Best Large Grants for Nonprofit Organizations in South Carolina

The Community Foundation of Carroll County supports nearly 70 academic, sports, special circumstances, and 4-H scholarships. Search scholarships by name, or sort by application type.

Rita M Medeiros (Rita's Closet) Scholarship

The purpose of the Rita's Closet Scholarship is to honor the memory of Rita Marie Medeiros by providing scholarship (s) for graduating seniors at any public High School in Carroll County, Maryland, and the Carroll County Career and Technology Center. Because Rita was a very caring friend and spent much of her short life, giving others her time, her friendship and ultimately her organ donor gift, the Rita's Closet Scholarship will be awarded to a graduating student (s) pursuing an undergraduate degree at an accredited college, university or technical school who meets the criteria established for the fund.

The Edna Mae Scholarship, offered by the Community Foundation of Southern New Mexico, aims to support women from rural communities in their pursuit of higher education at vocational community colleges or universities. This scholarship is open to applicants actively enrolled in any form of higher education, including undergraduate and vocational programs, with a special focus on assisting those in need. Applicants must be graduating high school seniors or currently enrolled students.

The Aaaron Ardoin Foundation offers Research and Education Grants aimed at supporting organizations that address the needs of individuals and families affected by sickle cell disease. With a focus on funding programs that advance awareness, treatment, and care, the foundation reviews grant requests biannually. Eligible applicants must be 501(c)(3) organizations dedicated to initiatives directly benefiting the sickle cell community, ensuring that funds are utilized efficiently and effectively.

The Wish You Well Foundation Grant supports U.S. non-profit organizations focused on adult literacy. Grants typically range from $200 to $10,000 and require proof of 501(c)(3) status. The foundation prioritizes programs that foster adult and family literacy. Organizations are encouraged to apply for funding that aligns with their specific needs. The Foundation communicates via email regarding proposal receipt and funding decisions, ensuring timely updates to applicants.

The National Endowment for Financial Education Grant supports innovative research aimed at enhancing the public's financial well-being. This grant prioritizes studies that address financial literacy, systemic inequality, and the effectiveness of financial education among U.S. youth. Eligible applicants include researchers from nonprofit organizations or educational institutions. The funding process involves multiple phases, including evaluations and proposals, ensuring that impactful projects receive necessary support. NEFE aims to foster rigorous research that contributes significantly to financial education.

The Cognitive Neuroscience (CogNeuro) Program by the National Science Foundation aims to fund proposals that deepen our understanding of the neural mechanisms of cognition and behavior. Successful applications will connect physiology, cognition, and behavior while also promoting outreach and mentoring within the field. Research topics include action, perception, memory, and decision-making. The program encourages broader impacts such as STEM outreach and public engagement in research, with a focus on diverse communities.

Gray for Glioblastoma Society

A 501 (c) 3 created to raise awareness for and funds to support Glioblastoma Multiforme research by accepting donations and donating to cancer care and research facilities. Our organization has gifted over $275,000 to support GBM research projects at renowned cancer centers including The Ty Miller Lab at Case Western Reserve University, Dana Farber Cancer Institute, Children’s Hospital LA/Saban Research Institute and The Preston Robert Tisch Brain Tumor Center at Duke. We accomplish this while simultaneously creating a hopeful and positive space and providing resources and a space of community through our social media and events.

Gray for Glioblastoma Grant

Gray for Glioblastoma Society (GFG) is dedicated to funding projects that advance glioblastoma (GBM) research and move the needle forward in care and quality of life. We invite proposals that align with our mission and demonstrate meaningful impact in the GBM space.

The Beckman Scholars Program offers a 15-month mentored research experience for outstanding undergraduate students in chemistry and biological sciences. Each participating institution can submit one application, with awards totaling $21,000 per student and $5,000 per mentor. The program emphasizes justice, equity, diversity, and inclusion, welcoming applicants from diverse backgrounds. For more details, refer to the FAQs on the Arnold and Mabel Beckman Foundation's website.

Betsy L. Bertoli Scholarship

Academic Focus:

• Accounting or business administration/management

Award Average:

• $250

For Torrington High School graduating seniors who plan to pursue a career in accounting or business administration/management at the university level and have had at least one successful high school semester of accounting.

The DoW Spinal Cord Injury Translational Research Award supports innovative research to transform promising spinal cord injury findings into clinical applications. It features an Early-Career Partnership Option, requiring at least one early-career principal investigator. Collaborations with SCI community partners are essential for providing guidance throughout the project. This funding opportunity aims to enhance the effectiveness of spinal cord injury interventions and improve patient outcomes.

The Crossroads Hospice Charitable Foundation is committed to enhancing community awareness of hospice and palliative care services. It supports nonprofit organizations that provide end-of-life care and grief recovery resources. Through educational initiatives and financial grants, the Foundation aims to promote excellent hospice care and assist caregivers. Organizations eligible for funding must be 501(c)(3) nonprofits, and the Foundation does not fund administrative costs or general funding. Grant applications are accepted once per year.

