Best Private Grants for Nonprofits in South Carolina

About Knight Foundation

John S. and James L. Knight believed that a well-informed community could best “determine its own true interests” and was essential to a well-functioning, thriving democracy. They pursued those beliefs, building and leading one of the largest and most successful newspaper companies in American history.

For 75 years, Knight Foundation has supported the people, ideas and insights that lead to thriving communities. The foundation invests in local journalism, arts and culture and community development in the 26 cities and towns where the Knight brothers once published newspapers.

Since our founding in 1950, we have been committed to the communities we serve and to providing those communities with the tools they need for residents to thrive.

Knight Cities Challenge

Knight Foundation is currently accepting applications for the Knight Cities Challenge, a $5 million open call inviting individuals and organizations across its 26 communities to submit new, creative ideas for projects that can spark change and leave a lasting local impact.

Building on a long history of open challenges across programs, Knight democratizes access to grantmaking to unlock the best and brightest ideas. This spring, KCC returns to invest in its first cohort of community-centered solutions to local challenges and help promising ideas take root and grow.

Project ideas must focus on at least one of Knight’s investment areas: strengthening local news and information, creating pathways for economic opportunity or cultivating connection through arts, culture and the places that bring people together.

You may submit one idea, either as an individual or on behalf of your organization. While you are limited to one application as the lead applicant, you may collaborate on other projects submitted by different partners. Each individual or organization may receive funding for only one project.

For large institutions such as universities or city governments, schools or departments are considered separate entities. 

The Latham Foundation for the Promotion of Humane Education, established in 1918, emphasizes humane education to foster kindness and respect for all living beings. With a focus on innovative programs for teenagers and animal-assisted activities, the foundation invites U.S. organizations, particularly nonprofits, to apply for grants. However, funding does not extend to capital projects, salaries, or conference travel. Latham aims to instill core values that promote compassion within communities and across nations.

The SC Ministry Foundation provides annual grants aimed at supporting nonprofit organizations aligned with the mission of the Sisters of Charity of Cincinnati. These grants can be used for core programs, planning, and program expansion. Eligible organizations must demonstrate financial sustainability and avoid duplication of services. The application process starts with a pre-application survey, and funding decisions are typically made by June 30. Priority is given to projects in education, healthcare, and social services.

The M.A. Essay Prize, awarded by the North American Conference on British Studies (NACBS), recognizes exceptional original research by students in stand-alone M.A. programs in the U.S. and Canada. With a prize of $500, it encourages scholarly excellence and invites winners to submit their work for publication. Faculty nominations are required, ensuring deserving candidates receive recognition for their academic contributions, thereby fostering a vibrant academic community within British studies.

The OJJDP FY 2026 Internet Crimes Against Children On-Line Child Protection System (ICACCOPS) funding opportunity aims to enhance and maintain critical investigative tools for child exploitation cases. ICACCOPS provides a robust IT infrastructure to support data services, network security, and management tools for law enforcement. This initiative strengthens the efforts of the national network of ICAC Task Forces, which are dedicated to combating technology-facilitated child sexual exploitation across the United States.

August Corso Scholarship Fund

Scholarships shall be awarded to residents of Erie County, Ohio pursuing a post-secondary education. Preference shall be given to students pursuing a degree in Horticulture, Environmental Science or Agricultural Business. Financial need is a consideration for the scholarship award.

Scholarships are available for students planning to attend an accredited nonprofit college or university, or planning to receive licensure, accreditation, or a certificate from a nonprofit vocational or apprenticeship program in the United States.

The scholarship may be renewed for a second, third, and fourth year.

The Judith R. Walkowitz Article Prize, awarded annually by the North American Conference on British Studies, recognizes the best published article addressing gender and sexuality in British culture. This prize honors Professor Walkowitz’s significant contributions to the fields of gender and cultural studies. Open to scholars in North America, it encourages diverse perspectives across disciplines and time periods, with a cash award of $250 to support ongoing research and scholarship in British Studies.

