Best Large Grants for Nonprofit Organizations in South Carolina

The Sidney R. Baer, Jr. Foundation focuses on improving the lives of individuals with schizophrenia and bipolar disorder through education grants. By funding programs that enhance educational opportunities, the foundation aims to reduce isolation and promote understanding. Grants are awarded to qualified organizations that prioritize mental health initiatives, ensuring that those affected have access to the resources and support necessary for a better quality of life. The foundation's mission is rooted in the belief that education can be transformative for those facing mental health challenges.

The ALA Spectrum Scholarship Program offers a one-time $5,000 scholarship to support diverse students pursuing graduate education in library and information studies. Recipients must enroll in an accredited program by fall, receiving funds in two installments. This initiative, supported by the American Library Association, enhances opportunities for over 800 past scholars through mentoring, networking, and professional development, fostering leadership within the library profession across North America.

The Louis N. Cassett Foundation provides grants to support a variety of charitable endeavors, particularly focusing on organizations in the Philadelphia and South Florida areas. As a private foundation operating under Section 501(c)(3) of the Internal Revenue Code, it empowers tax-exempt organizations to apply for funding. The Foundation does not impose religious affiliation requirements on recipients, ensuring that support is inclusive and aimed at a broad range of charitable, cultural, and educational projects.

About

Created by the community for the good of the community, the GLCCF is here to turn problems into opportunities through strategic grant making and initiatives created to address our region’s most pressing needs. We work with you to identify your charitable goals, and we ensure that they are carried out efficiently.

Work with us to make the kind of impact you want to see in your community. Let us take on the financial complexities and paperwork, while you focus on the important things like fostering good works throughout our community.

When you give to the Greater Lake City Community Foundation, you are making an investment that will benefit the community, now and in the future.

GLCCF Schreck Family Soccer Scholarship

To award annually a scholarship to a qualified applicant who intends to pursue education toward a 4-year college degree.

About Us

We are a philanthropic organization committed to catalyzing the impact of social entrepreneurs who are expanding access and opportunity in America. 

At New Profit, we partner with social innovators, philanthropists, and other impact leaders who are creating a more inclusive and prosperous America. We invest in and support leaders and organizations that are transforming our education, economic, and democratic systems. And we are guided by the belief that those who are most proximate to the communities we serve are the best positioned to develop effective and sustainable solutions.

We seek and support leaders and organizations with scalable solutions that match the size of the problems we face and expansive visions that match the scale of our ambitions for America.

Connected Futures Cohort Grant

New Profit is launching Connected Futures, a Catalyze cohort for organizations that bridge divides and bring people together to solve problems collectively. Submit a Discovery Form to signal your interest and to be considered to submit an application for this funding cycle. 

New Profit’s Catalyze cohorts support innovative social impact organizations expanding access and opportunity in America. This model brings together cohorts of organizations with similar focus areas and stages, providing each with a one-year $100,000 unrestricted grant, a $10,000 grant for leadership development, and strategic advisory support.

Social Entrepreneurs* participate in a year-long cohort experience designed to build community, facilitate peer learning, and provide capacity-building support, including workshops on topics such as board development, fundraising, scenario planning, and storytelling. 

About Connected Futures

Connected Futures is a new Catalyze cohort for organizations that help people move across active divides to take action toward common goals. We are looking for organizations that build trust, strengthen collaboration, and create ways for people to act together when mistrust, polarization, exclusion, or disconnection would otherwise keep them apart and prevent them from solving problems together.

These organizations may work in the health, economic mobility, democracy, and/or education sectors. What connects them is not a single issue area, but a common approach to bridgebuilding: creating the relationships, skills, and structures people need to work together toward positive change.

Catalyze cohorts are at their best when cohort members are fully engaged. The Social Entrepreneurs that lead selected organizations are expected to participate in the Catalyze support model and peer learning community in the following ways:

• Social Entrepreneurs attend three in-person convenings, each of which are held over 3-4 days in cities across the United States. Convening dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs attend three virtual learning sessions, each lasting 2-3 hours. Webinar dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs engage with the New Profit team via 1:1 strategic advising, including a minimum of six virtual sessions over the yearlong cohort.
• Entrepreneurs receive a $10,000 stipend specifically to support their own leadership development goals.
• Programming requires a commitment of 6-8 hours per month on average. New Profit covers the cost of travel, accommodation, and meal expenses for each in-person convening.

