Best Large Grants for Nonprofit Organizations in South Carolina

The Mary Means Leadership Award, introduced by Main Street America in 2019, celebrates outstanding leaders in local Main Street organizations. This annual award recognizes the vital role of leadership in revitalizing historic downtowns and enhancing community life. Nominees must be active members of Main Street America, showcasing their commitment to community, innovation, and collaboration. The award highlights the importance of diverse leadership in advancing local economic development and preserving cultural heritage across the nation.

Foundation

The Bureau County Farm Bureau Foundation was established in 1991 by members of the Bureau County Farm Bureau. The mission of the Farm Bureau Foundation is “To carry out charitable, scientific, literary and educational work that benefits Bureau County farm families and agriculture.”

The Foundation supports agricultural programs aimed at:

• Scholarship
• Education
• Leadership
• Research

Bureau County High School Senior Agricultural Scholarship

To provide for persons studying agriculture and agriculture-related fields including but not limited to education, vet medicine, and leadership development.

The Helen M. McLoraine Foster Care and Emancipated Youth Scholarship provides financial support for youth from the foster care system in Colorado. With a minimum award of $1,000, the scholarship is aimed at those pursuing post-secondary education, including trade schools and universities. Recipients are selected based on academic performance, resilience, and financial need, ensuring that deserving individuals receive the assistance they need to succeed in their educational goals.

The ARS Resident Research Grant aims to foster innovative research in rhinology, supporting residents engaged in basic, translational, or clinical projects. Applicants must collaborate with a preceptor and obtain departmental approval. Eligible residents in U.S. or Canadian programs can apply, ensuring that their projects align with the standards of the American Rhinologic Society. This grant does not cover salary for the Principal Investigator but allows funding for assistants.

The Active Fund Grant, offered by the Kelly Brush Foundation, supports individuals with paralysis from spinal cord injuries in acquiring adaptive sports equipment. This initiative aims to foster active lifestyles and inclusivity through sports. First-time applicants are prioritized for the Fall 2025 cycle, with grants averaging around $3,500, though they can vary. Eligible applicants can receive full or partial awards or a Try-It-First grant to gain experience with the equipment. For guidelines, please refer to the provided FAQs.

The Disaster Resilience Program Fellowship supports low-income communities affected by disasters by mobilizing lawyers and law students to provide free civil legal aid. This initiative ensures access to essential legal services, helping families navigate recovery barriers. Attorney Fellows receive a salary while Student Fellows earn a stipend for their service. Participants engage in outreach, build community relationships, and receive comprehensive training to enhance their legal skills, contributing to the resilience of affected communities.

The David Roy Kovacs Scholarship, offered by the Community Foundation of Greater New Britain, supports local high school graduates from New Britain who plan to pursue further education at community colleges, trade schools, or vocational schools. This scholarship emphasizes financial need as determined by the FAFSA and is intended to help students acquire the skills necessary for career success and economic independence, fostering a brighter future for the community.

The Mission Program Grants: New Worshiping Communities Seed Grant offers up to $10,000 to support the establishment of new worshiping communities connected to the Presbyterian Church (USA). These grants focus on covering initial operational costs for the first year, including salaries and educational materials. Eligible applicants must be newly formed communities established after July 2010, located in the U.S. or Puerto Rico. This initiative fosters community growth rather than expanding existing congregations.

The Deems Taylor/Virgil Thomson Awards, established in 1967 by the ASCAP Foundation, honor exceptional books, articles, and liner notes about music. With total prizes of $4000, awards are given to top submissions in Pop and Concert Music genres. Eligible works must be published in the previous year and meet specific criteria. The foundation aims to celebrate the legacy of Deems Taylor and Virgil Thomson, prominent figures in American music history.

The Public Wireless Supply Chain Innovation Fund Grant Program seeks to advance secure computing environments for AI-powered Radio Access Networks (RAN). This initiative aims to foster innovative solutions that can enhance operational revenue, provide cost efficiencies, and develop third-party services, thereby demonstrating viable business cases. By supporting the integration of AI capabilities, the program accelerates commercial deployments and promotes the export of secure, interoperable equipment.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

Steve Wagner Scholarship

Steve Wagner retired as executive director of the American Council of Engineering Companies of Michigan (ACEC/M) in 2003 after 34 years of service. As a member of the Capitol Club and Michigan Society of Association Executives, Steve was well respected by his peers and colleagues and is known for his honesty and integrity.

Steve and his wife, Lana, were married in 1965 and have two daughters, Shelley and Whitney. Throughout his career, Steve has been a proponent of community service and has given many hours himself to church and community programs. Steve also has been a strong proponent of education. ACEC/M has established this scholarship in honor of Steve Wagner to award engineering and surveying students who, like Steve, are active in the community and find it important and necessary to give something back.

