Best Grants for Grassroots Organizations in South Dakota

Bell's Brewery Small Grassroots Grants support projects focusing on water stewardship across the Great Lakes watershed. With grant amounts ranging from $500 to $5,000, eligible organizations can apply for funding to improve ecosystem health, enhance public health through better water resource management, and promote resilience against climate-related water risks. This initiative highlights Bell's commitment to environmental stewardship and community support in all 50 states and DC.

The Windgate Charitable Trust Grant supports contemporary craft and visual arts in the U.S. It offers funding for fellowships, residencies, educational outreach, and materials for craft programs. The foundation prioritizes strengthening visual arts in colleges and expanding K-12 art-integrated programs, providing opportunities for artists and educators to enhance their skills and foster creativity among students. Organizations with previous funding from Windgate can apply through the grantee portal.

The MDU Resources Foundation seeks to enhance community well-being through grants to qualified organizations. Established in 1983, the foundation primarily funds health, education, civic, cultural, and environmental projects. It prioritizes local initiatives and encourages applications for new programming that addresses unmet needs. Organizations must be IRS-recognized 501(c)(3) entities to be eligible. The foundation does not support requests from individuals or for endowment funds, focusing instead on charitable contributions that directly benefit the community.

The Dollar General Literacy Foundation offers Family Literacy Grants to nonprofit organizations that support family literacy initiatives. Eligible applicants must provide services such as adult education, children's education, and parent-child engagement activities. Organizations must be located within 15 miles of a Dollar General store and have a valid IRS tax ID. This funding aims to enhance literacy skills for families, empowering individuals to achieve their educational goals.

The NAACP X Society Awards Scholarship

The NAACP x Society Awards Scholarship is one of many funding opportunities available to students through NAACP's Inspire Initiatives. We offer scholarships to outstanding and qualified students pursuing undergraduate degrees. Through the generosity of our donors, we advance efforts to ensure equity in educational opportunity that prepares students for success in school, work, and life.

Scholarship amount: $1,000 to $5,000

This is a non-renewable scholarship opportunity.

The South Dakota Fund Grants provide financial support to non-profit organizations across South Dakota, focusing on culture, economic development, education, and health services. Grants typically range from $2,000 to $20,000, with exceptions possible. Applicants must be public, non-profit organizations or partner with a verified fiscal sponsor. The fund encourages community involvement and matching funds to enhance project sustainability and success.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 2: Care Coordination Program

Care Coordination program supports a patient-centered healthcare delivery model that provides comprehensive, proactive, and coordinated management for individuals with multiple chronic conditions, while explicitly identifying and addressing the non-medical social and environmental factors that impact their well-being.

Bristol Myers Squibb is dedicated to enhancing healthcare and advancing scientific knowledge through its Corporate Giving program. By supporting various organizations, BMS aims to improve health equity and access to essential medicines for underserved populations. Their focus includes charitable donations, medical education, and community support initiatives. This commitment reflects BMS's goal to make a positive impact on patients' lives and foster strong communities where their employees work and live.

The Larson Family Foundation, established in 1990 by Dale Larson, aims to enhance the quality of life for South Dakotans through grants to tax-exempt organizations. With a maximum grant of $100,000, the foundation supports diverse programs addressing basic human needs, including food, clothing, and education. Eligible applicants must be 501(c)(3) organizations in South Dakota. However, the foundation does not fund administrative expenses or individual scholarships, ensuring that contributions directly benefit community services.

The NCR-SARE Youth Educator Grant Program supports educators in the North Central Region to innovate ways of teaching sustainable agriculture. With funding up to $6,000, this program encourages educators to engage youth and promote sustainable practices. By sharing their experiences, grantees can create a ripple effect among peers, enhancing the reach and impact of sustainable agriculture education. This initiative aims to foster creativity and collaboration in teaching sustainable practices to the next generation.

The NCR-SARE Professional Development Program Grant supports agricultural educators through competitive grants aimed at enhancing training in sustainable agriculture. This initiative promotes cross-agency collaboration, utilizing farmers as educators to address pressing issues within the farming community. Projects funded are expected to demonstrate measurable outcomes, fostering knowledge and behavioral changes that lead to sustainable practices in agriculture and food systems. The program encourages diverse participation, ensuring a comprehensive approach to professional development.

Rape Prevention Education Grant

Sexual violence is any sexual activity where consent is not freely given. Sexual violence affects millions of people each year in the United States and can lead to serious health consequences, including mental health conditions, injury, and chronic physical health problems.

