Best Large Grants for Nonprofit Organizations in South Carolina

The Cherokee County Community Foundation Grant aims to inspire philanthropy and strengthen the local community by providing funding for projects that address critical needs in areas such as crime and safety, economic development, education, family and youth, and public health. Eligible organizations include 501(c)(3) nonprofits and educational institutions serving Cherokee County, SC. The Foundation prioritizes initiatives that create community gain and improve the quality of life for residents.

The Chronic Pain Medicine Research Grant, offered by the American Society of Regional Anesthesia (ASRA) and Pain Medicine, aims to enhance research in pain medicine, guiding clinical practice and improving patient care. With a funding limit of $200,000, the grant prioritizes studies in areas such as Regional Anesthesia, Outcomes Research, and Patient Safety, encouraging innovative proposals from North American physician members of ASRA.

The Patient-Centered Outcomes Research Institute (PCORI) will announce funding for patient-centered comparative clinical effectiveness research (CER) studies focusing on rare diseases. This initiative encourages collaboration and aims to fill critical research gaps affecting approximately 30 million Americans with rare diseases. Applications can request up to $12 million over five years, including coverage for patient care costs. This funding opportunity is set to open on August 12, 2025, with a focus on addressing pressing patient-centered CER questions.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

The St. Joseph Foundation Grants, administered by the Community Foundation for the Central Savannah River Area, aim to support nonprofit organizations addressing the evolving healthcare needs of individuals in the CSRA. With a commitment to enhancing community health, the foundation prioritizes initiatives related to health service education, medical uninsured populations, and hospice care. Grants are awarded based on a competitive process, ensuring that resources effectively meet local challenges.

The Ralph J. Torraco Fine Arts Scholarship, offered by the UNICO Foundation, awards two $2,500 scholarships to U.S. students studying Fine Arts, including Performing, Visual, or Technical Arts. Eligible applicants must be U.S. citizens with a minimum GPA of 3.0, enrolled full-time in an accredited college, and planning to continue their studies into the 2025-2026 academic year. This scholarship aims to support and promote Italian American culture and heritage through the arts.

The Get Schools Cooking Grant supports medium-sized U.S. school districts in transforming their meal programs from processed to scratch-cooked foods. In partnership with the Chef Ann Foundation, it offers a multi-year journey that includes workshops, assessments, and collaborative planning, with a value of nearly $250,000 per district. Eligible districts must demonstrate commitment to fresh, whole foods, leadership support, and self-operated food service.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

The Solidarity Fund Grant, part of the Black Feminist Fund, aims to empower Black feminist movements by providing essential resources. Acknowledging the historical underfunding of these movements, the fund supports groups led by Black women, girls, and gender-expansive individuals. It focuses on solidarity efforts that foster collaboration and joint campaigns, enabling activists to drive social change. This initiative is crucial for advancing justice, self-determination, and equity within communities, ensuring that Black feminist visions are amplified and sustained.

The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.

The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.

The Research Grants on Improving the Use of Research Evidence program aims to enhance the application of research findings for young people aged 5-25 in the U.S. It offers major grants ranging from $100,000 to $1,000,000 over 2-4 years, focusing on impactful studies and capacity-building for researchers. The foundation encourages collaboration among scholars and practitioners to strengthen research practices and evidence use in various settings.

Shaw's Foundation Grants support nonprofit organizations that enhance community well-being, focusing on hunger, youth education, and health. Eligible organizations must be 501(c)(3) certified and serve specific regions like California and Hawaii. An employee sponsor is mandatory for applications in these areas. The grant review process typically takes about eight weeks, and the foundation prioritizes collaborations with local partners to maximize community impact.

The Student Research Grant in Audiology, offered by the American Speech-Language-Hearing Foundation, supports doctoral students conducting research in clinical and rehabilitative audiology. Up to three grants of $2,000 each are available for eligible students enrolled in accredited programs in the U.S. This initiative honors the legacies of Ira Ventry and Brad Friedrich, who made significant contributions to the field of audiology. Interested candidates must submit proposals for research projects to be initiated in this vital area.

The California Specialty Crop Multi-State Program, established by the California Department of Food and Agriculture, aims to enhance the competitiveness of specialty crops through funding collaborative projects addressing key issues like food safety and marketing. Grants range from $250,000 to $1 million, supporting initiatives that span up to three years. This program emphasizes the importance of specialty crops, including fruits, vegetables, and horticulture, in California's agricultural landscape.

The Grants for Coordination of Tribal Temporary Assistance for Needy Families (TANF) and Child Welfare Services aim to support tribal families at risk of abuse or neglect. This funding encourages innovative projects that enhance case management, supportive services, and prevention strategies. Eligible applicants include federally recognized tribal governments and organizations. ACF prioritizes sustainable systems changes, enabling lasting improvements in the coordination of TANF and child welfare programs to better serve vulnerable tribal families.

The Sex Worker Giving Circle Grant, launched by the Third Wave Fund, prioritizes funding for grassroots movements led by individuals directly impacted by gender oppression, especially within the sex work community. With a commitment to gender justice, the grant supports organizations that operate with a participatory approach to grantmaking, enabling them to address systemic inequalities. In recent years, the fund has distributed significant resources to empower and sustain these vital movements across the United States.

