Best Large Grants for Nonprofit Organizations in South Carolina

The JFNY Grant for Arts & Cultural Exchange supports U.S. non-profit organizations aiming to enhance understanding of Japanese arts and culture. Eligible projects include performances, workshops, and exhibitions, with priority given to those with additional funding and in areas with limited access to cultural events. Applications must be submitted at least one month prior for online projects and three months for others. The grant covers expenses like travel, publicity, and artist fees, and is reimbursed upon project completion.

The Josephine Moffatt Stevenson Community Charitable Trust, established in 1973, supports medical, educational, and religious organizations in South Carolina, particularly in Abbeville County, Anderson County, and Due West. Administered by Wells Fargo Bank, the Trust awards approximately 10 grants annually, ranging from $1,000 to $7,000, to qualified 501(c)(3) organizations, addressing community needs and enhancing local services.

The James R. Bullock, Jr. Scholarship, offered by the American Society of Heating Refrigerating & A C Engineers, is a one-year scholarship aimed at undergraduate mechanical or architectural engineering students in ASHRAE Region IV. Eligible applicants must maintain a GPA of at least 3.0 and meet specific criteria, such as being enrolled in an accredited program or a school hosting an ASHRAE student branch. This scholarship promotes education in HVAC&R fields and supports future professionals.

The Truliant Mini Grants program offers $1,500 grants to 501(c)(3) nonprofits serving Truliant member communities. These grants support capacity building through staff training and development, along with materials for programs aligned with Truliant's focus areas: Social Mobility, Financial Wellness, and Workforce Education. Eligible organizations must have an operating budget under $500,000, be tax-exempt, and have been operating for at least three years, ensuring community engagement and sustainability.

The American Electric Power Foundation provides grants to 501(c)(3) organizations focused on educational improvement, particularly in STEM fields, and basic human services such as hunger and housing. Organizations must operate within AEP's service territory or have a broader beneficial purpose. The Foundation also supports social justice initiatives and environmental protection efforts. Eligible applicants must affirm compliance with anti-discrimination policies and demonstrate commitment to diversity and inclusion.

The Region IV Benny Bootle Memorial Scholarship offers a one-year financial award for undergraduate students in pre-engineering, engineering, or architecture within ASHRAE Region IV (North Carolina, South Carolina, Georgia). Candidates must maintain a minimum GPA of 3.0 and meet specific eligibility criteria, including affiliation with an ASHRAE student branch or an ABET-accredited program. This scholarship aims to support future leaders in the HVAC&R industry, promoting sustainability and innovation in engineering.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Milford H. Wessinger Scholarship ($2,000) 

This renewable scholarship is available to graduating seniors or graduates of a high school in Lexington County, South Carolina. 

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Mae and Wilbur Fulmer Scholarship ($2,000)

This renewable scholarship supports students who will graduate from a high school located in Chapin, South Carolina. 

The Ethnic Minorities and Women’s Internship Grant supports entry-level athletics administrative positions for one academic year, promoting diversity in NCAA Division II. It provides $30,000 for intern salaries and $3,000 for professional development, benefiting six schools annually from a total budget of $180,000. Eligible applicants must be active NCAA members, with a focus on enhancing ethnic minority and gender representation in athletics administration. This initiative encourages professional growth and compliance in diverse environments.

The Wellness Across the Lifespan Grant supports the health of communities by providing access to nutritious food and essential nutrition education. Grants ranging from $5,000 to $10,000 are awarded to 501(c)(3) nonprofits in areas where Sprouts Farmers Market operates. This funding emphasizes health and nutrition education, as well as programs that promote healthy lifestyles and nutrition security, ultimately benefiting adults and vulnerable populations.

