Best Large Grants for Nonprofit Organizations in South Carolina

The Vince Lombardi Cancer Foundation (VLCF) has played a pivotal role in cancer research and education since its inception in 1971, raising over $21 million to support innovative treatments and compassionate care. This private foundation invites applications from recognized healthcare institutions, focusing on funding scientific and medical fellowships. VLCF is dedicated to preventing cancer and improving patient care, ensuring that the spirit of excellence continues in the fight against this disease.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

John & Jackie Watkins Scholarship

This scholarship recognizes the long history of Marion County as an agricultural area and the importance of farming in our community. John and Jackie Watkins both grew up in Delaware County and attended Radnor schools. They knew the value of education and its lifelong benefits.

Following Jackie’s passing in 1998, the family established the John & Jackie Watkins Scholarship Fund in her memory to assist the youth of Marion County to attend college—specifically to study agriculture. The Watkins Fund makes awards to graduating seniors from any high school in Marion County who are pursuing an education in agriculture, with special consideration given to those who have participated in FFA.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Whirlpool Corporation One Power STEM Scholarship

Whirlpool Corporation, in conjunction with One Energy LLC, created a scholarship fund at Marion Community Foundation in 2017 to support education in science, technology, engineering, and math (STEM). For each wind turbine installed as part of a Wind for Industry® project, Whirlpool/One Energy scholarship partners are giving back to the community with scholarships. These scholarships will impact Marion County high school seniors and graduates pursuing studies in STEM fields.

Annually, this scholarship fund awards one $5,000 scholarship to a student attending any eligible educational institution. An additional $10,000 in scholarships is available to students attending The Ohio State University at Marion, Marion Technical College, or other eligible educational institutions.

The Libraries Transforming Communities: Accessible Small and Rural Libraries' Grant, initiated by the American Library Association (ALA), aims to enhance accessibility and community engagement in small and rural libraries serving people with disabilities. With funding up to $20,000, selected libraries will receive support for projects that improve library services and facilities. This initiative promotes collaboration with community members to identify and address accessibility needs, ensuring libraries effectively serve diverse populations.

The Cottrell Scholar Award supports early career faculty at U.S. and Canadian research universities, fostering innovative research and teaching in Chemistry, Physics, and Astronomy. This prestigious recognition emphasizes the importance of impactful research plans and educational strategies, aiming to enhance undergraduate and graduate science education. The award also encourages academic citizenship and collaboration within institutions, providing funding for three-year projects up to $120,000, thereby promoting excellence in both research and education.

The FY26 Spinal Cord Injury Research Program Clinical Trial Award supports innovative clinical trials aimed at significantly improving spinal cord injury treatment. This funding opportunity encourages collaboration by allowing two Principal Investigators, including an early-career investigator, to drive the research forward. Applicants must partner with at least two SCI community members, ensuring that the project is informed by lived experiences and community needs throughout its development and implementation.

The FY26 Spinal Cord Injury Research Program (SCIRP) Investigator-Initiated Research Award (IIRA) supports innovative research aimed at enhancing patient care and quality of life for individuals with spinal cord injuries. This award encourages collaboration, allowing an Early-Career Partnership Option for two Principal Investigators, where one must be an early-career investigator. Focused on impactful research from basic to translational science, this opportunity is crucial for advancing SCI knowledge and interventions.

This funding opportunity supports exceptionally promising Early Stage Investigators in genomics, encouraging innovative research across various fields such as genomic sciences and medicine. Applicants must submit their proposals by 5:00 PM local time of their organization. The initiative, led by the US Dept. of Health & Human Services through the NIH, aims to foster long-term career development in genomic research while addressing its ethical, legal, and social implications.

Community Foundation of Central Wisconsin

The Community Foundation of Central Wisconsin gives everyone the opportunity to make significant and lasting gifts to their community. We manage over 320 funds that enhance Portage and Waushara counties. Together with our generous donors, we create a strong culture of philanthropy in Central Wisconsin.

We are a tax-exempt, 501(c)(3) public charity founded in 1982 to provide scholarships and grants to organizations and projects that improve the quality of life in Portage and Waushara counties.

Scholarships

The Community Foundation proudly supports students in Portage and Waushara counties with over $325,000 in scholarships annually, thanks to the generosity of local individuals and families. Award amounts range from $500 to $40,000, opening doors to educational opportunities.

Whether you're a student seeking financial support or a donor looking to grow a scholarship fund, we invite you to explore available opportunities and learn how you can be involved.

Don & Mary Hamerski Memorial Scholarship Fund

Qualifications: Graduating High School seniors from a Central Wisconsin high school.

The Outdoor Recreation Legacy Partnership Program (ORLP) is a competitive grant initiative by the National Park Service, aimed at enhancing parks and recreational opportunities in urban, underserved communities. This program supports the acquisition, development, and renovation of outdoor recreation areas through federal funding, addressing the needs of community organizations, local governments, and recognized tribes. Applications are accepted twice a year, before June 1 and November 1.

The FY26 Peer Reviewed Cancer Research Program's Idea Award promotes innovative, high-risk cancer research initiatives. It supports groundbreaking concepts that advance cancer knowledge, patient care, and treatment options within the Military Health System. Projects must demonstrate creativity and innovation, avoiding incremental advancements. Notably, the Early Career Investigator Option is available to foster the growth of promising new investigators early in their careers. This award aims to make significant contributions to cancer research for Service Members and Veterans.

The DoW Peer Reviewed Cancer Clinical Trial Award supports the rapid initiation of clinical trials aimed at significantly improving cancer treatment. Projects may range from small pilot studies to large-scale phase III trials, focusing on innovative products, drugs, or devices. This award mandates the inclusion of patient advocates and prohibits animal studies, ensuring that all preclinical work is completed prior to the award start date. Regulatory applications must be submitted if required for the proposed trials.

