Best Large Grants for Nonprofit Organizations in South Carolina

The Park Foundation Grants for the Environment focus on ensuring clean and accessible drinking water while opposing shale gas extraction and infrastructure expansion. They fund diverse initiatives aimed at promoting sustainable practices and policies, particularly within New York State. The Foundation supports advocacy, organizing, and corporate responsibility efforts that align with their mission to foster a just and sustainable environment, empowering communities to protect their natural resources.

The Kenneth Rainin Foundation seeks to promote innovative research in Inflammatory Bowel Disease (IBD) by encouraging diverse perspectives from early career investigators and those underrepresented in science. The Innovator Awards do not require preliminary data and are evaluated based on the potential for innovation and scientific merit. Eligible researchers must hold advanced degrees and can apply for funding through their home institutions, fostering groundbreaking ideas that can transform IBD treatment and prevention.

The Northrop Grumman Corporation Graduate Education Scholarship, part of the Graduate Education Fund, supports Australian students pursuing graduate-level studies in the USA. Offering up to $40,000 for one year, it is aimed at fields such as Artificial Intelligence, Quantum Physics, and Aerospace Engineering. Eligible candidates must be Australian citizens or permanent residents and have a formal offer from an accredited American institution. This scholarship promotes academic exchange and fosters international collaboration in specialized disciplines.

The SHAPE America Major of the Year Award recognizes exemplary undergraduate students in health, physical education, recreation, and dance. This prestigious accolade aims to highlight nominees who demonstrate academic excellence and commitment to service within their communities. Faculty members from colleges and universities are encouraged to nominate one outstanding student per major, ensuring that the next generation of health educators is celebrated for their achievements and contributions to the field.

The Fiscal Year 2026 Wildlife Crossings Pilot Program aims to enhance public safety by reducing wildlife-vehicle collisions and improving habitat connectivity for various species. With approximately $80 million available through cost reimbursable grants, this initiative supports eligible projects that address these critical environmental and safety concerns. The program may also distribute leftover funds from previous years, contingent on availability, fostering innovative solutions in wildlife management and transportation safety.

The AAO-HNSF Percy Memorial Research Award offers $25,000 for one year to support innovative research projects in otolaryngology-head and neck surgery. This grant aims to fund projects with clinical significance, encouraging the development of new long-term research initiatives. Applicants must submit a detailed budget and secure letters of support from their Department Chair and key personnel involved in the project. Funds cannot cover salaries or purchase equipment exceeding $500.

The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) program invites applications to enhance communication and collaboration among researchers in digestive and liver diseases. Funded by the NIDDK, DDRCCs focus on shared resources that foster productivity and innovative research ideas. Each center must revolve around a central theme aligned with the NIDDK's mission, ensuring effective research support while avoiding overlap with other NIH Institutes' funding areas.

The Oklahoma City Community Foundation administers the Kirschner Trusts, established to honor Phil and Roberta Kirschner's philanthropic legacy. These trusts focus on supporting young individuals with disabilities, Muskogee nonprofits, and Jewish causes. Since their transfer to the foundation in 2013, the trusts have continued to provide vital grants to organizations that align with the Kirschners’ values, ensuring their charitable impact persists in the community.

The Audrey L. Wright Scholarship, offered by the Grand Rapids Community Foundation, supports undergraduate students who are long-term residents of Kent County. This scholarship is aimed at those pursuing education or language studies and requires a minimum GPA of 3.0. By removing barriers to academic success, it empowers local students to achieve their educational ambitions and contributes to a thriving and inclusive community in West Michigan.

The AAO-HNSF/ANS Herbert Silverstein Otology/Neurotology Research Award supports innovative clinical or basic science research focused on auditory and vestibular diseases. Established by Herbert Silverstein, MD, this award aims to assist young academic investigators in launching new projects. Since 2000, it has funded seven grants totaling $175,000, emphasizing projects with clear clinical relevance and potential for future funding. Applicants must demonstrate commitment to research and secure institutional support, with a priority for junior faculty and fellows.

The Turtle Trackers - Linda Zambelli Family Scholarship Fund, established in 2025 by the Turtle Trackers Board, honors Linda Zambelli's legacy through scholarships for students pursuing higher education in Marine Biology and Environmental Sciences. This initiative supports high school seniors from Beaufort and Jasper Counties, ensuring they have opportunities to excel academically while fostering a commitment to marine conservation. The fund is managed by the Community Foundation of the Lowcountry, which has invested over $125 million in local communities.

The Herman J. and Helen D. Wyngarden Memorial Scholarship, offered by the Grand Haven Area Community Foundation, supports students from Northern Ottawa County or local high schools. Established in memory of dedicated educators, this scholarship encourages academic advancement beyond high school. Eligible applicants should provide transcripts and relevant documents, with preference given to those pursuing economics or medicine. This competitive scholarship aims to honor the legacy of the Wyngardens while empowering future leaders.

The EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows program, funded by the National Science Foundation (NSF), aims to enhance research capacity and workforce development in STEM. This initiative fosters collaborations between underrepresented researchers and leading institutions, providing essential resources and support. With two tracks available—one focusing on NSF and the other on NASA—this program uniquely positions Fellows to leverage transformative research experiences and contribute to sustainable advancements in their respective fields.

About

Created by the community for the good of the community, the GLCCF is here to turn problems into opportunities through strategic grant making and initiatives created to address our region’s most pressing needs. We work with you to identify your charitable goals, and we ensure that they are carried out efficiently.

Work with us to make the kind of impact you want to see in your community. Let us take on the financial complexities and paperwork, while you focus on the important things like fostering good works throughout our community.

When you give to the Greater Lake City Community Foundation, you are making an investment that will benefit the community, now and in the future.

