Best Unrestricted Grants for Nonprofits in South Carolina

The OVC FY 2026 grant aims to improve outcomes for child and youth victims of human trafficking by integrating policies at state and Tribal levels. This funding opportunity focuses on developing strategic plans to address the challenges faced by minor victims, enhance coordination among systems like child welfare and juvenile justice, and ensure effective identification and prosecution of traffickers. By fostering multidisciplinary approaches, the program seeks to provide comprehensive support and services to these vulnerable populations.

The Food and Agriculture Defense Initiative Extension Disaster Education Network (FADI-EDEN) aims to enhance the resilience of the U.S. food and agriculture sector against various threats, including biosecurity risks and natural disasters. Through the Extension Disaster Education Network, the program fosters collaboration among CES professionals, providing essential education and technical assistance to farmers and communities to effectively manage domestic disasters and strengthen all-hazards preparedness.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

The AACR June L. Biedler Prize for Cancer Journalism

Prize Summary

The AACR June L. Biedler Prize for Cancer Journalism was established by the AACR in 2015 to raise awareness of the critical role that the media play in educating the public about cancer and cancer research.

Funded by a major bequest to the AACR from cancer research pioneer Dr. June L. Biedler, a scientist, mentor, and former member of the AACR Board of Directors, this prize showcases outstanding examples of cancer journalism and recognizes individual professional journalists who have produced accurate, informative, and compelling stories that enhance the public’s understanding of cancer, cancer research, cancer advocacy, or cancer policy.

The prize provides an unrestricted cash award of $5,000 and a commemorative award.

Categories

Each submission may be considered for only one category, as selected by the candidate on the application form.

Applicants may submit in any of the following categories:

Prize Acceptance

Awardees will be able to accept the prize during the AACR Annual Meeting 2027 in Orlando, April 2-7, 2027.

The ADCMS Competitive Grant Program, administered by the DOT Federal Highway Administration, aims to incentivize eligible State Departments of Transportation and partners to implement innovative technology in construction projects. This initiative promotes collaboration among various entities, including local governments and private industries, with a required cost share of 20% to enhance project viability and effectiveness. The program encourages joint applications to maximize the impact of technological advancements in the construction sector.

The FY 2026 funding opportunity aims to support Indian Tribes and intertribal consortia in implementing approved Nonpoint Source management programs under the Clean Water Act Section 319. This initiative, funded by the EPA, focuses on addressing NPS pollution through best management practices as outlined in Tribal NPS Management Program Plans, ensuring the protection of water resources and promoting sustainability in Tribal lands.

American Headache Society

The American Headache Society (AHS) is a professional society of healthcare providers dedicated to the study and treatment of headache and face pain. The Mission of the AHS is to improve the lives of people impacted by migraine and other headache disorders. AHS advocates for those impacted by headache and the headache field, to meet our core objectives. AHS provides educational courses, scientific meetings, a journal, research support, career development opportunities, Special Interest Groups, advocacy training, and a professional community. The AHS strives to meet its objectives while fostering an inclusive sense of belonging and community.

Headache & Migraine Competitive Grant Program

The Headache & Migraine Competitive Grant Program stands at the forefront of advancing headache medicine by funding groundbreaking quality improvement initiatives. This highly competitive grant program, offered through the collaboration between the American Headache Society and Pfizer, supports projects that have the potential to reshape the field by creating widely applicable tools and driving measurable improvements in patient care. 

Migraine & Women's Health

Migraine is a prevalent and debilitating neurological disease that disproportionately affects women, impacting quality of life, productivity, and overall health. Recognizing the need for innovative solutions and enhanced care, Pfizer and the American Headache Society (AHS) are collaborating to offer a new grant opportunity inviting proposals for collaborative quality improvement and research projects focused on migraine and women's health.

Spencer Educational Foundation Inc

The Spencer Educational Foundation was founded by the Rims Atlanta Chapter in 1979. To this day, Spencer remains the premier organization funding the education of tomorrow's risk management and insurance leaders.

The Spencer Educational Foundation: awards merit-based scholarships and grants to university students pursuing careers in risk management, insurance, and/or actuarial science; provides grants that create experiential learning opportunities both on and off campus; funds the development of risk management and insurance curricula in colleges and universities; supports Risk Managers by creating internship opportunities within the risk management function of their companies; and operates across the United States and Canada. 

Spencer Educational Foundation: General Grants

Spencer’s goal to help build a talent pipeline of Risk Management and Insurance professionals is achieved in part by our collaboration with Risk Management and Insurance educators across the United States and Canada. Since 2010, Spencer has awarded over $4.5 million in General Grants to support over 225 student-centered experiential learning initiatives at universities and RMI non-profit orgs.

Spencer's General Grants Program supports student-centered initiatives that (1) provide experiential learning opportunities for Risk Management & Insurance students and (2) attract new talent to risk and insurance careers. 

