Best Unrestricted Grants for Nonprofits

The Habitable Worlds Observatory (HWO) is a pioneering space mission concept aimed at discovering life beyond our solar system, as highlighted in the Astro2020 survey. The HWO-PSI program seeks to reduce risks for future missions by advancing scientific investigations that inform mission design. As HWO enters its pre-formulation phase, it addresses significant astrophysical questions and technical challenges, ultimately striving for groundbreaking discoveries in our understanding of the universe.

Bioprocessing Research Infrastructure Program (IL)

Notice of Funding Opportunity Intent

The Illinois Department of Commerce and Economic Opportunity (the “Department” or “DCEO”) is issuing this Notice of Funding Opportunity (“NOFO”) to seek to promote bioprocessing in Illinois by providing assistance with the infrastructure and capital equipment necessary to expand bioprocessing training and research capacity in the state.

Program Description

The bioprocessing industry continues to grow. With continued investments and expansions in infrastructure, Illinois has the existing industry, feed stock, and talented workforce to be a global leader in this market.

• Purpose of this Program
  • Invest in capital projects that increase bioprocessing company development in Illinois
  • Increase undergraduate student training opportunities in bioprocessing in Illinois
  • Increase short course offerings for existing industry workers in bioprocessing in Illinois.

Program History

This is a new program with limited awards and supported though the Enterprise Fund administered by the DCEO. Enterprise Fund grants may encompass a wide range of economic development projects including infrastructure, capital equipment purchases and any expenditures that will result in job creation in Illinois. The funds may be used for bondable costs, but can also be used for non-bondable capital expenses.

A successful grantee within this program will have the ability to purchase land within 30 days of notification of this grant award. Additionally, a successful grantee will be able meet all requirements included within the grant agreement. The grantee will be required to report on the expenditure of funds related to capital investment from the time of grant award through grant closure in order to receive the grant funds. The grantee must be able to articulate how the enterprise grant funds support economic development, the creation and retention of jobs in Illinois, and the overall wellbeing of citizens.

Funding

$5000000 - $10000000

The Kemble Fellowship in Maritime History, offered by The Huntington Library, supports scholars pursuing research in maritime history. This prestigious fellowship provides a stipend of $50,000 for nine to twelve months of residency. Applicants must hold a Ph.D. or have defended their dissertation by the application deadline. The fellowship encourages interdisciplinary exploration within The Huntington's vast collections, focusing on global trade, oceanography, and coastal studies, fostering innovative scholarship in maritime studies.

Regenerative Medicine Minnesota

The mission of Regenerative Medicine Minnesota (RMM) is to bring breakthrough regenerative medicine therapies to Minnesotans and patients worldwide. Achieving this vision requires not only advancing novel therapies, but also the innovations, capabilities, collaborations and pathways that enable them to ultimately reach patients. Recognizing the need for a multi-pronged innovation strategy, RMM is calling for proposals that align with this vision through the 2027 Request for Proposals (RFP). By strategically investing across these areas, RMM aims to accelerate transformative regenerative medicine therapies, strengthen Minnesota's leadership in regenerative medicine and generate lasting health and economic benefits for Minnesotans.   

Regenerative Medicine Minnesota (RMM) RFP

This RFP is designed to solicit projects that are aligned with one or more of the following objectives:

• Advance novel regenerative medicine therapies and products towards clinical application. Proposed therapies or products should have a clearly defined target use, indication or disease area.
• Develop enabling innovations and platforms that improve the ability to discover, develop, manufacture, or deliver regenerative medicine therapies across multiple applications.
• Build sustainable capabilities and infrastructure that accelerate clinical translation and commercialization in Minnesota.
• Foster collaborations across institutions and sectors that strengthen Minnesota’s regenerative medicine ecosystem.
• Expand patient access to regenerative medicine therapies to benefit patients across Minnesota, including greater Minnesota.

