Best Large Grants for Nonprofit Organizations in South Carolina

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Tracy Grove Community Club Scholarship

Applicant must graduate from a school in Henderson County and must intend to enroll in a degree-granting program in an accredited two- or four-year institute. 

The Teiger Foundation's Hosting Grant provides up to $75,000 for US-based curators or artistic directors to present contemporary visual art exhibitions that originated in different contexts. This grant encourages resource-sharing and collective learning, allowing institutions to expand their programming sustainably. It prioritizes projects affiliated with established non-profits, fostering community-building and positive change in the field of visual art while addressing issues of racial justice and climate crisis.

The Teiger Foundation Programming Grant supports innovative visual arts projects led by curators at smaller non-profit organizations with budgets under $3.5 million. Grants of up to $150,000 are available for three years, funding development, realization, and documentation of exhibitions and related programs. The foundation emphasizes community engagement, racial justice, and artistic experimentation while encouraging collaboration with other cultural institutions. Note: The next Call for Proposals opens in Fall 2026.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Valley Clinic Scholarship

Applicant must be pursuing a degree in the health care field who demonstrates financial need and academic merit. Applicant must be a full-time resident of the Hickory Nut Gorge community.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

VFW Hedrick-Rhodes Post 5206 Scholarship

Applicant must be a graduating senior or graduate of a public, parochial, or private school and intend to enroll in a degree-granting program at an accredited school. 

The schlarship is renewable.

About Us

We help shelters and rescue groups save pets.

Saving pets. Together.

The Petfinder Foundation has been helping animal shelters and rescue groups since 2003. We are the ONLY national organization that does nothing but give cash and product grants to adoption groups.

Operation Grant

Grants vary depending on the organization’s need to support the number of adoptable pets listed on Petfinder and are awarded on a monthly basis throughout the year until all funds are depleted.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Winifred M. Wyman Memorial Scholarship

Applicant must be a graduate of a Henderson County public school who wishes to pursue his or her education at an accredited college or university. 

The schlarship is renewable.

The Baskin Family Foundation Grant supports innovative organizations that focus on education and social justice. Established by Samuel and Hadassah Baskin, Sheldon Baskin, and Judy Wise, this grant aims to empower 501(c)(3) organizations to create meaningful change in their communities. By promoting forward-thinking initiatives, the foundation strives to enhance the lives of those it serves and foster equality in access to education.

The Teiger Foundation Single Project Grant supports innovative visual arts projects at non-profit exhibition spaces with annual budgets exceeding $3 million. Focused on curatorial practices, the grant encourages experimentation and creativity, aiming to drive positive structural change in contemporary art. Eligible expenses include artist fees, publication costs, and coalition-building efforts. The next Call for Proposals opens in Fall 2026, with funding of up to $150,000 available for selected projects.

Screen Actors Guild American Federation

The SAG-AFTRA Foundation is a 501(c)(3) nonprofit organization offering comprehensive professional development and educational resources as well as emergency financial and health assistance programs to SAG-AFTRA artists nationwide.

The Foundation values the essential contributions of performing artists to entertainment, media, the arts, and culture. In a rapidly changing industry and world, the Foundation is dedicated to providing SAG-AFTRA actors, voiceover artists, broadcasters, dancers, and other members with new and valuable tools to navigate industry shifts, along with training opportunities to hone and develop their craft.

In addition, the Foundation supports SAG-AFTRA artists throughout the various phases of a career in the arts, offering emergency assistance and scholarship programs to ensure no performer faces tough times alone.

The Foundation also encourages celebrated performers to give back through its children’s literacy program, Storyline Online, fostering a love of reading in millions of children worldwide.

Committed to education and community, the Foundation strives to create a supportive and innovative environment where performers can expand their skills to achieve their highest potential while staying grounded and knowing they have support in times of urgent need.

Disaster Relief Fund

Our Disaster Relief Fund is dedicated to addressing the most dire needs of SAG-AFTRA members impacted by government-declared natural disasters. 

The Urology Care Foundation Bridge Award, supported by Dornier MedTech, aims to assist established urology researchers facing financial challenges. It provides up to $60,000 over a 12-month period to sustain vital urologic projects at risk due to funding gaps or setbacks. This unrestricted funding targets independent researchers who are no longer under formal mentorship, ensuring that those actively engaged in research receive timely support to maintain their competitiveness in the field.