This program aims to enhance education for healthcare professionals regarding new therapies and patient management in ulcerative colitis (UC). It focuses on multi-channel educational strategies to address the evolving landscape of UC treatment. Key areas include educating on new oral therapies, transitioning to advanced therapies, and managing isolated proctitis. Organizations such as healthcare institutions and medical education companies are eligible to apply, ensuring a comprehensive approach to improving UC care.

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

The Porter Fleming Foundation, established in 1963, aims to enrich the Greater Augusta community through educational, artistic, and cultural initiatives. With no maximum requesting amount, the foundation supports local 501(c)(3) organizations that advance learning and cultural life in the region. While grants are available for innovative projects, they are not intended for usual operating expenses or expenses covered by governmental funding. The foundation encourages community engagement and philanthropy to enhance quality of life.

Howard Hughes Medical Institute

More than 70 years ago, the Howard Hughes Medical Institute (HHMI) was founded with a mission to advance basic biomedical research and science education. Today, we invest in exceptional scientists at all career stages, catalyzing breakthroughs, new technologies, and the next generation of transformative clinical therapies. Our pathbreaking science takes place at more than 60 host institutions across the US, and at our Janelia Research Campus.

Cech Fellows Program

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders. 

The Summer Undergraduate Research Program (the Cech Fellows Program) gives undergraduate students in the life sciences the opportunity to conduct hands-on research alongside leading scientists at HHMI laboratories across the US, from universities and research institutions to HHMI’s research campus outside of Washington, DC. Students are matched with HHMI scientists conducting fundamental research that advances our understanding of biology and health.

This immersive program gives students the chance to contribute to real scientific discovery, gain professional mentorship, and explore potential careers in biological and biomedical research.

Gain Hands-On Experience in Research & Lab Work

Through the summer, students will:

• Work full time conducting research and contributing to ongoing projects in an HHMI laboratory
• Learn and practice new techniques and approaches in disciplines such as cell biology, genetics, neuroscience, and more
• Work closely with and be mentored by exceptional scientists, from lab heads to PhD students
• Build critical thinking and communication skills necessary for future research careers

What the Program Offers

Beyond meaningful lab work, the program provides:

• A stipend to support summer travel, housing, and living expenses 
• An opportunity for participants to present their research and connect with a national cohort of peers at an end-of-summer research symposium at HHMl’s research campus outside of Washington, DC 
• An engaging virtual seminar series with HHMI scientists as well as professional development sessions focused on relevant skills building

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Senior Master Sergeant Texie C. Taylor, USAF Memorial Scholarship

Applicant must be a junior or senior undergraduate or graduate student majoring in physics, chemistry, biology, medicine, nursing (RN), engineering (aerospace, civil, chemical, electrical, mechanical) or mathematics with a minimum 3.0 GPA. This is a one-year scholarship reserved for Cherokee Nation citizens residing within the Cherokee Nation jurisdictional area.

Foundation of the Federal Bar Association

The Foundation of the Federal Bar Association provides the best way for practitioners to give back to the Federal legal community. Chartered by Congress in 1954, the Foundation serves people in communities across the United States through its generous grants, scholarships, and programming.

Our Mission: The Foundation’s mission is to:

• Promote and support legal research and education;
• Advance the science of jurisprudence;
• Facilitate the administration of justice;
• Foster improvements in the practice of Federal law

Foundation Grants

Foundation grants support community service projects and civics programs which comply with the Foundation’s mission to promote and support legal research and education; advance the science of jurisprudence; facilitate the administration of justice; and foster improvements in the practice of Federal law.

Civics Education Grant

The Civics Grant Program is designed to support projects and initiatives that promote a wider public understanding of democratic principles, the judicial system and the rule of law. Through targeted funding, the program empowers FBA chapters, sections, divisions, national standing committees (FBA entity), and other organizations to develop and support projects in their communities that foster public understanding of the rights and responsibilities of American citizenship, particularly among younger Americans.

Applicants may only receive one (1) Foundation grant per year.

The Eppley Foundation for Research, established in 1947, supports advanced scientific research in chemistry, physics, and biology. It prioritizes innovative studies, particularly in medical investigations and climate change. The foundation does not fund social sciences or projects with ample existing financial support. Applicants must hold a PhD or MD and be associated with a nonprofit in the US. The foundation aims to foster groundbreaking research that is unlikely to be replicated elsewhere.

The Stout Foundation Grant supports organizations aligned with the values of its founder, Mr. Stout. Grants are awarded exclusively to entities with 501(c)(3) tax-exempt status and focus on charitable, educational, and scientific purposes. Preference is given to organizations with low overhead costs and those located in areas frequented by Foundation members. The Foundation aims to promote effective use of funds while remaining flexible in its grant-making approach.

The Howard D. Colman Scholarship supports high school seniors from Boone and Winnebago Counties pursuing degrees in engineering or technology fields. Established in memory of entrepreneur Howard D. Colman, the scholarship offers $2,500 in the first year, with potential renewal up to $10,000 for three additional years, contingent on meeting criteria. Recipients gain hands-on experience through internships with local firms, fostering connections to the Rockford area.

The National Institutes of Health (NIH) is dedicated to advancing emergency care through the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN). This initiative seeks to establish clinical enrollment hubs that will enhance the network's ability to conduct trials aimed at improving outcomes for patients experiencing neurological and cardiovascular emergencies. Although applications are not currently being accepted, this notice encourages potential applicants to prepare collaborative and impactful proposals.