Best Unrestricted Grants for Nonprofits in South Carolina

The William C. Risser Charitable Trust Grants support mental health research, particularly in Schizophrenia. This private foundation assists 501(c)(3) nonprofit organizations across the U.S. with grants typically ranging from $25,000 to $55,000. Administered by Wells Fargo, the Trust awards 1-2 grants annually, focusing on program support for scientific and educational research. Eligible organizations must meet IRS exemption requirements.

The American Musicological Society offers Affiliate Grants to support study group activities with up to $500 in funding, covering no more than 50% of total costs. Applications are accepted twice a year, with deadlines on August 1 and January 15. Only elected representatives of AMS study groups can apply, and groups may receive funding only once in a twelve-month period. Funds must be utilized within a year of the award date.

About

What is FOXG1 Syndrome?

FOXG1 syndrome is a rare genetic neurodevelopmental disorder caused by a mutation in the FOXG1 gene. FOXG1 gene is one of the first and most important genes for early brain development and when impaired, causes developmental disabilities as well as medical complexities, including epilepsy.

Every child born with FOXG1 syndrome is unique as FOXG1 manifests as a spectrum where symptoms and severity vary between individuals. Our patient data shows characteristics of children with FOXG1 syndrome include: non-speaking, non-ambulatory, experience seizures, feeding problems, cortical vision impairment, movement disorders, and developmental delays. Less-severely-affected FOXG1 children often present with (ASD) Autism Spectrum Disorder as FOXG1 is an autism related gene. FOXG1 syndrome is found equally among both females and males and is geographically more prevalent where diagnostic testing is more advanced. 

Our Story & Mission

When our children were diagnosed with FOXG1 syndrome, we were told there was nothing we could do. No treatments, no concerted research underway, no roadmap. Just a devastating diagnosis for a disorder few had ever heard of.

But we refused to accept that. 

Research Assets & Grants

FOXG1 Scientific Research Project Grants

The FOXG1 Research Foundation is providing grants to scientists to deepen the understanding of the biology of FOXG1 with the goal of identifying innovative therapeutic strategies and finding a cure.

For the next few years, these are the strategic focus areas:

• Experiments designed to understand when, where, and levels of FOXG1 needed for normal brain development in mice
• Experiments designed to understand the biophysical properties of FOXG1 mutations
• Experiments designed to gain insights into the molecular and cell biological pathways regulated by FOXG1  

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA: Capital Improvement Grants

Any request to support a project that seeks to improve a facility is considered a capital improvement. This includes, but is not limited to:

• Range improvements
• Berm improvements
• Clubhouse/Classroom facility improvements
• Shelter structures/covered firing lines/pavilions
• Road improvements
• Commercial-grade trap machines (see section regarding trap machines, below)
• Any other permanent improvement to an organization’s property or facility

The Grant Program considers requests for certain trap machines to be a capital improvement to the facility. Specifically, requests for commercial grade trap machines that have a capacity of 300 clays and up.

The Anna B. Glauser Trust Grants provide financial support to organizations aiding physically handicapped individuals, particularly blind residents in Delaware County, PA. Established in memory of Willis K. Glauser, the trust awards 1-2 grants annually, ranging from $2,500 to $5,000. Eligible organizations must be 501(c)(3) certified, while funding for salaries is typically excluded. This initiative reflects Anna Glauser's lifelong commitment to assisting the visually impaired community.

Retina Research Foundation

Across the nation, there were only a handful of voluntary groups with the will and the means to tackle retinal disdorders. Retina Research Foundation, established in 1969, was one of those organizations. By the 1980s, RRF had become a voice for retina research in an effort to reduce the incidence of retinal disease, which was fast becoming the leading cause of blindness in developing countries.

Undaunted, the Foundation steadily raised funds each year for vision scientists who were nationally recognized for their work in retina research. Government funding for eye research increased dramatically, and the field of retina research matured. As this body of knowledge grew, RRF programs were expanded to include major awards that recognize established retina scientists and contribute to their ongoing research. The Foundation also developed scientific exchange programs to disseminate knowledge of the dramatic advances that were being made in the laboratory.