The Advanced Placement Teacher Institutes Grant Program aims to equip South Carolina public school teachers with the necessary endorsement to teach Advanced Placement (AP) courses. This program offers initial training in specific subject areas outlined by the College Board, ensuring teachers are well-prepared to implement AP classes effectively. Approximately $190,000 is available in this funding cycle, with around ten grants expected to be awarded based on application quality.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Ernest Morgan Memorial Scholarship, managed by CommunityGiving, supports central Minnesota student athletes and leaders to pursue higher education outside their home states. This scholarship aims to expand students' horizons and experiences, with a total award of $5,000 available. Open to high school seniors from specific schools, applicants are encouraged to apply online and demonstrate their leadership or athletic skills. This initiative enhances educational opportunities and fosters personal growth among local youth.

The Patrick Family Foundation Grant supports 501(c)(3) organizations in South Carolina, focusing on arts, healthcare, education, social services, and conservation. Established in 2005, the foundation aims to enhance the community through philanthropic efforts. Eligible applicants must utilize funds for charitable purposes only, and cannot engage in political activities. The foundation prioritizes operations, programs, and capital needs to benefit underserved populations and foster cultural enrichment.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

The South Carolina Department of Education is offering funding through the Abstinence Until Marriage Evidence-Based Programs RFP. With approximately $546,972 available, grants will be awarded to nonprofit organizations to implement evidence-based teen pregnancy prevention programs that promote abstinence until marriage for youth aged 10-19. These programs must comply with Title V, Section 510 requirements and be certified by the National Abstinence Education Association, ensuring they adhere to the South Carolina Comprehensive Health Education Act.

The Norfolk Southern Trades on Track SkillPointe Scholarship offers $5,000 scholarships for students pursuing trades education related to the rail industry. Eligible candidates must be enrolled in a post-secondary institution and focused on railway-related trades. With over 1,000 scholarships funded and a mission to close the skills gap, this initiative empowers individuals towards high-demand careers without requiring a four-year degree, ultimately strengthening the workforce and economy.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

South Carolina State Firefighters’ Association Grant

Foundation grants are awarded to assist individuals who experience tragedy or hardship due to circumstances beyond their control and demonstrate a financial or otherwise immediate need. The grants are available for those who experience natural disasters, home fires, medical emergency, act of terrorism or otherwise personal tragedy. Submit an application, letter from local Fire Chief and statistical information to the Association’s office in Columbia.

How much are grants? 

An individual may receive more than one grant. Each grant request will be evaluated separately. The Foundation will determine whether to award multiple grants based on all relevant factors, including the individual’s need and particular circumstances, the total amount of funds that the Foundation has available for grants, and the amount and needs of other applicants. The grant recipient may receive a minimum of $250 and maximum of $1,500 per grant awarded. 

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

Small Rental Development Program (SRDP)

The Small Rental Development Program (SRDP) offers both federal and state funding sources for the development of new construction and rehabilitation of projects with small numbers of affordable housing units (4-39). Funding available for the 2026 Small Rental Development Program (SRDP) will be approximately $40,483,611.93 through a competitive application cycle beginning in April. 

Approximately $40,483,611.93 of funding will be available. Applications will be placed in one of the three (3) set-asides:

• General New Construction/ Conversion– $20,241,805.97 50% of available funds. This set-aside will include new construction applications that contain 5-39 units.
• Micro Developments – $10,120,902.98, 25% of available funds. Thisset-aside will include new construction and rehabilitation applicationsthat contain 4 units.
• Rehabilitation – $10,120,902.98, 25% of available funds. This set-aside will include rehabilitation applications that contain 5-39 units.

About Us

The South Carolina Developmental Disabilities Council was established in 1971 by Executive Order of the Governor and was reauthorized in 2010 and again in 2015. Not less than 60% of the total Council membership is consumers and family members. Additional members come from state agencies, DD Act partners and non-governmental organizations.

The Council is federally funded under the Developmental Disabilities Act. The Council engages in activities that contribute to a coordinated, consumer and family centered and directed, comprehensive system that includes needed community services, individualized supports and other forms of assistance that promote self-determination for individuals with developmental disabilities and their families.

DD Council Small Grants

Small Grant Funding is awarded to evidence-based,organized activities that enhance knowledge and skills in priority areas outlined in our Five-Year State Plan, specifically Community Supports, Employment, and Self-Advocacy.

Organizations are limited to one small grant per program year, from July 1 to June 30.