The Bernau Family Foundation Grant aims to enhance individual lives and foster positive leadership through funding initiatives that provide long-term solutions. Grants are awarded to IRS-designated public charities or nonprofits, emphasizing projects that promote civic responsibility, education, and mentor programs. The foundation prioritizes smaller organizations that encourage meaningful community engagement and constructive change, ensuring a lasting impact on society.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Easterby Family Scholarship ($7,000)

This renewable scholarship is for students from Laurens County, South Carolina who are pursuing graduate or post-graduate education in the fields of theology or medicine. 

The Donaghue Foundation's Greater Value Portfolio Grant Program aims to enhance healthcare value by funding innovative research projects for two years, with awards up to $400,000. It encourages proposals that address issues such as high costs, disparities, and inefficiencies in care. Eligible applicants include Ph.D. researchers at nonprofit institutions partnered with healthcare organizations. The program seeks actionable solutions to improve patient care and reduce the burden of low-value healthcare on communities.

The Norman Foundation Grants aim to empower communities in the U.S. to enhance their economic, environmental, and social well-being. By supporting projects that promote economic justice, prevent toxic waste disposal, and link grassroots efforts to broader reform, the foundation seeks to foster systemic change. It prioritizes organizations with annual budgets under $1 million, ensuring funds are directed to initiatives that resonate with the aspirations of those most affected by social issues.

The Actions of Public Witness Grant, offered by the Unitarian Universalist Funding Program, provides matching grants of up to $1,500 to Unitarian Universalist congregations engaging in timely actions of public witness. This initiative supports efforts in social and environmental justice, encouraging congregations to mobilize during critical moments. Grants are available on a rolling basis and are intended for urgent projects that extend beyond the regular grant timeframe. Notably, individual applications are not accepted.

The Intellia Therapeutics UNCF Scholarship Program, in partnership with the United Negro College Fund, aims to support students pursuing careers in life sciences. With a commitment to educational equity, this program offers scholarships to eligible students who demonstrate financial need and maintain a minimum GPA of 2.75. By investing in future leaders, Intellia Therapeutics and UNCF continue to empower individuals and strengthen communities, ensuring that no mind is wasted.

The John Ben Snow Prize, awarded by the North American Conference on British Studies, recognizes the best book by a North American scholar focusing on British Studies from the Middle Ages to the eighteenth century. This prestigious annual award includes a $500 prize and encourages authors who are U.S. or Canadian citizens or permanent residents to submit their works. Nominations can be made by authors or publishers, with discretion advised for multiple entries.

About PLTW Computer SciencePLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities enhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Computer Science program.
  • Example expansion activities include but are not limited to adding an additional PLTW Computer Science  course not previously offered,
  • and/or adding additional class periods of an existing PLTW Computer Science courses previously offered,
  • and/or training additional teachers in PLTW Computer Science courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $5,000
  • 2027-2028: $5,000

The National Science Foundation (NSF) is offering Postdoctoral Research Fellowships in Biology to support innovative research at the intersection of Artificial Intelligence (AI) and Biological Sciences. These fellowships aim to cultivate expertise in both fields, enabling scientists to leverage AI for breakthroughs in biotechnology and bio-system design. The program encourages proposals that utilize existing biological data and infrastructure to enhance discovery and innovation, ultimately benefiting human lives and the U.S. economy.

The John M. O'Quinn Foundation Grant, established in 1986, has contributed over $192 million to various charitable activities, focusing primarily on Houston and its surrounding areas. The Foundation supports tax-exempt organizations and governmental units, emphasizing conservation, education, healthcare, and programs for underprivileged youth. Grants are not available for type III supporting organizations, individuals, or foreign charities, ensuring a targeted impact within the local community.

The Ed & Mildred Schroeder Scholarship, offered by the Coastal Bend Community Foundation, aims to enhance the quality of life in the Coastal Bend through educational support. This scholarship is available to graduating seniors or current college students pursuing a degree in education, demonstrating financial need, and enrolled in at least 12 credit hours. By providing effective grants and scholarships, the foundation fosters community philanthropy and addresses local educational needs.

