Best Large Grants for Nonprofit Organizations in Tennessee

The General Surgery Resident Research Initiation Grant aims to engage General Surgery Residents in research related to colorectal diseases. With an annual funding of $20,000, this grant supports both clinical and laboratory-based research. It is geared towards residents or recent graduates of approved General Surgery programs, prioritizing those with aspirations in Colon and Rectal Surgery. This initiative fosters innovative research to enhance patient care and surgical techniques in the field.

Sodexo Stop Hunger Foundation

The Sodexo Stop Hunger Foundation goes beyond food aid to create lasting change. Through innovative programs, strategic partnerships and volunteer action, Stop Hunger tackles the root causes of food insecurity.

In 2025, Sodexo Stop Hunger Foundation and the Hunger Center awarded grants to 131 programs representing 118 communities in 37 states plus the District of Columbia. Collectively, these programs provided an estimated 22,000 backpacks full of shelf-stable food items for students to take home for the weekend or holidays when school meals are not served.

Since 2006, the Sodexo Stop Hunger Foundation has been a driving force behind weekend and holiday hunger relief for students across the U.S. Through support of food backpack programs, the Foundation partners with local food banks and schools to discreetly provide K-12 students with backpacks filled with nutritious, shelf-stable meals. These backpacks are distributed in safe, familiar settings – typically on the last school day before a weekend or school break – ensuring that all children who rely on free or reduced-price school meals don’t go hungry when school is out.

K-12 Backpack Grant

The K-12 Backpack Grant is an initiative launched by the Sodexo Stop Hunger Foundation and administered in partnership with the Congressional Hunger Center to support community backpack programs. Grants of $1,000 will be issued to community organizations with established backpack feeding programs that provide students with shelf-stable, nutritious meals when school is out of session.

The Yamaha Outdoor Access Initiative supports outdoor enthusiasts and promotes responsible use of off-highway vehicles (OHVs). Its mission includes educating the public on land use and wildlife conservation while protecting access to public lands. Applications are accepted quarterly from nonprofit organizations and community groups focused on land stewardship and access improvements, ensuring a safe and sustainable outdoor experience for all.

The Robotic Research Grant, offered by the American Society of Colon and Rectal Surgeons, provides up to $150,000 over two years for innovative research in colorectal surgery and robotics. Emphasizing education, health equity, and novel techniques, the grant supports projects conducted in the U.S. or Canada, with a focus on scientific rigor. Applications must be submitted by ASCRS members who are principal investigators, ensuring alignment with ethical research standards.

The Kalamazoo Valley Chapter's Stanley Weber Projects Fund honors a dedicated member by supporting projects that enhance coldwater fisheries and their habitats. Offering grants up to $5,000 annually, the fund prioritizes non-profit initiatives that foster conservation, restoration, and public education while promoting volunteer engagement. Recognition through plaques or media announcements is requested for grant recipients, ensuring the legacy of Stanley Weber continues to impact the community positively.

The MMUF Dissertation Grant, funded by the Mellon Foundation, supports doctoral candidates who are alumni of the Mellon Mays Undergraduate Fellowship. This grant aids scholars in completing their dissertations, ensuring diverse perspectives are represented in academia. With up to $30,000 for a 12-month period, the program encourages candidates to secure additional funding from their institutions. The initiative aims to bolster access to education and foster understanding among varied backgrounds, ultimately enhancing the academic landscape.

The Research Foundation of the American Society of Colon and Rectal Surgeons offers a Career Development Award to support early career investigators in colorectal surgery. With a funding of $75,000 per year for two years, this award emphasizes mentorship and career growth. Applicants must be within five years of their first faculty position and demonstrate innovative research in colon and rectal diseases. The award aims to enhance academic careers while fostering advancements in surgical techniques.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Miller Family Scholarship

This scholarship has been made possible by the generosity of Michael K. Miller, who established the Miller Family Scholarship Fund of the Community Foundation for Mason County. This scholarship is presented to instrumentalists graduating from Ludington High School.

The Arthritis National Research Foundation supports early career researchers in their quest to advance understanding and treatment of arthritis and related autoimmune diseases. Annually, the foundation grants 10 to 20 awards of $125,000 each for two years. Focus areas include osteoarthritis, rheumatoid arthritis, lupus, and more. Eligible investigators must hold an M.D. or Ph.D., be affiliated with a U.S. nonprofit research institution, and commit significant research time. Applications from prior grant recipients or those with certain NIH grants are ineligible.

The H. Branch Howe Grant, offered by the Georgia Ornithological Society, supports graduate students conducting ornithological research in Georgia. This grant encourages the scientific study of birds and conservation efforts, providing funding for research that enhances knowledge of avian life. Eligibility is limited to graduate students in Georgia, and preference is given to projects within state boundaries. The GOS aims to foster collaboration and knowledge sharing among those passionate about birds and nature.

The Purple Martin Conservation Association offers the PMCA Research and Conservation Grant to support research on Purple Martins. This grant aims to promote conservation efforts and may cover expenses such as travel and supplies, though it does not fund salaries or overhead. Eligible applicants include students and professionals engaged in Purple Martin research, with a focus on projects that enhance the species' habitat and well-being.

The Dr. Eric W. Bond “Kickstart” Scholarship, initiated by the Community Foundation of the Central Blue Ridge, honors Dr. Bond's dedication to education. It supports three graduating seniors from each Augusta County public high school, focusing on those entering the workforce directly. The scholarship emphasizes financial need, community service, and extracurricular involvement, reflecting Dr. Bond's values. The inaugural scholarships will be awarded in 2026, ensuring a lasting legacy that enriches students' lives and promotes their successful transition into adulthood.

