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Best Large Grants for Nonprofit Organizations in Tennessee

Find the perfect Large Grants for Nonprofit Organizations in Tennessee on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in Tennessee in the United States.

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$3.75B

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$5K

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$3.75B total
$5K median

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Don & Mary Hamerski Memorial Scholarship Fund

Community Foundation of Central Wisconsin
Private
United States
Unspecified amount

Community Foundation of Central Wisconsin

The Community Foundation of Central Wisconsin gives everyone the opportunity to make significant and lasting gifts to their community. We manage over 320 funds that enhance Portage and Waushara counties. Together with our generous donors, we create a strong culture of philanthropy in Central Wisconsin.

We are a tax-exempt, 501(c)(3) public charity founded in 1982 to provide scholarships and grants to organizations and projects that improve the quality of life in Portage and Waushara counties.

Scholarships

The Community Foundation proudly supports students in Portage and Waushara counties with over $325,000 in scholarships annually, thanks to the generosity of local individuals and families. Award amounts range from $500 to $40,000, opening doors to educational opportunities.

Whether you're a student seeking financial support or a donor looking to grow a scholarship fund, we invite you to explore available opportunities and learn how you can be involved.

Don & Mary Hamerski Memorial Scholarship Fund

Qualifications: Graduating High School seniors from a Central Wisconsin high school.

Education - Higher Education Agriculture

Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
US $2,000,000 - US $20,000,000
The ASPECT program, initiated by the DOE, aims to bolster the U.S. energy future by enhancing domestic critical mineral supply chains and developing innovative chemical technologies. This Notice of Funding Opportunity (NOFO) invites proposals for research and pre-pilot testing of technologies that convert alternative and waste feedstocks into valuable chemicals. By offering distinct pathways for technologies at various stages of development, the program seeks to advance solutions that contribute to sustainable energy practices and promote resource efficiency.
Energy Chemical Engineering Emerging Technology Development +1 more

Grey Muzzle Grants

Grey Muzzle Organization
Private
United States
Unspecified amount
The Grey Muzzle Organization offers grants ranging from $2,500 to $10,000 to improve the lives of at-risk senior dogs across the U.S. Since 2008, they have awarded over $2.5 million to shelters and nonprofits focused on senior dog welfare. Eligible applicants must be 501(c)(3) organizations and demonstrate measurable outcomes. The initiative aims to ensure that every senior dog thrives, providing support for foster care, hospice services, and adoption programs.
Veterinary Science & Services Animal Welfare - Domestic Animals & Pets

Ted & Shannon Skokos Foundation Grant

Ted and Shannon Skokos Foundation
Private
United States
Unspecified amount
The Ted & Shannon Skokos Foundation Grant, established in 2008, supports nonprofit organizations in arts, education, humanity, and faith. It prioritizes visionary leadership, community impact, sustainability, organizational strength, and collaboration. The foundation seeks to fund eligible 501(c)(3) nonprofits that align with its mission and positively influence communities, particularly in Dallas, Texas, and Arkansas, where the founders have personal connections.
Art & Culture Human & Social Services Education +1 more

Gibson Foundation Donation Request

Gibson Gives
Private
United States
Unspecified amount
The Gibson Foundation, now known as Gibson Gives, is dedicated to enhancing lives through music by supporting 501(c)(3) organizations. Their mission is to inspire and amplify the power of music through guitars for all generations. With a commitment to music education and wellness, Gibson Gives is making a positive impact worldwide, ensuring that music continues to shape the lives of musicians and enrich communities. Donations are reviewed monthly, requiring a minimum of four weeks for processing.
Music Education

Alex Family Scholarship

Marion Community Foundation
Private
United States
Unspecified amount

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Alex Family Scholarship

Created in 2007 from the estate of Helen L. Alex, this fund makes annual awards in support of higher education for seniors from Marion Harding High School. The fund honors Helen’s son, Nicholas, a former faculty member at Harding who passed in 2008.

The Alex Family Fund was established by another of Helen’s sons and Nicholas’ brother, James L. Alex. The family, which includes a rich Greek heritage and numerous relatives in Greece, belonged to the Saints Constantine and Helen Greek Orthodox Church in Mansfield, Ohio. 

Recipients of the Alex Family Scholarship must rank in the upper 25th percentile of their graduating class. Those demonstrating excellence in the study of history or pursing a college major in history are given special consideration.

