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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,451 Results based on applied filters

Pierce's Disease & Glassy-winged Sharpshooter Board Research & Outreach Grants

California Department of Food & Agriculture
State/Local Government
United States
US $4,300 - US $383,000
The Pierce's Disease and Glassy-winged Sharpshooter Board offers grants to support research and outreach aimed at safeguarding California vineyards from serious pests and diseases. Prior funding has varied from $4,300 to $383,000, with projects typically lasting one to three years. Emphasis is placed on solutions that effectively address pest issues, encouraging multi-disciplinary teams to enhance the impact of their work on winegrape health.
Agricultural Pest Management Entomology Plant Pathology +1 more

Foam Recycling Coalition Grant Program

Foam Recycling Coalition
Association/Society
Canada, United States
Unspecified amount

About Foam Recycling

The process to recycle foam is like that of other recyclables. In the case of foam products, a special compactor – called a “densifier” – may be used in the processing of the material. Foam products are over 90% air, so densifying it allows the material to be transported more cost-effectively. To give you an example, a 48-foot truckload of baled foam polystyrene weighs only around 16,000 pounds, whereas a truckload of densified foam polystyrene weighs 40,000 pounds.

Innovative alternatives are being developed and deployed that are categorized as chemical recycling (vs. mechanical recycling). This will take the plastic resin back to its base state – in the case of foam PS, back to a styrene monomer. With chemical recycling, increased organic contamination will only impact the amount of foam for recovery (yield), but will not impact the recyclability of the plastic.

Foam Recycling Coalition Grant Program

Funding Source: Funding for the grant program comes from contributions from members of the Foam Recycling Coalition, a special interest group of the Foodservice Packaging Institute.

Grant Amounts: Funding amounts will be made on a case-by-case basis and will be dependent on equipment needs. The maximum amount per grant is $50,000.

Cash Match: No cash match is required, but additional costs by the grantee may be incurred for related items such as site preparation, provision of conveying system and electrical infrastructure, freight, and other installation costs.

Waste Management Recycling

Grants for Community Recycling Programs

The Recycling Partnership
Private
United States
Unspecified amount
The Recycling Partnership offers grants for community recycling programs, providing nearly $50 million to support 370 communities since 2014. Their mission is to create a robust and accessible recycling system that benefits people and the environment. Eligible applicants include publicly, privately, and non-profit owned MRFs in the U.S. This initiative aims to enhance curbside, drop-off, and multifamily recycling, ensuring that everyone can participate in sustainable practices.
Waste Management Recycling

Grants for Processors/Materials Recovery Facilities (MRF)

The Recycling Partnership
Private
United States
Unspecified amount

About Us

The Recycling Partnership is a team of experts, practitioners, and thought leaders who are deeply invested in protecting our natural resources, creating more sustainable communities, and delivering on our mission of building a better recycling system. We work alongside communities, companies, and policymakers to enact meaningful change across the entire recycling industry.

We firmly believe that if you want to recycle, you should be able to recycle. A robust and accessible recycling system is how we achieve this goal. A better system will deliver the true economic and environmental benefits that our people, our communities, and our entire recycling industry deserve.

This is our mission. This is our purpose. This is who we are. 

Grants for Processors/Materials Recovery Facilities (MRF)

Designed to help equipment manufacturers and MRFs boost throughput and increase capacity. 

Waste Management Recycling

Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation

Ducks Unlimited
Private
North America
Up to C $5,000
The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.
Ecology Ornithology Limnology +1 more

Improving Health Decision Making With Comparative Clinical Effectiveness Research: Retrospective Observational Studies Leveraging Existing Data Sources PCORI Funding- Cycle 1 2026

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $2,000,000
This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.
Cancer / Oncology Maternal And Perinatal Health Endocrine & Metabolic Diseases +2 more

The Zero Hunger | Zero Waste Foundation Grant

Kroger Co Zero Hunger Zero Waste Foundation
Corporate
United States
Unspecified amount
The Zero Hunger | Zero Waste Foundation Grant supports nonprofit organizations focused on ending hunger and reducing food waste. Since its inception, the foundation has allocated over $59 million to enhance food security through innovative programs and community engagement. Eligible applicants include 501(c)(3) nonprofits addressing critical needs such as food access, nutrition education, and support for vulnerable populations. This initiative aims to create equitable food systems and ensure that no one goes hungry.
Nutrition & Healthy Eating Food Access & Hunger Food Waste / Composting