Particular areas of interest for funding under this RFP include, but are not limited to:

• Platform-based approaches that can be applied to many diseases, particularly rare diseases, such as gene editing/replacement strategies, therapeutic approaches, delivery methods, manufacturing models, regulatory strategies, clinical trial designs, etc.
• Device-enabled regenerative medicine innovations such as biologic/cell-device combination therapeutics, biomanufacturing devices or tools, therapeutic delivery, etc.
• Strategies to improve immune compatibility and therapeutic durability, including promoting immune tolerance or reducing immune rejection.

The Infrastructure Innovation for Biological Research Program by NSF aims to enhance contemporary biology through innovative research tools and methods. It focuses on developing or redesigning infrastructure in bioinformatics, instrumentation, and research methods. Projects should significantly advance biological understanding and be applicable to a wider research community. Proposals should aim at transforming biological research by either creating novel tools or adapting existing ones in meaningful ways, addressing fundamental questions in the biological sciences.

MN Commercial Redevelopment Grants 

Commercial Redevelopment grants assist with the full and selective demolition of commercial and industrial buildings and the clean-up of brownfields to pave the way for new development. 

Full and selective demolition of commercial or industrial buildings and clean-up of brownfields. Abatement expenses are eligible and considered a component of the demolition project.

Funding Availability

• Funded at $1,000,000 for Fiscal Year 2026 from the Taconite Environmental Protection Fund.
• The number of grants awarded is variable and dependent upon the amount awarded to successful applicants.
• A 1:1 match per project is required.
• In-kind materials and/or labor are not eligible toward the project match.
• Applications should be submitted within nine months of the project construction start date.
• Multi-organization collaboration is welcomed.

The Owensville Area Community Foundation Grantmaking Program supports local 501(c)(3) organizations and other IRS-approved entities in enhancing the quality of life in the Owensville area. Governed by a knowledgeable Board of Directors, this program provides flexible grantmaking tailored to community needs. Grants up to $500 are available, with a focus on non-discrimination in funding use. The program aims to empower local leaders and foster impactful community initiatives.

The Green School Works Technical Assistance Services provide crucial support for public K-12 schools in Massachusetts to advance their decarbonization goals. Eligible participants can access low- or no-cost services including comprehensive building assessments and decarbonization roadmaps, ensuring that schools can modernize their facilities effectively. This initiative not only aids in planning for energy-efficient buildings but also offers insights into renewable energy options and funding opportunities, fostering a sustainable future for educational institutions.

The Stanly County Community Foundation Grant Cycle aims to enhance local community initiatives by providing funding for projects in arts, education, healthcare, housing, and human services. Eligible applicants include 501(c)(3) nonprofits and educational organizations serving Stanly County, NC. The Foundation prioritizes measurable results and collaborative funding efforts, with grants ranging from $1,000 to $8,000. Projects promoting political views or duplicating existing services are ineligible for funding.

The Preserve Route 66 Grant Fund offers financial support to public agencies, tribal governments, and nonprofit organizations aiming to preserve historic places along Route 66. This initiative prioritizes projects that enhance underrepresented narratives, including those related to diverse communities. Grants typically range from $2,500 to $10,000, with a focus on activities that restore, rehabilitate, or educate about significant historical sites, ensuring that this iconic American highway's legacy is maintained for future generations.

The Garrison Family Foundation, established in 2006 by Shirley and Mildred Garrison, is dedicated to philanthropy in the Texas panhandle and South Plains. The Foundation supports 501(c)(3) charities in education, religion, and health, emphasizing the importance of giving and community. The Garrison's legacy promotes a culture of generosity, allowing future generations to learn the value of philanthropy while making a positive impact in their communities.

The UACF Project Grants, previously known as Mini-Grants, offer competitive funding for arts, culture, science, and history projects in Lake, Orange, Osceola, and Seminole counties. These grants aim to enhance community access and participation, foster positive change, and amplify diverse voices through various public events, performances, and educational programs. Professional artists are required to be involved, ensuring high-quality execution and community impact.

