologic Society. This grant does not cover salary for the Principal Investigator but allows funding for assistants.

This funding opportunity aims to enhance the global response to rabies through innovative, cost-effective tools. The initiative focuses on reducing human rabies cases and advancing canine rabies elimination, particularly in high-burden regions. Research areas include tracking vaccination efforts, managing rabies exposure investigations, improving laboratory systems, and assessing the economic impact of interventions. Ultimately, it seeks to develop strategies that protect public health and ensure the sustainability of rabies-free status in the U.S.

The DoW Spinal Cord Injury Translational Research Award supports innovative research to transform promising spinal cord injury findings into clinical applications. It features an Early-Career Partnership Option, requiring at least one early-career principal investigator. Collaborations with SCI community partners are essential for providing guidance throughout the project. This funding opportunity aims to enhance the effectiveness of spinal cord injury interventions and improve patient outcomes.

The Clinical Research Grant: Collaborative Research Studies, offered by the American Speech Language Hearing Foundation, supports mid-career investigators in conducting innovative research on treatment efficacy in communication disorders. Emphasizing interdisciplinary collaboration, this grant encourages studies that yield pilot data for larger projects, with a budget cap of $50,000. Eligible applicants must hold a PhD in relevant fields and show commitment to independent research, avoiding overlap with other ASHFoundation grants.

Scholarships and Awards

The National Federation of the Blind offers several scholarships and awards that honor blind individuals as well as teachers, professionals, entrepreneurs, and organizations whose work benefits the blind community.

Dr. Jacob Bolotin Awards

The Dr. Jacob Bolotin Awards honor individuals and organizations that are a positive force in the lives of blind people.

Applicants for the Dr. Jacob Bolotin Awards must demonstrate exemplary leadership and extraordinary accomplishments in improving the lives of blind people in the United States.

An application for an award can be made either by the applicant directly or by third parties who nominate an applicant.

Each application requires an essay describing the work or project to be recognized. In addition, applications must have at least one letter of recommendation in support of the nominee.

The National Federation of the Blind determines the total amount available for the Dr. Jacob Bolotin Awards each year based on the trust income received. The number of awards and the amount of each award will be determined by the NFB’s Dr. Jacob Bolotin Award Committee based on its evaluation of eligible and deserving applicants.

Each year, to the extent feasible as determined by the committee’s evaluation of applications received, one or more awards will be made to applicants in each category: blind individuals, sighted individuals, and corporate or organizational entities. However, the committee is not bound to make an award in each category during each competition year and may not do so if an application meeting the selection criteria is not available.

Sponsored by the Alfred & Rosalind Perlman Trust. Presented by the National Federation of the Blind.

The New Century Scholars Doctoral Scholarship, offered by the American Speech-Language-Hearing Foundation, supports doctoral students who aspire to a teacher-investigator career in communication sciences and disorders in the U.S. Eligible candidates must be enrolled in a research doctoral program and show commitment to higher education. The foundation will award up to 15 scholarships of $10,000 each for the current cycle, fostering the next generation of educators and researchers in this vital field.

The Graduate Student Scholarship: International Student Scholarship supports non-U.S. citizens pursuing graduate studies in communication sciences and disorders in the U.S. Funded by the Kala Singh Memorial Fund, it awards up to three scholarships of $5,000 each. Eligible applicants must be accepted or enrolled in accredited programs and maintain full-time status. The scholarship aims to assist with educational expenses, ensuring that academic achievement and diversity are promoted within the field.