RRF Pilot Study Grants

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF is currently welcoming pilot study grant applications for the 2027 grant period. Each grant application must be signed by the principal investigator and either their Department Chair or Dean of Research.

The AMA Foundation Physicians of Tomorrow Scholarship: Alliance Grassroots provides $10,000 in tuition assistance to medical students entering their final year. With a commitment to supporting diversity in medicine, this scholarship focuses on candidates interested in women's and children's health issues. Open to all medical students, it recognizes volunteerism and research in health-related fields. Since 1950, the AMA Foundation has awarded over $61 million in scholarships, fostering a diverse cohort of future healthcare professionals.

The Karl A. Bickel and Madira Bickel Journalistic Scholarship Fund Grant supports journalism students at accredited colleges and universities. Established under Karl A. Bickel's Last Will and Testament, it awards approximately $40,000 annually. Eligible organizations must have journalism programs and qualify as 501(c)(3) exempt entities. While there are no geographical restrictions, preference is given to institutions in Florida. The fund is administered by Wells Fargo Bank, ensuring that deserving students receive necessary financial support.

The Harry and Myrtle Nabstedt Scholarship, offered by the Quad Cities Community Foundation, supports students from Scott County, Iowa, pursuing post-secondary education at accredited institutions. With a maximum award of $8,000 per year, this need-based scholarship is renewable for up to five years, contingent on maintaining eligibility. Applicants must demonstrate financial need and a minimum GPA of 2.00, showcasing merit through community involvement and other activities.

The Eastern Iowa Angus Association Oliver Hansen Memorial Scholarship, administered by the Quad Cities Community Foundation, supports students from specified Iowa counties pursuing education in agriculture. Applicants must be involved with the Angus breed, maintain a minimum 2.0 GPA, and enroll full-time at accredited institutions. Scholarships provide up to $1,000 annually and are renewable for two years, aiding students in achieving their academic and career goals.

This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.

The FY26 Breast Cancer Research Program's Breakthrough Award supports transformative research aimed at significant advancements in breast cancer treatment. This award offers various funding levels, including Population Science Studies, allowing for innovative approaches that can lead to clinical applications. Each application must align with overarching BCRP challenges, ensuring a focus on impactful research. The program acknowledges both individual and collaborative Principal Investigators, emphasizing the importance of timely submissions to avoid administrative issues.

The CLRA Research Grant Program, led by the Children’s Leukemia Research Association, focuses on funding innovative research aimed at uncovering the causes of leukemia and improving treatment options. Grants totaling $30,000 are awarded to U.S.-based researchers, with the intention of advancing scientific understanding and ultimately finding a cure. The program has made significant contributions to the high cure rates for childhood leukemia, showcasing the importance of continued research in this field.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

The Drs. James and Wanda Trefil Science Scholarship, offered by the Kosciuszko Foundation, supports undergraduate students majoring in natural sciences such as physics, biology, and chemistry. This competitive scholarship awards $5,000 and is available to U.S. citizens of Polish descent who maintain a GPA of 3.5 or higher. Applicants must be full-time students and can only receive the scholarship once, with a deadline for letters of recommendation set for March 3, 2026.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Marion Rotary Club’s Warren Brown Scholarship

The Marion Rotary Club was chartered in 1922, as club number 1051, with 23 charter members led by Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation, which was incorporated in 1959, has contributed to many organizations and scholarships over the years.

The Marion Rotary Club Warren Brown Scholarship migrated to Marion Community Foundation in 2017. It honors the late Warren Brown of Wyandot, Inc. and provides financial support for Marion County graduating seniors. Recipients will have been a resident of Marion County for at least two full years and maintain a cumulative grade point average of 2.5 or higher based on a 4.0 scale. Special consideration will be given to applicants who intend to pursue an education and career in or related to business or management.

The AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award provides $100,000 annually for three years to early-career faculty dedicated to gastric cancer research. Eligible candidates must have an MD, PhD, or equivalent and a full-time faculty position in North America. The award supports research in various areas related to gastric cancer, ensuring a minimum of 50% time commitment to the project, thus fostering independent careers in digestive diseases.

The American Diabetes Association's Postdoctoral Fellowship Awards aim to foster emerging leaders in diabetes research. With a focus on innovative research, these fellowships provide up to three years of funding, including a stipend and allowances. Eligible applicants must hold a recent advanced degree and conduct research at U.S. affiliated institutions. This initiative not only supports career development but also contributes significantly to the mission of preventing and curing diabetes.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Marion Rotary Club’s R.T. Lewis Scholarship

The Marion Rotary Club R.T. Lewis Scholarship migrated to Marion Community Foundation in 2017. It honors the late R.T. Lewis and provides financial support for Marion County graduating seniors pursuing an education in business, management, land development, real estate, or who will be attending the Marion Campus of The Ohio State University.

Born in 1877, R.T. Lewis became known as “Mr. Marion” for his grocery business, downtown and land development, and philanthropic efforts. In 1957, as Ohio State University began offering classes in Marion, he was among the first to create student scholarships. He also supported the YMCA and the Palace Theatre. He was among the 23 charter members of the Marion Rotary Club when it was formed in 1922 under the leadership of Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation which R.T. helped start, was incorporated in 1959 and has contributed to many organizations and scholarships over the years. Rotary honored Lewis’ contributions with the creation of the R.T. Lewis Fellowship, which recognizes members who contribute $1,000+ to the Marion Rotary Foundation.

The OVC FY 2026 Preventing Trafficking of Girls program aims to provide crucial prevention and early intervention services for girls at risk of human trafficking. This initiative, backed by the US DOJ's Office of Justice Programs, supports efforts to protect vulnerable populations, including young women up to age 25, from both sex and labor trafficking. Applicants are encouraged to outline their strategies to effectively serve survivors and address diverse needs in their proposals.

The Ida Halpern Fellowship and Award, offered by the Society for Ethnomusicology, supports research on Native American music in the U.S. and Canada. Established scholars, recent Ph.D.s, and Ph.D. candidates are eligible, while previous awardees must wait three years to reapply. The fellowship includes a $4,000 grant and a $1,000 award for published research, with preference given to studies based on Dr. Halpern's Northwest Coast music collection.

The REI Cooperative Action Fund Grant supports U.S.-based organizations that align with its mission to serve communities, particularly those connecting historically excluded individuals to the outdoors. The fund prioritizes initiatives that promote equitable access to outdoor spaces, enhance community health through nature, and create inclusive outdoor experiences. Eligible applicants must have a 501(c)(3) status and demonstrate a commitment to these values. However, individuals and certain organizations are not eligible for funding.

The Earthwatch Institute's Teach Earth Fellowship connects K-12 teachers with scientists through immersive research expeditions. Celebrating 50 years, this program empowers educators to inspire students with hands-on environmental science experiences. Teachers gain confidence, collaborate with peers, and develop impactful curricula. The fellowship includes workshops, networking opportunities, and resources to enhance environmental education in classrooms. Participants return with renewed purpose, ready to engage their communities in conservation efforts.

The Choose Your Future Scholarship Fund, established by a passionate anonymous donor through the Community Foundation of Middle Tennessee, aims to empower Davidson County graduates of Metropolitan Nashville Public Schools. With a minimum GPA of 2.5 and a 21 ACT score, eligible students can pursue higher education without financial barriers. Preference is given to first-generation college attendees and those maintaining good academic standing for renewal. This initiative embodies the belief that education opens doors to opportunity.

Bass Pro Shops & Cabela's Outdoor Fund supports conservation-focused nonprofits through fundraising events and donation of merchandise or gift cards. Organizations eligible for funding must be registered 501(c)(3) entities in the U.S. or provincially registered nonprofits in Canada. This initiative aims to connect communities to outdoor activities while promoting wildlife conservation and support for military veterans. Grants of up to $1,000 are available to enhance local fundraising efforts.