GLCCF Schreck Family Soccer Scholarship

To award annually a scholarship to a qualified applicant who intends to pursue education toward a 4-year college degree.

The Environmental Grantmaking Program at the Educational Foundation of America (EFA) aims to support projects that facilitate a transition to a net-zero electricity system. Focused on reducing greenhouse gas emissions, the program emphasizes initiatives that enhance access to affordable clean energy, accelerate regional transitions, and strengthen financial investment in electric utilities. Eligible applicants include 501(c)3 public charities, academic institutions, and government entities committed to sustainable energy solutions.

The Atmospheric and Geospace Sciences Postdoctoral Research Fellowships (AGS-PRF) support early career researchers conducting independent studies in diverse areas such as Atmospheric Chemistry and Space Weather Research. These fellowships, lasting up to 24 months, aim to enhance the research capabilities of promising individuals while fostering interdisciplinary collaboration and leadership within the scientific community. AGS encourages applications from diverse backgrounds to promote inclusivity and equity in geoscience.

The Sidney R. Baer, Jr. Foundation focuses on improving the lives of individuals with schizophrenia and bipolar disorder through education grants. By funding programs that enhance educational opportunities, the foundation aims to reduce isolation and promote understanding. Grants are awarded to qualified organizations that prioritize mental health initiatives, ensuring that those affected have access to the resources and support necessary for a better quality of life. The foundation's mission is rooted in the belief that education can be transformative for those facing mental health challenges.

The Sparkplug Foundation Grant supports innovative projects from early-stage organizations and established non-profits in education, community organizing, and music. The foundation emphasizes community-led initiatives that address systemic injustices and engage marginalized populations. Grants are available for one year and prioritize projects with small budgets that lack extensive funding sources. The foundation encourages applications from diverse communities, particularly those led by Black, Indigenous, People of Color, and LGBTQ individuals, fostering equitable access to resources.

The Tribal Solar Accelerator Fund (TSAF) empowers tribal communities across the U.S. by promoting renewable energy projects and workforce development. Launched by GRID Alternatives, TSAF provides critical funding for solar initiatives, enhancing energy sovereignty and resilience. Since its inception, TSAF has integrated community participation into its projects, ensuring that tribes can access sustainable energy solutions. By prioritizing education and equity, TSAF supports a transition to a clean energy economy, aiming for a sustainable future for generations to come.

The Ray and Sue Barrett Scholarship, offered by the Grand Haven Area Community Foundation, supports high school seniors in the Tri-Cities pursuing higher education in law, criminal justice, mental health, social work, or psychology. Established in honor of Ray and Sue Barrett, who valued education and mental health, this scholarship considers financial need and requires a minimum 2.5 GPA. Applicants must submit transcripts and relevant documents to qualify.

The Ray Rowe Trusts for Animals Grant provides funding for programs aimed at the welfare of animals, particularly dogs, and the protection of wildlife habitats, especially for canid species. There are no application deadlines; grants are distributed from early March until the year's funding is exhausted, typically by the end of November. To apply, organizations must hold 501(c)(3) status, while general administrative costs are generally not supported.

The Hispanic-Serving Institutions Education Grants Program aims to enhance the educational capabilities of HSIs through innovative teaching and community development initiatives. Funded projects will not only serve the Hispanic population but will benefit the entire student body, promoting inclusivity. This program encourages applications that integrate applied research with community outreach, fostering experiential learning opportunities for students. The initiative aspires to set benchmarks for educational excellence at regional and national levels.

This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.

The Cyrus M. Quigley Foundation Grant supports tax-exempt organizations that empower young people through initiatives focusing on courage, self-reliance, and service. Since its inception in 1993, the foundation has awarded over $300,000 in grants, with amounts ranging from $1,000 to $7,500. The foundation emphasizes physical challenges and community service to help develop essential life skills. Grant proposals are accepted annually until the third Friday in April, with decisions communicated by May 31.

Citizen Security Research Initiative

IPA's Citizen Security Research Initiative (CSRI) supports rigorous impact evaluations, pilot studies, infrastructure and public goods projects, and foundational and contextual research to inform policies and programs on building safer communities and strengthening justice and law enforcement systems. Funding for CSRI comes from the United States Department of State's Bureau of International Narcotics and Law Enforcement Affairs (INL).

Supported projects will generate actionable evidence to inform policy and programming in the citizen security and justice sector, with a focus on studies that challenge common beliefs, pioneer innovative interventions, and produce evidence where little currently exists. Priority areas of research include:

• Countering organized crime
• Combating drug trafficking and production
• Preventing crime and violence
• Strengthening law enforcement and criminal justice institutions

Budgets are expected to adhere to the budget caps outlined in our Call for Proposals (US$75,000 for pilots, US$400,000 for full impact evaluation studies, US$250,000 for infrastructure and public goods creation projects, US$75,000 for foundational and contextual research projects). In recognition that research in some locations or with some populations is more costly, on a case-by-case basis, we will consider budgets over the above award maximums with appropriate justification.

Awards are normally paid on a cost-reimbursable basis.

The Ruby Bridges Walk to School Day Mini-Grant supports events that honor civil rights activist Ruby Bridges by encouraging students to walk to school and engage in discussions about activism, anti-racism, and anti-bullying. Grants of $500 or $1000 are available based on the number of students reached. This initiative aims to inspire positive changes within communities and promote meaningful dialogue among young people about social justice issues.

The Louis N. Cassett Foundation provides grants to support a variety of charitable endeavors, particularly focusing on organizations in the Philadelphia and South Florida areas. As a private foundation operating under Section 501(c)(3) of the Internal Revenue Code, it empowers tax-exempt organizations to apply for funding. The Foundation does not impose religious affiliation requirements on recipients, ensuring that support is inclusive and aimed at a broad range of charitable, cultural, and educational projects.