Best Large Grants for Nonprofit Organizations in South Carolina

The Lead-Safe and Healthy Homes Financing Demonstration aims to allocate approximately $10 million for a National Fund Manager to create a national platform that pools public and private capital. This initiative seeks to reduce residential lead exposure, particularly for children, and enhance housing-related health conditions in low-income communities. By leveraging public funds and encouraging private investments, the fund will support local financing programs addressing lead-safe and healthy homes activities effectively.

The Lead Hazard Reduction Grant Program aims to protect children under six from lead poisoning by funding comprehensive programs that identify and control lead-based paint hazards in eligible housing. This initiative supports states, Native American Tribes, and local governments to undertake necessary actions. Additionally, Healthy Homes Supplemental funding is available to address other health-related housing hazards, ensuring a holistic approach to occupant safety in homes affected by lead hazards.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Fruit of the Vine Scholarship

The Fruit of the Vine Scholarship Fund benefits graduating Napa County high school seniors and Napa Valley College transfer students who will find the cost of higher education a financial hardship. Consideration is given to applicants who are the first in their family to attend college or are employed (or have a parent or guardian who is employed) in the Napa County wine or grape industry. Recipients of the scholarship will receive funding for up to four years of undergraduate study.

The Ryan White HIV/AIDS Program Part B AIDS Drug Assistance Program Training and Technical Assistance aims to enhance the capacity of ADAPs. By providing essential tools and expert guidance, the program seeks to improve health outcomes for individuals living with HIV in an evolving healthcare landscape. This initiative is funded by the US HHS through the Health Resources & Services Administration, ensuring support and resources are effectively allocated to meet the needs of vulnerable populations.

This project aims to enhance health outcomes for women living with HIV in the South by integrating HIV care with comprehensive women's health services through coordinated Clinic and Community Collaboratives. By funding organizations to implement targeted strategies such as culturally responsive services and learning collaboratives, the initiative seeks to improve access to essential health services, increase the number of women initiating rapid ART, and foster sustainable healthcare models that address the unique needs of this population.

The Store-Based Giving Program by Ross Stores Foundation supports socioeconomically disadvantaged youth by providing gift cards for school or professional clothing. Organizations must be federal tax-exempt and serve at least 60% low-income youth. Eligible programs include academic achievement and life skills initiatives. Award amounts typically range from $300 to $500, depending on budget and mission alignment. Applications are not accepted from organizations that have received donations within the past 12 months.

The Metropolitan Water District of Southern California's Innovative Conservation Program (ICP) has funded innovative water savings projects since 2001, with $250,000 available biannually. The program aims to evaluate and demonstrate the reliability of new water-saving technologies. Nearly 400 proposals have sought $36 million in funding. The ICP, supported by multiple agencies, encourages projects that can benefit Southern California's water efficiency, inviting proposals from outside its service area to enhance regional water management.

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

The Alcohol Research-Related Resource Award (R24 Clinical Trial Not Allowed) aims to support investigator-initiated resources that enhance biomedical research on a national level. Through this non-hypothesis-driven grant, essential data, materials, and services will be provided to facilitate progress in the alcohol research community. The resources must be available to qualified investigators and should not replicate existing commercial offerings, ensuring high-quality and cost-efficient support for diverse research activities.

The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.

The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.

The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.

The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Affordable Housing and Supportive Services Demonstration (AHSSD) aims to enhance housing stability and well-being for American citizens residing in affordable housing. By funding Community Action Agencies and tribes, the initiative fosters public welfare engagement and service enrollment. The program addresses diverse needs, offering referrals, case management, and direct services in education, childcare, mental health, and more, ultimately supporting economic mobility and reducing dependency among vulnerable populations.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a funding opportunity for Exploratory Clinical Trials Grants. This program aims to support innovative clinical trials that enhance the understanding and treatment of arthritis and other musculoskeletal and skin conditions. Research proposals should focus on early-stage trials, including first-in-human studies, dose-finding, and biomarker evaluation. The initiative encourages the translation of promising laboratory findings into effective clinical practices, ultimately improving patient outcomes.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is inviting applications for the Clinical Trial Cooperative Agreement Program. This funding opportunity supports investigator-initiated, interventional clinical trials at various phases. Initial funding will facilitate the preparation needed to start trials, with successful milestones leading to further support. NIAMS emphasizes hypothesis-driven trials that promise significant clinical impact within its research mission.

The NATIVE Act Tribal Tourism Cooperative Agreement aims to enhance cultural heritage tourism through collaboration with Tribes, Tribal organizations, and Native Hawaiian organizations. By providing technical assistance and capacity-building support, this initiative seeks to increase visitation and enrich tourism activities while respecting native traditions and values. The selected recipient will coordinate with federal agencies to ensure effective implementation, with funding available for an initial year and potential continuation for up to five years based on performance.

The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.

The Limited Competition NOFO aims to provide ongoing support for specific pathogen-free (SPF) macaque colonies that facilitate vital HIV/AIDS research. Only recipients funded under previous ORIP-supported SPF colony announcements are eligible to apply. These breeding colonies are crucial for maintaining SPF macaques, which are free from certain viruses that could jeopardize research outcomes. The project emphasizes the genetic characterization of macaques to enhance understanding of immune responses related to HIV and SIV.

The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.

The OVW Fiscal Year 2026 Tribal Sexual Assault Services Program provides crucial support to Indian Tribes and organizations in addressing sexual assault through intervention and advocacy. This program aims to assist victims of all ages, including youth and children, as well as their families and those affected by the trauma, except for perpetrators. Applications must be submitted by September 3, 2026, at 4:59 PM ET in JustGrants.

The Cardiovascular & Pulmonary Research Grants aim to support impactful research that enhances cardiovascular and pulmonary health through physical therapy interventions. This grant emphasizes studies that assess patient characteristics, improve health outcomes, and address disparities. Research proposals must align with the 2023 APTA Research Agenda and prioritize clinical relevance, employing various investigative designs. The goal is to foster innovative approaches that significantly reduce cardiovascular disease risks and improve patient care in the U.S.

The Tribal Transportation Safety Strategy Pilot Program, funded by the Office of the Assistant Secretary for Research and Technology, aims to address high traffic fatality rates among American Indian and Alaska Native populations. With a $2 million budget over three years, the program will create a university-led consortium to develop a strategic safety plan using artificial intelligence for risk analysis, culminating in a pilot project that showcases effective safety infrastructure in a Tribal community.

The Hearing Health Foundation's Emerging Research Grants (ERG) program supports innovative research in hearing and balance, providing up to $50,000 per year for promising projects. Since 1958, it has fostered early-career researchers and led to significant advancements in the field. Eligible applicants must be affiliated with U.S. institutions and hold relevant advanced degrees. The program emphasizes underfunded areas and encourages applications that expand knowledge and research capabilities in hearing health.

The TACF External Grants Program aims to support research on American chestnut restoration, with funding opportunities available for projects up to $50,000. The program encourages proposals addressing various priority research areas, including gene product investigations, pathogen interactions, and ecological studies. Grants cover one year of funding, with the possibility of extending for up to five years. Applicants must be in good standing and demonstrate matching fund support. Note: The program is on hiatus in 2025.