Best Private Grants for Nonprofits in South Carolina

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The E. C. Lloyd & J.C.U. Johnson Scholarship Fund, established by Mrs. Mary Elizabeth Johnson, supports full-time students pursuing associate or bachelor’s degrees at accredited institutions in the U.S. The scholarship is renewable for up to four years for both undergraduate and graduate studies, contingent on maintaining eligibility standards. It can cover tuition, housing, supplies, books, and fees. However, awards depend on available assets, and future funding is not guaranteed.

The PCC Rapid Response Grants provide support for cultural initiatives that aim to shape narratives during critical cultural moments. These grants prioritize projects that engage communities of color, immigrants, refugees, and other marginalized groups, focusing on intersectionality, gender justice, and social equity. Eligible projects include pop culture campaigns, research, and public spectacles that respond to urgent political and cultural events, aiming to reach mass audiences and disrupt harmful narratives.

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support postdoctoral fellows from underrepresented backgrounds in transitioning to tenure-track positions. This award provides essential funding for salary and research support for three years, enabling candidates to establish independent biomedical careers. Key deadlines for applications range from February 2025 to October 2027, ensuring ample opportunity for eligible researchers to secure funding for their career development.

The Northern Lowcountry Grants: Blackbaud Fund offers annual grants up to $5,000 for nonprofit organizations in Berkeley, Charleston, and Dorchester counties. Focused on supporting special needs youth and education for underserved youth, this fund encourages nonprofits that are 501(c)(3) compliant and do not engage in political lobbying. Organizations must not have received more than $5,000 in the previous grant cycle to be eligible.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The NSCDA National American Indian Medical Scholarship Award Program provides scholarships to students of American Indian descent, originally focusing on women in nursing. Launched in 1928, the program now supports males and various health-related fields. Eligible applicants must demonstrate tribal enrollment or ancestry, maintain academic standing, and have a commitment to serving their communities. The scholarship awards $1,500 each semester for tuition and academic expenses, helping students fulfill their educational and career goals.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

The TTP Bridge Program aims to enhance the safety and accessibility of bridges in Tribal communities, addressing the urgent need for infrastructure improvements. With aging bridges affecting economic development and children's transportation, this program allows federally recognized Indian Tribes to apply for funding for planning, construction, and rehabilitation of bridges. By focusing on TTP bridges in poor condition, the initiative seeks to strengthen economic foundations and ensure better connectivity with markets, benefiting both families and communities.

The Community Foundation of the Rappahannock River Region

The Community Foundation is a devoted advocate for the vitality and well-being of the Rappahannock River Region. We are a 501(c)(3) nonprofit that manages and distributes charitable giving in the counties of Stafford, Spotsylvania, King George, and Caroline, and the City of Fredericksburg.

Scholarships

One of The Community Foundation’s strategies for preserving and growing the quality of life in our region is supporting higher education for area students. Generous individuals and families, companies and organizations establish endowed scholarship funds and the proceeds from these funds benefit deserving students. Donors work with foundation staff to determine appropriate criteria for each fund. The Community Foundation currently administers more than fifty scholarship funds.

The Robert H. Bradley, Jr. Memorial Golf Scholarship Fund

This scholarship fund was established in December 2013 by M.J. Bradley, Bob Bradley’s wife of 38 years, and his many friends, family members and golf buddies.

Robert Holyman Bradley, Jr., known to all as Bob, grew up in Clifton Forge, Virginia. He moved to the Fredericksburg area in 1971 but never lessened his close ties to his hometown. Sports were a major part of Bob’s life from an early age. Bob and his brother David began playing baseball as children and he was known to love – and excel at – basketball, football and especially golf.

Family members, friends and colleagues admired Bob for his seemingly endless resources of strength and positive energy – in his golf game, in the face of serious health concerns and, indeed, in life. Bob battled kidney failure, which included two transplant surgeries and five years of dialysyis, as well as cancer with dignity, determination and humor.

This scholarship is intended to memorialize Bob Bradley and his lifetime passion for golf. Bob “lived and breathed” golf. He lived next to the Country Club where he was a thirty-five year member, an organizational leader and a very active player. Bob was a successful player at that. He and his brother won the Fredericksburg Country Club member/guest tournament so many times they influenced the club to change the tournament format. He won the club championship on two occasions and he also won the Virginia State Golf Association Championship as part of a two-man team.

