Best Large Grants for Nonprofit Organizations in South Carolina

The Juliette Low’s Amazing Girls Scholarship, established in 2011 by the East Texas Communities Foundation, is aimed at female graduating seniors from Smith County who have been active in Girl Scouts. This scholarship supports educational pursuits for students attending any college in the U.S. Applicants must demonstrate financial need and have a minimum GPA of 3.00. The award amount is $1,000, and preference is given to recipients of the Girl Scout Gold Award. Reapplication is encouraged.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

CDC Foundation

The CDC Foundation helps the Centers for Disease Control and Prevention (CDC) and the public health system save and improve lives by unleashing the power of partnerships to protect the health, safety and security of all communities, everywhere. The CDC Foundation is authorized by Congress to mobilize philanthropic partners, corporations, organizations and individuals to support the critical health protection mission of CDC and the public health system.

The CDC Foundation manages hundreds of programs each year aimed at protecting communities across the country from a variety of health threats—from chronic disease conditions including cardiovascular disease and cancer, to infectious diseases like malaria and HIV to emergency responses, such as Ebola and Zika.

Contractor for Implementation and Evaluation of Healthy Native Babies Project Materials

This RFP request proposals from Tribes, Tribal Serving Organizations (TSOs) and Urban Indian Organizations (UIOs) [T/TSOs/UIOs] to implement and evaluate the updated Healthy Native Babies Project (HNBP) materials within their service areas. This initiative aims to strengthen culturally relevant infant safe sleep education, increase community awareness and support Native families in reducing sleep related infant deaths. Selected T/TSOs/UIOs will adapt, disseminate and assess the use of HNBP materials in ways that reflect the cultural, linguistic and community-specific needs of the Native populations they serve. 

This project is a rapid turnaround project to support T/TSOs/UIOs in:

• Implementing HNBP materials in clinical, community, and family setting
• Training staff and community partners
• Evaluating reach, effectiveness, and community feedback
• Identifying barriers, facilitators, lessons learned, and best practices for future replication

The NRF Foundation Bright Futures Scholarship provides a unique opportunity for undergraduate students to attend the 2026 NRF Foundation Student Program in New York City at no cost. This need-based scholarship allows students to explore career paths in the retail industry, meet leading recruiters, and gain insights from industry executives. Eligible students can receive free travel and accommodation for this enriching experience, which takes place from January 8-11, 2026.

The Ag Health and Safety Grants, awarded by CHS and the CHS Foundation, aim to enhance agricultural safety and foster community well-being. These grants focus on educating youth and farmers about agricultural hazards, providing training for rural professionals, and developing essential safety guidelines. With a commitment to improving safety standards, the program has benefitted over 32,000 youth and supported more than 450 communities through safety initiatives and equipment, ensuring a safer future for all involved in agriculture.

The National Institute on Drug Abuse (NIDA) is launching a specialized entrepreneurship program aimed at life science researchers in the field of substance use disorders (SUD). This initiative will equip researchers with essential skills to transform their innovative ideas into viable products, focusing on aspects such as market evaluation, customer discovery, and intellectual property. The course will be delivered in a hybrid format to engage US-based SUD researchers effectively, fostering collaboration and advancing the field.

The Furer-Barag-Wolf Post 126 Jewish War Veterans Scholarship Award supports children or grandchildren of JWV Post 126 members, providing merit-based assistance for college or vocational education. Eligible applicants must reside in specific counties in New Jersey or be related to a JWV member. The scholarship covers tuition, books, and living expenses and is open for reapplication annually. This initiative by the Jewish Community Foundation fosters educational opportunities for deserving students.

The Diversity Mentorship Grant Program aims to enhance ethnic diversity in dermatology by providing mentorship to underrepresented medical students. Participants receive 160 hours of hands-on experience with a dermatologist, fostering a deeper understanding of the field. A stipend of $1,500 is available for travel and living expenses. Applications are open until November 1 for the upcoming year, encouraging students from diverse backgrounds, including Black, Hispanic, and Native American groups, to apply.

The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.

The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.