The Horton PhD Research Grant supports up to three Ph.D. students annually in hydrology and related fields, funded by the Robert E. Horton Fund. It provides a maximum of $10,000 for research and travel, along with $500 for U.S. and Canadian applicants participating in AGU's annual meeting. Eligible students must be active AGU members, enrolled for the award's duration, and meet all application requirements. This grant promotes excellence in hydrological sciences.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5426 - Investigation of Non-Point Sources of PFAS in Sewersheds and Potential Mitigation Strategies

Grant Information

Evaluate the impact of non-point or dispersed sources of per- and polyfluoroalkyl substances (PFAS) in the sewershed (including PFAS-contaminated groundwater infiltration) on PFAS mass loading to wastewater treatment plants.

Assess how PFAS loading from non-point or dispersed sources of PFAS in the sewershed may affect treatment efficiency and reuse water quality.

Improve understanding of PFAS precursor contributions.

Identify potential strategies to mitigate PFAS loading from non-point or disbursed sources of PFAS in the sewershed.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5411 - Practical Playbook for Adaptive Utility Capital Improvement Planning Under Deep Uncertainty

Grant Information

• Assess current utility practices for incorporating adaptive or flexible decision making into capital improvement planning (CIP) at the portfolio or programmatic level.
• Identify where deep uncertainty most affects CIP decision points, including investment areas prone to lock-in or points of no return.
• Document the institutional processes, frameworks, and governance structures that have enabled utilities to embed adaptive and flexible investment strategies.
• Quantify how adaptive capital strategies compare to traditional CIP approaches in terms of lifecycle costs, rate stability, financial risk exposure, and avoided or deferred capital investments across a range of plausible future conditions.
• Establish practical criteria to help utilities determine which types of capital investments are well suited for adaptive approaches.
• Develop a practitioner-focused playbook that equips utilities to apply adaptive CIP in practice, including case studies, decision trees, trigger points, vulnerability assessment tools, financial and risk insights, and governance guidance.
• Produce tiered recommendations that allow utilities to adopt adaptive CIP practices incrementally.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The Science Policy Fellowship, offered by the American Chemical Society, provides a unique opportunity for trained scientists to engage in public policy. This program enhances understanding of the policy-making process, allowing Fellows to work alongside experienced Government Affairs staff. The Fellowship focuses on key areas such as federal research funding, education in STEM, and environmental policies. Candidates with a strong background in chemical sciences or engineering are encouraged to apply, regardless of holding a doctorate.

The Lundbeck US Charitable Fund focuses on enhancing brain health through impactful donations. Established to support organizations dedicated to brain health, it addresses pressing needs by funding innovative strategies and community collaborations, particularly for at-risk populations. The Fund aims to transform lives and improve mental health care, with a commitment to responsible giving. With over 20 organizations supported in 2023, it drives meaningful change in communities affected by brain disorders.

The AISES Stellantis Scholarship aims to enhance the representation of Indigenous peoples in STEM fields. Funded by Stellantis, this scholarship offers $20,000 for full-time students enrolled in colleges with Mopar Career Automotive Programs. Eligible candidates must be current AISES members and either enrolled citizens or descendants of recognized Indigenous groups. The program not only supports education but also fosters a diverse and inclusive workforce within the automotive industry.

The AISES Indian Motorcycle Academic Scholarship offers $5,000 annually to support Native students pursuing degrees in STEM fields. Sponsored by the American Indian Science and Engineering Society, this scholarship aims to empower Indigenous students and enhance diversity in STEM. Eligible applicants must be current AISES members, full-time students, and enrolled citizens or descendants of recognized Native tribes. This scholarship not only provides financial assistance but also fosters community and innovation within the STEM landscape.

The KTGF Fellowship Programs, funded by the Klingenstein Third Generation Foundation, offer $100,000 over two years to support post-doctoral and junior faculty research on ADHD and depression in children, particularly from low-income and under-resourced backgrounds. This initiative aims to foster promising early-career scientists while producing impactful research that benefits affected children and families. Applications are accepted from September 1 to December 15, with specific eligibility criteria outlined for candidates.

The CFGC Community Impact Grants support nonprofit organizations in Chattanooga, providing up to $30,000 in unrestricted funding. Focused on addressing key issues like hunger, affordable housing, mental health, and healthcare access, these grants aim to empower local communities. Organizations serving Hamilton County residents are encouraged to apply, fostering systemic change and stability for vulnerable populations. The Community Foundation of Greater Chattanooga is committed to enhancing community well-being through strategic grantmaking.

The Goldberg, Joseph and Ruth Scholarship, offered by the Beatrice Educational Foundation, aims to support students pursuing medical professions, such as nursing, dental, and physical therapy. Established in 1987, the Foundation provides over $55,000 annually in scholarships to Beatrice High School seniors. Eligible applicants must be in the top quarter of their class and complete the application independently. This scholarship is part of the Foundation's commitment to enhancing educational opportunities in the Beatrice School District.

The BTCF: Simple Gifts Fund Grant supports young artists aged 13-19 in the Berkshire Taconic region, providing financial assistance for summer enrichment programs in the arts. Established in 1998 in memory of folk singer Bill Crofut, the fund aims to empower youth through small grants that can cover costs for tuition, art supplies, or living expenses. The grant fosters creativity and personal growth, ensuring that young individuals have opportunities to pursue their passions.

The Rapid Response Opioid and Pain Management ECHO Funding Opportunity by the Association of State and Territorial Health Officials (ASTHO) aims to enhance clinician training in effective pain management strategies. This initiative focuses on non-opioid treatments, substance use screening, and risk reduction counseling, promoting compassionate care while addressing public health challenges and ensuring continuity for patients affected by prescription disruptions. The program seeks to improve overall health outcomes and reduce risks associated with opioid use.

The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.