Best Large Grants for Nonprofit Organizations in South Carolina

Amazon Web Services

Amazon Web Services (AWS) is a cloud computing service that offers servers and data centers to organizations worldwide. AWS is a part of Amazon dedicated to delivering web services to developers and businesses who build online applications.

AWS support offers a range of plans that provide access to tools and expertise to aid the success and operational health of your AWS solutions. All support plans provide 24/7 access to customer service, AWS documentation, white papers, and support forums. For technical support and more resources to plan, deploy, and improve your AWS environment, you can select a support plan that best aligns with your needs.

AWS Nonprofit Credit Program

The AWS Nonprofit Credit Program provides access to up to $5,000 USD in AWS Promotional Credit, helping to offset costs for nonprofits associated with implementing cloud-based solutions. This helps nonprofits meet mission goals without upfront investment in physical infrastructure.

Your organization needs reliability and efficiency to run applications that support your website and operations. AWS infrastructure for websites, fundraising, database management, and more provide rapid access to flexible and low-cost IT resources.

Reduce IT costs

• AWS gives you the flexibility to scale and save on IT costs by not having to invest in physical infrastructure. Use only the resources you need when you need them.

Increase giving

• AWS offers advanced, cost-effective services that let you simply process, analyze, and visualize data so you can make well-informed targeting and fundraising decisions.

Scale globally

• AWS lets you widen your global reach and deploy solutions where they are needed. Equip volunteers and staff with the tools, resources, and access they need without long-term licensing agreements.

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Kile, David O. & Marjorie B. Kile Scholarship

This scholarship is available to any Noble County resident who is at least 19 years of age with a high school diploma, or GED, in pursuit of higher education in a field of their choice. This scholarship is available to applicants planning to attend, or are currently enrolled, either full-time or part-time, in an accredited vocational school, or two-year or four-year college or university. The award is given one time, with no restriction on applying in subsequent years, for educational purposes only.

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Schermerhorn, John and Mary Memorial Scholarship Fund

For a high school senior who is a Noble County resident who will graduate from Central Noble High School or East Noble High School or West Noble High School and is pursuing a career in an agriculture-related field. One-time payment of $500. 

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Slater, Jonah W. Memorial Scholarship Fund

For a resident of Noble County who is pursuing any sort of post-secondary education. Pays $500 one time for the fall.

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Sneary, M.D. Max Memorial Scholarship Fund

Awards $2,500 one-time for a high school senior from Noble County to pursue a career in the medical field, with preference given to East Noble applicants.

Rochester Area Community Foundation

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission: We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Victor and Janet Salitan BOCES 2 Scholarship

Purpose of Scholarship

To provide scholarship assistance for BOCES 2 Career and Technical Education students planning to pursue post-secondary education.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

Renewability

This scholarship is a one-time award and is not renewable.

Donor Information

This scholarship was established in 1979 to honor Victor Salitan. Victor served for 30 years as a school district attorney for several school districts and specifically for the Monroe 2-Orleans BOCES.

United Negro College Fund

“A mind is a terrible thing to waste.”®

For more than seven decades, this principle has remained at the heart of UNCF, enabling us to raise more than $5 billion and help more than 500,000 students and counting not just attend college, but thrive, graduate and become leaders.

We do this in three ways: By awarding more than 12,000 students scholarships, worth more than $65 million, each year. By providing financial support to 37 historically Black colleges and universities (HBCUs). And by serving as the nation’s leading advocate for the importance of minority education and community engagement.

MetLife Foundation Legacy Endowed Scholarship

The MetLife Foundation Legacy Endowed Scholarship Program was established by the MetLife Foundation to provide need-based scholarship support to college junior enrolled at US four-year HBCUs. Successful applicants must be currently pursuing a STEM, business, finance, or accounting degree, as a full-time student at a four-year HBCU.

Community Foundation of Monroe County

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Scholarship Opportunities

We award over 120 scholarships each year to Monroe County residents. Whether you’re heading to college, pursuing a technical career, or furthering your education as an adult, there’s a scholarship for you.