Academic Scholarship Programs Education - Higher Education

Edwards Lifesciences Foundation Grants

Edwards Lifesciences Foundation
Private
United States
Unspecified amount
The Edwards Lifesciences Foundation Grants program aims to improve the health of underserved communities by supporting initiatives focused on education, screening, and treatment of cardiovascular disease. The Foundation seeks to enhance care access for patients, promote awareness of heart health, and foster community engagement through volunteer opportunities. By 2025, the goal is to positively impact the lives of 2.5 million patients affected by structural heart issues. The program emphasizes collaboration and innovation in healthcare.
Cardiovascular Diseases & Systems

Art Jess Scholarship Fund

The Alaska Community Foundation
Private
United States
Unspecified amount

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

Art Jess Scholarship Fund

The Art Jess Scholarship is open to Alaska residents who are Alaska Native, American Indian, and/or Hawaiian Native, and is intended to assist Alaskans with their post-secondary education, including but not limited to trade schools, vocational schools, undergraduate and graduate schools, community colleges and distance learning. Applicants may be full or part-time students.

Art Jess was a champion for the spiritual and social advancement of humanity in general and of Native American people in particular. According to his daughter, “Art believed in the best of people, that the world is a beautiful place, that all is well, and that everything will work out.” Art was a lifelong learner and believed that a person never really graduated until life was over.

Education - Higher Education Vocational & Trade Education

Extreme Terrain’s Clean Trail Initiative Program

ExtremeTerrain
Corporate
United States
US $250
Extreme Terrain’s Clean Trail Initiative Program aims to enhance trail integrity by supporting groups in the U.S. with grants for projects like trail clean-up, restoration, and expansion. Eligible applicants include Wrangler and 4x4 clubs, environmental organizations, and those managing public or private trails. The initiative emphasizes responsible off-roading while encouraging volunteers to engage in improving our natural landscapes. This program fosters community involvement and promotes sustainable practices in outdoor activities.
Trail Creation & Maintenance

Limited Competition: NIMHD Initiative for Improving American Indian and Alaska Native Cancer Outcomes (U19 - Clinical Trial Optional) (363217)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
This funding opportunity aims to enhance cancer research among American Indian and Alaska Native populations, focusing on prevention, diagnosis, and treatment in rural areas. The initiative seeks to reduce cancer incidence and mortality rates while ensuring that research findings significantly improve health outcomes for these communities. Eligible organizations are invited to apply, with applications undergoing rigorous peer review to ensure only the most promising projects receive funding.
Cancer / Oncology

DoW Rare Cancers Idea Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $490,000
The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.
Cancer / Oncology

DoW Rare Cancers Resource and Community Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,120,000
The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.
Cancer / Oncology

Reeves Foundation: Macular Degeneration Research Grant

Carl Marshall Reeves and Mildred Almen Reeves Foundation Grant
Private
United States
US $2,500 - US $125,000
The Reeves Foundation supports research aimed at understanding and treating macular degeneration, a condition that has personally affected the founder's family. Established in 1997, the foundation allocates 50% of its grants to research and the other half to local charities in Columbus, Indiana. Nonprofit organizations exempt under IRS code 501(c)(3) are eligible to apply, but funds cannot be used for administrative costs. The foundation prioritizes equipment purchases and partnerships with other funding sources.
Eye Diseases & Disorders

Brandon C. Reiley Scholarship Fund

The Alaska Community Foundation
Private
United States
Unspecified amount

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

Brandon C. Reiley Scholarship Fund

Brandon was nothing if not a true adventurer and a friend to all. His laugh was almost always mischievous but also contagious. Brandon was a citizen of the world, living and visiting countless countries and maybe getting into a little trouble along the way. He loved meeting new people and roping them into projects and ideas or connecting them to like minded souls.

This scholarship, established in memory of Brandon C. Reiley, supports Alaskan students pursuing higher education degrees in the fields of science, sustainability, mathematics, education, or aviation. All of these areas were important to Brandon and it is the goal of this scholarship fund to support students with similar interests and goals.

