Best Large Grants for Nonprofit Organizations in South Carolina

The SAA First Book Award, presented by the Shakespeare Association of America (SAA), honors the legacy of Jerome Singerman and supports early career scholars. This prestigious award recognizes the best monograph with a significant Shakespeare component, published as the first book by a current SAA member between September 1, 2024, and September 1, 2025. The award will be announced during the SAA’s Annual Luncheon, celebrating contributions to Shakespeare studies.

The OREF Michael P. Kelly Sr Leadership Fellowship Program is a one-year virtual fellowship aimed at developing leadership skills in orthopedic residents. The program includes individual coaching, clinical research mentoring, educational opportunities, and an annual leadership retreat. It prioritizes candidates like orthopedic residents (PGY3-PGY5), fellows, and early-career surgeons who show a commitment to orthopedic clinical research and leadership in the orthopedic community.

The Accredited Airport Executive (A.A.E.) Scholarship, offered by the AAAE Foundation, provides financial support to aspiring leaders in aviation. With over $518,900 in scholarships available for 2025, this program aids students whose families are involved in the A.A.E. community. Applicants are evaluated based on academic performance, financial need, and community engagement. This initiative not only helps students pursue their education but also strengthens the future of the aviation industry.

The Shigeo and Winifred Ito Scholarship Fund, established by a former recipient of the Hawai‘i Community Foundation, aims to support students from Hawaii pursuing higher education on the U.S. mainland. With awards averaging around $6,000, the fund prioritizes residents demonstrating financial need and maintaining good academic standing. The scholarship reflects a commitment to fostering educational opportunities and giving back to the community, ensuring that deserving students can achieve their academic goals.

The Pharmacy Residency Excellence Award: Preceptor Award recognizes exceptional pharmacy residency preceptors with over ten years of contributions in training and mentoring. Established in 2006, this award promotes innovation and excellence in pharmacy education. Recipients are acknowledged at the ASHP Midyear Clinical Meeting, highlighting their achievements and serving as role models for future preceptors. This award aims to inspire others in the pharmacy field to enhance resident training and support optimal medication use.

The BioLEAP Classroom Grant, funded by the National Anti Vivisection Society, provides educators with up to $1,000 to purchase humane anatomy models, replacing traditional animal dissection methods. This initiative supports the use of innovative learning tools like 3D digital models and synthetic specimens, enhancing educational experiences while promoting ethical practices in science education. Eligible applicants must be U.S. educators teaching an anatomy lab in the upcoming school year.

Sioux Falls Area Community Foundation

Founded in 1984, we are a 501(c)(3) public charity. Today, we manage more than 1,000 charitable funds, serving as the trusted stewards for more than $390 million in assets.

Our Community Investment team works with local nonprofits, schools and community leaders to identify gaps, assess critical needs and explore opportunities and possibilities. Our Philanthropy team works with individuals, families, advisors, businesses, and nonprofits, offering deep and broad experience and expertise in philanthropic strategy, charitable and organizational endowments, and legacy planning.

Scholarship Opportunities

The Sioux Falls Area Community Foundation manages one of the state's largest scholarship programs, awarding more than $500,000 in scholarships to local students each year. If you’re interested in pursuing higher education, it's likely we have a scholarship that can help you achieve your dream.

Equitable Sioux Empire Scholarship

Awarded to a graduating senior of an accredited public or private high school in the Sioux Falls area. Equitable employees, associates, immediate family members of employees, and associates of the Donor are ineligible for this award.

The Pharmacy Residency Excellence Award: New Preceptor Award aims to honor preceptors in their first 3-5 years of residency training who demonstrate excellence and innovation. Established in 2006, the award recognizes individuals who contribute significantly to residency education and serve as role models. Recipients are acknowledged at the ASHP Midyear Clinical Meeting, promoting their achievements widely. This award is part of ASHP's commitment to enhancing pharmacy education and practice.

