Best Unrestricted Grants for Nonprofits in South Carolina

The MOORE Equity in Mental Health Community Grants Program, initiated by the American Psychiatric Association Foundation, aims to enhance mental health services for young people of color. With grants up to $10,000 over two years, it supports community organizations addressing mental health and substance use inequities. Eligible applicants include non-profits with a focus on culturally relevant care and sustainable solutions. The program fosters collaboration and awareness through innovative initiatives aimed at improving access to essential mental health services.

The AO Spine NA Young Investigator Research Grant Award supports early-career surgeons and researchers focusing on clinically relevant spinal or spinal cord research. With funding of $20,000, this initiative encourages new investigators by providing essential start-up capital. Successful applicants are required to present their findings at the Annual AO Spine North America Fellows Forum and submit progress and final reports detailing their research outcomes. This grant aims to foster innovation and excellence in spinal care.

The AISES National Conference Travel Scholarship provides financial support for full-time students in STEM fields to attend the annual conference. Covering registration, airfare, and lodging, recipients must commit to attending all events and uphold the AISES Code of Conduct. Selection is based on the quality of essays, letters of recommendation, and academic performance. Announcements for awarded scholarships will be made in late August/early September 2025, facilitating networking and professional development for indigenous students.

The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Marion Rotary Club’s Karl W. Schell Scholarship

The Marion Rotary Club was chartered in 1922, as club number 1051, with 23 charter members led by Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation, which was incorporated in 1959, has contributed to many organizations and scholarships over the years.

The Marion Rotary Club Karl W. Schell Scholarship migrated to Marion Community Foundation in 2017. It honors the late Karl Schell and provides financial support for Marion County graduating seniors. Recipients will have been a resident of Marion County for at least two full years and maintain a cumulative grade point average of 2.5 or higher based on a 4.0 scale.

Special consideration will be given to applicants who intend to pursue an education and career in, or related to, business, management, or the real estate industry.

The Athene Charitable Foundation focuses on corporate social responsibility through community involvement, aiming to create positive social impacts in education, health, human services, and the environment. Their initiatives include partnerships, employee volunteering, and donations aligned with their mission. They prioritize organizations that support diversity and inclusion while ensuring compliance with their non-discrimination policies. Eligible entities must be registered 501(c)(3) organizations or equivalent, enhancing community welfare where Athene employees live and work.

The Gerald C. Corcoran Education Grant, offered by the North American Native Fishes Association (NANFA), supports educational projects focused on native fish ecology and conservation. With a generous matching grant from the Corcoran family, eligible NANFA members can receive up to $2000 biennially for various environmental education initiatives, including materials production, aquatic surveys, and teacher training workshops. This program honors the legacy of past NANFA President Gerald C. Corcoran, emphasizing the importance of public education in fish conservation.

The American Heart Association (AHA) is launching the RFP for a Strategically Focused Research Network (SFRN) aimed at enhancing the early detection and delaying the progression of valvular heart disease. This initiative seeks collaborative proposals from researchers to address critical questions and advance understanding in this field. With a maximum budget of $4.4 million and a duration of four years, the AHA plans to award at least three grants based on scientific merit and alignment with its mission.

The Updated National Dislocated Worker Grant Program Guidance informs workforce development systems about the policies and priorities for using National Dislocated Worker Grant funds. This guidance outlines grant types, funding approaches, performance periods, cost limitations, and application requirements. It emphasizes the critical role of DWGs in supporting economic recovery, community resilience, and equitable workforce development, ensuring that these funds effectively contribute to creating good jobs and enhancing local economies.

The Society of Toxicology offers the Supplemental Training for Education Program (STEP), which provides up to $1,000 to support graduate students in toxicology seeking additional training to address skill gaps. Eligible applicants must be PhD students who have completed coursework and passed comprehensive exams. The funding covers workshops or courses not available through their graduate program, enhancing career prospects in toxicology.

The Rapid Outcomes from Agricultural Research (ROAR) Grant Program, managed by the Foundation for Food and Agriculture Research (FFAR), provides urgent funding for research addressing unexpected threats to the food supply. This program supports diverse projects related to pest and pathogen outbreaks, facilitating quicker responses than traditional funding avenues. With grants up to $150,000, ROAR aims to enhance agricultural resilience by fostering collaborations among researchers, institutions, and organizations to combat emerging challenges in the food and agriculture sector.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

The ISTAART Grant Program for Conferences and Convenings (IGPCC) Grant, funded by the Alzheimer's Association, aims to support innovative initiatives that enhance research discussions among Professional Interest Areas (PIAs). This funding mechanism encourages collaboration and networking opportunities for ISTAART members, allowing for the organization of educational workshops and conferences. Grants of up to $20,000 are available, with a focus on new projects that haven't received funding in the last 24 months. Applications are reviewed year-round.

Joseph G Markoly Foundation Inc

When Joseph Markoly originally established the foundation more than thirty years ago, its focus was on Alzheimer’s and heart disease support, funded through a number of the larger national disease-related organizations. Over time the focus has shifted to helping small to mid-size organizations in our local communities which support children and seniors in a variety of effective ways. 

