Best Foundation Grants for Nonprofits in California

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

The Virtual Living Room Grant Program aims to create welcoming spaces for veterans in rural communities, providing access to advanced medical technologies via telehealth. By establishing these rooms in accessible locations, veterans can connect with VA resources without the burden of travel, ensuring they receive essential care in a comfortable environment. This initiative not only supports health access but also fosters community engagement and enhances the quality of life for our nation's heroes.

The Steven Berkeley Marine Conservation Fellowship, established by the American Fisheries Society in 2007, honors a dedicated fisheries scientist. This $15,000 award supports graduate students engaged in thesis research on marine conservation topics. Applicants must be enrolled in a North American university's M.S. or Ph.D. program and be AFS members in good standing. The fellowship encourages innovative research addressing various conservation issues, not limited to fisheries.

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

The Lakken’s Legacy Sibling Scholarship, established by the Children’s Brain Tumor Foundation, honors Lakken Burzynski's courage and resilience in her battle with cancer. This $1,000 scholarship is designed for siblings of children diagnosed with brain tumors, emphasizing support for families impacted by such challenges. Eligible applicants must be 21 or younger at diagnosis and reside in the U.S. This initiative promotes positivity and hope, continuing Lakken's legacy of strength and family support.

This grant aims to enhance global polio eradication efforts through innovative modeling approaches. It focuses on developing effective strategies for cVDPV2 outbreak response and optimizing surveillance following global WPV eradication. The initiative also seeks to build a skilled public health workforce in statistical and mathematical modeling, assess economic impacts of response strategies, and foster capacity among students to address polio and other vaccine-preventable diseases.

The O.L. Halsell Foundation, established in 1948, is dedicated to enhancing the quality of life in Orange County through targeted grants. It supports community-based organizations focused on youth, senior citizens, battered women, health services, and education. The Foundation seeks to empower individuals to take responsibility for their well-being and foster social change. By investing in local initiatives, it aims to create a brighter future for residents, reflecting its commitment to community engagement and support.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

LinkScholars Program Scholarship ($2,000) 

This renewable scholarship supports graduating high school seniors from Fairfield, Kershaw, Lexington, Richland, or Sumter counties in South Carolina.

The Imogene Coca Compassion in Care Scholarship, offered by the Delaware Community Foundation, aims to support Delaware residents pursuing degrees in nursing or medical fields. Applicants must demonstrate financial need and either have been employed for at least five years or hold an Associate's degree from a community college. This one-time award of $2,000 is part of DCF's broader commitment to enhancing educational opportunities and equity in Delaware.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Rogers and Meredith Scholarship (College) ($4,000) 

This renewable scholarship is available to students who have been residents of Epworth Children’s Home, Thornwell Home for Children or students who’ve been in custody of the South Carolina Department of Juvenile Justice. 

The Lakken’s Legacy Survivor Scholarship, offered by the Children’s Brain Tumor Foundation, awards $1,000 to brain tumor survivors pursuing education beyond high school. This initiative honors Lakken, who faced challenges during her cancer journey yet remained passionate about education. The scholarship aims to support individuals diagnosed with brain or spinal cord tumors before age 21, ensuring they have the opportunity to continue their studies in various educational institutions. It's a commitment to empower survivors and foster their dreams.

The Annunziata Sanguinetti Foundation Grant provides year-round support for organizations focused on the care, treatment, rehabilitation, or education of children with physical or mental handicaps in San Francisco, California. Eligible entities must be 501(c)(3) organizations dedicated to serving children ages 21 and under. The program emphasizes educational, health, and human services, ensuring a better quality of life for affected youth, while excluding specific entities like Shriners Hospitals.

The Native Forward CPA Examination Funding provides crucial financial assistance to American Indians and Alaska Natives for covering the costs associated with the CPA examination. This initiative empowers students and professionals to pursue CPA licensure by assisting with application, registration, and exam fees. Eligible applicants can receive support for one section of the exam at a time, ensuring access to essential resources for advancing their careers and contributing positively to their communities.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Washington County 4-H Dairy Scholarship

Established to support post-secondary scholarships to participants in Washington County 4-H dairy programs.

The Native Forward Direct Scholarship supports American Indian and Alaska Native students by providing mid-year funding opportunities to alleviate educational costs. With over 50 years of experience, Native Forward has empowered more than 22,000 students from diverse backgrounds. This scholarship recognizes the limited access these students face in higher education and aims to enhance their academic journeys while fostering community engagement and mentorship through a strong alumni network.

Parkview Legacy Foundation

The Parkview Legacy Foundation was created in July of 2019 by the sale of Parkview Community Hospital Medical Center (a non-profit hospital) to AHMC (a for-profit hospital group). With the sale, the State of California required that the proceeds of the non-profit hospital be put to use for the benefit of the community through the creation of non-profit public charity or private foundation. The Parkview Legacy Foundation is the result of that transaction, and Parkview Legacy Foundation now exists as an independent Public Charity serving the Riverside region. With the funds endowed to the foundation, we are honored to invest back into the local community with a broader scope of ensuring the equitable probability of wellness through social determinants of health.

Parkview Legacy Foundation is committed to support organizations, collaborations, and initiatives that directly address the root causes which negatively affect the four focus areas of housing stability, social mobility, whole health accessibility, and integrated solutions, and therefore, prevent residents of the Inland Region from achieving wellness and stability. 

