Best Unrestricted Grants for Nonprofits in South Carolina

Nurses Educational Funds

Nurses Educational Funds, Inc. depends solely on donations to advance our only mission, to promote nursing leadership through annual scholarship support for professional nurses seeking masters and doctoral degrees in nursing education, practice, research, and administration.

NEF’s only purpose is to provide nursing scholarship assistance to make graduate level nursing education possible. NEF is one of the largest, national, private, professionally endorsed source of funds for advanced nursing study with over one hundred years of service to and for professional nursing. NEF is a non-profit organization with 501(c) status.

Martha Rodriguez Scholarship Fund

Martha Rodriguez Memorial Scholarship was initiated in 2025 by Lisa Ackerman, close friend and then Director of the Columbus Citizens Foundation. Raised in Gary, Indiana and a true New Yorker, Martha died as the result of traumatic head injuries from a tragic accident just outside her NYC apartment. Martha Rodriguez gave in life, working as a nurse helping patients navigate the trauma of breast cancer at Memorial Sloan Kettering Cancer Center. In her death, she was lauded by the President of LiveOnNY, an organization that coordinates and oversees organ donations, for her last selfless act of giving. Martha donated organs that gave life and hope and helped three people lead better lives. Her zest for life was contagious, and her dedication, compassion, and expertise left an indelible mark on the lives of countless MSKCC patients and caregivers. She was a friend and mentor to many. She loved being a nurse at MSKCC and worked for more than 28 years as a nurse practitioner and for the last 15 years of her life dealing with breast cancer patients. This scholarship is awarded to nurses studying in master's or doctoral programs who are dedicated to oncology care, or women’s health, or are Latinx nurses.

The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.

The Jenna’s Rainbow Moving Forward Grant, offered by the Children’s Brain Tumor Foundation, provides crucial financial assistance to adult survivors of brain or spinal cord tumors. Aimed at fostering independence, this grant supports costs associated with job transitions, new living situations, and resources to enhance self-sufficiency. Eligible applicants must be at least 18 years old, diagnosed before 21, and not have received recent funding from CBTF or JRF. This initiative empowers survivors to overcome challenges and move forward in their lives.

The Amazing Grace Scholarship, established by the Children's Brain Tumor Foundation, honors Grace Fulcher, a brain tumor survivor. This scholarship supports students diagnosed with brain or spinal cord tumors before age 21, who reside in the U.S. and are pursuing higher education. With a $1000 award, the scholarship aims to empower survivors to achieve their educational goals, inspired by Grace's resilience and academic success despite her challenges.

The National Cancer Institute (NCI) invites applications for studies on mechanisms by which bariatric surgery influences cancer risk. This funding opportunity encourages exploration beyond short-term outcomes like weight loss and diabetes. The goal is to support innovative proof of concept studies, emphasizing feasibility without prior development in the literature. Unpublished data is not allowed, but references from preprints with a DOI are acceptable. Deadlines for applications span from February 2025 to November 2027.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Patient Care Fund

The NAFC Patient Care Fund supports direct patient services that expand immediate access to care. This funding is designed to help NAFC members meet urgent patient needs by supporting clinical supplies, expanded services, contracted providers, transportation assistance, medication access, and other direct care resources.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved. The Yawkey Foundation is committed to providing support for program and small capital needs connected to a nonprofit’s established mission and proven program/service delivery connected to the mission.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Health Care Support

Access to high quality health care, particularly for those disadvantaged members of the community, was an issue of great importance to Tom and Jean Yawkey. Tom Yawkey was instrumental in the founding of Georgetown Memorial Hospital, which brought much-needed health care to the rural area of Georgetown, South Carolina. In addition, the Yawkeys first lent their extraordinary support to Dr. Sidney Farber by initiating the Red Sox relationship with Dr. Farber, and laid the groundwork for establishment of The Jimmy Fund in 1953. That relationship lasted throughout both of their lifetimes and continues to this day.

The Yawkey Foundation continues to support medical institutions, including transformational construction and renovation projects to help leading medical institutions expand their footprints and ability to provide expert medical care. Understanding the real link between medical needs and behavioral health needs, particularly in children, the Foundation has also played a leading role in supporting organizations providing access to behavioral and mental health treatment programs. 

The Lakken’s Legacy Survivor Scholarship, offered by the Children’s Brain Tumor Foundation, awards $1,000 to brain tumor survivors pursuing education beyond high school. This initiative honors Lakken, who faced challenges during her cancer journey yet remained passionate about education. The scholarship aims to support individuals diagnosed with brain or spinal cord tumors before age 21, ensuring they have the opportunity to continue their studies in various educational institutions. It's a commitment to empower survivors and foster their dreams.