The Bee Vradenburg Foundation Grant supports equity and inclusion in the arts within the Pikes Peak region. It aims to advocate for the importance of arts education, support diverse artists and art forms, and foster resilience among local arts organizations. With a straightforward application process, the foundation encourages community engagement and partnerships, making it easier for applicants to contribute to the region's cultural landscape. Grants are reviewed quarterly, and applications are accepted year-round.

The Christine Brice Stevenson Community Charitable Trust Grant supports medical, educational, and religious organizations in South Carolina, especially in Abbeville County, Anderson County, and Due West. Grants, averaging $1,000, aim to enrich the lives of local residents. Eligibility is limited to 501(c)(3) organizations, excluding Erskine College and Erskine Seminary. The trust prioritizes initiatives that align with its mission, providing approximately four grants annually with a total giving of around $5,000.

The Louis K. Snipes Foundation for Animal Care Grant supports organizations in Tarrant County, TX, that focus on preventing cruelty to animals through various care services. With an average grant size of $38,000, the foundation prioritizes requests for capital improvements, equipment purchases, and program support. Eligible organizations must be 501(c)(3) exempt and located in Tarrant County, ensuring their efforts benefit local animals in need.

The D.S. Flikkema Foundation Scholarship, administered by the Quad Cities Community Foundation, supports graduates of Fulton High School pursuing higher education at accredited institutions. With a focus on students entering the fields of mathematics or science, this scholarship reflects the foundation's commitment to community empowerment through education. Annually, over $500,000 is awarded to help students meet their academic goals, ensuring that financial barriers do not hinder their educational aspirations.

The Charter School Facilities Credit Enhancement Grant Program, managed by the California State Treasurer's Office, aims to support charter schools in California by providing grants that fund debt service reserve accounts. This initiative is designed to lower borrowing costs for charter schools, thereby facilitating the acquisition, renovation, or construction of school facilities. Eligible applicants must demonstrate a strong financial position and utilize funds within six months of approval to ensure effective resource allocation.

The Central Energy Trust offers community grants up to $5,000 for energy-related projects in the Manawatu/Tararua regions. These grants aim to benefit local community organizations, including cultural, educational, and health initiatives. Eligible projects must promote energy conservation or support business growth. Notably, funding cannot cover annual electricity costs or short-life electronic equipment unless part of a broader energy project. This initiative reflects the Trust's commitment to enhancing energy efficiency and supporting community development.

Community Foundation of the Ozarks

The Community Foundation of the Ozarks (CFO) provides philanthropic leadership to build stronger communities. Our mission is to enhance the quality of life in our region through resource development, community grantmaking, collaboration and public leadership.

We help donors achieve their philanthropic goals through professional management and investment of charitable funds. We work with nonprofit organizations to help them fulfill their missions through fund administration, grantmaking and learning opportunities. We award scholarships to deserving students to help them achieve their educational goals.

Cabool Affiliate Grantmaking Program

The Cabool Community Foundation works to improve the quality of life for individuals in Cabool through thoughtful grantmaking and community leadership. Grant proposals are accepted according to an announced timetable, and grant recommendations are made as funds are available. 

The Hurricane Katrina 20th Anniversary Disaster Preparedness Grants, funded by the ASPCA, offer up to $500,000 to enhance disaster preparedness for animals in high-risk coastal areas of Alabama, Mississippi, and Louisiana. Grants between $20,000 and $50,000 will be awarded to eligible non-profit organizations and municipal agencies focusing on animal welfare or disaster assistance. This initiative aims to improve the safety and well-being of animals during disasters, reflecting lessons learned from past experiences.

The Berkshire Hills Fund for Excellence (BHFE) is dedicated to enhancing the educational experience for students and teachers in the Berkshire Hills Regional School District. It provides grants that cover direct project costs, prioritizing innovative proposals that rely on volunteer efforts and additional support. Applications are reviewed by a diverse board, ensuring community involvement and a focus on excellence in education.