The Pharmacy Resident Research Grant, offered by the ASHP Foundation, aims to support practice-based research conducted by residents in ASHP-accredited pharmacy residency programs. This grant not only fosters the development of research skills among pharmacy residents but also encourages mentoring relationships with senior investigators. Research proposals should align with the ASHP Foundation Research Agenda and focus on advancing pharmacy practices within various healthcare settings to enhance patient care.

The National Center for Construction Safety and Health Research and Translation (U54) aims to enhance worker safety in the construction industry through innovative research and intervention strategies. By fostering partnerships and focusing on evidence-based solutions, the Center will address critical safety and health challenges faced by construction workers. The initiative aligns with NIOSH's strategic objectives, promoting collaboration among academic institutions and organizations to improve health outcomes and reduce the occupational health burden in this vital sector.

The Philip & Louise Wang Scholarship Fund, established by the Hawai‘i Community Foundation in 2022, aims to support U.S. residents who demonstrate financial need, academic merit, and good character while attending accredited post-high school institutions. Eligible applicants must be Hawaii residents maintaining a minimum GPA of 2.0. Preference is given to first-generation college students and previous recipients who continue to meet eligibility criteria. This initiative embodies our vision of a thriving and equitable Hawai‘i.

The NDEP STEM Open NFO invites innovative proposals for research and implementation of effective STEM education and outreach programs. This continuously open announcement from the Department of Defense encourages submissions that align with key initiatives, including support for community colleges and strategic partnerships. As funding becomes available, amendments detailing specific topics and submission guidelines will be released. Applicants must submit white papers to express interest in full applications for potential funding consideration.

Sioux Falls Area Community Foundation

Founded in 1984, we are a 501(c)(3) public charity. Today, we manage more than 1,000 charitable funds, serving as the trusted stewards for more than $390 million in assets.

Our Community Investment team works with local nonprofits, schools and community leaders to identify gaps, assess critical needs and explore opportunities and possibilities. Our Philanthropy team works with individuals, families, advisors, businesses, and nonprofits, offering deep and broad experience and expertise in philanthropic strategy, charitable and organizational endowments, and legacy planning.

Scholarship Opportunities

The Sioux Falls Area Community Foundation manages one of the state's largest scholarship programs, awarding more than $500,000 in scholarships to local students each year. If you’re interested in pursuing higher education, it's likely we have a scholarship that can help you achieve your dream.

Joe Foss "An American Hero" Scholarship

Awarded to graduating seniors from South Dakota high schools. 

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Rebecca S. Poole Scholarship

This educational scholarship is for a Henderson County student pursuing his or her education beyond high school.

The schlarship is renewable.

The Joan Mitchell Fellowship supports 15 US-based artists in painting and sculpture with $60,000 over five years. It offers crucial financial resources, skills development, and community building. The fellowship also includes workshops, consultations, and opportunities for residencies, particularly for those in their fourth year or beyond. The program emphasizes diversity, encouraging nominations from underrepresented artists to foster a rich cultural discourse in the arts.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Robert C. Edwards, Jr. and Sandra Edwards Waggoner Memorial Scholarship

This scholarship is to provide financial aid to a deserving student who has a desire and commitment to pursue his or her education.

The CSA Scholars’ Roundtable Honor recognizes individuals who exemplify excellence in costume scholarship. Since its establishment in 1997, it fosters dynamic discussions on pertinent costume scholarship issues during the CSA National Symposium. Nominees are evaluated based on their innovative experiences, insights into scholarly topics, and ability to collaborate effectively. This initiative not only celebrates scholarship but also encourages interdisciplinary dialogue and engagement among scholars in the field.

The Robotic Thoracic Surgery Access Award, funded by The Thoracic Surgery Foundation, supports underrepresented general thoracic surgeons and cardiothoracic surgery residents in training. This award aims to develop robotic surgical practices through mentorship and training opportunities, providing up to $10,000 for travel expenses. Eligible applicants must demonstrate significant experience in general thoracic surgery and have access to the DaVinci robotic system. This initiative fosters diversity and accessibility in advanced surgical education.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

Thomas Oliver and Louise Jordan Mulcahy Scholarship

This scholarship is for a graduate of a high school in Henderson County and shall be awarded based on academic standing and financial need. The recipient need not be at the top of his or her class academically nor at the bottom of his or her class financially.