The Impact Fund provides recoverable grants to legal services nonprofits and small law firms working on social, environmental, and economic justice issues. With over $10 million awarded since 1992, the fund supports impactful litigation addressing systemic injustices. Grants range from $10,000 to $50,000 and prioritize cases directly involving affected communities. Recipients must repay the grant amount with interest if they recover fees or costs, ensuring sustainability for future funding.

The CAPTRUST Community Foundation provides Crisis Grants to support nonprofit organizations aiding families impacted by natural disasters or emergencies. By dedicating over 10% of its annual budget for crisis assistance, the foundation ensures that funds directly benefit those in need. Grants can be requested up to $5,000 to help rebuild lives during challenging times, reflecting the foundation's commitment to integrity and support for children and families in crisis.

The Ruth Abernathy Presidential Scholarship is awarded annually by SHAPE America to honor outstanding undergraduate and graduate students in health and physical education. Established in 1995, this scholarship supports three undergraduate and two graduate recipients. Candidates must be SHAPE America members, majoring in relevant fields, and demonstrate academic excellence and leadership. In addition to financial support, recipients receive a three-year membership to SHAPE America, fostering a commitment to health education and physical activity.

The Cyrus M. Quigley Foundation Grant supports tax-exempt organizations that empower young people through initiatives focusing on courage, self-reliance, and service. Since its inception in 1993, the foundation has awarded over $300,000 in grants, with amounts ranging from $1,000 to $7,500. The foundation emphasizes physical challenges and community service to help develop essential life skills. Grant proposals are accepted annually until the third Friday in April, with decisions communicated by May 31.

The PTA Connected: Be Internet Awesome program, sponsored by Google and YouTube, aims to empower elementary and middle schools by providing $1,500 in funding to 50 local PTAs. This initiative fosters engaging discussions among parents about digital safety and well-being, while educating children on responsible online behavior. The program emphasizes the importance of digital citizenship, equipping kids with the necessary skills to navigate the online world confidently.

The Firehouse Subs Public Safety Foundation Scholarship Program supports students aiming to enroll in firefighter, law enforcement, or emergency medical programs at accredited institutions. Established in 2005, the foundation provides $5,000 scholarships to eligible candidates, including high school seniors and current college students. The program emphasizes commitment to public safety and community service, assisting those pursuing careers as first responders. This initiative highlights the foundation's dedication to enhancing lifesaving capabilities within local communities.

The AES Hawaiʻi Foundation Grant supports communities near AES Hawaiʻi’s renewable energy projects, focusing on social justice, education, environmental stewardship, and community health. Preference is given to nonprofit organizations in these areas, but statewide entities may also apply. Successful projects should align with the Foundation’s impact pillars, demonstrate measurable community benefits, and address unmet needs, ensuring long-term positive effects on the local community.

The Tribal Solar Accelerator Fund (TSAF) empowers tribal communities across the U.S. by promoting renewable energy projects and workforce development. Launched by GRID Alternatives, TSAF provides critical funding for solar initiatives, enhancing energy sovereignty and resilience. Since its inception, TSAF has integrated community participation into its projects, ensuring that tribes can access sustainable energy solutions. By prioritizing education and equity, TSAF supports a transition to a clean energy economy, aiming for a sustainable future for generations to come.

The Park Foundation Grants for the Environment focus on ensuring clean and accessible drinking water while opposing shale gas extraction and infrastructure expansion. They fund diverse initiatives aimed at promoting sustainable practices and policies, particularly within New York State. The Foundation supports advocacy, organizing, and corporate responsibility efforts that align with their mission to foster a just and sustainable environment, empowering communities to protect their natural resources.

OneRural provides essential technical assistance to rural organizations, fostering the development of affordable housing and community initiatives. This program offers tailored support, helping organizations enhance their operational capabilities and drive impactful change. By accessing expert resources and training, participants can effectively navigate challenges, improve program outcomes, and strengthen community resilience. This initiative targets nonprofits and tribal entities, ensuring that rural communities receive the guidance needed for sustainable growth and development.

The Herman J. and Helen D. Wyngarden Memorial Scholarship, offered by the Grand Haven Area Community Foundation, supports students from Northern Ottawa County or local high schools. Established in memory of dedicated educators, this scholarship encourages academic advancement beyond high school. Eligible applicants should provide transcripts and relevant documents, with preference given to those pursuing economics or medicine. This competitive scholarship aims to honor the legacy of the Wyngardens while empowering future leaders.