The Truckee Core Values Event Fund, established by the Truckee Chamber of Commerce and the Tahoe Truckee Community Foundation, aims to support community events that reflect Truckee's core values: Healthy Lifestyle, Family-Friendly, Natural Beauty, Community-Mindedness, and Arts, Culture, History. Grants ranging from $500 to $2000 will be awarded to nonprofit organizations or partnerships that align with these values, fostering community engagement and enhancing local culture.

Executive Office of Economic Development, Commonwealth of Massachusetts

The Executive Office of Economic Development works to strengthen the state’s economy by supporting business growth, attracting investment, expanding economic opportunity, and helping communities across Massachusetts thrive.

Massachusetts Downtown Initiative Capital Program

This competitive program increases downtown vitality through planning and capital implementation grants to municipalities.

The Massachusetts Downtown Initiative Capital Grant Program (“MDI Capital”) strengthens the economic and cultural vitality of the Commonwealth’s downtowns, village centers, and main streets by investing in vibrant, livable centers that attract residents, stimulate business activity, and promote equitable regional growth.

Building on the foundation of the original MDI Technical Assistance program, MDI Capital helps municipalities transform their downtowns into thriving, walkable, and inclusive destinations.

MDI Capital funds the following project types: 1) Planning and 2) Implementation

Capital Planning Grants

• Downtown/Village Center Improvement Plan
• District Management Creation

MDI Capital Design Grants support communities in developing action-oriented plans to guide public investment in their downtown or village centers. These grants help communities identify and apply strategies to help drive foot traffic, attract private investment, support small business and ultimately create lively, welcoming places for people to live, work, and visit.

The Community Foundation of Harrisonburg & Rockingham County

At The Community Foundation of Harrisonburg & Rockingham County, we make it easy to give back to the community we all love through comprehensive and trusted charitable giving. We partner with donors, professional advisors and nonprofits to fund local needs through community endowments and support to charities. By expertly managing these funds in-house or with local financial advisors, we’re able to power the arts, faith-based initiatives, environmental grants, human services, domestic and wildlife animal organizations and educational initiatives that help to strengthen our community and make it a vibrant place to live and work. 

Dennis & Patricia Early Scholarship (STEM)

Dennis and Patricia Early have dedicated their lives to education and to encouraging and supporting students in every way. They taught multiple generations of the same families in Rockingham County. Patricia taught biology and chemistry and Dennis taught math.

This scholarship supports graduates of Rockingham County public high schools interested in studying math or science, or in becoming a K-12 math or science teacher. Candidates may pursue other career paths related to math and science. 

This scholarship is renewable.

The Gateway Fund Grant aims to enhance the educational experiences of students and teachers in the North Adams Public Schools. This endowed fund supports diverse projects, including independent studies, extracurricular activities, and professional development for educators. Community proposals are encouraged to ensure educational excellence, with a focus on volunteer efforts and additional support. Review criteria include project worthiness, potential impact on the community, and the applicant's ability to complete the project.

The NIAID is dedicated to advancing research on medical countermeasures against chemical and radiation threats, focusing on innovative technologies to diagnose and treat exposure effects. The initiative promotes the development of models, biomarkers, and devices that enhance survival and reduce morbidity during public health emergencies. It supports preclinical efforts to address injuries from designated Chemicals of Concern, emphasizing the need for effective solutions in civilian mass casualty scenarios.

The A.I.R. Fellowship Program, established in 1993, empowers emerging women and non-binary artists in New York City by providing them with their first solo exhibition, mentorship, and professional development opportunities. Each year, six artists benefit from a 12-month fellowship that includes workshops, curatorial support, and a stipend of $3,000, fostering an inclusive community that encourages creative exploration and dialogue among diverse artists.