Collective Impact Grant

Parkview Legacy Foundation’s Impact Grants Program is driven by our core values and intended to support organizations seeking to make transformational progress in addressing needs and seizing opportunities in our four focus areas throughout the Riverside region.   

Collective Impact funding is intended to support the advancement of efforts toward specific and stated objectives (goals, outcomes, and/or impacts) being carried forth by strategically coordinated and operated multi-sector collaborations and initiatives involving multiple organizations and/or institutions. Examples of ways the Collective Impact Grant may be used include:

• funding the operations of a backbone organization for the effort,
• providing participation funding to the participating organizations to help sustain the effort, and
• paying consultants or partner organizations to accomplish specific tasks on behalf of the effort.  

The NIDCD Research Career Enhancement Award for Established Investigators (K18) supports seasoned researchers in enhancing or redirecting their research through new skills acquisition. This funding opportunity addresses critical questions in hearing, balance, smell, taste, voice, speech, and language sciences. Key deadlines for applications span from June 2024 to February 2027, ensuring ample opportunity for researchers to apply and contribute to these vital fields.

The NIDCD Research Career Enhancement Award (K18) supports established investigators in enhancing or redirecting their research efforts. This program is crucial for acquiring new skills relevant to hearing, balance, smell, taste, voice, speech, and language sciences. Key deadlines for applications span from June 2024 to February 2027, including specific dates for AIDS-related grants, ensuring timely funding opportunities for innovative research.

The Audrey Hillman Fisher Foundation Grant aims to enhance health and healing for communities through investments in the arts, education, human services, and environmental initiatives. With a focus on Pittsburgh, PA, Santa Barbara, CA, and Squam Lakes, NH, the foundation accepts grant applications year-round, with deadlines of January 5 for June funding and July 1 for November funding. The foundation prioritizes projects from new organizations within these regions.

The C. Edward and Edith Strobel Charitable Trust Grant aims to support conservation and health-related initiatives in the San Francisco Bay Area. Established in 1968, this foundation honors the legacy of its founders, Carolus Edward and Edith McCammon Strobel, who tragically lost their lives in an accident. The trust primarily funds medical research for children's diseases and heart and lung health, along with various environmental and animal welfare projects.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Washington County 4-H Livestock/Market Sale Scholarship

Established to support post-secondary scholarships to participants in Washington County 4-H Livestock and Market Sale programs.

The A.D. and Peggy Hewlett and Colonel David R. Inman Medical Scholarship, established by Steve Hewlett, Pam Inman, and Faye Houston, honors their parents' commitment to education and healthcare. This scholarship supports students pursuing nursing, pharmacy, or physical therapy, prioritizing applicants from Hancock, Ohio, or Daviess County, Kentucky. Applicants must demonstrate academic potential and compassion through relevant experiences. The Community Foundation of Middle Tennessee administers this fund to foster a more inclusive and thriving community.

The National Parks Business Plan Internship aims to enhance the operational health of national parks through a graduate-level program that trains students in business management and NPS operations. Participants will engage in substantive analysis, gain insights into park management, and promote federal careers in conservation. This initiative seeks to involve underrepresented graduate students from disciplines such as business administration and public policy, fostering a commitment to stewardship of public lands.

Parkview Legacy Foundation

The Parkview Legacy Foundation was created in July of 2019 by the sale of Parkview Community Hospital Medical Center (a non-profit hospital) to AHMC (a for-profit hospital group). With the sale, the State of California required that the proceeds of the non-profit hospital be put to use for the benefit of the community through the creation of non-profit public charity or private foundation. The Parkview Legacy Foundation is the result of that transaction, and Parkview Legacy Foundation now exists as an independent Public Charity serving the Riverside region. With the funds endowed to the foundation, we are honored to invest back into the local community with a broader scope of ensuring the equitable probability of wellness through social determinants of health.

Parkview Legacy Foundation is committed to support organizations, collaborations, and initiatives that directly address the root causes which negatively affect the four focus areas of housing stability, social mobility, whole health accessibility, and integrated solutions, and therefore, prevent residents of the Inland Region from achieving wellness and stability.

Core Operations and Capacity Impact Grant

Parkview Legacy Foundation’s Impact Grants Program is driven by our core values and intended to support organizations seeking to make transformational progress in addressing needs and seizing opportunities in our four focus areas throughout the Riverside region.   

Core Operations and Capacity funding is intended to support the advancement of the organization’s mission toward specific and stated objectives (goals, outcomes, and/or impact) through use of the funding by the organization in whatever way they deem necessary to do so (excluding prohibited uses). Examples of ways organizations may choose to use the Core Operations and Capacity Impact Grant include: funding a reserves fund, covering indirect costs, covering direct costs, seeding a new program or project.  

The Harry Sudakoff Foundation Grant supports qualified charities in Sarasota, Florida, focusing on arts, community, education for youth, environment, human services, and science. Established by builder Harry Sudakoff, the foundation prioritizes organizations with a history of support. Grants are restricted to 501(c)(3) entities, excluding individuals and certain funding types like endowments and operating expenses. A commitment to impactful contributions is central to the foundation's mission.