The schlarship is renewable.

The Find Your Light Foundation is committed to providing every child with access to quality arts education. By focusing on direct support for exceptional programs, along with education, advocacy, and outreach, they aim to highlight the importance of arts in youth development. Grants are awarded to arts education initiatives in low-income areas across North America, typically ranging from $5,000 to $15,000, with awards issued in the Summer and Winter each year.

The Farmers Advocating for Organic Grant (FAFO) supports impactful projects that enhance the organic agricultural sector, focusing on initiatives that assist family farmers and promote organic soil health. Eligible applicants include non-profit organizations and research institutions. FAFO prioritizes projects that address the needs of organic dairy, meat, and produce farmers while fostering cooperative growth. This grant aims to strengthen the organic industry and ensure the livelihood of organic farmers across the nation.

The Military Heroes Program, funded by the Pentagon Federal Credit Union Foundation, offers high impact grants to support both active duty and retired service members in their transition to civilian life. This initiative focuses on harnessing military skills for community leadership, promoting educational programs that honor service, and providing resources for meaningful employment. Non-profit organizations can apply for funding to create programs that align with these priorities and positively impact veterans and their communities.

The Make a SPLASH! Grant Contest, co-hosted by Inside Edge Safety Surfaces, offers two all-expenses-paid awards for Life Floor safety surfaces, aimed at enhancing community splash pads. The Need-Based Award targets municipalities and non-profits demonstrating financial need, with design options including planks, bubbles, and geometric shapes. Grant values range from $50,000 to $65,000, depending on project size, ensuring safety and accessibility for all users.

The Teiger Foundation's Curatorial Research and Development Grant offers support for innovative curatorial practices within the contemporary visual arts sector. Designed to address gaps in funding, this grant provides up to $50,000 for curatorial research projects, including travel and collaborative investigations. It emphasizes the importance of experimentation and creativity while aligning with values of racial justice and environmental sustainability. The next Call for Proposals will open in Fall 2026, with funding opportunities available to U.S.-based curators.

The Amy Heryford Ousley and James Heryford Ousley Educational Fund, established in 2005, provides scholarships to Klamath and Lake County students attending nonprofit colleges in the U.S. The fund, initially valued at $6.5 million, has awarded over $2.5 million in scholarships. Eligible students must have attended a Klamath County high school for four years, maintain a minimum GPA, and enroll as full-time students. Scholarships can reach up to $3,000 annually for up to five years.

The Alpha Delta Pi Foundation, a private funder, established the Ronald McDonald House Charities (RMHC) Endowment to support local RMHC Chapters in the U.S. and Canada that lack adequate backing from Alpha Delta Pi collegiate or alumnae associations. Since 1979, over $22 million has been contributed to RMHC, with grants ranging from $2,000 to $10,000 available for houses, renovations, and family room expansions, fostering a strong philanthropic partnership.

Community Foundation of Henderson County

Individuals, families, organizations and businesses establish funds at the Foundation to carry out their charitable giving now and in the future.

Community Foundation of Henderson County is a 501(c)(3) nonprofit, public charity, governed by a volunteer board of directors, that has been assisting donors fulfill their philanthropic dreams since 1982.

Our Mission: Helping people who care make lasting contributions to causes that matter.

Scholarships

Community Foundation of Henderson County's Scholarship Program began in 1984. Thanks to the generosity of passionate donors, over 2,000 traditional and non-traditional students have been provided more than $10 million in scholarships to pursue higher education.

T. Llyle and Marion S. Keith Scholarship

The applicant must be a graduating senior or a graduate of a public high school in Henderson County. This scholarship is not based on merit (however, must have a cumulative GPA of at least 2.0 or better), but on financial need. Students must be pursuing their undergraduate education in a two or four year accredited institution.

The schlarship is renewable.