Down Syndrome – Aim High Scholarship

The Community Foundation for the Greater Capital Region
Private
United States
Unspecified amount
The Down Syndrome – Aim High Scholarship, offered by The Community Foundation for the Greater Capital Region, empowers students pursuing careers in special education or therapy for individuals with Down Syndrome. This scholarship supports dedicated individuals committed to improving the lives of others through education and professional development. Since 1968, the foundation has focused on enhancing community well-being, making this scholarship a vital resource for aspiring professionals in the field.
Academic Scholarship Programs Education - Higher Education Disability Care & Services +5 more

Therapeutic Giving: Cardiovascular & Metabolism: National Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.
Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases Health Care Access & Delivery +3 more

Therapeutic Giving: Cardiovascular & Metabolism: Local & Regional Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.
Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases Health Disparities & Social Determinants of Health +3 more

Paul L. Busch Award

Water Research Foundation
Private
United States
Up to US $100,000
The Paul L. Busch Award, provided by the Water Research Foundation, honors individuals for innovative research in water quality. This prestigious award supports promising researchers with a $100,000 grant to advance their work. The selection process is inclusive, with no restrictions based on race, gender, or nationality, and encourages applications from diverse candidates. Recipients are expected to collaborate with U.S.-based organizations, fostering practical applications of their research in the water environment.
Sanitation & Clean Drinking Water Water Resource Management Freshwater Conservation

Confluence Program Grants

Conservation Alliance
Private
Canada, United States
US $140,000
The Confluence Grant Program, initiated by the Conservation Alliance in 2021, aims to strengthen partnerships with historically racially excluded groups. It awards four grants of $100,000 over two years to support projects that protect or restore natural places. The program emphasizes building meaningful relationships and sharing resources, ensuring that funded projects center on solutions led by impacted communities. By fostering collaboration and addressing funding gaps, the program enhances the conservation landscape for diverse voices.
Environmental Justice & Advocacy Environmental Conservation Asian / Pacific Island Culture & Heritage +3 more

Alzheimer's Disease Programs Initiative (ADPI) - Developing Dementia-Capable Community Health Worker Programs in the National Aging Network

US HHS: Administration for Community Living (ACL)
Federal Government
American Samoa, Guam +4 more
US $200,000 - US $250,000
The Alzheimer's Disease Programs Initiative (ADPI) aims to foster the development of dementia-capable community health worker programs within the National Aging Network. This initiative, supported by the US HHS: Administration for Community Living (ACL), seeks to enhance dementia screening, reduce barriers to care, and improve access to essential services for individuals with dementia and their caregivers. By integrating community health workers into aging services, the program aspires to elevate the quality of life for those affected.
Aging / Gerontology Mental Health & Psychiatric Diseases Health Care Access & Delivery +2 more

St. Mary's Bank Charitable Foundation 1908 Fund Grant

St. Marys Bank Charitable Foundation
Private
United States
US $500 - US $5,000
The St. Mary's Bank Charitable Foundation 1908 Funds Grants provide financial support to nonprofit organizations in New Hampshire, focusing on community development and services. Established to uphold St. Mary’s Bank's commitment to social responsibility, these grants, ranging from $500 to $5,000, aim to foster financial independence and address issues like homelessness, youth support, and civic engagement. The Foundation prioritizes projects that benefit local communities and promote long-term sustainability.
Financial Literacy Basic Human Needs Military & Veterans Services +5 more

Tick-Borne Disease Research Program Idea Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.
Acarology Lyme Disease

Rapid Impact Research Award

American Heart Association
Association/Society
United States
Up to US $100,000

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

  • Sudden cardiac arrest/resuscitation science
  • Cardiovascular Kidney Metabolic Syndrome
  • Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

Cardiovascular Diseases & Systems Neurological Diseases & Disorders Stroke +1 more