The Lakken’s Legacy Sibling Scholarship, established by the Children’s Brain Tumor Foundation, honors Lakken Burzynski's courage and resilience in her battle with cancer. This $1,000 scholarship is designed for siblings of children diagnosed with brain tumors, emphasizing support for families impacted by such challenges. Eligible applicants must be 21 or younger at diagnosis and reside in the U.S. This initiative promotes positivity and hope, continuing Lakken's legacy of strength and family support.

The Carson Bailey Memorial Scholarship for Siblings, established by the Children’s Brain Tumor Foundation, honors the memory of Carson Bailey. This scholarship aims to support brain tumor survivors pursuing their educational goals. Eligible applicants must have been diagnosed with a brain or spinal cord tumor before age 21, reside in the U.S., maintain a GPA of 2.0 or higher, and be at least a senior in high school. A $1000 scholarship is available for those attending various educational institutions.

The Carson Bailey Memorial Scholarship, established by the Children's Brain Tumor Foundation, honors the memory of Carson Bailey, a dedicated student and beloved family member. This scholarship is aimed at brain tumor survivors who have been diagnosed before the age of 21 and seek to pursue higher education. It provides $1000 to eligible applicants, supporting their educational aspirations while promoting inclusiveness and respect for all backgrounds within the brain tumor community.

The Charles B. Decker Memorial Scholarship, established in 1991, supports college and graduate students from the Tri-Lakes area pursuing journalism careers. This scholarship emphasizes the importance of education in the Adirondack region by providing essential financial assistance to students dedicated to journalism. Candidates are evaluated based on financial need, demonstrated commitment to journalism, and academic achievements, ensuring that the scholarship aligns with the foundation's mission to invest in educational opportunities.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

About

Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

David Bruce Belcher Fund

About the fund

The David Bruce Belcher Scholarship Fund was established for the training of professionals in nursing, special education, and therapy (physical, speech and occupational) as a legacy of David Bruce Belcher and the caregivers who comforted him. This fund reflects David’s rare spirit and bright love in its support of those who seek to advance their nurturing skills in nursing, therapy, and special education.

The Children and Youth with Special Health Care Needs Research Network aims to enhance the lives of children and youth with special health care needs (CYSHCN) and their families. By establishing a robust research infrastructure, the program will generate evidence-based solutions to foster well-being and community engagement. It focuses on identifying effective interventions and measures that can be integrated into essential services and supports, ultimately helping CYSHCN thrive throughout their lives.

The MyGOAL Autism Grant Program provides essential financial support for families caring for individuals with Autism Spectrum Disorders. This need-based grant assists with non-reimbursable medical expenses, nutritional needs, personal care, and educational enrichment activities. With a funding amount of $1000, the program prioritizes first-time applicants and aims to enhance the well-being and development of children with ASD, addressing gaps left by other funding sources.

U.S. Small Business Administration

SBA works to ignite change and spark action so small businesses can confidently start, grow, expand, or recover. Created in 1953, the U.S. Small Business Administration (SBA) continues to help small business owners and entrepreneurs pursue the American dream. SBA is the only cabinet-level federal agency fully dedicated to small business and provides counseling, capital, and contracting expertise as the nation’s only go-to resource and voice for small businesses.

Manufacturing grants

SBA provides grants to help empower small manufacturers.

Empower To Grow (E2G) Manufacturing in America Grant

The goal of this grant is to provide workforce development in key manufacturing industries, such as timber, energy, aluminum, steel, digital, and automotive.

SBA is looking for organizations that will provide technical proficiency and essential skills, including operating machinery, quality control, welding, utilizing industrial software, and workplace safety. 

Who We Are

Our Mission

UNCF envisions a nation where all Americans have equal access to a college education that prepares them for rich intellectual lives, competitive and fulfilling careers, engaged citizenship and service to our nation.

UNCF’s mission is to build a robust and nationally-recognized pipeline of under-represented students who, because of UNCF support, become highly-qualified college graduates and to ensure that our network of member institutions is a respected model of best practice in moving students to and through college.

UNCF’s North Star is to increase the total annual number of African American college graduates by focusing on activities that ensure more students are college-ready, enroll in college and persist to graduation. This is done through a three-pillar strategy. Positioning member institutions as a viable college option for students and investing in institutional capacity to improve student outcomes; creating transformational support programs to ensure students are enrolling and persisting through college completion; building awareness of educational attainment and cultivating college-going behaviors within the African American community.

For Students

UNCF is more than just scholarships. We’re the nation’s leading minority education organization and our goal is to help you get to and through college.

Our support takes many different forms. From merit scholarships to financial assistance, on-campus assistance to professional development, emergency financial aid to community support, UNCF is committed to getting more students like you to and through college.

