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Get unrestricted grants for nonprofits providing flexible funding to meet pressing organizational or program needs
32,000+
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$8.64B
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$6.3K
Median grant
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About Us
The Indiana Clinical & Translational Sciences Institute (CTSI) has been at the forefront of translational research since 2008. From the lab bench to clinical trials and beyond, we help researchers move their scientific findings through the development pipeline.
Our Mission & Vision
Our mission is to bring together Indiana’s brightest minds to solve the state’s most pressing health challenges. We envision Indiana as one of the nation’s healthiest states.
RFA- Research Project Development Teams: Project Refinement ( first external submissions)
Research Project Development Teams (PDTs) are groups of experienced senior faculty located on each of the Indiana CTSI campuses who will connect you with resources, collaboration opportunities, and small (typically up to $15,000) awards for preliminary or additional data. Each PDT is designed around a common research theme.
There are biostatisticians and regulatory experts on each team, and other experts are added, as needed, to the team to when your application is discussed. You will have access to the expertise and knowledge you need all in one place.
The PDT application process is contingent on the stage of the project. You have selected the application process for pilot funding from the PDTs for a first time external submission. If you are seeking pilot funding prior to an external resubmission please use Research Project Development Teams (PDTs): Project Revision
La Crosse Area Community Foundation
Founded in 1930, La Crosse Area Community Foundation is one of Wisconsin’s earliest community foundations. For more than 90 years, we have helped individuals, families, businesses, and professional advisors make meaningful charitable gifts that stay local and grow over time.
Today, we steward hundreds of endowed and non-endowed funds, award grants and scholarships each year, and serve as a trusted convener for people who care about strengthening the greater La Crosse community.ty.
Standard Grants Program
Standard grants are part of our historic competitive grants program to be responsive to the needs of nonprofit organizations serving La Crosse County. La Crosse Area Community Foundation has allocated grant dollars this year specifically for nonprofits seeking standard grants for result-oriented projects and programs that address a proven community need or priority aimed at making La Crosse County a better place now and for future generations.
All grant requests that represent a portion of a capital campaign will be eligible for a maximum of $25,000. See RFP details here.
The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.
Community Foundation of Greater Des Moines
The Community Foundation of Greater Des Moines improves quality of life for all by promoting charitable giving, connecting donors with causes they care about and providing leadership on important community issues…we’re simply better together.
Guthrie County Community Foundation
Mission of the Guthrie County Community Foundation:
The mission of the Guthrie County Community Foundation is to foster giving, strengthen service providers, and improve the local conditions and quality of life. To these ends, the Guthrie County Community Foundation promotes philanthropy, endowment building, community-building, capacity-building, grant making, organizational collaborations, and public leadership for the benefit of Guthrie County, Iowa.
The Guthrie County Community Foundation is committed to improving the quality of life throughout Guthrie County by investing in area nonprofits through our grant programs and by providing individuals, families and area businesses who love our communities with a way to give back.
Guthrie County Community Foundation Grants
Grants are available to 501(c)3 organizations and government entities serving Guthrie County. Grant selections are made in an effort to create a better quality of life for people in Guthrie County. The local governing committee reviews the applications from charitable organizations serving their community.
MissionOur mission is to connect people and resources to address local challenges and opportunities.
Impact AreasThe Community Foundation will prioritize local, mission-aligned grants in impact areas that:
RequirementsOperational support refers to general organizational expenses such as staffing, administration, and ongoing program delivery, rather than a specific project.
The Kansas Department of Commerce is committed to helping individuals, businesses and communities achieve prosperity in Kansas. One of the ways it accomplishes this mission is by providing financial assistance and partnership support to further identified goals.
Kansas Main Street Program
Main Street is a self-help, technical assistance program that targets revitalization and preservation of downtown districts through the development of a comprehensive strategy.
The program has a long history of success throughout the United States and in Kansas. What started as a small pilot program in the late 1970s has now grown to include nearly 2,000 communities in more than 40 states. Throughout the country, communities have utilized the Main Street Approach to rally residents around a focused plan of action that transforms their community and enhances their quality of life.
From 1985 to 2012, more than $600 million in redevelopment took place in participating Kansas communities. This included the opening or expansion of 3,800 small businesses, creating more than 8,600 new jobs. With the return of the state program in 2020, 25 previously participating communities and new programs will once again have the resources and tools they need to breathe new life into their communities and historic commercial districts.