Zero Suicide Initiative

Indian Health Service
Federal Government
United States
Unspecified amount
The Zero Suicide Initiative aims to enhance suicide prevention within Indian health systems by implementing the Zero Suicide framework. This program focuses on culturally informed strategies to empower Tribal health systems, fostering leadership, workforce development, and effective suicide risk identification. It emphasizes timely engagement and evidence-based treatment, ensuring continuity of care and quality improvement, ultimately enhancing outcomes for American Indian and Alaska Native individuals at risk for suicide.
Suicide Prevention Native American Services Indigenous Services

H Hovnanian Family Foundation Grant

H Hovnanian Family Foundation Inc
Private
United States
Up to US $10,000
The H. Hovnanian Family Foundation Grant supports the Armenian community in Armenia and the U.S., focusing on Monmouth and Ocean Counties, New Jersey. The Foundation prioritizes education, healthcare, arts, and youth development through grants to registered non-profits. Proposals should demonstrate sustainability and community impact, with favorable consideration given to projects that engage local stakeholders and foster collaboration. Applications are accepted year-round, with a maximum funding limit of $10,000 for operational expenses.
Art & Culture Education Health & Medicine +8 more

Ann W. Dooley Advancement Scholarship

Community Foundation of Northern Illinois
Private
United States
Unspecified amount
The Ann W. Dooley Advancement Scholarship supports individuals aged 18-25 with intellectual disabilities who reside in Boone, Ogle, Stephenson, or Winnebago County. This scholarship encourages empowerment through education, enabling recipients to enhance their life skills for employment and independence. Established in memory of Ann Dooley, a dedicated educator, this scholarship honors her legacy of service and commitment to helping others. Applicants must provide verification of their disability and enrollment in a post-secondary program.
Academic Scholarship Programs Education - Higher Education College Success / Persistence +5 more

Advancing coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management.

National Oceanic and Atmospheric Administration (NOAA)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $2,000,000
The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.
Habitat & Ecosystem Restoration Climate Change Resilience & Equity Coastal Conservation

AAAAI Allied Health Recognition Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Allied Health Recognition Award honors non-physician members who have significantly contributed to allergy and immunology education or research. As part of the American Academy of Allergy, Asthma & Immunology, this award emphasizes the importance of allied health professionals in advancing patient care. Eligible recipients include AAAAI Allied Health members who demonstrate excellence in their field, ensuring that contributions to the specialty are recognized and celebrated.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

LeverAging StraTegies to Maximize ImpLementation and Effectiveness for HIV (LAST MILE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.
Epidemiology & Public Health Infectious & Parasitic Diseases Health Care Access & Delivery +1 more

AAAAI Distinguished Clinician Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Clinician Award honors individuals with a significant impact on allergy, asthma, and immunology. Recognizing those dedicated to patient care and clinical research, the award emphasizes excellence in diagnosing and treating allergic diseases. Recipients are selected based on their extensive clinical research and contributions to the field, including published works and presentations at national and international meetings. This prestigious recognition reflects the important role of clinicians in advancing allergy and immunology practices.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

AAAAI Distinguished Layperson Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Layperson Award recognizes non-medical citizens for their significant contributions to the field of allergy, asthma, and immunology. Established by the American Academy of Allergy, Asthma & Immunology (AAAAI), this annual award honors individuals who have promoted public education, supported research, and influenced positive change in legislation related to allergies. This acknowledgment reflects the growing importance of citizen volunteers in advancing the specialty and improving patient care.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

GLS Campus Suicide Prevention (363809)

Substance Abuse and Mental Health Services Adminis
Federal Government
United States
Unspecified amount
The GLS Campus Suicide Prevention program aims to enhance behavioral health services for college students, addressing critical issues such as suicide, depression, and substance use disorders. By fostering a culture of help-seeking and reducing stigma, this initiative ensures that at-risk students receive timely intervention and support. The program represents a vital investment in the mental well-being of students, promoting a healthier campus environment through evidence-based strategies and comprehensive public health approaches.
Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders Health Care Access & Delivery +1 more

AAAAI Distinguished Service Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Service Award recognizes outstanding contributions from members of the American Academy of Allergy, Asthma & Immunology. This prestigious award honors those who have demonstrated long-standing commitment and service to the organization, focusing on their influence in advancing the field of allergy and immunology. Eligible recipients include senior members and past presidents, particularly those nearing retirement, thereby celebrating their dedication to the specialty and the patients they serve.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

40 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
25.2%
Q3
24.8%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$535,356 $535.4 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081