The CHEERS Open Period 1 invites white papers focused on enhancing operational medicine and support for Airmen and Guardians. Managed by the Air Force Research Laboratory and USAFSAM, this opportunity aims to address future demands in Aerospace Medicine, Occupational Health, and Public Health. Proposals should align with the objectives outlined in the Continuing Human Enabling, Enhancing, Restoring and Sustaining announcement. This initiative emphasizes innovative solutions to support the Department of Defense's mission.

The AAO-HNSF/ANS Herbert Silverstein Otology/Neurotology Research Award supports innovative clinical or basic science research focused on auditory and vestibular diseases. Established by Herbert Silverstein, MD, this award aims to assist young academic investigators in launching new projects. Since 2000, it has funded seven grants totaling $175,000, emphasizing projects with clear clinical relevance and potential for future funding. Applicants must demonstrate commitment to research and secure institutional support, with a priority for junior faculty and fellows.

The AAO-HNSF Percy Memorial Research Award offers $25,000 for one year to support innovative research projects in otolaryngology-head and neck surgery. This grant aims to fund projects with clinical significance, encouraging the development of new long-term research initiatives. Applicants must submit a detailed budget and secure letters of support from their Department Chair and key personnel involved in the project. Funds cannot cover salaries or purchase equipment exceeding $500.

The Yawkey Foundation's Transformational Capital Grant provides significant funding, up to $5 million, for nonprofit organizations to enhance their mission delivery through the development of impactful physical spaces. The grants are highly competitive and require compelling proposals demonstrating project need, community support, and financial commitment. Organizations must align with the Foundation's priority Areas of Giving, primarily serving Eastern Massachusetts and Georgetown County, South Carolina. Review timeframe for proposals is approximately 12-18 months.

The VIA Art Fund provides Artistic Production Grants to support innovative artistic commissions for public spaces. These grants, ranging from $25,000 to $100,000, are awarded twice a year to artists and organizations that exemplify artistic excellence and public engagement. Projects must have a confirmed exhibition venue, ensuring artworks reach diverse audiences and foster meaningful community experiences beyond traditional gallery settings.

The Yawkey Foundation's Strategic Investment Grant supports nonprofit organizations aiming for strategic growth through board-approved plans. Grants, ranging from $250,000 to $1 million, may fund regional expansions, collaborative efforts among nonprofits, and organizational mergers. Initial Proposals are highly competitive and must demonstrate strong leadership, proven impact, and alignment with the Foundation's Areas of Giving. Review periods for proposals can take 6-12 months, during which feedback is not provided.

The Community Traffic Safety Grants, initiated by the Road to Zero Coalition, aim to eliminate traffic fatalities by 2050 through innovative, evidence-based approaches. The program invites proposals from Road to Zero Coalition members, particularly non-profits and government entities, to implement effective countermeasures that enhance traffic safety and address mobility disparities. Projects should be replicable and scalable, demonstrating measurable outcomes and contributing to a positive safety culture on U.S. roads.

The OneAmerica Financial Community grant supports 501(c)(3) organizations focused on education, workforce development, safety, wellness, and community vibrancy. With a commitment to making a difference, OneAmerica aims to transform lives through strategic philanthropy. Their initiatives include disaster relief, arts support, and civic engagement, fostering resilient communities. By investing in meaningful change, they build a foundation for shared success across the country, ensuring that community needs are met and future generations thrive.

The Ray Rowe Trusts for Animals Grant provides funding for programs aimed at the welfare of animals, particularly dogs, and the protection of wildlife habitats, especially for canid species. There are no application deadlines; grants are distributed from early March until the year's funding is exhausted, typically by the end of November. To apply, organizations must hold 501(c)(3) status, while general administrative costs are generally not supported.

The Ray and Sue Barrett Scholarship, offered by the Grand Haven Area Community Foundation, supports high school seniors in the Tri-Cities pursuing higher education in law, criminal justice, mental health, social work, or psychology. Established in honor of Ray and Sue Barrett, who valued education and mental health, this scholarship considers financial need and requires a minimum 2.5 GPA. Applicants must submit transcripts and relevant documents to qualify.

The Audrey L. Wright Scholarship, offered by the Grand Rapids Community Foundation, supports undergraduate students who are long-term residents of Kent County. This scholarship is aimed at those pursuing education or language studies and requires a minimum GPA of 3.0. By removing barriers to academic success, it empowers local students to achieve their educational ambitions and contributes to a thriving and inclusive community in West Michigan.