Gilead Medical Education Grants fund innovative, data-driven programs that enhance healthcare infrastructure and support vulnerable communities globally. Focused on core therapeutic areas like HIV, liver diseases, and oncology, these grants aim to deliver impactful continuing medical education for healthcare providers. Eligible applicants include for-profit medical education companies and nonprofit organizations. Gilead prioritizes programs that demonstrate a strong capacity to achieve specific educational outcomes, ensuring that support reaches those who need it most.

Screen Actors Guild American Federation

The SAG-AFTRA Foundation is a 501(c)(3) nonprofit organization offering comprehensive professional development and educational resources as well as emergency financial and health assistance programs to SAG-AFTRA artists nationwide.

The Foundation values the essential contributions of performing artists to entertainment, media, the arts, and culture. In a rapidly changing industry and world, the Foundation is dedicated to providing SAG-AFTRA actors, voiceover artists, broadcasters, dancers, and other members with new and valuable tools to navigate industry shifts, along with training opportunities to hone and develop their craft.

In addition, the Foundation supports SAG-AFTRA artists throughout the various phases of a career in the arts, offering emergency assistance and scholarship programs to ensure no performer faces tough times alone.

The Foundation also encourages celebrated performers to give back through its children’s literacy program, Storyline Online, fostering a love of reading in millions of children worldwide.

Committed to education and community, the Foundation strives to create a supportive and innovative environment where performers can expand their skills to achieve their highest potential while staying grounded and knowing they have support in times of urgent need.

Emergency Financial Assistance

The SAG-AFTRA Foundation offers critical financial assistance programs for eligible SAG-AFTRA members experiencing urgent financial need due to an unexpected life crisis.

This program cannot replace government unemployment/disability assistance and is meant to provide temporary relief during unexpected crises. The financial programs adhere to IRS guidelines to qualify as an emergency hardship program; grants cannot be given simply because someone is a SAG-AFTRA member, and the programs are not offered as a membership benefit.

We Help Members Facing:

• Eviction, foreclosure, or immediate temporary housing emergencies (only once per member’s lifetime)
• Catastrophic damage rendering primary residence dangerous or uninhabitable
• Auto or other accidents causing injury or personal property destruction
• Costs associated with the burial or cremation of a SAG-AFTRA member, or a member’s spouse/legal dependent
• Financial impacts of experiencing a verifiable crime
• Senior members, age 65 and older, experiencing a life crisis
• Medical expenses due to serious illness or injuries (not covered by insurance)
• In limited cases, we can help pay your SAG-AFTRA health insurance or COBRA premiums (restrictions apply). We cannot extend health insurance eligibility, which is determined by the SAG-AFTRA Pension & Health Plan based on qualifying SAG-AFTRA earnings
• Other emergencies as described in IRS guidelines for emergency financial grants to individuals

The NIOSH Small Research Grant Program (R03) aims to enhance the understanding of occupational disease risks and develop strategies for risk reduction. This grant supports research projects that require limited resources, including pilot studies and data analysis, to effectively translate scientific findings into practice. Applicants are urged to articulate the health burdens addressed and the anticipated impacts of their research on workplace safety and health, thereby contributing to the reduction of work-related illnesses and injuries.

The Gerber Foundation provides research grants focused on pediatric nutrition, aiming to enhance the health and well-being of infants and young children. Key areas of interest include applied research on nutritional issues, benefits of specific nutrients, and innovative treatment regimens. The foundation prioritizes projects that promise significant advancements in health outcomes for children from birth to age three, ensuring that grant dollars effectively address critical development challenges.

The Charlotte W. Newcombe Doctoral Dissertation Fellowship supports Ph.D. candidates in the humanities and social sciences with a $31,000 stipend for their final year of dissertation writing. This prestigious fellowship encourages original research that engages with religion, ethics, and values. Candidates must have completed all coursework and preliminary exams, and be in the writing stage of their dissertation. The fellowship aims to alleviate living expenses and is open to students whose work significantly contributes to scholarly discussions in their fields.

The ASM Minority Travel Award aims to enhance diversity in microbial sciences by supporting faculty from underrepresented institutions, including community colleges and historically black colleges. This initiative ensures that diverse perspectives are included in the field, fostering a richer academic environment. Awardees receive complimentary registration and housing for ASM Microbe 2026, promoting professional development and networking opportunities in microbiology.

