Best Large Grants for Nonprofit Organizations in South Carolina

The FY 2026 Competitive Funding Opportunity for the Public Transportation on Indian Reservations (Tribal Transit) Program provides $18,954,885 in grants. This program supports tribes in rural areas, enhancing public transportation through planning, capital projects, operating costs, and job access initiatives. It is part of the Section 5311 program, ensuring tribes have the resources to improve transportation services effectively. Additionally, the Tribal Transportation Self-Governance Program empowers tribes with greater control over DOT funds for their transportation needs.

• Innovative: An approach that brings fresh thinking, tools, or models to homeownership in ways that challenge the status quo and demonstrate a disruptive, future-oriented vision with potential to inspire or shift broader field practice.
• Impactful: A solution with meaningful potential to expand homeownership through knowledge and action, featuring clear and measurable progress indicators that demonstrate capacity to shift trajectories for low- and moderate-income households.
• Bridge-Building: An initiative that effectively connects and unifies a wide range of stakeholders, fostering meaningful collaboration across sectors or perspectives. The strongest submissions will reflect strong community partnerships across the housing ecosystem.
• Durable: A sustainable pathway that addresses root causes of homeownership barriers rather than just symptoms, with compelling evidence of potential to elicit robust support from broad private, philanthropic, and public funding sources over time.

The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.

The Alliance for Innovation on Maternal Health (AIM) Capacity Program aims to enhance the capacity of state, territorial, and Tribal entities in the U.S. to implement and sustain AIM Patient Safety Bundles. By promoting evidence-based maternal safety practices, the program strives to improve the quality of maternity care, enhance maternal health outcomes, and significantly reduce preventable maternal mortality and severe morbidity.

About

A History Of Making Waves

Carnival Foundation oversees the many philanthropic endeavors of Carnival Corporation as well as its employee-driven service group, the “Friends Uniting Neighbors” (F.U.N.) Team.

Carnival Foundation’s contributions are widespread, touching the communities where the brands visit and operate. From the cities where our brands are headquartered to ports we visit around the world, we endeavor to make a difference to the lives of many.

Through monetary and in-kind donations, innovative philanthropic programs, employee fundraisers and hands-on volunteer initiatives, Carnival Foundation and the brands of Carnival Corporation support a variety of organizations. Whether it’s providing meals to the homeless and abuse prevention or working toward medical advancement and educating youth, Carnival Foundation’s reach is communitywide.

In-Kind Donations

To apply for an in-kind donation from Carnival Foundation, submit an online application complete with the following information:

• A letter of request with a brief description of the organization including its legal name, history, activities, purpose and governing board
• Contact name and information, including phone number and address for the individual who is organizing the event
• Name and date of the event
• Average amount of funds raised from the auction in previous years and estimated number and demographics of the event audience
• Description of how funds raised from the donation will be used within the organization
• List of other cruise suppliers, if any, participating in the event
• An outline with details of Carnival’s publicity/promotional opportunities associated with the event
• Copy of Internal Revenue Service determination letter indicating 501© (3) tax-exempt status as an organization that is not a private foundation.
• Copy of organization’s most recent 990 filed with the Internal Revenue Service
• Geographical area(s) served

The Eastern Bird Banding Association is offering the Memorial Fund Research Grants to support research utilizing avian marking techniques, such as banding. Applicants must submit a detailed project proposal, including significance and budget, alongside their background in ornithology. Grants are open to all, particularly encouraging student applications, with no lifetime award limit per individual. Projects must focus on species within EBBA territory, ensuring marking techniques are integral to the research.

The National Institutes of Health is launching a funding opportunity to explore the mechanisms of skin injuries caused by toxic chemicals. This initiative aims to understand the common pathways of injury from various harmful substances, facilitating the discovery of therapeutic targets. Researchers are encouraged to collaborate and apply their expertise in cutaneous wound healing. The goal is to develop broad-spectrum medical countermeasures for mass casualty events involving toxic exposures, enhancing public health safety.

The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to enhance the research careers of residents and fellows focused on radiation oncology, specifically benefiting lung cancer patients. This initiative supports basic, translational, and clinical research endeavors. With a maximum award amount of $50,000 for one year, it provides essential funding to foster innovative projects that can lead to significant advancements in lung cancer treatment.

The Resident Opportunity and Self-Sufficiency Service Coordinator (ROSS-SC) Program for Fiscal Year 2026 aims to empower residents of Public and Indian Housing by addressing barriers to economic self-sufficiency. Through grant funding from HUD, Service Coordinators assess individual needs, linking residents to educational, professional, and health resources. This support enables participants to achieve financial stability and independence, facilitating their journey towards self-sufficiency and enhancing their quality of life.