The Annual Recurring University Training and Research grant aims to foster the next generation of engineers and scientists by funding research and development at U.S. colleges and universities. This initiative focuses on supporting early-stage research and enhancing opportunities for underrepresented communities, ensuring that students gain essential skills for successful careers in the U.S. workforce and economy. It is a vital step toward inclusive educational advancement and workforce development.

This project aims to enhance the ability of Tribal communities to identify and respond to emerging drug threats. By funding researchers, it addresses the challenges these communities face in capacity building. A pilot project will be conducted to improve their detection and response capabilities, ensuring a proactive approach to drug-related issues. The Executive Office of the President supports this initiative, highlighting the importance of strengthening community resilience against substance abuse.

About Lions Club International FoundationLions Clubs International Foundation (LCIF) provides grants that empower the service of our members. Since its inception in 1968, LCIF has awarded more than US$1.3 billion in grant funding.  Mission :Our mission is to empower Lions clubs, volunteers and partners to improve health and wellbeing, strengthen communities, and support those in need through humanitarian service and grants that impact lives globally, and encourage peace and international understanding. And we fulfill it every day, everywhere we serve.Lions Club International Hunger Grant ProgramHunger Grants focus on strengthening infrastructure and providing essential equipment for Lions’ hunger-relief efforts. These grants empower Lions to support vital initiatives such as school feeding programs, food banks and feeding centers, ensuring that those in need receive the nourishment they require. These grants support infrastructure and equipment acquisition for Lions’ projects focused on alleviating hunger.Grant Examples: 

• Construction or expansion of food banks, feeding centers and food storage facilities.
• Purchase of refrigerators and freezers to store perishable food items.
• Vehicles to transport, collect and deliver food.

The Bicycle Advocacy Grants Program, supported by New Belgium Brewing Co, aims to foster community engagement through bicycle projects. With over $11.3 million donated since its inception in 1995, the program focuses on breaking down barriers to cycling and promoting accessibility for all. Projects targeting increased ridership and addressing systemic inequities are prioritized. This initiative reflects New Belgium's commitment to sustainability and social equity, enhancing community connections through the joy of cycling.

The FY26 Bollards Competitive Grant Program aims to enhance pedestrian safety by funding bollard installation projects. This initiative targets areas frequented by large crowds to prevent injuries and potential acts of terrorism. Eligible applicants include State Departments of Transportation and local government entities, with a 100% federal funding share for projects. This program is vital for improving public safety in urban environments.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Dr. Marlene Caroselli Excellence-in-Communication Scholarship

Purpose of Scholarship

To recognize those high school seniors who have consistently demonstrated excellence in both the spoken and written word and plan to pursue college and a career that requires excellence in communication.

Number and Size of Awards

Number of recipients and award amounts vary; award amount may be split between two or more recipients. Award paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters. Average award $5,000; not to exceed the cost of tuition.

Donor Information

A former St. John Fisher College professor who understood and greatly admired the hard work and challenges of single-parent students created this scholarship to support their higher education endeavors and to improve their employability, their lives, and the lives of their children.

Rico Memorial Scholarship

Provides a scholarship to graduating seniors in Lincoln County with a GPA between 2.5 and 2.99 and must participate in sports (preference will be given to football and or track/field)

Scott Cornelius Memorial Scholarship (Piedmont)

To honor the memory of Scott Cornelius by supporting students pursuing careers in sales, marketing, insurance or related business fields who demonstrate leadership and integrity.

About

What is the Pizza Hut Foundation?

In pursuit of happiness, the Pizza Hut Franchisee community, in partnership with Pizza Hut U.S. is proud to announce the formation of the Pizza Hut Foundation.

Our foundation is seeking to touch the lives of over 100 youth annually by partnering with youth-serving nonprofit organizations focusing on literacy education programs to enable our team members and their peers to be career and life ready.

Pizza Hut Foundation, Inc. is a nonprofit, tax-exempt charitable organization under the Section 501(c)(3) of the Internal Revenue Code. Donations are tax deductible as allowed by law.

Financial Assistance & Scholarships for Education

Education is key to success in life. However, each year two million students drop out of college due to financial hardship and a lack of financial assistance. In the United States there are more than 900,000 college-bound students who qualify for federal financial assistance each year. Yet almost 90% of these students don’t receive adequate guidance or support, leaving hundreds of thousands of students’ needs unmet.

The Pizza Hut Foundation is proud to partner with Kaleidoscope as our scholarship platform provider, pairing education dreams with funding.

Mentorship Program

While the Scholarship program financially supports the awarded students enrolled in higher education, it doesn’t stop there. The Pizza Hut Foundation offers a mentorship opportunity, through leaders from within the Pizza Hut organization and Vendor partners, to engage Scholarship recipients in a meaningful way throughout their educational journey.

The Pizza Hut Foundation will support engagements with the students via monthly connections to ensure a positive experience for both the mentors and the mentees.