The AHRQ Mentored Clinical Scientist Research Career Development Award (K08) aims to foster a diverse pool of skilled health services researchers. This funding opportunity supports career development for individuals pursuing research that aligns with AHRQ's mission and priorities. Eligible applicants will receive mentorship to enhance their research skills and contributions to the field. Overall, this initiative is crucial for addressing pressing healthcare research needs.

TechAccess: AI-Ready America is a nationwide initiative aimed at enhancing AI readiness across the U.S. by fostering collaboration and resource sharing. It targets businesses, organizations, and individuals, ensuring widespread access to AI tools and knowledge. The program includes State Coordination Hubs to connect stakeholders, a National Lead for collaboration, and AI-Ready Catalyst Award Competitions to drive innovative solutions. This comprehensive approach seeks to prepare all sectors for an AI-driven economy, benefiting Americans through practical implementation and workforce development.

The NIH Common Fund is planning to issue a NOFO to continue the Bridge2AI program, which aims to develop AI-ready datasets and best practices for biomedical research. This next stage will leverage these datasets to address significant health challenges and foster multidisciplinary collaboration. The initiative will support 3-5 Centers focused on trustworthy AI in biomedical research, creating frameworks for reproducibility, transparency, and advancing the AI workforce in health sciences.

The Rea Charitable Trust, established in 2009 by Mrs. Isabel McClintic Rea, prioritizes support for charitable organizations that focus on the arts. Administered by Comerica Bank & Trust, the trust provides funding through structured application periods for organizations based on their names. Eligible applicants must be 501(c)(3) organizations, limited to one application per year. The trust aims to uphold Mrs. Rea's legacy by fostering artistic endeavors within the community.

The Early Stage Innovations (ESI26) program by NASA invites U.S. institutions of higher education to propose innovative, early-stage space technology research. Focused on technologies with low Technology Readiness Levels, the program emphasizes civil-space applications. Proposals should address specific topics, including advancements in hypersonic flows, autonomous technologies for lunar and Martian environments, and new materials for aerospace applications. Collaboration is encouraged among eligible institutions, with support from NASA's Space Technology Research Grants Program.

The ACLS Graduate Internships on the Spiritual Infrastructure of the Future program offers summer opportunities for current PhD students in the humanities and social sciences to engage with organizations addressing the evolving American religious landscape. This initiative aims to cultivate future leaders by providing practical experiences that demonstrate the value of doctoral training beyond academia. Supported by the Templeton Religion Trust, the internships encourage collaboration between fellows and community organizations, fostering a deeper understanding of spiritual infrastructures.

The Nature Awards for Inspiring Women in Science celebrate outstanding contributions by women in STEM fields. These awards recognize early-career female researchers who demonstrate exceptional achievements, face challenges, and inspire the next generation through outreach. Winners receive prizes totaling $50,000, mentorship opportunities, and invitations to prestigious ceremonies. This initiative promotes inclusivity and aims to enhance the representation of women in science, thereby supporting a diverse and equitable scientific community.

The Nature Awards for Inspiring Women in Science, particularly in the Science Outreach category, honors initiatives that empower girls and young women in STEM fields. With a focus on engagement and retention, the awards aim to celebrate projects that encourage participation in natural sciences, technology, engineering, mathematics, and medicine. Winners will receive significant cash prizes and opportunities for mentorship, creating pathways for future generations of women in science.

The RTK Scholars Program, funded by RTK Environmental Group, provides a $1,500 scholarship to support students pursuing careers in science, particularly in environmental studies, biology, and engineering. This initiative aims to cultivate the next generation of experts in environmental testing and technology. Eligible applicants must maintain a GPA of 3.0 or higher and be enrolled in an accredited institution. The application deadline is May 31 each year, promoting academic excellence and dedication to environmental sciences.

The NSF Core Research in Biological Sciences (BIO Core) program supports innovative research that enhances our understanding of biological systems, from molecular to biome scales. This funding opportunity encourages interdisciplinary proposals and can fund both single and multi-investigator projects. The awards will vary in scope and duration, accommodating exploratory projects and long-term commitments, depending on available funding and alignment with the program's objectives.

The NIH Independent Scientist Award (K02) supports the development of outstanding scientists by providing three to five years of salary support and protected time for newly independent researchers. This funding opportunity is specifically for applicants proposing research that does not involve leading an independent clinical trial, allowing them to gain experience in trials led by others. Key deadlines for applications span from June 2024 to February 2027.

The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.

Lexington Medical Center Foundation Inc

Since 1971, Lexington Health has grown and expanded to meet the needs of our community. The Lexington Health Foundation Remains Committed to Quality Care. Foundation-funded programs aim to enhance patient experiences and touch the various areas of care at Lexington Health — Patient, Employee, and Community Care.

Event and Project Sponsorship

Lexington Medical Center supports local organizations and nonprofits throughout the Midlands.

We support local events and causes that enhance the health and vibrance of our community. You can request sponsorship or other assistance for a project or event based in the South Carolina Midlands community.