The MIND Prize, funded by The Pershing Square Foundation, supports innovative research to combat neurodegenerative diseases like Alzheimer's. It empowers early-to-mid-career investigators to explore unconventional approaches and fosters collaboration across disciplines. Each winner receives $250,000 annually for three years, promoting advancements in neuroscience and creating a unique network for researchers. The initiative aims to enhance our understanding of brain health and tackle pressing societal challenges.

The Mishler Brown Fund Grant, managed by the Community Foundation of Elkhart County, supports nonprofits dedicated to agriculture and historic preservation. Applications are accepted annually from October 1 to December 31, with funds awarded in January. Organizations must have a 501(c)(3) status but do not need to be located in Elkhart County. The fund honors Helen Mishler's legacy by preserving farming heritage, including her family's historic homestead.

The Native Performing Arts Live Production Grant (LPG) supports Native artists and organizations in staging live performances, fostering cultural expression. With a $30,000 grant for one year, this initiative prioritizes projects that actively engage Native performers, enhancing their artistic skills and community connections. By addressing the unique needs of Native creators, the program aims to empower them with resources, mentorship, and equitable opportunities in the performing arts landscape.

The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.

The Bank of America Charitable Foundation focuses on improving economic mobility and social progress through partnerships with nonprofits. It prioritizes basic needs, income creation, stable housing, and community empowerment. By supporting vulnerable populations, the foundation aims to enable individuals to achieve their goals and contribute positively to their communities. The foundation emphasizes sustainable progress, ensuring that all community members have access to essential resources and opportunities for growth.

Our Mission

Empower donors to fulfill their passions and dreams by establishing charitable vehicles designed to create a positive and enduring impact on Jewish Buffalo, Western New York and the World.

Geoff Richter Performing Arts Award

The Geoff Richter Performing Arts Award Committee announces the availability of an Award up to $2,000! The GRPAA was founded in memory of Geoff Richter, Western New York Musician and Educator of the Arts.

About Geoff Richter

A native of Eden, New York, Geoff received his Bachelor of Music degree with a Performer’s Certificate in trumpet and a Master’s with a Performers Fellowship, from the Eastman School of Music.

Geoff played trumpet professionally with the Rochester, San Antonio, and Buffalo Philharmonic Orchestras and Niagara Falls, Binghamton, Chautauqua, Orchard Park, Clarence, Cheektowaga, and Amherst Symphony Orchestras. He co-founded the Buffalo Brass Quintet, the Buffalo Niagara Concert Band, and The Frankfurters, an internationally known Bavarian show band. He also acted as the summer/pops conductor of the Erie County Wind Ensemble and the Amherst Symphony Orchestra.

After retiring from a long career at Williamsville North High School, Geoff started working part time as director of the orchestra for musicals at St. Joseph Collegiate Institute. He also worked with the Mount Saint Mary Academy band and recruited and directed the orchestra for the annual school musical.

The National HIV Behavioral Surveillance (NHBS) aims to conduct ongoing bio-behavioral surveillance among populations disproportionately affected by HIV. This initiative collects vital data on behavioral risk factors, testing behaviors, and the use of prevention strategies. Participants are offered HIV tests and linked to necessary services, with findings utilized to improve local and national HIV prevention programs. By assessing trends in risk factors, NHBS informs tailored responses and enhances access to prevention services.

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story – Joest, Brian H. Memorial Fund

Brian Henry Joest was born in Lagrange, Indiana in 1957. He grew up on the Atwood family farm that was settled by his ancestors in the mid-1800s. Now a historical Hoosier Homestead, the Atwood Farm provided him with all the outdoor activities possible for a farm boy in northern Indiana. Brian’s love of nature and the outdoors continued throughout his life. After high school, he attended Glen Oaks Community College and then Purdue University, where he earned a Bachelor of Science degree in Agricultural Economics

For decades, Brian went on annual backcountry camping and canoeing trips across the US and Canada. He paddled some of the most beautiful rivers in North America. He took a road trip to remote northern Alaska. He camped out on an active volcano in Guatemala. He explored most of the US National Parks. In his later years, his travels were less rustic but still adventurous as he and his wife, Cindy, checked off many items on his bucket list. They traveled to Paris, Rome, Florence, the Amalfi Coast of Italy, Ireland, and all around the US and Canada.