Charles and Virginia Whitten Scholarship

For Monroe County high school seniors pursuing skilled trades.

Community Foundation of Monroe County

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Scholarship Opportunities

We award over 120 scholarships each year to Monroe County residents. Whether you’re heading to college, pursuing a technical career, or furthering your education as an adult, there’s a scholarship for you.

Graceful Memories Memorial Endowed Scholarship

For Monroe County residents pursuing a career in medicine.

The NICHD Resource Program Grants in Bioinformatics aim to support the operation and enhancement of vital bioinformatics databases for research on animal models of embryonic development. These grants promote user training, data curation, and interoperability with NIH resources, ensuring wide dissemination of critical tools and resources to the research community. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the proposal deadline.

The World Childhood Foundation aims to eradicate child sexual abuse and exploitation through innovative programs. Organizations eligible for funding must be based in the U.S. and focus on child safety, supportive environments, and responses to abuse. The grant does not support emergency relief, orphanages, or established program costs. Interested applicants should start the process 1-2 months prior to the deadline to ensure they can fulfill the necessary requirements, including a site visit.

Harvey E. Anderson Scholarship

To be awarded to students who participate in Section V sports, have been diligent in academic and athletic endeavors, and exhibit self-motivation and extraordinary effort.

Number and Size of Awards

One award of $4,000 each to both a male and a female athlete; paid as $1,000 per year for up to four consecutive years of undergraduate study. Additionally, one non-renewable award of $1,000 to both a male and a female runner-up. Award paid in the Fall and divided equally between the Fall and Spring semesters.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

We award over 120 scholarships each year to Monroe County residents. Whether you’re heading to college, pursuing a technical career, or furthering your education as an adult, there’s a scholarship for you. 

Community Foundation of Monroe County Scholarship

For adult Monroe County residents pursuing skilled trades training.

The Skatepark Project Grants aim to support underserved communities in building public, free, concrete skateparks for youth. Eligible applicants include public charities and local agencies committed to designing inclusive spaces. The projects must engage local skaters in planning and fundraising, promote safety, and be open year-round without entry fees. The initiative fosters community involvement and addresses social inequalities, ensuring that all types of skatepark users can benefit from these vital recreational resources.

The Brooks and Joan Fortune Family Foundation Grant supports educational, artistic, and outreach initiatives. Applications are accepted year-round, with a focus on projects that yield specific outcomes rather than general operating expenses. While historically centered in Indiana and Florida, the foundation welcomes proposals from across the country. Eligible organizations must hold a 501(c)(3) designation. This grant is an excellent opportunity for nonprofits aiming to make a tangible impact in their communities.

The Russell Sage Foundation's Immigration and Immigrant Integration Grants aim to fund innovative research that explores the dynamics of race, citizenship, and legal status in relation to immigrant outcomes in the U.S. This initiative seeks to understand the complex interplay of policies and social factors affecting immigrants and native-born populations across various racial and ethnic groups. Researchers are encouraged to utilize diverse data sources to deepen insights into immigration integration and the societal implications of legal status.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Mildred Culbert Kelly & Fred W. Kelly Traditional Student Scholarship

Mildred Culbert Kelly and Fred W. Kelly never had children, but they were generous with contributions of time and talent to church and community groups that focused on youngsters.

Prior to his death in 1989, Mr. Kelly had been employed as an insurance agent and later purchased the Wheeler Insurance Agency which he owned and operated until his retirement in 1977. He was a founding member and past president of the Optimist Club and he assisted in establishing Big Brothers and Big Sisters of Saginaw and the READ Saginaw program.

Mrs. Kelly retired from the Accounting Department at Chevrolet Saginaw Grey Iron Foundry after 39 years of service. She volunteered at First United Methodist Church as director of the Children’s Choir, the Interpretive Choir and the Sacred Dance Group for many years. She was also a volunteer at READ Saginaw and Delta College Channel 19 and was a past president of the Opti-Mrs. Club. She died in 2000 at the age of 94.