Agog Open Call: Climate Futures + Immersive Media

This open call supports immersive media projects that help people better understand and respond to climate challenges and imagine what a better world could be.

We are looking for projects that use immersive technologies—including smart glasses, augmented reality, spatial sound, and mixed reality—to create more engaging, experiential forms of climate storytelling and civic participation.

The open call will support projects across a range of stages and formats, from early ideas to more developed work. What matters most is a compelling story or experience, a clear sense of purpose, and a thoughtful approach to bringing the work to life.

Grants may be awarded in denominations ranging from $25,000 to $200,000. In addition to funding, selected projects may receive mentorship, advisor support, and opportunities for partnership and distribution.

The Richard K. Sauret Viticulture and Enology Scholarship, offered by the San Luis Obispo County Community Foundation, supports students pursuing degrees in viticulture or enology at a four-year college. This scholarship aims to empower high school seniors, undergraduates, and returning students in San Luis Obispo County. By providing financial assistance, it encourages academic and career advancement, fostering the next generation of leaders in the viticulture and enology fields.

Across the United States, small and micro businesses (SMBs) play a critical role in driving economic opportunity, job creation, and community prosperity. Yet many entrepreneurs continue to face challenges accessing the training, resources, and support needed to grow and remain competitive in an evolving economy. To help address these needs, Visa Foundation is committing $2M to launch an open-call grant program that will support nonprofit Entrepreneurial Support Organizations (ESOs) that provide direct services to SMBs. Through this program, Visa Foundation aims to strengthen the capacity of high-impact organizations that help small businesses build greater resilience, expand economic opportunity, and contribute to thriving local economies. 

The A. O. Smith Foundation, established in 1955, provides grants to support charitable, educational, and human services organizations primarily in communities where A. O. Smith Corporation operates. With a mission focused on enhancing community well-being, the Foundation promotes education, arts, culture, and health initiatives. It encourages employees to engage in volunteerism, fostering a culture of community involvement. Notably, the Foundation does not fund politically active organizations or those primarily aiming to influence legislation.

The National Institutes of Health is funding a groundbreaking project to enhance our understanding of Type 1 diabetes (T1D) through multimodal AI. This initiative aims to integrate diverse datasets to explore the interactions of biological processes in T1D development. By leveraging advanced AI models, the research will uncover critical insights, identify biomarkers, and pave the way for personalized medicine approaches, ultimately improving prevention and treatment strategies for this complex disease.

Retina Research Foundation

Across the nation, there were only a handful of voluntary groups with the will and the means to tackle retinal disdorders. Retina Research Foundation, established in 1969, was one of those organizations. By the 1980s, RRF had become a voice for retina research in an effort to reduce the incidence of retinal disease, which was fast becoming the leading cause of blindness in developing countries.

Undaunted, the Foundation steadily raised funds each year for vision scientists who were nationally recognized for their work in retina research. Government funding for eye research increased dramatically, and the field of retina research matured. As this body of knowledge grew, RRF programs were expanded to include major awards that recognize established retina scientists and contribute to their ongoing research. The Foundation also developed scientific exchange programs to disseminate knowledge of the dramatic advances that were being made in the laboratory.

RRF Pilot Study Grants

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF is currently welcoming pilot study grant applications for the 2027 grant period. Each grant application must be signed by the principal investigator and either their Department Chair or Dean of Research.

The Richard J. Weyhrich Leadership Scholarship, offered by the San Luis Obispo County Community Foundation, aims to support high school seniors, undergraduates, and returning students with demonstrated leadership potential. This scholarship, established in memory of Richard Weyhrich, a West Point graduate and U.S. Army officer, provides financial assistance to help students achieve their educational and career aspirations. The foundation fosters an inclusive environment, encouraging all students to apply and reach their full potential.

The Autism Care Today SOS Program is dedicated to providing immediate assistance to families affected by autism across the United States. Established in 2005, this program addresses urgent needs for effective treatments and services for autism spectrum disorders. Unlike typical grant cycles that may take up to 12 weeks, the SOS Program prioritizes those in critical situations, ensuring timely support based on available funding. Eligibility includes a family income below $45,000 and a demonstrated immediate need for treatment.