The Boeing Interfaith Fund, established by Boeing South Carolina in 2024, aims to uplift faith-based outreach ministries in Charleston, Dorchester, and Berkeley Counties. Through this initiative, the Coastal Community Foundation supports vital community services such as education, health access, and economic mobility. By fostering collaboration among local organizations, the fund enables impactful outreach efforts that enhance the well-being of residents and address pressing community needs effectively.

The Emergent Fund Grant, established in 2016, supports BIPOC-led social justice movements through rapid response funding. It addresses urgent community needs by providing low-barrier grants to organizations facing crises such as family separation and systemic oppression. The fund prioritizes initiatives that foster Black liberation, multiracial solidarity, and empower communities to build transformative power. By investing in innovative strategies, the Emergent Fund aims to challenge oppressive structures and advance social justice, ensuring that impacted communities are at the forefront of their own advocacy.

The Oak Advisors Scholarship of Excellence, offered by the Community Foundation of the Lowcountry, supports southern Beaufort County high school seniors pursuing a major in business, economics, or finance. Established by philanthropic leaders, the scholarship recognizes students for their academic achievements, talents, and community involvement. With a minimum GPA of 3.2 required, this scholarship aims to empower students to make a positive impact in their communities.

The NACBS Undergraduate Essay Prize, awarded by The North American Conference on British Studies, recognizes outstanding essays on British topics from undergraduates at U.S. and Canadian universities. Each year, up to eight prizes of $100 are given, encouraging submissions from diverse fields including History, English, and Cultural Studies. This initiative aims to promote scholarly engagement with British Studies, fostering a deeper understanding of its historical and cultural contexts during the 2023-24 academic year.

The Alexandra Hallock Capacity Building Grant for Small Nonprofits, established in 2024, honors the legacy of Alexandra Hallock by supporting small nonprofits focused on human rights, women's empowerment, and LGBTQ+ causes. This grant offers a one-time $20,000 unrestricted funding along with pro-bono capacity building support. It aims to strengthen organizational infrastructure and governance, ensuring impactful community engagement. Eligible organizations must be 501(c)3 nonprofits with revenue under $400,000, operating for at least one year, and based in the U.S.

The Katie Cannon Scholarship honors Rev. Dr. Katie Geneva Cannon, a pioneering figure in the Presbyterian Church (U.S.A.). This scholarship aims to empower Presbyterian women of color, clergywomen, and college women by providing financial assistance for leadership development events and educational opportunities. It promotes spiritual growth and mission involvement within the church, ensuring that women are equipped for greater service and leadership roles. This fund is part of the Women's Ministry Fund at the Presbyterian Mission Agency.

The Artist in Business Leadership (ABL) Fellowship supports Native artists in building sustainable art-centered businesses. This yearlong program provides $10,000 in funding along with professional development and networking opportunities. Eligible applicants must be 18 years or older, reside in the U.S., and be enrolled in or have lineage from a federally recognized tribe. The fellowship aims to empower artists to thrive within their communities while honoring their cultural heritage.

The U.S. Department of Energy (DOE) is launching the PROSPECT Program to enhance education in critical technologies, targeting an investment of up to $100 million. This initiative aims to develop a skilled workforce across the critical minerals and materials sector, supporting the entire value chain from resource extraction to recycling. By fostering collaboration among academia, industry, and national laboratories, the program seeks to strengthen U.S. economic competitiveness and energy security.

The Roger Arliner Young (RAY) Fellowship Program, managed by the Environmental Leadership Program, aims to foster conservation and clean energy careers for emerging leaders of color. This two-year paid fellowship provides recent graduates with professional development, mentorship, and networking opportunities. Ideal candidates are those with a passion for social and environmental justice, who identify as part of historically marginalized groups, and are committed to community engagement. The program emphasizes diversity, equity, and inclusion in the environmental sector.