The Lynne Goldsborough Yowell Scholarship, managed by the Northern Piedmont Community Foundation, supports students from Madison and Culpeper County public high schools. It is awarded to high school graduates or current college students pursuing an Arts Major, defined as visual arts, music, theater, or culinary arts. Emphasizing academic merit and financial need, this scholarship honors the legacy of Lynne Goldsborough Yowell, a dedicated community advocate.

The NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required) grant supports small businesses in conducting innovative clinical trials relevant to neurological disorders. This funding opportunity encourages investigator-initiated projects evaluating drugs, devices, and therapies aligned with NINDS goals. Applications are accepted only from SBIR Phase II and Fast-Track applicants, with a submission deadline of 5:00 PM local time. Letters of Intent are encouraged 30 days prior to the full proposal deadline.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Implementation Grants

Implementation Grants fund projects and strategies identified in an Action Plan that address roadway safety problems. Implementation Grants may also fund supplemental planning and demonstration activities, as well as project-level planning, design, and development activities for projects and strategies identified in an Action Plan (e.g., project-level 21 National Environmental Policy Act (NEPA) compliance, associated environmental review activities, permits and approvals, construction design, etc.). 

• Expected number of awards: 40 to 70

The NBA Foundation Grants aim to empower Black youth by providing economic opportunities through skills training, mentorship, and career advancement programs. Established by all 30 NBA teams, the foundation focuses on organizations aligned with its mission, specifically those serving Black youth in NBA markets. Applications for 2024 grants are now open, with a review process taking 12-14 weeks. This initiative is crucial for promoting sustainable economic and racial justice in communities.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Planning and Demonstration Grants

Planning and Demonstration Grant Eligibility Requirements

Eligible activities for a Planning and Demonstration Grant include: develop a new Action Plan, conduct supplemental safety planning to update an existing Action Plan, or carry out safety demonstration activities to inform the development of or update to an Action Plan.

These activities may be bundled in any combination, provided that the requirements in this Notice are met. DOT encourages complementary but distinct activities, including but not limited to safety demonstration activities that will help inform the development of an Action Plan. Any applicant that meets the eligibility requirements may apply for a Planning and Demonstration Grant to develop an Action Plan. 

• Expected number of awards: 400 to 700

The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.

The Susie Kubié Symphonic Music Scholarship, established in 2017, provides financial support to talented young musicians from the Albuquerque Youth Symphony Program (AYSP). Each year, up to $4,000 is awarded to new or renewing scholars pursuing a music degree. Applicants are required to submit a personal essay, letters of reference, and a video performance. This scholarship not only aids students in their educational pursuits but also honors Susie Kubié's legacy of dedication to music education.

Farmer First Regenerative Pilot Program

Regenerative Agriculture is a conservation management approach that emphasizes natural resources through improved soil health, water management, and natural vitality for the productivity and prosperity of American agriculture and communities.

In December 2025, NRCS launched the NRCS Regenerative Pilot Program, a farmer first, outcomes-based approach to conservation designed to return the agency to its core mission – helping people help the land. NRCS is investing $700 million to specifically support regenerative agriculture, including:

• $400 million through the Environmental Quality Incentives Program (EQIP); and
• $300 million through the Conservation Stewardship Program (CSP)

This pilot program addresses whole-farm resource concerns through support for voluntary regenerative agriculture conservation plans. It also puts American farmers first as a part of the solution to Make American Healthy Again (MAHA) by supporting access to American-grown whole foods, critical to addressing the chronic disease crisis nationwide.

For too long, divided and highly specific funding pools have unintentionally encouraged isolated, practice-by-practice conservation, rather than holistic management. By integrating bundled regenerative practices into single applications, closing program loopholes, and recognizing outcomes, NRCS will deliver lasting benefits for farmers, natural resources, and the American consumer.

Emphasizing regenerative agriculture builds upon NRCS’s 90 years of existing conservation work by restoring land health, improving long-term productivity, and ensuring American grown production for the future. 

The contract length will be a minimum of 5 years.