Brian began his professional career with management positions at Many Glacier Hotel at Glacier National Park in Montana; the Grand Hotel on Mackinac Island, Michigan; the Mountain View Grand Resort in New Hampshire; and Copper Mountain Ski Resort in Colorado. He also worked for Marriott Corporation where he opened new hotels across the Midwest.

Upon the birth of his first child, Brian moved his young family back to Lagrange County so his children could grow up on the Atwood Farm near their family. Brian worked for Life Care Center of Lagrange, was a substitute teacher for the Lakeland School District, and worked for fifteen years for East Noble School Corporation, most recently as an Instructional Assistant for high school students with special needs.

Brian enjoyed doing things for other people and took so much joy in their happiness. His career choices reflected his servant’s heart. He loved working in the hospitality industry and being able to make someone else’s vacation more memorable. He helped the patients and their families at Life Care Center. He spent years making a difference for students in our local schools.

Brian experienced first-hand the unique challenges faced by the families of individuals with special needs. He was a father, stepfather, and step-grandfather to children with different disabilities. He understood the difficulties of navigating support systems and knew there are gaps in these systems that result in unmet needs. At the end of his life, while he was fighting cancer, Brian dreamed of being able to return to the classroom to help special needs students. This was not to be. In 2022, his family created this fund in his honor with the intent of continuing his dream to help improve the lives of individuals with special needs.

The Little Giraffe Foundation is dedicated to supporting neonatal health through research grants ranging from $5,000 to $10,000. Since 2011, they have provided substantial resources to hospitals and institutions, focusing on both immediate and long-term health challenges faced by premature infants. Eligible applicants include scientists and healthcare professionals from U.S.-based institutions. The foundation aims to advance research in biological processes, genetics, clinical studies, and more, improving outcomes for vulnerable populations.

The Little Giraffe Foundation, a national non-profit based in Chicago, provides NICU Support Grants ranging from $100 to $1,000. Since 2011, they have positively impacted countless families by delivering over 32,000 gift bags and funding essential research. These grants aim to enhance the experience for parents and patients in neonatal intensive care units, supporting initiatives like holiday gift bags and resources for bonding with babies. Applications are welcomed from eligible U.S.-based institutions.

The United States Adult Cystic Fibrosis Association (USACFA) offers a Higher Education Scholarship, honoring Lauren Melissa Kelly. This scholarship awards up to $2500 to two adults with cystic fibrosis pursuing various educational paths. Applicants must show proof of enrollment for the relevant academic year and can cover education-related costs, including tuition and materials. This initiative not only supports education but also commemorates Lauren's legacy, inspiring others to pursue their dreams despite challenges.

The NIDCD Mentored Research Education Pathway (R25) aims to enhance research education for otolaryngology residents and medical students. This program provides essential career development activities and mentored research experiences, fostering a new generation of researchers in biomedical and clinical sciences. By focusing on specialized training, it supports the recruitment of individuals from diverse backgrounds into impactful research careers, ultimately benefiting the field of otolaryngology and related health sciences.

The NIAID is focused on advancing the research and development of next-generation malaria vaccines, aiming to leverage innovative vaccine design techniques. This initiative not only aims to enhance malaria prevention but also serves as a model for combating other mosquito-borne diseases. By utilizing cutting-edge methods such as structure-based immunogen design and combination vaccines, the program seeks to significantly reduce both parasite infection rates and the overall disease burden associated with malaria.

The FY26 DoW Pancreatic Cancer Research Program Focused Pilot Award aims to drive innovative and impactful research in pancreatic cancer, enhancing patient quality of life. This award encourages the development of preliminary data to support future clinical or real-world applications. While allowing for clinical research studies, it does not permit clinical trials or preclinical animal studies, ensuring a strong patient-centered approach in its research focus.

The FY26 Pancreatic Cancer Research Program (PCARP) Translational Research Partnership Award encourages collaboration among clinicians and scientists to expedite the clinical application of innovative pancreatic cancer research. A minimum of two Principal Investigators is required, with one designated as the Initiating PI. This award supports preliminary data collection and various research methodologies, excluding large-scale clinical trials, to enhance pancreatic cancer understanding and treatment.

The Allergic Respiratory Diseases Award, supported by the American Lung Association and the American Academy of Allergy, Asthma & Immunology, aims to bolster research in allergic respiratory diseases. Designed for faculty in Clinical Allergy and Immunology at academic medical centers, this award offers $75,000 annually for up to two years. It seeks to empower researchers at pivotal points in their careers, enhancing understanding and treatment of these conditions while promoting lung health.