Education - Higher Education Sustainability Mathematics +2 more

DoW Joint Warfighter Medical, Military Medical Research and Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $1,400,000 - US $3,000,000
The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.
Military Operations

OREF Prevention of Musculoskeletal Youth Sports Injuries Research Grant

Orthopaedic Research and Education Foundation
Private
Canada, United States
US $25,000
The Prevention of Musculoskeletal Youth Sports Injuries Grant provides essential funding for new investigators focused on clinical and social research aimed at reducing youth sports injuries. This initiative emphasizes the importance of clinical relevance in project proposals, ensuring that outcomes are practical and applicable. Only one grant will be awarded per institution each year, supporting innovative approaches to enhance youth sports safety and health.
Orthopedics Children’s Health & Pediatrics

Creating Opportunity & Independence Grant

Craig H. Neilsen Foundation
Corporate
Canada, United States
US $25,000 - US $200,000
The Craig H. Neilsen Foundation's Creating Opportunity & Independence Grant supports programs and research that enhance the quality of life for individuals with spinal cord injuries (SCI). It welcomes applications from nonprofit organizations and rehabilitation facilities in the U.S. and Canada, focusing on projects that foster independence, community participation, and capacity-building. Priority is given to initiatives that demonstrate broad impact and involve individuals with SCI, ensuring their needs and perspectives shape the proposed activities.
Spinal Cord Injuries

Alcon Foundation Grant (Requests greater than $10,000)

Alcon Foundation
Corporate
United States
More than US $10,000
The Alcon Foundation Grant aims to enhance eye care services and improve patient access, with a focus on educational and training programs. The foundation also supports cultural and community development initiatives that uplift the quality of life in areas where Alcon operates, including cities like Fort Worth, Houston, and Irvine. However, it does not fund non-501(c)(3) organizations, athletic leagues, or fundraising events, among other exclusions.
Eye Diseases & Disorders

Cael Askin Memorial Scholarship Fund

The Alaska Community Foundation
Private
United States
US $1,000

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

Cael Askin Memorial Scholarship Fund

The donors establish the Cael Askin Memorial Scholarship in memory of their son, Cael (pronounced Kale) who died at age 25 in 2013 as a result of complications of Epilepsy. Cael was diagnosed with Asperger’s while in school and completed high school with a certified diploma utilizing an Individual Education Plan (IEP) through his time in school. The fund is intended to provide scholarships to Kenai students who have had Individualized Educational Plans (IEP’s).

The family of Cael Askin is honored to offer a $1,000 scholarship in his memory to support a graduating high school or home school senior receiving Special Education Services and intends to pursue secondary education or vocational/technical training.

Education - Higher Education Vocational & Trade Education

Addie's "Grace" Fund

Emporia Community Foundation
Private
United States
Up to US $2,000

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Addie's "Grace" Fund

The purpose of Addie's "Grace" Fund is to provide help to children with life threatening illnesses and support to their families. Grant requests will be considered for children under the age of 18.

Children’s Health & Pediatrics Health Care Access & Delivery

CARTA Scholarship Endowment Fund - Liability

The Alaska Community Foundation
Private
United States
Unspecified amount

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

CARTA Scholarship Endowment Fund - Liability

Central Alaska Retired Teachers' Association Scholarship Fund was established to provide financial support for undergraduate and graduate students majoring in education or working towards certifications that will enable them to become teachers or administrators in the public schools.

Education - Higher Education Teacher Development & Training

PLTW Gateway - Program Expansion (John Deere)

Project Lead The Way Inc
Private
Aiken County, South Carolina, Alamance County, North Carolina +143 more
US $10,000
The PLTW Gateway program expansion, funded by the John Deere Foundation, aims to enhance access to STEM education for underserved students in John Deere communities. With a commitment to support 1 million youth by 2030, this initiative provides grants to schools seeking to expand their existing PLTW programs. Eligible schools must be within proximity of John Deere facilities and demonstrate a significant enrollment of students participating in free and reduced lunch programs, ensuring equitable educational opportunities.
STEM / STEAM Education Teacher Development & Training

Community’s Memorial Scholarship

Marion Community Foundation
Private
United States
Unspecified amount

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Community’s Memorial Scholarship

Memorial scholarships are one of the top categories of funds created at Marion Community Foundation, but not all donors who wish to memorialize a loved one in this distinctive and perpetual way start their own fund. The Community’s Memorial Scholarship Fund was created to memorialize a number of individuals collectively. All of the persons memorialized are recognized during Marion Community Foundation’s annual Scholarship Program.

The Mary H. Hollaway Trust provided seed money for this special purpose. Mary was well known in Marion, due to her long career with Fahey Bank. Upon her passing, she had arranged for several funds to be created from her estate, this scholarship among them. Other organizations she chose to support include the Marion Area Humane Society, Marion Palace Theatre, and the Marion Family YMCA.