The Fiscal Year 2027 National Sea Grant College Program Dean John A. Knauss Marine Policy Fellowship offers an opportunity for students to engage in marine policy through a fellowship funded by the National Oceanic and Atmospheric Administration (NOAA). With anticipated funding for at least 35 applications, each receiving $97,200, this program encourages applicants to connect with their local Sea Grant program for support. Early registration with SAM.gov, Grants.gov, and eRA Commons is crucial for eligibility.

The Community Charter Network Scholarship, provided by the Central Indiana Community Foundation, assists students from Fall Creek Academy or University Heights Preparatory Academy in covering post-secondary educational expenses. This scholarship aims to support those who demonstrate financial need and excel academically. Eligible applicants include former students of these institutions or residents within the IPS district. Awards vary based on available funds and may cover tuition, fees, and other educational costs.

Mr. Holland’s Opus Foundation

Who knew that a movie made 30 years ago would become the catalyst for the creation of a namesake non-profit, changing the lives of hundreds of thousands of kids by giving them access to learn and play music in school – keeping music education alive and strong across the country?

Mr. Holland’s Opus Foundation was inspired by the acclaimed motion picture Mr. Holland’s Opus, the story of the profound effect a dedicated music teacher had on generations of students. Michael Kamen, who wrote the score for the film, started the foundation in 1996 as his commitment to the future of music education.

The Foundation donates high-quality musical instruments to deserving, under-funded music programs, and provides an array of support services to school districts. By increasing the school’s inventory of quality, playable instruments, music teachers are given the tools they need to deliver a quality music education to students who want to learn. In collaboration with committed school districts, the Foundation’s investments are strategically placed as part of a K–12 district-wide plan to achieve positive and lasting results. Generations of students will benefit.

Instrument Grants

Mr. Holland’s Opus Foundation donates musical instruments to schools nationwide with a focus on increasing student access to music education programs in low-income communities.

Mr. Holland’s Opus Foundation grants consist of musical instruments and equipment only; no cash grants are provided. Our team handles sourcing, ordering, and delivering the instruments. As part of the application process, we work with the teacher to assess the program’s needs to determine the appropriate instruments and equipment. Note that only student model instruments are provided, and the brand is at the Foundation’s discretion.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

Social Workers & School Counselors

Social workers and school counselors can submit a request application for a student if they have access to instruction through a music program. 

Home

The Middle Run Foundation is a family-governed foundation based in Newark, Delaware. The Board of the foundation is chaired by Sarah Ives Gore, its founder, and includes her children, grandchildren, and non-family members who bring experience and expertise to our work.

About

Purpose:

The purpose of the foundation is to fund and support non-profit programs which focus on building healthy, self-sufficient families.

Apply

The Middle Run Foundation makes grants up to $500,000 annually with individual grants ranging from $5,000 to $50,000.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

Title One School Music Teachers

Our music instrument donation program for Title One public schools is designed to support teachers who have a few students who cannot participate in class because of financial need. We do not outfit entire music programs. 

Samardzija-Gutesha Family Fund

The Field of Interest Fund reflects the Samardzija-Gutesha family’s values and commitment to giving back. It supports education and hands-on learning in farming, soil health, and water conservation, with a focus on FFA members and associate-level college students.

Scholarships benefit graduating seniors and second-year post-high school students who are originally from DeKalb County high schools with FFA programs.

The Samardzija-Gutesha Family Fund provides scholarships for post-high school students pursuing education in agriculture or conservation, as well as paid internships with local farmers, and conservation professionals. It also supports educational seminars on topics such as sustainable farming and agricultural business, and provides grants to local organizations that align with the donor’s values.

In its first year, the Fund awarded $65,000 in scholarships to eight graduating seniors from DeKalb, Genoa-Kingston, Indian Creek, Somonauk, and Sycamore high schools (pictured above). Each student attending a two-year college received a $5,000 scholarship, while students planning to attend a four-year university received $10,000.

The Indigo Oak Fund, a Colorado-based private foundation, focuses on empowering women and children through various initiatives. By funding organizations that address issues such as domestic abuse, food insecurity, and gender equity, the Fund aims to improve lives and foster lifelong learning. Their mission emphasizes recognizing individual potential and ensuring equal opportunity for all, making a significant impact in communities across Colorado and the Bay Area.

The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.