Mildred Culbert Kelly and Fred W. Kelly’s legacy continues to assist youth with scholarships for students who might not otherwise obtain a college or Career and Technical Education (CTE) degree/certificate.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Omega Psi Phi – Jesse Johnson Scholarship

Applicant must be a child, stepchild, or grandchild of an Omega Psi Phi Fraternity member.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Washington County Arts Council, Inc. Foundation Scholarship Fund

The Washington County Arts Council, Inc. welcomes all applicants interested in pursuing a 2- or 4-year degree, or a certificate program, from an accredited educational institution with an emphasis on the arts. All students, including those individuals who have pursued a non-traditional education path, will be considered for this scholarship.

The purpose of America’s Healthy Food Financing Initiative (HFFI) is to improve access to healthy food in underserved areas, to support food supply chain resiliency, to create and preserve quality jobs, and torevitalize low-income communities by providing financial and technical assistance, either directly orthrough other partners and intermediaries, to eligible fresh, healthy food retailers and enterprises toovercome the higher costs and initial barriers to entry in underserved areas. HFFI offers fundingopportunities and technical assistance to eligible applicants.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

The Tim Moffatt Career Advancement Award

This scholarship will be awarded to deserving students who are graduating from a WCPS high school, or are a non-traditional learner with equivalent education, who have been accepted into a trade school/program/apprenticeship, or who have enlisted in the military. 

The Venturous Capital Grants aim to empower small and medium-sized not-for-profit theaters to produce bold and experimental new plays. Grants range from $5,000 to $35,000, covering extraordinary costs that enable productions to thrive. The program supports text-based, author-driven works that are ambitious, challenging, and innovative, while emphasizing the importance of playwright compensation and adhering to AEA standards. This initiative fosters creativity and helps overcome financial barriers in theater production.

The Coors Light Líderes Grant Program honors exceptional Latino leaders across the U.S. and Puerto Rico, awarding five individuals with a $10,000 grant each for their nonprofit organizations. This initiative, active for 17 years, aims to empower emerging leaders who demonstrate significant community impact through innovative programs. Eligible nominees must be between 21-39 years old, associated with a 501(c)(3) nonprofit, and committed to fostering positive change in their communities.

The Charles L. Brewer Distinguished Teaching of Psychology Award honors psychologists with outstanding teaching records. Awardees receive a plaque, a $2,000 monetary prize, and a $1,000 travel stipend, along with the opportunity to present at the APA Annual Convention. This prestigious award encourages nominations from diverse backgrounds, emphasizing achievements in teaching, curriculum development, and research in psychology education. Note that self-nominations are not permitted, and international applicants must meet specific eligibility criteria.

The Riding for Focus Grants program supports public middle schools serving low-income students, providing them with bicycles, helmets, and educational resources to promote cycling. Through this program, schools can enhance their students' cognitive, physical, and socio-emotional well-being. The curriculum consists of 14 lessons focused on rider safety and skills, designed to be delivered over 6-8 weeks. Eligible schools can apply for grants or purchase the program to access these invaluable resources.

The DoW Rare Cancers Concept Award for FY26 promotes groundbreaking ideas in rare cancer research. This award encourages innovative applications that explore novel courses of investigation without requiring preliminary data. Unique to this program is the prohibition against mentioning the Principal Investigator or collaborators in the proposal materials, ensuring an unbiased review process. This funding opportunity aims to advance scientific discovery in the rare cancer domain.

The NIDCR Dentist Scientist Career Transition Award (K22) supports dentists transitioning from NIH postdoctoral roles to tenure-track faculty positions. It provides two years of mentored research training in the NIH Intramural Research Program, followed by three years of independent research funding at an extramural institution. Key deadlines for grant applications include February 12, 2025, and subsequent dates in June and October 2025, with additional deadlines for renewal and AIDS-related applications.