The National Intimate Partner and Sexual Violence Survey (NISVS, 2016–2017) reports:

• More than 1 in 2 women (over 54%) and nearly 1 in 3 men (about 31%) have experienced contact sexual violence—including rape, being made to penetrate someone, sexual coercion, or unwanted sexual contact—at some point in their lives.
• Nearly 1 in 4 women (about 27%) have experienced completed or attempted rape in their lifetimes.
• About 1 in 26 men (3.8%) have experienced completed or attempted rape, and more than 1 in 10 men (10.7%) have been made to penetrate someone during their lifetime.

The South Dakota Rape Prevention Education (RPE) program is funded by the Centers for Disease Control and Prevention. This funding is authorized through the Violence Against Women Act.

The goal of the RPE program is to strengthen sexual violence prevention efforts by focusing on primary prevention: preventing sexual violence before it occurs. It operates in all 50 states, the District of Columbia, Puerto Rico, and six U.S. territories. The CDC provides tools, training, and technical assistance to the RPE program to prevent sexual violence, reduce risk factors, enhance protective factors, promote best practices, analyze data and evaluate prevention efforts.

With the RPE program, South Dakota hopes to lower sexual violence rates against everyone, but especially the target audiences of children, teens, young adults, and Native Americans.

The Fence Authority Scholarship offers a $1,000 award to students pursuing a bachelor’s degree in fields that enhance community beautification, such as architecture, civil engineering, and environmental sciences. Applicants must be U.S. citizens, enrolled full-time, and involved in community service. This scholarship aims to empower students to contribute positively to society while furthering their education in impactful disciplines.

The JFNY Grant for Arts & Cultural Exchange supports U.S. non-profit organizations aiming to enhance understanding of Japanese arts and culture. Eligible projects include performances, workshops, and exhibitions, with priority given to those with additional funding and in areas with limited access to cultural events. Applications must be submitted at least one month prior for online projects and three months for others. The grant covers expenses like travel, publicity, and artist fees, and is reimbursed upon project completion.

The American Electric Power Foundation provides grants to 501(c)(3) organizations focused on educational improvement, particularly in STEM fields, and basic human services such as hunger and housing. Organizations must operate within AEP's service territory or have a broader beneficial purpose. The Foundation also supports social justice initiatives and environmental protection efforts. Eligible applicants must affirm compliance with anti-discrimination policies and demonstrate commitment to diversity and inclusion.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

The Ethnic Minorities and Women’s Internship Grant supports entry-level athletics administrative positions for one academic year, promoting diversity in NCAA Division II. It provides $30,000 for intern salaries and $3,000 for professional development, benefiting six schools annually from a total budget of $180,000. Eligible applicants must be active NCAA members, with a focus on enhancing ethnic minority and gender representation in athletics administration. This initiative encourages professional growth and compliance in diverse environments.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Dale Lokke Law Enforcement Scholarship, managed by the Sioux Falls Area Community Foundation, offers financial assistance to graduating seniors from Minnehaha County high schools. This scholarship aims to support students planning to attend accredited four-year colleges in South Dakota while promoting involvement in community activities and addressing financial needs. With over $500,000 awarded annually, it helps students pursue their educational goals and career aspirations.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Good Relatives Collaborative Grants, funded by the Bush Foundation, aim to empower grassroots and Native-led organizations across Minnesota, North Dakota, South Dakota, and the 23 Native nations. This initiative provides responsive grants of $50,000 and $100,000 to support community leadership, healing, and cultural revitalization. By fostering collaboration and innovation, the program seeks to address the unique needs of Native communities while promoting accessible philanthropy and sustainable growth.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The South Dakota Jobs Grant program provides financial assistance to companies for the upfront costs of relocating, expanding operations, or upgrading equipment within the state. Eligible applicants include businesses with project costs under $20 million for new facilities and $2 million for equipment upgrades. The program aims to support projects that demonstrate a clear necessity for the grant, ensuring economic growth and development in South Dakota.

The Minnesota Twins Community Fund, established in 1991, has significantly impacted youth sports in Twins Territory by providing over $24 million in support. Through grants and donations, they empower young athletes, emphasizing the importance of teamwork and personal growth. The fund focuses on 501c3 nonprofits in their region, ensuring that initiatives foster both athletic skills and character development. With strict guidelines for donations, the Twins continue to enhance community engagement and inspire the next generation of leaders.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.