Markoly Foundation was established in honor of Joseph G. Markoly, an entrepreneur and philanthropist who wanted to make a positive impact in people’s lives. Joseph’s family was affected directly by both Alzheimer’s and heart disease having lost a family member to each condition. For that reason, the foundation dedicates a majority of their resources to providing grants to organizations that focus on the treatment of each of these diseases. In addition, Markoly Foundation supports a variety of programs dedicated to helping children and seniors by providing services, supplies, programs and research in areas impacting these demographics.

Joseph G. Markoly Foundation Grant Support for Children’s Organizations

Children are the future of this world and the Markoly Foundation is proud to fund local programs dedicated to improving the lives of children and their families. From providing vision services for school kids to classes on parenting, we are proud to do our part to help fund critical community programs for families.

We are dedicated to providing funding for local nonprofit programs that improve the quality of life for all, but particularly for the children and elders in our community.

The We Are Moving The Needle Scholarship supports women, trans, and non-binary creators in the music industry by offering two full scholarships for a masterclass with GRAMMY-nominated producer Alissia in Paris. This initiative aims to empower underrepresented voices through education and mentorship, fostering a more inclusive music industry. Participants will engage in hands-on workshops designed to enhance their production skills and gain insights from a leading industry professional, contributing to lasting cultural change.

Fred W. Homann Jr. Research and Education Scholarship

Scholarships awarded to Marshall area residents or former graduates pursuing higher education in the health sciences with preference given to applicants with a particular interest in research/preventative medicine. Applicants must maintain a 3.0 GPA average in their previous year of education, whether it be high school or college, or postgraduate. Students who receive this scholarship are encouraged to apply for further support in subsequent years. 

The NESOT Fall Meeting Oral Presentation Award, sponsored by the Society of Toxicology, recognizes outstanding presentations by students in the Northeast. Up to four students will be selected to present their research, with one receiving a $1,000 prize for the best oral presentation. Eligible candidates must be NESOT members affiliated with institutions in Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, or Vermont. Previous winners of the oral award may not compete but can participate in the poster competition.

The Aim High Grant Program offers one-year grants of $20,000 to support out-of-school time programs for middle school youth. Funded by the New York Life Foundation, this initiative aims to enhance students' transition to high school by providing essential skills and guidance. Programs must demonstrate effective engagement strategies and serve low-income communities. This grant represents a vital investment in the future of young people, helping them develop academically, socially, and emotionally.

The Hank Riley Zolla Scholarship Fund, administered by the San Antonio Area Foundation, supports students pursuing nursing careers, including neonatal and child care. Eligible applicants must maintain a minimum 2.5 GPA and demonstrate financial need. This renewable scholarship can cover various degree levels, including associate, bachelor's, and vocational certificates. The fund aims to empower future healthcare professionals in the USA, ensuring quality education and community support for generations to come.

The Ajay Castro Scholarship Fund, managed by the San Antonio Area Foundation, supports female undergraduate students pursuing a degree in communications. This scholarship is aimed at adult learners or current college students who have graduated high school or earned a GED. Although it is not renewable, recipients can reapply annually. Preference is given to those returning to college after a break, ensuring that the fund continues to empower women in education.

The Arnold Shultz Fund, established by the IBMA Foundation, aims to enhance diversity in bluegrass music by providing $30,000 annually in grants. This initiative supports individuals, schools, and organizations dedicated to inclusivity, particularly among underrepresented racial and ethnic groups. The fund honors Arnold Shultz, a pivotal African American musician who mentored Bill Monroe, and continues his legacy by funding educational opportunities for young musicians and promoting bluegrass music in diverse communities.

The Land Trust Bird Conservation Initiative, led by the Cornell Lab of Ornithology, aims to support land trusts in conserving private lands for bird protection. With funding for up to fourteen grants, the initiative encourages capacity building and management projects that enhance bird habitats. Eligible organizations can apply for grants to expand conservation efforts through collaboration and innovative strategies, fostering partnerships that leverage additional funding and community support. This initiative highlights the importance of birds in land stewardship and conservation.

The Friends of Reservoirs: Small Grant program offers annual grants of $2,000 to member organizations of Friends of Reservoirs, with additional product donations bringing the total value over $3,500. This initiative, supported by generous sponsors, aims to enhance reservoir fisheries habitats. Applicants should note a $25 application fee, which contributes directly to the grant fund. This program focuses on fostering community engagement and improving aquatic ecosystems.

The Spotlight Fund Grants aim to enhance racial equity in K-12 education by providing flexible funding to BIPOC educators. With grants ranging from $500 to $1,000 per educator, these funds are essential for sourcing tools and materials that support diverse student needs. As schools face budget cuts exacerbated by COVID-19, this initiative focuses on proven strategies that foster an inclusive learning environment for students of color, ensuring they have equal opportunities to thrive.

The WAEF Scholarships, supported by the Washington Apple Education Foundation, offer over $1 million in educational awards to more than 300 students this year. These scholarships are primarily for individuals with ties to the tree fruit industry in Washington, with a special focus on the Danna Gebbers Guzman Memorial Scholarship, aimed at nursing students. Eligible recipients can use the funds at accredited institutions with nursing programs.

The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.

The Alzheimer’s Association Research Grant For All (AARGA) Program supports early-career investigators in their first seven years as independent researchers. This grant aims to fund projects that develop preliminary data and test new hypotheses in Alzheimer’s and related dementia research. Areas of interest include disease mechanisms, biomarker development, and health equity. Applications are welcome from both U.S. and international researchers, fostering innovation and collaboration in the fight against dementia.