The Autism Care Today Grant provides vital funding assistance to families affected by Autism Spectrum Disorders across the United States. Since its inception in 2005, it has supported over 1,562 families with more than $1.85 million in grants. The program focuses on enhancing the quality of life for children with autism through various initiatives, including safety measures, assistive technologies, and behavioral therapy funding, while also addressing the unique challenges faced by military families.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Project Types and Area of Interest

Potential applicants are encouraged to identify and address preclinical/basic science data generation for TFPI modulation/rebalancing in their local setting. This may include:

• Rare bleeding disorders which arise from deficiencies in different clotting factors or pathway components but converge on a common functional endpoint which is an impaired thrombin generation (e.g., Factor II, Factor V, Factor VII, Factor X and Factor XI deficiencies, as well as von Willebrand disease).
• Other diseases such as Glanzmann's thrombasthenia (GT) that have a distinct pathophysiological mechanism.
• Other rare bleeding disorders whose mechanisms are not well understood (e.g., Bleeding Disorder of Unknown Cause, BDUC).

The Greater Evansville USBCA Scholarship, established by the Greater Evansville USBCA, supports students from Posey, Vanderburgh, and Warrick counties who engage in community service and bowling activities. Eligible applicants must have been members of the USBCA for two of the past four years or be children of members with a minimum 2.0 GPA. The selection process considers academic performance, bowling involvement, community service, and submitted essays and recommendations.

Judge Richard S. (Stan) Gault Education Scholarship

The Judge Richard S. (Stan) Gault Education Scholarship was established in 2010 by his family to honor his memory and support residents of his hometown, Forsyth County, Georgia, in pursuing their educational goals. The Honorable Richard S. Gault was a distinguished Georgian, a highly respected jurist, a dedicated community leader, and a lifelong advocate for education.

This scholarship is available to non-traditional students or graduating high school seniors who attend Forsyth Central High School, North Forsyth High School, or East Forsyth High School. Applicants must be a resident of Forsyth County, Georgia. Students must be planning to enroll in an accredited college, university, technical school, or secondary training program. In 2026, one scholarship award of $2,500 will be offered.

Our Story

Established over 50 years ago, our founders redefined local philanthropy, fostering connections around a shared sense of place and purpose. As Virginia's largest community foundation, we bring people together to pool resources, co-create solutions and align actions for impactful change in the Richmond region.

Scholarships are offered to students living in the Richmond region and other Virginia locations. Each scholarship was established by a generous individual, family, or organization with a desire to assist high school students, recent high school graduates, and adult learners to continue their education. 

School Bus Road Scholarship Fund

The School Bus Road Scholarship Fund was established in 2023 by the Louisa County, VA Chapter of the NAACP. The purpose of the scholarship is to support postsecondary educational scholarships for qualifying graduates of Louisa County Public High School. and any future high schools built by Louisa County Public Schools in Louisa County, VA, attending an accredited two or four-year community college, techical or vocation school, college or university in the United States.

The We Are Moving The Needle Scholarship supports women, trans, and non-binary creators in the music industry by offering two full scholarships for a masterclass with GRAMMY-nominated producer Alissia in Paris. This initiative aims to empower underrepresented voices through education and mentorship, fostering a more inclusive music industry. Participants will engage in hands-on workshops designed to enhance their production skills and gain insights from a leading industry professional, contributing to lasting cultural change.

The Eastern Iowa Angus Association Oliver Hansen Memorial Scholarship, administered by the Quad Cities Community Foundation, supports students from specified Iowa counties pursuing education in agriculture. Applicants must be involved with the Angus breed, maintain a minimum 2.0 GPA, and enroll full-time at accredited institutions. Scholarships provide up to $1,000 annually and are renewable for two years, aiding students in achieving their academic and career goals.

The Houston Marathon Foundation Grant supports running-related programs and initiatives, especially those that promote health and fitness in the greater Houston area. Organizations can submit unsolicited Letters of Inquiry, which must be pre-approved before submission. The Foundation prioritizes funding for programs that demonstrate fiscal responsibility and operational integrity, and applications are reviewed quarterly. Additionally, programs aiding elite athlete development outside Houston may also be considered.