Designated Communities
To become a Designated Kansas Main Street community, registrants must participate in a competitive, annual application process. This process includes attending our Application Workshop and attaining recommendation by the Review Team based on their evaluation of a community’s capacity to achieve success. The completed application must demonstrate:
Once selected, Designated Communities receive:
Community Foundation of Greater Des Moines
The Community Foundation of Greater Des Moines improves quality of life for all by promoting charitable giving, connecting donors with causes they care about and providing leadership on important community issues…we’re simply better together.
Madrid Community Endowment Fund
Mission of the Madrid Community Endowment Fund:
The Madrid Community Endowment Fund is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our community that lasts forever.
The Madrid Community Endowment Fund is committed to improving the quality of life throughout Madrid by investing in area nonprofits through our grant programs and by providing individuals, families and area businesses who love our community with a way to give back.
Madrid Community Endowment Fund Grants
Grants are available to 501(c)3 organizations and government entities serving the Madrid community. Grant selections are made in an effort to create a better quality of life for people in Madrid. The local governing committee reviews the applications from charitable organizations serving their community.
Blue Mountain Community Foundation
Blue Mountain Community Foundation (BMCF) started in 1984 based on the idea that the area needed a place for donors who cared about the community to make long-term charitable investments. A group of 36 local leaders and citizens, under the guidance of Pete Peery and John Reese, met and resolved to form a community foundation. Too many endowment gifts from people who cared deeply about their communities were lost to local control for lack of a community foundation. Since 1984, BMCF has received and grown assets to exceed $115 million in more than 440 charitable funds which benefit the entire community!
Walla Walla County Community Grants
Funding Focus: General operating support
Greater Salina Community Foundation
Our mission is to build permanent endowment funds and meet charitable community needs. The Foundation achieves its mission by:
Clifton Community Fund
The Clifton Community Fund is an unrestricted community grant fund that supports the Clifton, KS community. The Fund was created by the generosity of individuals who have contributed money for the charitable use to address the present and future needs of Clifton, KS.
From this endowed fund, the advisory committee annually determines and designates the amount of available funding in the form of community grants.
The Foundation’s Clifton Community Fund accepts applications once a year. Applications received outside of the grant cycle are not accepted.
All non-profit organizations are encouraged to apply as well as groups and individuals working on a charitable community project. For-profit organizations will not be considered unless the request is for a charitable project. Grants will be limited to projects within Clifton, KS.
What type of support is funded?
Unrestricted grants for nonprofits provide flexible funding to support operating expenses, program development, and general organizational needs. The following grants empower organizations to allocate resources where they are needed most to achieve long-term impact and sustainability.
Discover 8,000+ funding opportunities for unrestricted grants, with $3.84B available. Instrumentl connects nonprofits to tailored funding options, offering tools for tracking deadlines, customized searches, and insights to support organizational flexibility and growth.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Unrestricted grants for Nonprofits?
Most grants are due in the first quarter.
Unrestricted grants are open to nonprofits across various sectors, including education, healthcare, social services, and the arts. Unlike project-specific grants, these funds aren’t tied to a particular initiative, making them great for organizations that need flexibility to strengthen their operations, build capacity, and expand their reach.
Based on Instrumentl’s live grant database for unrestricted grants, grant deadlines are most common in Q1, accounting for 28.0% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Unrestricted grants aim to give nonprofits the freedom to focus funding where it’s needed most. Whether it’s covering administrative costs, hiring staff, investing in technology, or expanding prgrams, these grants help nonprofits strengthen their organization. Funders see unrestricted grants as a way to help nonprofits remain adaptable as new challenges come up while building long-term sustainability.
Funding for unrestricted grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $37,500, while the average grant awarded is $734,409. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Unrestricted grants are typically funded by private or community foundations, corporate giving programs, and individual donors. Well-known funders like the MacArthur Foundation and the Ford Foundation offer unrestricted grants to nonprofits that align with their mission. Community foundations and corporate programs (Target Foundation, Toyota) also fund these types of grants for organizations.
To improve the chances of receiving unrestricted grants, applicants should:
For more information on unrestricted grants, dig into our guide on the differerences between restricted and unrestricted funding.
Instrumentl simplifies the process of applying for unrestricted grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.
Learn more about Instrumentl’s and how you can scale your grant funding.