Community Foundation of Carroll County

The Community Foundation of Carroll County, Inc. was established in 1994 to ensure financial support for Carroll County not-for-profit organizations. It is governed by a Board of Directors and is a 501c(3) public charity. The Community Foundation of Carroll County is trusted partner for donors and nonprofits. We provide one central place where anyone can create a charitable fund, support what matters most, and leave a legacy of lasting impact.

Scholarships

The Community Foundation of Carroll County supports more than 75 scholarships. These scholarships vary in the amounts they award and cover a wide variety of student interests. Qualifiers range from academic achievements, sports played, and community service performed, to 4-H and FFA involvement. While the majority are for graduating Carroll County high school seniors, there are several for students in college or technical school, and even opportunities for students attending private primary school. 

Bee a Rae of Sunshine Foundation 4-H Scholarship

A 4-H scholarship from the Bee A Rae of Sunshine Foundation for a graduating high school senior or continuing college student who is active in 4-H in Carroll County, MD. College major must be in the agricultural sciences or other ag-related field. 2.0 GPA or higher required. A 500 word essay on the importance of ag programs in the community is also required. This scholarship is on the 4-H portal.

Community Foundation of Carroll County

The Community Foundation of Carroll County, Inc. was established in 1994 to ensure financial support for Carroll County not-for-profit organizations. It is governed by a Board of Directors and is a 501c(3) public charity. The Community Foundation of Carroll County is trusted partner for donors and nonprofits. We provide one central place where anyone can create a charitable fund, support what matters most, and leave a legacy of lasting impact.

Scholarships

The Community Foundation of Carroll County supports more than 75 scholarships. These scholarships vary in the amounts they award and cover a wide variety of student interests. Qualifiers range from academic achievements, sports played, and community service performed, to 4-H and FFA involvement. While the majority are for graduating Carroll County high school seniors, there are several for students in college or technical school, and even opportunities for students attending private primary school. 

4-H Brenda Barber 4-H Family Memorial Scholarship

The purpose of The Brenda Barber Family Memorial Scholarship is to honor the life and family of Brenda Barber by providing scholarship(s) for graduating high school seniors and continuing students who are members of Carroll County 4-H Clubs. 

Applicants must be starting college in the fall OR current college student at any community college, trade school or four-year institution. The scholarship check will be written out and mailed directly to said college or trade school. 

CSA Creative Work Honor

The CSA Creative Work Honor recognizes excellence in dress in its many forms, with emphasis on creative works and the making of dress objects. It pays attention to originality of concept, strength of research and concept development, inspiration and purpose, diversity, equity, inclusion and accessibility, as well as communication about craftsmanship and the process of making. The honor is given every year to (1) one entry accepted and shown at the annual Symposium’s Exhibition of Creative Work. This entry may be the result of individual work or a collaborative endeavor. It is open to all CSA members, including career professionals, seasoned members, and young and emerging scholars who produce creative works related to dress and fashion.

All types of creative work submissions may be considered including (but not limited to): theatrical costume design, reenactment garb, reproduction, cosplay, and dress and/or conceptual design, etc. The submitters of creative works abstracts that score in the top (5) five will be eligible for this honor. The honoree will be announced at the symposium after the committee has reviewed the abstract and the creative work presented at the symposium. The recipient will receive a certificate and be recognized at the symposium. 

Rooted + Relational Community Micro-Grant Program

The Center for Puerto Rican Studies (CENTRO) at Hunter College has announced that it is now accepting applications for the 2026-2027 Rooted + Relational Community Micro-Grant program. CENTRO will award up to 12 grants, each up to $5,000, to non-institutionally affiliated and non-academic community organizations, individuals, or projects for community-based programs. 

The 2026-2027 the Rooted + Relational theme is Black Cuerpas: Race, Body Politics & Culture. CENTRO seeks to fund projects that examine

• How do race, gender, sexuality, and body politics shape the everyday lives and histories of Boricuas across the archipelago and diaspora? 
• What happens when we center race and Blackness in a field of study that has too often championed color-blindness and the myth of racial democracy to avoid the hard questions about racism, anti-Blackness, complicity, and erasure?

During the 2026-2027 academic year, grantees will implement their funded projects within their chosen communities. They will also present their work at a CENTRO event, attend three virtual meetings, and have their work highlighted through CENTRO’s communications and media channels. We invite community organizers, artists, creatives, writers, agricultural workers, activists, and cultural workers who reside in Puerto Rico and/or the United States and its territories to apply. 

The FY26 Spinal Cord Injury Research Program Clinical Translation Research Award funds innovative clinical research aimed at bridging the gap to larger clinical trials. It focuses on accelerating the application of new techniques and improving patient outcomes through effective diagnosis and rehabilitation strategies. Key features include an Early-Career Partnership Option for principal investigators and a requirement for community partner involvement, ensuring collaborative research that meets real-world needs.