The Community’s Memorial Scholarship is available to graduates and seniors from any Marion County high school who rank in the upper 50 percent of their class.

Education - Higher Education Academic Scholarship Programs

Dr. John Halligan Scholarship Fund

The Alaska Community Foundation
Private
United States
Unspecified amount

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

Dr. John Halligan Scholarship Fund

This is a scholarship fund established for students in pursuit of a medical career.

Dr. John Halligan graduated from The United States Military Academy at West Point in 1985 and the Uniformed Services University of the Health Sciences with an MD. After completing his residency in Radiation Oncology at the University of Washington, Dr. Halligan served in the US Army as a Radiation Oncologist until his retirement as a Colonel in 2008. After retiring from the military, Dr. Halligan fulfilled a decades-long dream and moved to Alaska to become the Medical Director of Radiation Oncology at Providence Alaska Medical Center. He has since expanded state-of-the-art cancer care in Alaska by opening Radiation Oncology Clinics in Soldotna, Juneau, and the MatSu Valley so Alaskans could receive care closer to their homes.

Education - Higher Education Medical Education & Professional Training

AHNS Endocrine Surgery Section ThyCa: Thyroid Cancer Survivors’ Association Award for Thyroid Cancer Research Grant

American Head & Neck Society (AHNS)
Association/Society
Canada, United States
Up to US $10,000
The AHNS Endocrine Surgery Section ThyCa Research Grant offers $10,000 for one year to support innovative research projects focused on thyroid cancer. Eligible candidates include U.S. or Canadian AHNS members, including medical students and faculty. Proposals should advance understanding of thyroid cancer's diagnosis, prevention, and treatment. Preference is given to early-stage investigators or those pursuing new inquiries. Applications require letters of support and a detailed budget, with funding limitations on indirect costs.
Cancer / Oncology Thyroid Cancer Otorhinolaryngology

Harry H. Hirshik Scholarship Fund

The Alaska Community Foundation
Private
United States
Unspecified amount

The Alaska Community Foundation

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Scholarships at ACF

Each year, more than 60 scholarships are available to Alaska students—and it all starts with one simple application. With one login and one application, you’ll be considered for every scholarship you may be eligible for. Whether you’re taking your first step toward college, training for a career, or continuing your education, these scholarships are here to help carry you forward, backed by donors who believe in Alaska’s students and the futures they’re building. 

Harry H. Hirshik Scholarship Fund

A scholarship fund focused on automobile mechanic education.

The Harry H. Hirshik Scholarship supports Alaskan students pursuing education or training in the field of automotive mechanics. Harry H. Hirshik was military-civil employee-mechanic. He lived in Eagle River and loved Alaska.

Education - Higher Education Vocational & Trade Education

Large Grants for Nonprofit Organizations in Tennessee Highlights

Looking for large grants for nonprofit organizations in Tennessee?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Tennessee recommended for your specific programs.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Tennessee

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in Tennessee grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

39 Large Grants for Nonprofit Organizations in Tennessee over $25K in average grant size

28 Large Grants for Nonprofit Organizations in Tennessee over $50K in average grant size

22 Large Grants for Nonprofit Organizations in Tennessee supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in Tennessee supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Tennessee?

Most grants are due in the first quarter.

Q1
31.8%
Q2
22.5%
Q3
26.1%
Q4
19.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Tennessee?

Grants are most commonly $12,250.

$500 $500 Min.
$12,250 $12.3 K Median
$74,557 $74.6 K Average
$2,300,000 $2.3 M Max.

Average Grant Size

What's the typical amount funded for Tennessee?

Grants are most commonly $122,522.

$122,522

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Tennessee year over year?

In 2024, funders in Tennessee awarded a total of 44,541 grants.

2022 39,759

2023 39,873

2024 44,541

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Tennessee given out in Tennessee, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Tennessee changing over time?

Funding has increased by 25.17%.

2022 $3,809,568,961

2023 $4,350,973,827
14.21%

2024 $5,446,107,598
25.17%

Tennessee Counties That Receive the Most Funding

How does grant funding vary by county?

Shelby County, Davidson County, and Knox County receive the most funding.

County Total Grant Funding in 2024
Shelby County $2,664,074,547
Davidson County $1,298,691,246
Knox County $294,292,803
Hamilton County $283,062,013
Henderson County $215,691,648