The Fiscal Year 2026 United States Marine Highway Program (USMHP) aims to reduce congestion on land by designating Marine Highway Routes, enhancing alternatives to land transportation. Administered by the U.S. Department of Transportation, this program encourages the use of Marine Highway Transportation, supporting projects that promote expansion and development of this sustainable transport option. Eligible projects may include innovative logistics solutions that alleviate traffic and contribute to environmental sustainability.

The TTF Advertising for the Environment Grant, established by the Temper of The Times Foundation in 1997, aims to enhance awareness of wildland conservation through marketing initiatives. This grant is exclusively available to 501(c)(3) nonprofit organizations and funds various advertising campaigns to protect native ecosystems. Priority is given to projects that demonstrate measurable impacts on conservation, rather than those focused solely on education.

Confederated Tribes of Siletz Indians

We the Confederated Tribes of Siletz Indians are the most diverse confederation of Tribes and Bands on a single reservation in the United States. Our ancestors spoke 10 completely different languages, each of which had multiple dialects. Our ancestors brought with them deep connections to more than 20 million acres of ancestral territory combined, including all of Western Oregon from the summit of the Cascade mountains to the Pacific and extending into what’s now SW Washington State and northern California. Our ancestors signed many treaties with the United States. We were promised the 1.1 million acres Siletz Reservation as our permanent home, but following massive reservation reductions Congress passed the Western Oregon Termination Act in 1954 (took effect in 1956), and our federally recognized status as a tribe was also taken. In 1977 our lobbying of Congress to repeal our Termination was successful, and we became the second formerly Terminated Tribe to regain federal recognition as a Tribe.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

NWIHA – Youth Scholarship Program

Scholarship applications will be reviewed to meet the following minimum eligibility before any further review of the application will be done.

• Applicant must either have an application pending or a letter of acceptance from a higher education institution such as a four (4) year college or a two (2) year community college prior to the funds being sent to the higher educational institution.
• Applicant must be less than twenty four (24) years old on the deadline submission date.
• Applicant must be an enrolled member from one of the NWIHA member Tribes.
• Payments are made directly to the school, organization, etc. and not to the Applicant or their families.
• All of these items must be postmarked on or before March 31st of each year, or the Application will be automatically rejected.
• Faxed applications will NOT be accepted.
• All Applications become the property of NWIHA. NWIHA reserves the right to publish essays.

Whitley County Builders’ Association Scholarship

This scholarship is available to a graduating senior who attends Columbia City High School, Churubusco High School, or Whitko High School and is planning to pursue a technical, associate or baccalaureate degree in the building trades field (such as Construction Engineer, Architecture, Building trades, etc.)

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

About the Bertin Family Foundation

Founders: Kim and Jennifer BertinAfter a successful career innovating orthopedic surgical techniques, devices, and implants, Kim and his wife Jennifer feel a deep sense of stewardship to dedicate their resources to helping others. They engage all three generations of the Bertin family in hands-on service and grantmaking decisions, fostering a shared commitment to giving back. Through the foundation’s work, the Bertin family seeks to strengthen communities, support meaningful causes, and inspire future generations to lead with compassion and purpose. 

NOW Grants

A limited number of grants are available for one time projects or programs that emerge outside of the standard review period. These grants are for $5000 or less.

AMS Organology Study Group Travel Grants

The AMS Organology Study Group Travel Grants program provides travel grants to support AMS Annual Meeting attendance for students and recent graduates with research interests in organology and/or other intersections of music and material culture studies. In addition to supporting attendance at the annual meeting, this program also introduces recipients to a network of scholars working in the field of organology. In 2026, selected recipients will not receive travel grants because the 2026 AMS Annual Meeting is being held online, but will instead receive complimentary registration for the conference. The 2026 AMS Annual Meeting will be held 14–15 November and 19–20 November 2026.

The purpose of the program is to defray costs associated with attending the AMS Annual Meeting and participating in Organology Study Group (OSG) activities. Recipients will be required to attend the Organology Study Group's paper session at the 2026 AMS Annual Meeting.

The Organology Study Group Travel Grants program was established in 2024 with the generous support of the American Musical Instrument Society (AMIS). In addition to complimentary registration for the 2026 AMS Annual Meeting, recipients will receive one year of complimentary membership in the AMIS.

The Frances Parker Rupert Memorial Fund for Music and the Performing Arts provides scholarships to talented students pursuing music or performing arts degrees. Established by the Community Foundation Serving Western Virginia, this fund aims to support high school seniors from specific counties, considering their potential and financial need. Applicants must demonstrate their artistic abilities and articulate how this scholarship will aid their educational goals in a two-page essay.

Healthcare Assistance Grant

The MS Focus Healthcare Assistance Grant assists uninsured individuals with the cost of visiting their MS specialist as well as dental assistance. The grant, which can pay for one visit and one follow-up, is designed to assist those already diagnosed with MS who may need a visit to their treating physician to renew a prescription or handle other important needs. 

Applicants give MS Focus staff authorization to negotiate costs directly with the provider, and the fee is paid directly to the doctor. 

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.