The FY26 Peer Reviewed Cancer Research Program Impact Award promotes significant research aimed at enhancing clinical cancer care. It requires preliminary data to ensure feasibility and emphasizes projects with a strong potential for immediate impact. This funding supports clinical trials and allows for either a single Principal Investigator or a duo of partnering PIs, ensuring that both can contribute distinct aspects of the research. Applications must be carefully coordinated to avoid withdrawal risks.

The FY26 Traumatic Brain Injury and Psychological Health Research Program's Clinical Trial Award aims to fund impactful clinical trials that address psychological health issues and traumatic brain injury (TBI). This award supports a variety of interventions, requires preliminary data, and mandates community-based participatory research approaches. It offers two research levels: one for pilot studies and early trials, and another for larger, advanced trials assessing effectiveness in relevant populations.

The FY26 Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP) aims to support impactful health services research that connects research, practice, and policy. It emphasizes building real-world evidence for interventions and clinical guidelines tailored to specific populations. Key features include requirements for clinical trials, preliminary data, and community-based participatory research approaches. The program also offers an Early-Career Investigator Partnering Option to foster collaboration between seasoned and emerging researchers.

The NCI Research Specialist Award (R50) supports clinician scientists involved in NCI-funded clinical trials. This funding opportunity encourages the development of stable research careers by providing salary support and autonomy, allowing clinician scientists to contribute to national clinical trial development and implementation. They play a critical role in sustaining the NCI clinical trials network without serving as principal investigators. This award aims to ensure continuity in cancer research careers.

The NCI Research Specialist Award (R50) supports non-tenure track scientists in cancer research who provide essential contributions within laboratories and core facilities. This award aims to enhance research careers for skilled scientists who do not seek independent investigator funding. Eligible candidates must possess an advanced degree, have at least two years of contribution to NCI-funded research, and dedicate a significant portion of their time to this work. The R50 offers salary support and travel funds to recognize and stabilize these vital roles in cancer research.

The DoW Traumatic Brain Injury and Psychological Health Translational Research Award aims to transform scientific discoveries into clinical applications. This program encourages innovative research approaches and requires preliminary data. It prohibits basic research and clinical trials, emphasizing the need for relevant animal models or community-based participatory research for human subjects. Funding supports two research levels, refining ideas into tangible products or evaluating them for clinical trials, with options for early-career investigator partnerships.

The Mentored Clinical Scientist Research Career Development Award (K08) supports individuals with clinical doctoral degrees to develop their research careers in biomedical and behavioral fields. This program emphasizes a structured mentoring approach, aiming to address the nation's health-related research needs. Key application deadlines include June 12, 2024, and October 12, 2024, among others, providing opportunities for both new and renewal submissions.

The NIH Blueprint Initiative aims to enhance neuroscience research by funding the development and application of germline and somatic gene-editing techniques. This initiative builds on existing marmoset gene-editing frameworks and integrates New Approach Methodologies (NAMs) to improve understanding of human brain function and disease. High-priority areas include complex conditions like autism and schizophrenia. The initiative emphasizes the use of appropriate models to address critical questions in neuroanatomy, cognition, and behavior related to human brain health.

The ACS Professor Award, presented by the American Cancer Society, recognizes full professors who have significantly advanced cancer research. This honorific award aims to support innovative pursuits in cancer research with a budget of up to $80,000 per year for five years. Applicants are expected to demonstrate impactful contributions and leadership in the field, along with a commitment to mentorship and community engagement. The award highlights the importance of ongoing advocacy and research in improving cancer treatment and prevention.

The Research Scholar Grants (RSG) by the American Cancer Society support independent researchers engaged in cancer-related studies. Eligible applicants must be affiliated with US academic institutions and have been appointed as independent faculty for less than ten years. Grants provide funding up to $215,000 annually for direct costs and allow for 10% indirect costs, with project durations of up to four years, fostering innovative cancer research across various priority areas.

Maryetta’s Mission Scholarship

Established by Maryetta's Mission at the First Church of God of Eldred, PA, this scholarship is awarded to students who are entering or currently in a post-secondary program for Christian-based ministerial studies including majors or fields of study such as theology, music liturgy, youth development, Christian administration, etc.

The Ella T. Grasso Literary Scholarship, provided by the UNICO Foundation, offers two $1,000 awards to college students of Italian descent. Candidates must submit an original essay or short story celebrating their heritage while being enrolled in a full-time, accredited U.S. college for the 2026-2027 academic year. This initiative highlights UNICO's commitment to supporting educational endeavors and preserving Italian culture within America.

The Dermatology Foundation offers a Research Grant of $25,000 annually to support innovative projects in dermatology and cutaneous biology. This funding is aimed at junior investigators in the early stages of their academic careers who demonstrate a strong commitment to skin research. Eligible applicants must conduct research within ACGME-approved departments in the U.S. and must not have received funding from other sources for the same project.

The Darlene Hooley Scholarship for Oregon Veterans supports military veterans who served in the post-9/11 conflict, prioritizing those in the Oregon National Guard and Reservists. This scholarship is designed for students enrolling in higher education institutions across the United States, providing financial assistance to those who have bravely served their country.

The UHCCF Medical Grant provides financial assistance to families with children under 16 years old who need access to medical services not fully covered by insurance. The grant offers up to $5,000 per year, with a lifetime maximum of $10,000. Families can apply regardless of their insurance provider, and the grant covers a wide range of medical expenses, ensuring children receive essential health care. Applicants must meet specific income and eligibility criteria to qualify for funding.