The FY26 Spinal Cord Injury Research Program Clinical Trial Award supports innovative clinical trials aimed at significantly improving spinal cord injury treatment. This funding opportunity encourages collaboration by allowing two Principal Investigators, including an early-career investigator, to drive the research forward. Applicants must partner with at least two SCI community members, ensuring that the project is informed by lived experiences and community needs throughout its development and implementation.

The FY26 Spinal Cord Injury Research Program (SCIRP) Investigator-Initiated Research Award (IIRA) supports innovative research aimed at enhancing patient care and quality of life for individuals with spinal cord injuries. This award encourages collaboration, allowing an Early-Career Partnership Option for two Principal Investigators, where one must be an early-career investigator. Focused on impactful research from basic to translational science, this opportunity is crucial for advancing SCI knowledge and interventions.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Everett J. Liebetreu Education Scholarship

This scholarship has been made possible by the generosity of Everett J. Liebetreu, who established the Everett J. Liebetreu Scholarship of the Community Foundation for Mason County.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Alberta Muzzin Chamber Alliance of Mason County Scholarship

This scholarship has been made possible by the generosity of the Ludington & Scottville Chamber of Commerce, which established the Alberta Muzzin Chamber of Commerce Scholarship Fund of the Community Foundation for Mason County.

Every Battle Creek area resident shall have the resources to access post-secondary education and training.

Your dreams matter — and we want to help you achieve them. Whether you’re a graduating high school senior, an adult returning to school, or a graduate student pursuing advanced education, we’re here to support you by opening doors to opportunity.

Beyond tuition, many funds support total cost of attendance — books, fees, equipment, and in some cases childcare or transportation.

Checks are made payable to the educational institution indicated on the follow-up and mailed directly to the educational institution. Checks are typically mailed in early August.

Larry Inman Skilled Trades Scholarship Fund

The Larry Inman Skilled Trades Scholarship Fund has been established to provide scholarships to Harper Creek Community Schools graduating seniors pursing degrees and future employment in the skilled trades. Larry Inman was a Harper Creek High School, class of 1967 graduate. He excelled in many sports, but was an exceptional baseball player. After high school Larry attended Kellogg Community College pursuing a career in Graphic Arts before serving in the United States Army during the Vietnam Conflict. Larry fought for his country and was awarded many medals including the Bronze Star. He returned to Battle Creek and retired from the Kellogg Company after 35 years of dedicated employment. Larry was a very kind and generous person who cared about the education of local youth.

The Sheep Production and Marketing Grant Program (SPMGP) for FY 2026 aims to bolster the sheep industry in the U.S. by enhancing production and marketing initiatives. It supports innovative projects that address long-term challenges and improve infrastructure, business practices, and resource development. The program fosters collaboration among industry organizations to maximize benefits for sheep producers while minimizing duplicated efforts, ultimately strengthening the economic viability of the sector.

The AGA Fellowship-to-Faculty Transition Award offers $65,000 per year for two years, totaling $130,000, to clinical and postdoctoral fellows. This funding is intended to support their transition to independent research careers focused on inflammatory bowel disease in gastroenterology. Applicants must hold an MD or equivalent, be in a fellowship position in North America, and demonstrate a commitment to clinical or translational research. AGA membership is required, and applicants should have a mentor who is also an AGA member.

The Philanthropic Impact Fund (PIF) by Vanguard Charitable aims to strengthen nonprofit organizations and philanthropic infrastructure. It focuses on integrating AI, educating donors, and enhancing the narrative around the nonprofit sector. Grants typically range from $50,000 to $100,000, with larger requests considered. Organizations must be 501(c)(3) registered nonprofits to apply. This funding is a strategic investment in resilience and sustainability, addressing critical needs in the sector.

The AANA Research Grants support clinical and basic science research in arthroscopic surgery, with a funding pool for 2024 reaching $350,000. One project may receive $50,000, while six others can be awarded $25,000 each. Applications are evaluated based on scientific validity, feasibility, clinical relevance, and completion ability. Special consideration is given to innovative surgical techniques and patient-reported outcomes. Travel expenses for study participants may also be considered during grant reviews.

The Pompe Disease Fund, supported by the Patient Advocate Foundation, offers vital financial assistance to individuals diagnosed with Pompe disease. This fund covers out-of-pocket healthcare costs including medication copays and health insurance premiums. Eligible patients must have a confirmed diagnosis and be receiving treatment or planning to start within 60 days. With over 3.8 million patients helped since its inception, the fund aims to alleviate financial burdens and enhance access to necessary treatments.

The Fiscal Year 2027 Department of War Defense University Research Instrumentation Program (DURIP) aims to enhance the capabilities of U.S. higher education institutions by providing funding for essential research equipment. This initiative supports the education of scientists and engineers in fields critical to national defense. However, for-profit organizations are not eligible for participation, ensuring that funds are directed towards accredited educational institutions.