About Community Foundation of Henderson County

• Mission: Helping people who care make lasting contributions to causes that matter.
• Vision: Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

About Hans and Margo Nagel Scholarship

This scholarship provides assistance with education expenses for a citizen and resident of Henderson County who graduates from a high school in Henderson County. This scholarship is for someone who is doing things to prevent and break the cycle of desperate need and is to act as an incentive for the recipient to do something, primarily in using education, to pull his or her life together and make a better life for himself or herself and the next generation.

This is a renewable scholarship.

The Sara Corrie Memorial Grants, administered by the National Speleological Society, support group cave exploration in the U.S. and its territories. Up to six grants of $1,000 each are awarded annually to NSS members. Applications must detail exploration plans, including costs for necessary equipment. Grants are not provided for activities outside of exploration. Successful recipients must report findings and may have their proposals published on the NSS website.

The National Institute on Aging intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Coordinating Center (CC) of the Claude D. Pepper Older Americans Independence Centers (OAIC) program. The CC serves as a facilitator for OAIC site interactions and as a conduit for translating OAIC objectives and findings to both scientific and general audiences. The proposed CC must demonstrate an ability to work cooperatively with all OAIC sites and possess sufficient scientific expertise in geriatrics and related areas to serve the national coordination functions of the OAIC program. Applicants should have a demonstrated ability to coordinate multi-site projects.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.

The Recordings at Risk Grant, administered by CLIR, supports the preservation of rare audio and audiovisual media of scholarly value through digital reformatting. With funding from The Andrew W. Mellon Foundation, the program aims to award $6.75 million across twelve competitions, offering grants between $10,000 and $50,000. It encourages U.S. nonprofit institutions to preserve vulnerable media, helping them to develop strategies for effective digital reformatting and promoting best preservation practices.

The MPS Mathematical Sciences Research Programs (MPS MathSci) by the NSF supports diverse research initiatives in theoretical and applied mathematical sciences. Key areas include Algebra, Applied Mathematics, Combinatorics, and Mathematical Biology. The program encourages groundbreaking foundational research with flexible budgets and durations. Proposals do not need to promise immediate outcomes, allowing researchers to explore innovative concepts without the pressure of commercial viability.

The Morris Animal Foundation is dedicated to improving the health of animals through scientific research and funding. With a focus on domesticated cats, the Feline Health First Award supports innovative research that addresses the welfare of both community and pet cats. Grants are available for projects lasting up to 24 months, with a maximum budget of $120,000. This initiative encourages collaborations that translate research findings into practical applications for veterinarians and cat caretakers.

The Morris Animal Foundation offers the Annual Feline Health Pilot Study Award to support innovative research that enhances the health and welfare of domesticated cats. This funding is aimed at proof-of-concept studies, advancing animal health research through collaborative projects. With a maximum funding of $20,000 for a 12-month duration, the foundation seeks proposals that have a significant impact on both scientific and community stakeholders, ensuring a healthier future for feline populations.

The Morris Animal Foundation offers the Annual Feline Proposals: Feline Health Established Investigator Award to support research aimed at improving the health and welfare of domesticated cats. Established in 1948, the foundation funds innovative, hypothesis-driven studies that demonstrate high scientific merit. This grant encourages collaboration between academia and industry and has a maximum project duration of 36 months, with average awards around $100,000. Eligible proposals should focus solely on domesticated cats, excluding other feline species.

The Morris Animal Foundation invites proposals for the Feline Health Fellowship Training Award, aimed at advancing the health and welfare of domesticated cats. This program supports new investigators by providing salary funds in a mentoring environment. Proposals should focus on hypothesis-driven research with high scientific merit, targeting community and pet cats (Felis catus). The maximum award duration is 24 months, with budgets not exceeding $145,000. Join us in making impactful contributions to feline health.

U.S. Venture Sponsorships, supported by the Us Venture Schmidt Family Foundation, aim to enhance community engagement by addressing the root causes of poverty through collaboration and social innovation. Grants typically do not exceed $10,000, ensuring that eligible public charities, especially those with 501(c)(3) status, can benefit. Each organization can receive one sponsorship grant annually, reflecting U.S. Venture's commitment to giving back and fostering meaningful partnerships.