2026-2027 The Edward and Sandra Meyer Family Scholarship

The Edward and Sandra Meyer Family Scholarship is directed towards current talented high school seniors within the Class of 2026 from the state of New York, who will be enrolling at any accredited UNCF member institution or other accredited Historically Black College/University.

The Edward and Sandra Meyer Family Scholarship is directed towards academically achieving high school seniors, who are seeking enrollment at any accredited UNCF member institution or other Historically Black College/University. 

The Edward and Sandra Meyer Foundation, Inc. is a social impactful philanthropic organization based in New York. The foundation actively focuses on funding critical initiatives in the arts and culture, education, health and religion.

The Edward and Sandra Meyer Foundation, Inc. has partnered with UNCF to establish the Edward and Sandra Meyer Family Scholarship. This scholarship is focused on providing vital financial assistance to ensure that high school seniors within the state of New York have access to a quality college education.

The candidates will have the opportunity to enroll in any accredited field of study at their selected institution. The candidates must be enrolled as first-time freshman within the 2026-27 Academic year. The eligible candidates must have maintained a cumulative grade point average of 2.50 throughout the entire application process. 

The selected recipients will be eligible for renewal awards upon their continual adherence to the program guidelines and have established financial need by their institution each year.

The James Knott Memorial Scholarship, established by the New Mexico Manufactured Housing Association, supports graduating high school seniors residing in manufactured homes. Awards of up to $1,000 are given annually to students with a minimum GPA of 3.0 who attend a nonprofit or public educational institution full-time. Applicants must provide proof of residency, a written statement of financial need, and a reference from a teacher or counselor. This scholarship aims to empower students to achieve their educational goals.

The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.

The Herbek Humanitarian Award honors a CAP member pathologist for significant contributions to the See, Test & Treat® program, which offers free cancer screenings to underserved women. Established in 2011, it commemorates Gene N. Herbek, MD, FCAP, who pioneered this initiative for Native Americans. Nominees must have led or significantly contributed to the program, with submissions due by May 3, 2024. Self-nominations or incomplete entries will not be accepted, ensuring high standards in recognition.

The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.

The NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment supports individuals pursuing higher education who have engaged in equestrian activities. Open to undergraduates, graduates, and adult re-entry students, the scholarship aims to assist those attending various educational institutions in the United States. Applications for NCCF scholarships will be accepted from December 16, 2025, to March 3, 2026. Be sure to check specific eligibility requirements for each scholarship.

The Joyce Price Johnson’s Samaritan Fund provides scholarships for young people in North Carolina who are exiting foster care or facing poverty. Eligible candidates include undergraduates, graduates, and adult re-entry students attending various accredited institutions. Applications for NCCF scholarships open on December 16, 2025, and close on March 3, 2026. Preference is given to applicants from Wayne County and adjacent areas, ensuring support for those with exceptional financial need.

The Jeannett Slesnick Community Spirit Scholarship offers up to four years of college tuition assistance for graduating seniors from Coral Gables High School, Miami Senior High School, or ISPA. Applicants should demonstrate an interest in communications, journalism, leadership, or historic preservation, and must maintain a 3.0 GPA. Established in 2022 by Jeannett and Don Slesnick, this scholarship honors Jeannett's commitment to community service and education, supporting local high school graduates in their academic pursuits.

Scholarships

We partner with donors to administer scholarships for students across the state. Most NCCF scholarships open for applications on Dec. 16, 2025, and close on March 3, 2026.

Undergraduates, graduates, medical and professional school students and adult re-entry students who are attending community colleges, four-year universities, career/technical schools, teaching credential programs and graduate, medical or professional schools in the United States are eligible for scholarships offered at NCCF.

Each scholarship has specific eligibility requirements defined by the donor when the scholarship was established. Be sure to read the requirements of each scholarship carefully as directed through the universal application and address those elements as needed in your application.

Grayce Wills MacDonald and Ivan A. MacDonald Endowment

Shall support students who attended high school in Cherokee, Graham, Clay, Swain, Macon, Jackson, Haywood, Buncombe, and Henderson counties, and who are pursuing a college or post-graduate level degree in the field of nutrition with emphasis on the study of natural foods and the vegetarian lifestyle. Scholarships may be based on both need and merit.

The AISES RISE Scholarship offers $2,000 annually to support Indigenous students pursuing careers in STEM, particularly in the casino gaming industry. This initiative, powered by Aristocrat Gaming, aims to empower Indigenous talent through exposure, resources, and programming. Eligible applicants must be full-time students and current AISES members, demonstrating a commitment to their education and community. The scholarship seeks to enhance diversity in STEM fields by providing critical financial support to deserving students.